Impact of heteroresistance on treatment outcomes of people with drug-resistant TB by R. Crowder, M. Kato-Maeda, B. Schwem, A. dela Tonga, D.M. Geocaniga-Gaviola, E. Lopez, C.L. Valdez, A.R. Lim, N. Hunat, A.G. Sedusta, C.A. Sacopon, G.A.M. Atienza, E. Bulag, D. Lim, J. Bascuña, K. Shah, R.P. Basillio, C.A. Berger, M.C.D.P. Lopez, S. Sen, C. Allender, M. Folkerts, U. Karaoz, E. Brodie, S. Mitarai, A.M.C. Garfin, M.C. Ama, D.M. Engelthaler, A. Cattamanchi, R. Destura

“…CONCLUSIONS: Heteroresistance was relatively common (8.3%) among people with DR-TB in the Philippines. …”
Get full text

Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS by Weiyi Cao, Hezhi Yao, Zhenzhen Qian, Yi Wu, Shuge Wang, Rui Li, Rui Gao

“…Salvianolic acid B is the main active ingredient in salvianolate injection, which is produced by extracting danshen, the most commonly used Chinese herbal medicine for cardiovascular treatment. …”
Get full text

Fungal Biocontrol Agents in the Management of Postharvest Losses of Fresh Produce—A Comprehensive Review by Phathutshedzo Ramudingana, Ndivhuho Makhado, Casper Nyaradzai Kamutando, Mapitsi Silvester Thantsha, Tshifhiwa Paris Mamphogoro

“…Secretion of antifungal compounds, parasitism, as well as competition for nutrients and space are the most common antagonistic mechanisms employed by these BCAs. …”
Get full text

Challenges of healthcare financing in the world’s largest refugee camp: a mixed-method study among healthcare stakeholders for Rohingya refugees in Bangladesh by Isabel Smith, Imdadul Haque Talukdar, Sayeeda Tarannum, M A Rifat, Priyanka Boga, Jubayer Mumin, Pablo André Veronés, Ziba Mahdi, Syeda Saima Alam, Arif Faysal Khan

“…Financial documents (available online) and reports from respective coordinating agencies were also reviewed.Setting Online key informant interviews (KIIs) were conducted from Stockholm with participants residing in Bangladesh between June 2022 and September 2022.Participants Eight KIIs were conducted with professional health programme managers, executives and personnel involved in policy coordination and implementation in refugee camps in Cox’s Bazar district of Bangladesh.Results We identified four themes and three subthemes outlining key challenges in healthcare funding, including decreasing funds (supported by a quantitative assessment) due to macroglobal issues, conflicting short-term and long-term priorities between implementing partners, insufficient efficacy due to challenges with collaborative priority-setting and implementing common processes, and a lack of consensus regarding equity between host and refugee communities.Conclusions The study identified unique challenges beyond the commonly discussed health financing issues in a resource-deficient setting: stakeholders’ conflicting priorities regarding funding and undecided equity issues among the host and refugee communities are worth scholarly and policy focus. …”
Get full text

Acute-Onset Vitreous Hemorrhage of Unknown Origin before Vitrectomy: Causes and Prognosis by Dong Yoon Kim, Soo Geun Joe, Seunghee Baek, June-Gone Kim, Young Hee Yoon, Joo Yong Lee

“…RVO, retinal break, and AMD are the most common causes of acute-onset preoperatively unknown origin VH and the most common causes of VH change with age. …”
Get full text

Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration by Lewis E. Fry, Lauren Major, Ahmed Salman, Lucy A. McDermott, Jun Yang, Andrew J. King, Michelle E. McClements, Robert E. MacLaren

“…We compare the Cas13 effectors PspCas13b and Cas13bt3 for the repair of the gene USH2A, a common cause of inherited retinal disease and Usher syndrome. …”
Get full text

