Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy by Atsushi Musha, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Masahiro Onishi, Takeru Ohtaka, Midori Tamura, Osamu Nikkuni, Yuichi Tomidokoro, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno

“…Conclusion: Our findings highlight the importance for considering disease-specific characteristics and the need for developing targeted strategies that address the complex nature of HN-ACC, particularly in cases involving PNTS, to enhance treatment outcomes and potentially reduce recurrence rates.…”
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Insights from the single-cell level: lineage trajectory and somatic-germline interactions during spermatogenesis in dwarf surfclam Mulinia lateralis by Yajuan Li, Huilan Wei, Xiaoting Dai, Lijing Zhang, Liangjie Liu, Xiaomei Chen, Tian Liu, Ya Shu, Yaxin Yang, Shi Wang, Zhenmin Bao, Lingling Zhang

“…Abstract Background Spermatogenesis is a complex process of cellular differentiation that commences with the division of spermatogonia stem cells, ultimately resulting in the production of functional spermatozoa. …”
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Leishmania mexicana: Novel Insights of Immune Modulation through Amastigote Exosomes by Laura Enedina Soto-Serna, Mariana Diupotex, Jaime Zamora-Chimal, Adriana Ruiz-Remigio, José Delgado-Domínguez, Rocely Buenaventura Cervantes-Sarabia, Adriana Méndez-Bernal, Alma Reyna Escalona-Montaño, María Magdalena Aguirre-García, Ingeborg Becker

“…Expressions of antigen-presenting (major histocompatibility complex class I, MHC-I, and CD1d) and costimulatory (CD86 and PD-L1) molecules were modulated in a dose-dependent fashion. …”
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Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis by Levent Kart, Hakan Buyukoglan, Ishak O. Tekin, Remzi Altin, Zuhal Senturk, Inci Gulmez, Ramazan Demir, Mustafa Ozesmi

“…The precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. …”
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Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…Under various fibrogenetic conditions, shedding of syndecan’s extracellular domain took place, becoming a soluble form that binds different growth factors and inhibits further fibrosis. This complex molecule is also involved in the lipid metabolism, by altering the clearance of cholesterol particles, and in chronic hepatitis, by enhancing the viral invasion of hepatocytes. …”
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A framework for dynamic assessment of soil erosion and detection of driving factors in alpine grassland ecosystems using the RUSLE-InVEST (SDR) model and Geodetector: A case study... by Hucheng Li, Jianjun Chen, Ming Ling, Zizhen Chen, Yanping Lan, Qinyi Huang, Xinhong Li, Haotian You, Feng Wang, Xiaowen Han, Guoqing Zhou

“…The results indicated that: (1) From 2000 to 2020, the soil erosion intensity in the SRYR exhibited an overall declining trend, despite some fluctuations, with areas of slight erosion (< 5 t/(hm2·a)) accounting for over 78 % of the region; (2) The multi-year average SDR was below 15 %, with erosion-prone areas primarily located in the central region of the SRYR and topographically complex edge regions; (3) The areas where soil erosion had significantly improved were mainly located in the western half of the SRYR. …”
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Students’ Perspectives on Learning Practical Nursing Skills: A Focus Group Study in Norway by A. G. Gregersen, M. T. Hansen, S. E. A. Brynhildsen, V. A. Grøndahl, A. C. Leonardsen

“…Practical nursing skills are complex and involve technical, theoretical, and practical aspects, caring perspectives adjusted to both patient and circumstances, as well as ethical and moral considerations. …”
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Optimizing Image Feature Extraction with Convolutional Neural Networks for Chicken Meat Detection Applications by Azeddine Mjahad, Antonio Polo-Aguado, Luis Llorens-Serrano, Alfredo Rosado-Muñoz

“…This highlights the potential of CNNs, especially when combined with advanced architectures, for efficient detection and analysis of complex food matrices. In conclusion, these techniques can be applied to food quality control and other detection and analysis domains.…”
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Novel Genomic Aberrations in Testicular Germ Cell Tumors by Array-CGH, and Associated Gene Expression Changes by Rolf I. Skotheim, Reija Autio, Guro E. Lind, Sigrid M. Kraggerud, Peter W. Andrews, Outi Monni, Olli Kallioniemi, Ragnhild A. Lothe

“…Introduction: Testicular germ cell tumors of adolescent and young adult men (TGCTs) generally have near triploid and complex karyotypes. The actual genes driving the tumorigenesis remain essentially to be identified. …”
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Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“…This study aims to explore the educational and healthcare challenges faced by this community, as perceived by its members, to gain deeper insight into the complexities of their lived experiences. Methodology:  This qualitative study conducted in-depth interviews with ten hijra individuals from three areas in Lahore, Pakistan. …”
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Tribological behaviors of AZ91D magnesium alloy under the lubrication of oil suspended synthetic magnesium silicate hydroxide nanotubes by Y.L. Yin, H.L. Yu, H.M. Wang, X.C. Ji, Z.Y. Song, X.Y. Zhou, M. Wei, P.J. Shi, W. Zhang, C.F. Zhao

