Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…Our findings indicate that Smads and SMA-9/Schnurri have previously unappreciated complex genetic and genomic regulatory interactions that in turn regulate the secretion of extracellular components like collagen into the cuticle to mediate body size regulation.…”
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Analysis of the Propagation Characteristics of Meteorological Drought to Hydrological Drought and Their Joint Effects on Low-Flow Drought Variability in the Oum Er Rbia Watershed,... by Ismaguil Hanadé Houmma, Abdessamad Hadri, Abdelghani Boudhar, Ismail Karaoui, Sabir Oussaoui, El Mahdi El Khalki, Abdelghani Chehbouni, Christophe Kinnard

“…Thus, by exploring for the first time the complex interactions among the severity of low-flow regimes, meteorological and hydrological drought indices and meteorological factors, this study provides a new perspective for understanding the characteristics of propagation from meteorological to severe hydrological drought.…”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Therefore, integrative multifaceted approaches are crucial to understanding the complex nature of cancer biology. Bcl-2 (B-cell lymphoma 2), encoded by the human Bcl-2 gene, is a critical anti-apoptotic protein that regulates cell death pathways, primarily by inhibiting apoptosis. …”
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Peculiar Dust Emission within the Orion Molecular Cloud by Parisa Nozari, Sarah Sadavoy, Edwige Chapillon, Brian Mason, Rachel Friesen, Ian Lowe, Thomas Stanke, James Di Francesco, Thomas Henning, Qizhou Zhang, Amelia Stutz

“…Recent studies of the Orion Molecular Cloud (OMC) 2/3 complex, however, show a flattening in the spectral energy distribution (SED) at λ > 2 mm, implying nonconstant indices on scales ≳0.08 pc. …”
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Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards by Cosima Strantz, Dominik Böhm, Thomas Ganslandt, Melanie Börries, Patrick Metzger, Thomas Pauli, Andreas Blaumeiser, Alexander Scheiter, Ian-Christopher Jung, Jan Christoph, Iryna Manuilova, Konstantin Strauch, Arsenij Ustjanzew, Niklas Reimer, Hauke Busch, Philipp Unberath

“…Abstract Background Molecular tumor boards (MTBs) play a pivotal role in personalized oncology, leveraging complex data sets to tailor therapy for cancer patients. …”
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ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling by Man Sup Kwak, Myeonggil Han, Yong Joon Lee, Seoyeon Choi, Jeonghwa Kim, In Ho Park, Jeon-Soo Shin

“…Many cellular proteins form homo- or hetero-oligomeric complexes through dimerization, and ligand oligomerization is crucial for inducing receptor oligomerization. …”
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Functional Verification of Differentially Expressed Genes Following DENV2 Infection in <i>Aedes aegypti</i> by Xiaoli Chen, Xinyu Zhou, Xiaoxue Xie, Bo Li, Teng Zhao, Haotian Yu, Dan Xing, Jiahong Wu, Chunxiao Li

“…In this study, to assess the role of genes related to DENV2 replication, and transient transfection and overexpression models in Aag2 cells and mosquito gene knockdown models were established, and five genes, defensin-A, defensin-A-like, SMCT1, UGT2B1, and ND4, were found to have an impact on the replication of DENV2, providing a reference basis for studying the complex mechanism of mosquito–virus interactions.…”
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How Does Listening to “Fetal Heartbeats” Affect the Feelings of Pregnant Women? by Mehmet Sinan Beksac, Canan Unal, Burcu Yalaniz, Murat Cagan, Atakan Tanacan, Erdem Fadiloglu, Hanife Guler Donmez

“…Demographic variables, feelings in response to listening to FHBs (negative, neutral, positive), grade mark (0-10) of feelings, color (warm, neutral, cold), and figure (simple, complex) preferences were retrospectively evaluated. …”
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Photometric Determination of Unresolved Main-sequence Binaries in the Pleiades: Binary Fraction and Mass-ratio Distribution by Rongrong Liu, Zhengyi Shao, Lu Li

“…The variations of f _b and q with ${{ \mathcal M }}_{1}$ reveal a complex binary distribution within the Pleiades, which might be attributed to a combination of primordial binary formation mechanisms, dynamical interactions, and the observational limit of photometric binaries imposed by ${q}_{{\rm{lim}}}({{ \mathcal M }}_{1})$ .…”
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Using Days Alive and Out of Hospital to measure inequities and explore pathways through which inequities emerge after coronary artery bypass grafting in Aotearoa New Zealand: a sec... by Sarah-Jane Paine, Luke Boyle, Alan Forbes Merry, Elana Curtis, Thomas Lumley, Jade Tamatea