New biomarkers for diagnosis of bladder cancer: a bibliometric analysis by Roberto Falabella, Valentina De Simone, Felice Crocetto, Francesco Del Giudice, Angelo Porreca, Nazario Foschi, Biagio Barone, Luca Di Gianfrancesco, Valentina Di Pasquale, Vincenzo Francesco Caputo

“… Background/Objectives: Bladder cancer is a multifactorial disease, ranking as the 10th most common cancer globally and the fourth most common cancer in men and the ninth in women in the Western world. …”
Get full text

Radiographic Features of Spinal Meningioma and Schwannoma: A Novel Specific Feature―Ginkgo Leaf Sign by Yu Toda, Masashi Miyazaki, Takaomi Kobayashi, Yoshiaki Egashira, Deokcheol Lee, Hideaki Hamanaka, Shigeo Ueda, Hiromu Yoshizato, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Hiroaki Konishi, Tatsuya Tanaka, Koji Otani, Masaaki Mawatari, Tadatsugu Morimoto

“…Introduction: Meningiomas and schwannomas are common intradural-extramedullary spinal tumors. Because of their different origins, they necessitate different surgical procedures, which makes preoperative diagnosis important. …”
Get full text

Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population by Tharanga Mudalige, Vindya Pathiraja, Gayathri Delanerolle, Heitor Cavalini, Shuqi Wu, Julie Taylor, Om Kurmi, Kathryn Elliot, Sharron Hinchliff, Carol Atkinson, Kristina Potocnik, Paula Briggs, Lucky Saraswat, Helen Felicity Kemp, George Eleje, Toh Teck Hock, Cristina Laguna Benetti‐Pinto, Irfan Muhammad, Rabia Kareem, Yassine Bouchareb, Peter Phiri, Ruishu Zhang, Yunfei Weng, Ieera Aggarwal, Jian Qing Shi, Ashish Shetty, Ian Litchfield, Nirmala Rathnayake, Sohier Elneil

“…Data were analysed using random‐effects and common‐effects models with subgroup and sensitivity analyses. …”
Get full text

Anthropometrics Analysis of Mental Foramen and Accessory Mental Foramen in Zambian Adult Human Mandibles by Balakrishnan Subramanian, Severine N. Anthony, Lumamba Mubbunu, Chitinti Hachombwa, Majuto S. Mlawa, Mudhihiri M. Majambo, Rajab M. Sasi

“…The foramens were mostly oval in shape and their most common position was between the second premolar and first molar and the most common orientation was posterior-superior. …”
Get full text

Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation by E U Wessels, K Kinandu, M Beretta, S Berkenfeld, B Bobat, L Brannigan, R Britz, D Demopoulos, L Doedens, P Gaylard, H Maher, A Mahomed, V Mudau, D Parbhoo, S Rambarran, M Reynders, F van der Schyff, B Ströbele, J Fabian, J Loveland

“…In the paediatric population, the most common aetiologies for both pretransplant candidates and transplant recipients remained cholestatic disease and acute liver failure. …”
Get full text

Risk Assessment of Trace Element Contamination in Drinking Water and Agricultural Soil: A Study in Selected Chronic Kidney Disease of Unknown Etiology (CKDu) Endemic Areas in Sri L... by W. P. R. T. Perera, M. D. N. R. Dayananda, D. M. U. C. Dissanayake, R. A. S. D. Rathnasekara, W. S. M. Botheju, J. A. Liyanage, S. K. Weragoda, K. A. M. Kularathne

“…This study evaluates the contamination status of heavy metals/metalloids of the drinking water and agricultural soil in two CKDu endemic areas compared with a reference area in Sri Lanka based on common indexes and attribute of the commonly used fertilizers evaluated to identify the basic sources of toxic metals in the agricultural soil. …”
Get full text

Self-Limiting OX513A Aedes aegypti Demonstrate Full Susceptibility to Currently Used Insecticidal Chemistries as Compared to Indian Wild-Type Aedes aegypti by Prabhakargouda B. Patil, Kevin J. Gorman, Shaibal K. Dasgupta, K. V. Seshu Reddy, Shirish R. Barwale, Usha B. Zehr

