Chromosome synapsis, recombination and epigenetic modification in rams heterozygous for metacentric chromosome 3 of the domestic sheep Ovis aries and acrocentric homologs of the ar... by T. I. Bikchurina, E. K. Tomgorova, A. A. Torgasheva, V. A. Bagirov, N. A. Volkova, P. M. Borodin

“…The karyotypes of argali and domestic sheep differ for a Robertsonian translocation, which occurred in the common ancestor of mouflon and domestic sheep (Ovis aries) due to the centric fusion of chromosomes 5 and 11 of the argali (O. ammon) into chromosome 3 of sheep. …”
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Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…Yet, administering differentiation biomolecules through conventional scaffolds poses a persistent challenge. Alginate (Alg) is commonly employed in CTE for its biocompatibility, though it lacks sufficient mechanical properties. …”
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Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU by Hirsh Makhija, Kyle Digrande, Omar Awan, Russell G. Buhr, Rajan Saggar, Victoria Ramirez, Rainbow Tarumoto, Janelle M. Fine, Atul Malhotra, Dale M. Needham, Jennifer L. Martin, Biren B. Kamdar

“…<b>Background/Objectives:</b> Although delirium is common during critical illness, standard-of-care detection and prevention practices in real-world intensive care unit (ICU) settings remain inconsistent, often due to a lack of provider education. …”
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Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…Background: Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. …”
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Heterogeneity of Treatment Effects of Laser Epilation on Pilonidal Disease Recurrence: A Randomized Clinical Trial by Katherine C. Bergus, MD, MPH, Carley Lutz, BS, Jennifer Cooper, PhD, Lindsey Asti, PhD, MPH, Lindsay Gil, MD, MPH, Cory Criss, MD, Katherine J. Deans, MD, MHSc, Peter C. Minneci, MD, MHSc

“…Pilonidal disease is a common, painful disease affecting 1% of the population aged 15 to 30 years with postoperative recurrence rates as high as 30% to 40%. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Moreover, increased levels of markers associated with epithelial–mesenchymal transition (EMT) and fibrosis (TNF-α, Acta2, IL-1β, and MMP9), as well as elevated levels of TGF-β, a common downstream signaling factor of TLR4 and PPAR-γ, were identified. …”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

“…As recommended, L. brevis should be commonly distributed as a postbiotic GABA in pharmaceutical and nutritional applications.…”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Abstract Background Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are the pathogenetic events most commonly occurring in myelofibrosis (MF). There is great evidence indicating that tumor microenvironment is characterized by high lactate levels, acting not only as an energetic source, but also as a signaling molecule. …”
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Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma by Amir Hossein Alizadeh Bahmani, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Corinna Bang, Susanne Brandstetter, Paula Corcuera-Elosegui, Andre Franke, Mario Gorenjak, Susanne Harner, Parastoo Kheiroddin, Leyre López-Fernández, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Antoaneta A. Toncheva, Christine Wolff, Michael Kabesch, Aletta D. Kraneveld, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, on behalf of the SysPharmPediA consortium

“…<b>Background/Objectives</b>: Metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. …”
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Body mass index and B‐lines on lung ultrasonography in chronic and acute heart failure by Philip Brainin, Brian Claggett, Eldrin F. Lewis, Kristin H. Dwyer, Allison A. Merz, Montane B. Silverman, Varsha Swamy, Tor Biering‐Sørensen, Jose Rivero, Susan Cheng, John J.V. McMurray, Scott D. Solomon, Elke Platz

“…Abstract Aims Increased body mass index (BMI) is common in heart failure (HF) patients and is associated with lower levels of N‐terminal pro‐brain natriuretic peptide (NT‐proBNP). …”
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Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination by Yingling Liu, Yuli Cai, Si Chen, Yawen Gou, Qiaomin Wang, Mingli Zhang, Yetao Wang, Haiou Hong, Kaiguang Zhang

