lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587 by Xirui Ma, Ziming Mao, Jing Zhu, Huifang Liu, Fengling Chen

“…Hepatocellular carcinoma (HCC) is one of the most common subtypes of malignant liver tumors, characterized by high morbidity and mortality. …”
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Rationale and Design of a Randomized, Open‐Label, Parallel‐Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calci... by Kazuomi Kario, Tomohiro Katsuya, Tatsuo Shimosawa, Takashi Taguchi, Ayumi Tanabe, Mitsuru Ohishi, the ESCORT‐HT investigators

“…ABSTRACT Angiotensin II receptor blockers (ARBs) and calcium channel blockers (CCBs) are commonly prescribed as first‐ and second‐line treatments for older Japanese patients with hypertension. …”
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Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant by Danielle N. Lopes, José M. Moraes Ramos, Maria Elizabeth Lopes Moreira, Jofre A. Cabral, Manoel de Carvalho, José Maria de Andrade Lopes

“…Respiratory distress are very common in Very-low-birth-weight (VLBW) infants and Myocardial injury may play a role in the disease outcome. …”
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Morphological and Molecular Identification of Obligatory Myiasis-Causing Species in Wild Cervids in Croatia by Ema Gagović, Daria Jurković Žilić, Krunoslav Pintur, Adnan Hodžić, Šimun Naletilić, Relja Beck

“…The fly species most commonly responsible for myiasis have been well studied in many parts of the world, but less so in southeastern Europe. …”
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Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single‐Gene BDH1... by A. A. Kashevarova, M. E. Lopatkina, O. Yu. Vasilyeva, D. A. Fedotov, A. D. Lobanov, E. A. Fonova, I. Z. Zhalsanova, A. A. Zarubin, O. A. Salyukova, E. O. Belyaeva, V. V. Petrova, E. G. Ravzhaeva, A. A. Agafonova, A. D. Cheremnykh, N. B. Torkhova, S. L. Vovk, I. N. Lebedev

“…Most of the phenotypes were observed in both groups but were significantly less common among individuals with 3q29 duplications. Mirrored phenotypes in patients with duplications and deletions included overweight and weight deficit. …”
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One size does not fit all: revising traditional paradigms for assessing accuracy of QSAR models used for virtual screening by James Wellnitz, Sankalp Jain, Joshua E. Hochuli, Travis Maxfield, Eugene N. Muratov, Alexander Tropsha, Alexey V. Zakharov

“…For this increasingly common task, we now recommend the use of models with the highest positive predictive value (PPV) built on imbalanced training sets as preferred virtual screening tools. …”
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Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of <i>Camellia oleifera</i> Abel by Shengjia Lu, Yali Zhang, Yanghui Ou, Jianghui Xin, Hongliang Yao, Litao Guan

“…Objectives: In this work, we obtain a natural polysaccharide from the branches of <i>C. oleifera</i> and optimize its extraction using Box–Behnken design (BBD), which is a statistical method commonly used in response surface methodology. Additionally, we study its properties, such as monosaccharide composition, structural features, antioxidant, and anti-inflammatory abilities. …”
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Ulrike Wehkamp, Martine Bagot

“…Abstract Background Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. …”
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Low-Level Zoonotic Transmission of Clade C MERS-CoV in Africa: Insights from Scoping Review and Cohort Studies in Hospital and Community Settings by Andrew Karani, Cynthia Ombok, Silvia Situma, Robert Breiman, Marianne Mureithi, Walter Jaoko, M. Kariuki Njenga, Isaac Ngere

“…Human outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) are more common in Middle Eastern and Asian human populations, associated with clades A and B. …”
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Clinical Evidence in the Treatment of Obstructive Sleep Apnoea with Oral Appliances: A Systematic Review by Andrea Rossi, Antonino Lo Giudice, Camilla Di Pardo, Alberto Teodoro Valentini, Francesca Marradi, Nicola Vanacore, Cristina Grippaudo

“…The 17 selected studies were very heterogeneous in the type of included RCTs in terms of patient inclusion criteria, sample size, distribution of the two genders in the various groups, duration of treatment, and definition of primary and secondary outcomes, without any restriction on the definition of the control group. A common finding was the positive responsiveness of oral appliance treatment in subjects affected by mild-to-moderate OSA with some evidence for cases of severe OSA. …”
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4-Thiobenzoic acid-functionalized nanocomposite probes for surface-enhanced raman spectroscopy-based detection of CA19-9 in colorectal adenocarcinoma by Yinan Hu, Tao Liu, Bo Guo, Miao Ni, Yanrong Li

