Biogeography and complex traits: dispersal syndromes, in the sea by Michael N Dawson

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Variants affecting exon skipping contribute to complex traits. by Younghee Lee, Eric R Gamazon, Ellen Rebman, Yeunsook Lee, Sanghyuk Lee, M Eileen Dolan, Nancy J Cox, Yves A Lussier

“…DNA variants that affect alternative splicing and the relative quantities of different gene transcripts have been shown to be risk alleles for some Mendelian diseases. However, for complex traits characterized by a low odds ratio for any single contributing variant, very few studies have investigated the contribution of splicing variants. …”
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Sensitivity to Photoperiod Is a Complex Trait in Camelina sativa by Bryan A. Ramirez‐Corona, Erin Seagren, Carissa Sherman, Takato Imaizumi, Christine Queitsch, Josh Cuperus

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Trade-offs in modeling context dependency in complex trait genetics by Eric Weine, Samuel Pattillo Smith, Rebecca Kathryn Knowlton, Arbel Harpak

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Genetic effects on molecular network states explain complex traits by Matthias Weith, Jan Großbach, Mathieu Clement‐Ziza, Ludovic Gillet, María Rodríguez‐López, Samuel Marguerat, Christopher T Workman, Paola Picotti, Jürg Bähler, Ruedi Aebersold, Andreas Beyer

Subjects: “…complex traits…”
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regionalpcs improve discovery of DNA methylation associations with complex traits by Tiffany Eulalio, Min Woo Sun, Olivier Gevaert, Michael D. Greicius, Thomas J. Montine, Daniel Nachun, Stephen B. Montgomery

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An integrative approach to prioritize candidate causal genes for complex traits in cattle. by Mohammad Ghoreishifar, Iona M Macleod, Amanda J Chamberlain, Zhiqian Liu, Thomas J Lopdell, Mathew D Littlejohn, Ruidong Xiang, Jennie E Pryce, Michael E Goddard

“…Genome-wide association studies (GWAS) have identified many quantitative trait loci (QTL) associated with complex traits, predominantly in non-coding regions, posing challenges in pinpointing the causal variants and their target genes. …”
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Comparing statistical learning methods for complex trait prediction from gene expression. by Noah Klimkowski Arango, Fabio Morgante

“…Accurate prediction of complex traits is an important task in quantitative genetics. …”
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Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs by Lei Liu, Guoqiang Yi, Yilong Yao, Yuwen Liu, Jiang Li, Yalan Yang, Mei Liu, Lingzhao Fang, Delin Mo, Longchao Zhang, Yonggang Liu, Yongchao Niu, Liyuan Wang, Xiaolu Qu, Zhangyuan Pan, Lei Wang, Muya Chen, Xinhao Fan, Yun Chen, Yongsheng Zhang, Xingzheng Li, Zhen Wang, Yijie Tang, Hetian Huang, Pengxiang Yuan, Yuying Liao, Xinjian Li, Zongjun Yin, Di Liu, Dongjie Zhang, Quanyong Zhou, Wangjun Wu, Jicai Jiang, Yahui Gao, George E. Liu, Lixian Wang, Yaosheng Chen, Kui Li, Martien A. M. Groenen, Zhonglin Tang

“…Abstract The genetic basis of complex traits and phenotypic differentiation remains unclear in pigs. …”
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The evolution of hemostasis genetics: from monogenic disorders to complex traits. A historical perspective by Augusto Di Castelnuovo

“… The genetics of hemostasis factors has evolved over the past five decades, transitioning from the study of rare Mendelian disorders to the exploration of complex traits influencing cardiovascular disease risk. …”
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Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits. by Ruth Johnson, Kathryn S Burch, Kangcheng Hou, Mario Paciuc, Bogdan Pasaniuc, Sriram Sankararaman