“…History of antibiotic misuse and H. pylori infection showed significant associations with LGIN (odds ratio OR=6.767, 95% confidence interval (CI) 3.873-11.825 and OR=3.803, 95% CI 3.009-4.808, respectively). The most common endoscopic classification of LGIN was erosive gastritis (50.78%), and the major endoscopic appearance was Paris IIa (flat with slight elevation located mostly in the antrum). …”
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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…Objective Thalassaemia is the most common inherited blood disorder in Malaysia. This study aims to report the current status of thalassaemia in Malaysia and provide a comprehensive understanding of the disease through data obtained from the Malaysian Thalassaemia Registry.Design Data were extracted from the Malaysian Thalassaemia Registry, a web-based system accessible to enrolled users through www.mytalasemia.net.my.Setting The Malaysian Thalassaemia Registry data was recorded from reports obtained from 110 participating government and university hospitals in Malaysia.Participants The patients were those attending the 110 participating hospitals for thalassaemia treatment.Intervention Data were collected from the Malaysian Thalassaemia Registry from 2007 until the fourth quarter of 2018.Primary outcome measure 7984 out of 8681 patients with thalassaemia registered in the Malaysian Thalassaemia Registry were reported alive.Results Majority of the patients were reported in the state of Sabah (22.72%); the largest age group affected was 5.0–24.9 years old (64.45%); the largest ethnic group involved was Malay (63.95%); and the major diagnosis was haemoglobin E/β-thalassaemia (34.37%). …”
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Visualization of Right Adrenal Vein in Non‐Contrast‐Enhanced MDCT and Its Guiding Role for Right Adrenal Venous Sampling by Hong‐liang Xiong, Li Du, Jiao Yang, Wei‐Tong Hu, Jia‐Bing Huang, Yun‐De Li, Xi Chen, Yi‐Fei Dong

“…In 6.2% (n = 12) of patients who can display RAV, RAV formed a common trunk with the accessory hepatic vein and then merged into the inferior vena cava. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…The oncologists prescribing CDK4/6i switch reported that most of these patients were in first line treatment (85 %) and the most common second CDK4/6i most frequently initiated was palbociclib (69 %), then abemaciclib (17 %) and ribociclib (14 %). …”
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Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review by Irfan Anjum, Ayesha Nasir, Faiza Naseer, Faiza Naseer, Ahsan Ibrahim, Bisma Rehman, Fawad Bashir, Qura Tul Ain

“…Hemorrhagic cystitis is a common manifestation in patients undergoing chemotherapy with cyclophosphamide and related alkylating agents. …”
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The impact of food-based incentive behaviors on oral health among Saudi children: a cross-sectional study by Yasir Dilshad Siddiqui, Saud Hamdan Almaeen, Ahmed Shawkat Hashem, Ahmed Ali Ahmed Almuntashiri, Mohammed Nadeem Baig, Abdullah Hammad Alshammari, Rital Jamal Alwaqid, Haifa Ali Almutairi, Raha Ahmed, Rakhi Issrani, Farooq Ahmad Chaudhary

“…Abstract Background Childhood dental caries is a common and significant oral health issue globally, resulting in pain, infection, and difficulties in eating and speaking. …”
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Spatially resolved transcriptomics reveals gene expression characteristics in uveal melanoma by Jing-Ying Xiu, Yu-Ning Chen, Ya-Li Mao, Jing-Ting Luo, Hao-Wen Li, Yang Li, Wen-Bin Wei

“…Abstract Purpose Uveal melanoma (UM) is the most common intraocular malignancy in adults. Previous studies have examined the intra-tumoral heterogeneity. …”
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…Metformin and pioglitazone are two commonly prescribed oral hypoglycemic agents for diabetes. …”
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HDL Particle Size and Functionality Comparison between Patients with and without Confirmed Acute Myocardial Infarction by Raissa de Miranda Teixeira, Nicole Cruz de Sá, Ana Paula Caires dos Santos, Vanessa Rocha Anjos e Silva, Elaine Christine de Magalhães Cabral Albuquerque, Luiz Claudio Lemos Correia, Ricardo David Couto

“…Cardiovascular diseases (CVDs) continue to be the most common cause of death worldwide, and acute myocardial infarction (AMI) is noteworthy due to its great magnitude. …”
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GWAS identifies a polyembryony locus in mango: development of KASP and PACE markers for marker-assisted breeding by Gul Shad Ali, Shamseldeen Eltaher, Shamseldeen Eltaher, Jin Li, Barbie Freeman, Sukhwinder Singh

“…Comparative genomic analyses revealed synteny between the citrus and the mango polyembryony loci, suggesting a common evolutionary mechanism for this trait. A total of 29 SNP markers in this locus were significantly associated with polyembryony in M. indica. …”
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