“…The results confirm that, aside from historical resistance to DDT, OX513A has retained full sensitivity to these commonly used compounds and exhibits responses akin to those of susceptible Indian wild-type strains.…”
Get full text

Case Report: Combined Autoimmune Pancreatitis, Ulcerative Colitis and Sclerosing Cholangitis in 28-y.o. Patient by A. R. Khurmatullina, A. V. Okhlobystin, L. N. Androsova, R. T. Rzayev, A. S. Tertychnyy, A. P. Kiryukhin, O. Z. Okhlobystina, M. S. Zharkova, O. S. Shifrin, V. T. Ivashkin

“…This required differential diagnostics between PSC with IgG4 elevation, UC and type 2 autoimmune pancreatitis (AIP) (more common in European population) on one hand and IgG4-associated systemic disease (more common in Asian population) with bile ducts, pancreas and large intestine involvement on the other. …”
Get full text

Distinct relative abundances in pathogens detected in mechanically ventilated patients with suspected pneumonia in the intensive care unit at King Abdulaziz University Hospital by Haifa Algethamy, Diyaa H. Bokhary, Ibrahim Abushoshah, Abdulrahman A. Alalyani, Maan K. Baamer, Dalya M. Attallah, Ruba M. Alotaibi, Shehla N. Amin, Shaza A. Mass, Nisreen R. Tashkandy

“…K. pneumoniae and S. maltophilia were the most common taxa detected in the samples, although some variations in microbial composition were observed. …”
Get full text

Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation by Ruixin Wu, Ruixin Wu, Sihao Chen, Sihao Chen, Yi He, Yi He, Ya Li, Song Mu, Aishun Jin, Aishun Jin

“…Molecular data with the most common mutations in CNEC were extracted from the Catalogue of Somatic Mutations in Cancer (COSMIC) database.ResultsIn this prognostic analysis, the data from 714 participants with HCNEC were evaluated. …”
Get full text

Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis by Xiaoming Li, Xiaoming Li, Rui Xu, Rui Xu, Dan Zhang, Ji Cai, Ji Cai, He Zhou, He Zhou, Tao Song, Tao Song, Xianyao Wang, Xianyao Wang, Qinghong Kong, Liujin Li, Zhaohui Liu, Zhixu He, Zhengzhen Tang, Jun Tan, Jidong Zhang, Jidong Zhang, Jidong Zhang

“…Acute kidney injury (AKI) is a common critical clinical disease that is linked to significant morbidity, recurrence, and mortality. …”
Get full text

Role of the androgen receptor in melanoma aggressiveness by Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria

“…Abstract Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. …”
Get full text

Prevalence and Presentation of Paediatric Coronavirus Disease 2019 in Lagos, Nigeria by Abideen Salako, Oluwatosin Odubela, Tomilola Musari-Martins, Priscilla Ezemelue, Titilola Gbaja-Biamila, Babasola Opaneye, Ayorinde James, Osaga Oforomeh, Kazeem Osuolale, Adesola Musa, Emelda Chukwu, Nurudeen Rahman, Agatha David, Rosemary Audu, Oliver Ezechi, Babatunde Salako

“…The median age (interquartile range (IQR)) was 9 (4–14) years. Common symptoms reported by the positive cases were fever (40.0%), cough (32.9%), sore throat (17.1%), and runny nose (15.7%). …”
Get full text

Outpatient visits and treatment methods of patients with hand and wrist injuries in Vreden National Medical Research Center of Traumatology and Orthopedics by Eugeniy V. Veber, Alexander P. Zavyalov, Alexander I. Avdeev, Margarita A. Zhogina, Sergey S. Smirnov

“…Of the operations performed, K-wire osteosynthesis and primary suture of the extensor or flexor tendons of the fingers were most often used. Significantly less common were the following operations: primary surgical debridement, suture of nerves and blood vessels, replantation and revascularization. …”
Get full text