“…A dense tribolayer with a complex composition and composite structure was formed on the worn surface. …”
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Investigation of the influence of the heterogeneous structure of concrete on its strength by V.M. Volchuk, M.A. Kotov, Ye G. Plakhtii, O.A. Tymoshenko, O.H. Zinkevych

“…Results of the analysis of complex and separate influence of statistical characteristics on the indicators of the breaking load of concrete are shown with regression linear models. …”
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Case report: Deciphering the clinical significance of a novel partial BRCA1 exon 10 duplication in a patient with triple-negative breast cancer by Alice Faversani, Debora Manuelli, Davide Barteselli, Giulia Melloni, Carlo Santaniello, Luigi Corsaro, Luigi Corsaro, Davide Sacco, Davide Sacco, Davide Clerici, Laura Gargiulo, Fulvio Ferrara, Lucy Costantino

“…Although new ClinGen ENIGMA guidelines have been produced to provide tools for the accurate interpretation of variants in the BRCA1 and BRCA2 genes, defining the clinical significance of copy number variants, particularly duplications, remains a challenging goal that requires complex approaches to accurately determine the role of such variants. …”
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Research trends and prospects in global riverine carbon fluxes: A bibliometric analysis by Wei Fang, Mohd Remy Rozainy Mohd Arif Zainol, Xianbao Zha, Pingping Luo

“…The analysis of keywords demonstrates that current study on RCFs mainly focus on monitoring the fluxes of multiple forms of carbon in the fluvial systems, modeling the fluxes of riverine carbon at larger scales, elaborating the complex biogeochemical processes of riverine carbon transport. …”
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Novel insights into palatal shelf elevation dynamics in normal mouse embryos by Jeremy P. Goering, Michael Moedritzer, Marta Stetsiv, Dona Greta Isai, Brittany M. Hufft-Martinez, An J. Tran, Zaid Umar, Madison K. Rickabaugh, Paul Keselman, Munish Chauhan, Pamela V. Tran, William M. Brooks, William M. Brooks, Kenneth J. Fischer, Andras Czirok, Andras Czirok, Irfan Saadi, Irfan Saadi

“…Current models indicate that this elevation process involves a complex vertical-to-horizontal PS reorientation. While earlier studies have implied that reorientation occurs rapidly, the precise timing has not been resolved. …”
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Effects of floodplain decoupling on taxonomic and functional diversity of terrestrial floodplain organisms by Franziska Wenskus, Christian Hecht, Daniel Hering, Kathrin Januschke, Georg Rieland, Andrea Rumm, Mathias Scholz, Arnd Weber, Peter Horchler

“…Our results underscore the complex responses of different organism groups to differences in river-floodplain connectivity and suggest that floodplain specialist species of less mobile groups are disproportionately negatively affected by floodplain decoupling, contrary to the flight-active carabids. …”
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Qualitative focus group study investigating experiences of accessing and engaging with social care services: perspectives of carers from diverse ethnic groups caring for stroke sur... by Geoffrey Cloud, Nan Greenwood, Jess Holley, Theresa Ellmers, Gill Mein

“…Many themes were common to all the included ethnic groups but some related to specific groups.Conclusions Across ethnic groups there were many similarities in the experiences of people caring for stroke survivors with complex, long-term care needs. Accessing services demands effort and persistence on carers’ part. …”
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Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice by Weimin Guo, Nicholas Crossland, Jimmy W. Crott

“…To date, preclinical models have only evaluated specific MED diet components and therefore, although supportive, fall short of confirming the chemoprotective capacity of this complex dietary pattern. We sought to address this gap. …”
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Morphological typification ofel negro stream in its lower basin. Ventania system, argentina by Alicia M. Campo, Verónica Gil, Guadalupe Ybarra Alcaráz, Antonela Volonté

“…Rivers are natural, dynamic and complex systems. Its main function is the transportation of water, sediments and nutrients, conforming areas of great ecological and territorial value. …”
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Acute Angiographic and Intermediate-Term Clinical Results of Patients with Non-Left Main Coronary Bifurcation Lesions Treated with BVS by Jailed Semi-Inflated Balloon Technique and... by Chieh-Shou Su, Keng-Hao Chang, Chih-Hung Lai, Yu-Wei Chen, Tzu-Hsiang Lin, Hung-Chih Pan, Tsun-Jui Liu, Wen-Lieng Lee

“…Our study results demonstrate that JSIBT might be a safe and alternative SB protection tool for BVS in patients with complex CABD.…”
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