“…Excellent selectivity was observed against common serum interferents, with normalized SERS intensities within 10 % of CA19–9 alone. …”
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Acute pain pathways: protocol for a prospective cohort study by Christine Lee, Joseph S Ross, Molly Moore Jeffery, Nilay D Shah, David B Page, Nancy Chang, Fernanda Bellolio, Sam Torbati, Jessica D Ritchie, Gregg H Gilbert, Lindsay Emanuel, Mitra Ahadpour, Summer Allen, Richardae Araojo, Laura Ciaccio, Jonathan Fillmore, Patricia Koussis, Heather Lipkind, Celeste Mallama, Tamra Meyer, Megan Moncur, Teryl Nuckols, Michael A Pacanowski, Elektra Papadopoulos, Mat Soukup, Christopher O St. Clair, Stephen Tamang, Douglas W Wallace, Yueqin Zhao, Rebekah Heckmann

“…An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.Methods and analysis This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. …”
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Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix by Patrícia Mendonça Ventura, Isabel Cristina Chulvis do Val Guimarães, Luis Guillermo Coca Velarde, Susana Cristina Aidé Viviani Fialho, Douglas Guedes Ferreira, Matheus Madureira Fernandes, Rafael Augusto Chaves Machado

“…Abstract Objective: HPV infection is considered the most common sexually transmitted virus today. The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. …”
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Preparation of pH-Responsive Tanshinone IIA-Loaded Calcium Alginate Nanoparticles and Their Anticancer Mechanisms by Tianying Ren, Jing Wang, Yingxin Ma, Yichen Huang, Somy Yoon, Lijun Mu, Ru Li, Xuekun Wang, Lina Zhang, Pan Li, Lusha Ji

“…<b>Background:</b> Tanshinone IIA (Tan IIA) is a lipophilic active constituent derived from the rhizomes and roots of <i>Salvia miltiorrhiza Bunge</i> (Danshen), a common Chinese medicinal herb. However, clinical applications of Tan IIA are limited due to its poor solubility in water. …”
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Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das

“…From the binding pockets, the common interacting amino acid residues participating strongly within the binding pocket were identified and compared. …”
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Trends for Diarrhea Morbidity in the Jasikan District of Ghana: Estimates from District Level Diarrhea Surveillance Data, 2012–2016 by John Tetteh, Wisdom Kwami Takramah, Martin Amogre Ayanore, Augustine Adoliba Ayanore, Elijah Bisung, Josiah Alamu

“…High incidence of diarrhea was found to be common among under-five children and among females. …”
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The Prevalence of Dental Anxiety Associated with Pain among Chinese Adult Patients in Guangzhou by Jiali Yu, Rui Jiang, Er-Min Nie, Chun-Yuan Zhang, Xiang Li

“…Anxiety towards dental procedures is a common difficulty that may be experienced by dental patients all over the world. …”
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The prevalence and distribution of hypodontia inorthodontic patients in Bosnia and Herzegovina by Azra Jelešković, Indira Mujić Jahić, Aida Selmanagić, Sara Mujić, Lejla Redžepagić Vražalica

“…After stratifying the sample by jaw, the most common hypodontic tooth was the second premolar in the mandible and the lateral incisor in the maxilla. …”
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Risk of infection and conversion time from external to definitive fixation in open tibial fracture by Wazzan S. Aljuhani, Yasir A. Alshabi, Abdullah M. Alanazi, Meshal A. Alothri, Saleh A. Almutairi, Ziad A. Aljaafri, Abdullah M. Alzahrani

“…Abstract Background An open fracture of the tibia is one of the most common and dangerous type of open fractures. In the management of these injuries, the primary focus is on reducing the infection rate, as this is crucial for achieving the best clinical outcomes. …”
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Bedside cerebral microvascular imaging of patients with disorders of consciousness: a feasibility study by Qianqian Ge, Lijie Huang, Qiang Fu, Shuai Han, Rui Wang, Jianghong He, Changhui Li, Changhui Li, Jianwen Luo, Long Xu

“…This constraint is circumvented in common post-craniectomy DoC patients, who present a unique observational window for uPDI.MethodsWe conducted uPDI scans on five DoC patients of different ages and consciousness levels who had undergone decompressive craniectomy. …”
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