“…Importantly, our results illustrate the value of DAOH as a sophisticated outcome metric that can reflect the complex and accumulative impacts of disadvantage and discrimination faced by Indigenous peoples both here in New Zealand and worldwide. …”
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Lopinavir and Ritonavir have High Affinity Toward the SARS-CoV-2 S-protein Receptor-binding Domain Sequenced in Brazil by Aline Diogo Marinho, Helyson Lucas Bezerra Braz, João Alison de Moraes Silveira, Danilo Galvão Rocha, Roberta Jeane Bezerra Jorge, Geanne Matos de Andrade

“…Ritonavir showed a binding affinity of −8.9 kcal/mol, interacting with residues ARG148, ASN130, VAL23, SER81, ASN33, PHE29, TYR33, SER31, ASN132, ALA26, ALA30, ALA34, and TYR133.Molecular dynamics simulations confirmed the stability of the complexes formed between lopinavir and ritonavir and the RBD active site. …”
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Follicular Occlusion Syndrome — a Possible Option of Follicular-Retension Origin of Pilonidal Sinus by D. D. Shlyk, M. N. Pikuza, Yu. E. Kitsenko, A. S. Pirogova, N. B. Paramonova, R. T. Rzaev, N. P. Teplyuk, P. V. Tsarkov

“…Deroofing of the lining of the cavity, often used in dermatologic practice, along with complex treatment within the framework of multidisciplinary (together with a dermatologist) management of patients with FOS, looks promising.…”
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An Investigation of Infrared Small Target Detection by Using the SPT–YOLO Technique by Yongjun Qi, Shaohua Yang, Zhengzheng Jia, Yuanmeng Song, Jie Zhu, Xin Liu, Hongxing Zheng

“…To detect and recognize small-size and submerged complex background targets in infrared images, we combine a dynamic receptive field fusion strategy and a multi-scale feature fusion mechanism to improve the detection performance of small targets significantly. …”
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Hubble Space Telescope Observations within the Sphere of Influence of the Powerful Supermassive Black Hole in PKS 0745-191 by Julie Hlavacek-Larrondo, Hyunseop Choi, Minghao Guo, Annabelle Richard-Laferrière, Carter Rhea, Marine Prunier, Helen Russell, Andy Fabian, Jonelle L. Walsh, Marie-Joëlle Gingras, Brian McNamara, Steve Allen, André-Nicolas Chené, Alastair Edge, Marie-Lou Gendron-Marsolais, Michael McDonald, Priyamvada Natarajan, Jeremy Sanders, James F. Steiner, Benjamin Vigneron, Anja von der Linden

“…These results provide valuable insights into the complex mechanisms driving galaxy evolution, highlighting the intricate relationship between SMBH fueling and AGN feedback within the host galaxy.…”
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The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review by Yajia Cheng, Yue Shang, Shuqin Zhang, Saijun Fan

“…The diverse radiation types in medical treatments and the natural environment elicit complex biological effects on both cancerous and non-cancerous tissues. …”
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Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

“…Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disease associated with metabolic comorbidities. …”
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An in vitro study on comparative evaluation of shear bond strength of bioactive composite to tooth structure with various dentin conditioning agents by Priyanka Pokkula, Shaik Mohammed Asif, Abdullah Alqarni, Shahabe Saquib Abullais, Shaik Mohamed Shamsudeen, Syed M Yassin, Abosofyan S. Atta, Wahaj Ahmad Khan

“…A potent resin hydroxyapatite complex is formed due to ionic interaction, further preventing microleakage. …”
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Dynamic changes in soil erosion and challenges to grain productivity in the black soil region of Northeast China by Jiawang Zhang, Ming Wang, Kai Liu, Zhan’ao Zhao

“…The average thickness of soil complex erosion reached 48.48 mm/a, affecting 25.23 million hectares and 1.90 million tons grain yield. …”
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The Temporal and Spatial Evolution of Flow Heterogeneity During Water Flooding for an Artificial Core Plate Model by Chen Jiang, Qingjie Liu, Kaiqi Leng, Zubo Zhang, Xu Chen, Tong Wu

“…In the process of reservoir water flooding development, the characteristics of underground seepage field have changed, resulting in increasingly complex oil–water distribution. The original understanding of reservoir physical property parameters based on the initial stage of development is insufficient to guide reservoir development efforts in the extra-high water cut stage. …”
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First whole genome report of Mangrovibacter phragmitis PSU-3885–11 isolated from a patient in Thailand by Nattarika Chaichana, Thunchanok Yaikhan, Mingkwan Yingkajorn, Nonthawat Thepsimanon, Sirikan Suwannasin, Kamonnut Singkhamanan, Sarunyou Chusri, Rattanaruji Pomwised, Monwadee Wonglapsuwan, Komwit Surachat

“…This isolate was initially misidentified as part of the Enterobacter cloacae complex (ECC) by MALDI-TOF. However, WGS subsequently confirmed its correct identity as M. phragmitis. …”
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