A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by motor and non-motor symptoms. …”
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In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Background: This study investigated the phytochemical composition and potential medicinal properties of arecanut grown in various regions of Karnataka. Arecanut, commonly chewed in the Indian subcontinent and Southeast Asia for its purported medicinal benefits, contains arecoline, a pyridine alkaloid known for its pharmacological effects. …”
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Machine learning identification of a novel vasculogenic mimicry-related signature and FOXM1’s role in promoting vasculogenic mimicry in clear cell renal cell carcinoma by Chao Xu, Sujing Zhang, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Shengtao Dai, Bowei Zhang, Meng Zhu, Yuepeng Liu, Junfei Gu

“…Background: Clear Cell Renal Cell Carcinoma (ccRCC), the predominant subtype of renal cell carcinoma (RCC), ranks among the most common malignancies worldwide. Vasculogenic mimicry (VM) plays a pivotal role in tumor progression, being closely linked with heightened chemoresistance and adverse prognosis in cancer patients. …”
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Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…Abstract Alcohol‐related liver disease (ALD) is a common chronic liver disease caused by long‐term excessive alcohol consumption and responsible for more than half of all liver‐related deaths worldwide. …”
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Four decades of phenology in an alpine amphibian: trends, stasis, and climatic drivers by Lenzi, Omar, Grossenbacher, Kurt, Zumbach, Silvia, Lüscher, Beatrice, Althaus, Sarah, Schmocker, Daniela, Recher, Helmut, Thoma, Marco, Ozgul, Arpat, Schmidt, Benedikt R.

“…The goal of this study is to assess the main factors determining the timing of breeding in an alpine population of the common toad (Bufo bufo) and to describe the observed shifts in its breeding phenology. …”
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Transcriptomic reprogramming and epigenetic regulation underlying pollination-dependent and auxin-induced fruit set in tomato by Xiaohan Li, Xiaohan Li, Xiaohan Li, Bing He, Anis Djari, Pierre Frasse, Elie Maza, Farid Regad, Julien Pirrello, Guojian Hu, Guojian Hu, Guojian Hu, Guojian Hu, Mondher Bouzayen

“…Genome-wide transcriptomic profiling of the flower-to-fruit transition, either pollination-induced or triggered by auxin treatment, shows that both types of triggers modulate the expression of a common large set of genes primarily expressed in maternal tissues. …”
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Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs by Lin Wang, Jiaxi Wang, Chao Lin, Furong Wang, Xiangping Li, Wanhui Liu

“…Combination therapy is a common approach for clinical treatment of type 2 diabetes mellitus, especially for patients with poor monotherapy. …”
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Catastrophic expenditure associated with childhood hospitalisation for acute illness in Kenya and Uganda: a cross-sectional study by Sassy Molyneux, Johnstone Thitiri, Laura Mwalekwa, Molline Timbwa, Anna Vassall, Kirkby D Tickell, Judd L Walson, James Berkley, John Mukisa, Ezekiel Mupere, Peter Olupot-Olupot, Priya Sukhtankar, Sheila Murunga, Julie Jemutai, George Paasi, Benson Singa, Shalton Mwaringa, Rebecca Gathoni Njuguna, Yoko V Laurence, Caroline Ogwang, Mwanajuma Juma, Narshion Ngao, Christina Lancioni, Md Fakhar Uddin

“…Caregivers reported borrowing, selling property and withdrawing other children from school to cope with costs.Conclusions Despite intentions of free healthcare services for under 5, families of acutely ill children very commonly faced catastrophic expenditure, especially for children with CSM. …”
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Serum Antidiuretic Hormone Level in Nocturnal Enuretic School Children in a Tertiary Care Hospital in Bangladesh: A Cross‐Sectional Study by Jannatul Fardous, Anjuman Ara, Md. Iqbal Hossain, Asma Labony, Tanjila Afrin, Rezwana Ashraf, Reaz Uddin, Habiba Jesmin, Md. Kabir Alam, Mohammad Ashraful Amin, Anwar Hossain Khan, Zahid Hasan Khan

“…ABSTRACT Background and Aims Primary nocturnal enuresis (PNE) is a common pediatric condition characterized by involuntary nighttime bed wetting. …”
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Osilodrostat treatment in patients with Cushing’s disease of Asian or non-Asian origin: a pooled analysis of two Phase III randomized trials (LINC 3 and LINC 4) by Akira Shimatsu, Beverly MK Biller, Maria Fleseriu, Rosario Pivonello, Eun Jig Lee, Rattana Leelawattana, Jung Hee Kim, Rama Walia, Yerong Yu, Zhihong Liao, Andrea Piacentini, Alberto M Pedroncelli, Peter J Snyder