“…The number of variants that have a non-zero effect on a trait (i.e. polygenicity) is a fundamental parameter in the study of the genetic architecture of a complex trait. Although many previous studies have investigated polygenicity at a genome-wide scale, a detailed understanding of how polygenicity varies across genomic regions is currently lacking. …”
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Genomic prediction in Persian walnut: Optimization levers according to genetic architecture of complex traits by Anthony Bernard, Juliette Bénéjam, Morgane Roth, Fabrice Lheureux, Elisabeth Dirlewanger

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Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping. by Yoshitaka Nagamine, Ricardo Pong-Wong, Pau Navarro, Veronique Vitart, Caroline Hayward, Igor Rudan, Harry Campbell, James Wilson, Sarah Wild, Andrew A Hicks, Peter P Pramstaller, Nicholas Hastie, Alan F Wright, Chris S Haley

“…The limited proportion of complex trait variance identified in genome-wide association studies may reflect the limited power of single SNP analyses to detect either rare causative alleles or those of small effect. …”
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Leveraging eQTLs to identify individual-level tissue of interest for a complex trait. by Arunabha Majumdar, Claudia Giambartolomei, Claudia Giambartolomei, Na Cai, Tanushree Haldar, Tommer Schwarz, Michael Gandal, Jonathan Flint, Bogdan Pasaniuc

“…Genetic predisposition for complex traits often acts through multiple tissues at different time points during development. …”
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Comprehensive multi‐tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding by Deyin Zhang, Jiangbo Cheng, Xiaolong Li, Kai Huang, Lvfeng Yuan, Yuan Zhao, Dan Xu, Yukun Zhang, Liming Zhao, Xiaobin Yang, Zongwu Ma, Quanzhong Xu, Chong Li, Xiaojuan Wang, Chen Zheng, Defu Tang, Fang Nian, Xiangpeng Yue, Wanhong Li, Huibin Tian, Xiuxiu Weng, Peng Hu, Yuanqing Feng, Peter Kalds, Zhihua Jiang, Yunxia Zhao, Xiaoxue Zhang, Fadi Li, Weimin Wang

“…Overall, this research provides foundational resources and a successful case for future investigations of complex traits in sheep through the integration of multi‐omics data sets.…”
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Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line by Xiaoning Zhu, Chong Li, Chenglong Luo, Zhonghao Bai, Dingming Shu, Peng Chen, Jiangli Ren, Ran Song, Lingzhao Fang, Hao Qu, Yuzhe Wang, Xiaoxiang Hu

“…Abstract Complex traits exhibit a highly polygenic architecture that complicates gene mapping and molecular characterization. …”
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Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice. by Jon Krohn, Doug Speed, Rupert Palme, Chadi Touma, Richard Mott, Jonathan Flint

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Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits by Jeffrey Okamoto, Xianyong Yin, Brady Ryan, Joshua Chiou, Francesca Luca, Roger Pique-Regi, Hae Kyung Im, Jean Morrison, Charles Burant, Eric B. Fauman, Markku Laakso, Michael Boehnke, Xiaoquan Wen

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Economic Characters and Heritability Analysis of F2 and F3 Progeny of Larimichthys crocea With Complex Traits by HUANG Weiqing, ZHANG Yi, LIU Zheng, CHEN Qiongjun, ZENG Zhikun, YE Huiling, XIAO Yipeng, ZHOU Zhenping

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Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens by Fangren Lan, Xiqiong Wang, Qianqian Zhou, Xiaochang Li, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Guiqin Wu, Guangqi Li, Yiyuan Yan, Ning Yang, Congjiao Sun

“…Conclusions Our findings highlighted a novel concept of $${r}_{b}^{2}$$ r b 2 to quantify the phenotypic variance attributed to gene expression and emphasize the superior role of intestinal mucosal gene expressions over host genomic variations in elucidating host‒microbe interactions for complex traits. This understanding could assist in devising strategies to modulate host–microbe interactions, ultimately improving economic traits in chickens. …”
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