“…Improvements in cardiovascular and metabolic-related parameters, physical manifestations of hypercortisolism, and quality of life were similar in both groups. Most common adverse events (AEs) were adrenal insufficiency (44.6%) in Asian and nausea (45.5%) in non-Asian patients. …”
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Trabeculectomy versus stepwise treatment for breaking the attack of acute primary angle closure in patients with long attack duration: study design and protocol for a multicentre r... by Jing Jiang, Qing Zhang, Bo Qu, Chao Dai, Mingguang He, Ye Zhang, Ning-Li Wang, Shuning Li, Guangxian Tang, Su Jie Fan, Zhi Li, Chi Liu, Xinqi Chang, Yanyan Cheng

“…Introduction Acute primary angle closure (APAC) is a common ophthalmic emergency for Chinese patients causing potential visual disabilities. …”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Objectives Proton pump inhibitors (PPIs) are widely prescribed medications and commonly used for the treatment of gastric acid-related disorders. …”
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Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning by Sajid Naveed, Mujtaba Husnain, Ali Samad, Amna Ikram, Hina Afreen, Ghulam Gilanie, Najah Alsubaie

“…Glioblastoma (GBM), a common cancer of the central nervous system (CNS), is considered incurable worldwide. …”
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Efficacy of natural and synthetic inhibitors in the elimination of viruses in potato (<i>Solanum tuberosum</i> L.) by E. V. Shishchenko, I. V. Kim, E. N. Barsukova, I. M. Yermak, A. O. Kravchenko, A. G. Klykov

“…The use of virus inhibitors (mainly synthetic ones) is the most common method in potato virus control. Products of natural origin might be a way to reduce the dependence on synthetic inhibitors. …”
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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways by Hong Duan, Wei Wang, Shu Li, Han Li, Ghulam Jilany Khan, Yong Ma, Fawang Liu, Kefeng Zhai, Henggui Hu, Zhaojun Wei

“…Collectively a total of 209 possible linkages against 18 chemical components from I. suzhouensis and 1194 COVID-19 related targets were selected. Among these, 164 common targets were obtained from the intersection of I. suzhouensis and COVID-19. …”
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Seasonal trends of pyogenic spondylodiscitis in Japan: a nationwide inpatient database study by Takayuki Motoyoshi, Takahisa Ogawa, Kazuyuki Fukushima, Satoshi Kutsuna, Haggai Schermann, Kiyohide Fushimi, Toshitaka Yoshii

“…Mortality rates were highest in fall and winter (3.0 % each) and lowest in summer (2.6 %) (P = 0.024). Sepsis was the most common concomitant infection, occurring in 10.4 % of patients.The risk factors for in-hospital mortality were being elderly, male, having a low BMI, and high comorbidities. …”
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The roles of cannabis potency and gender in cannabis dependence and anxiety in recent cannabis users with trauma exposure histories by T. Snooks, S.H. Stewart, P. Romero-Sanchiz, S. DeGrace, S.P. Barrett, H.C.R. Bernusky, P.G. Tibbo

“…Cannabis with higher THC potency (commonly assessed via THC:CBD ratio) may increase the risk for cannabis dependence and trigger/exacerbate anxiety. …”
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Alzheimer’s disease diagnosis using rhythmic power changes and phase differences: a low-density EEG study by Juan Wang, Juan Wang, Jiamei Zhao, Xiaoling Chen, Xiaoling Chen, Bowen Yin, Xiaoli Li, Xiaoli Li, Ping Xie, Ping Xie

“…Electroencephalography (EEG) is a non-invasive and cost-effective technique commonly used in the study of neurodegenerative disorders. …”
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Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study by Xiaopeng Guo, Jian Cao, Peijun Liu, Yihan Cao, Xiao Li, Lu Gao, Zihao Wang, Ligang Fang, Zhengyu Jin, Yining Wang, Bing Xing

“…Cardiac abnormalities are the most common and deadly comorbidities of acromegaly. Assessments using cardiac magnetic resonance (CMR) imaging in acromegaly patients are rare. …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

“…Background: Pain and depression are common complications in patients with advanced cancer, which significantly affects their quality of life and survival. …”
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