Polypharmacy and anticholinergic burden scales in older adults: a cross-sectional study among psychiatric outpatients in a tertiary care hospital by Manjunath Bidarolli, Biswadeep Das, Vikram Singh Rawat, Sachin Manocha, Hannah Theresa Sony, Akash Agnihotri, Mahima Gupta, Franklin Agera

“…Abstract Introduction Mental disorders are prevalent among older adults, often leading to the use of multiple medications, many with anticholinergic properties. Polypharmacy, common in this population, is a major contributor to anticholinergic burden, which is linked to cognitive and physical decline. …”
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Using artificial intelligence to predict post-operative outcomes in congenital heart surgeries: a systematic review by Ida Mohammadi, Shahryar Rajai Firouzabadi, Melika Hosseinpour, Mohammadhosein Akhlaghpasand, Bardia Hajikarimloo, Sam Zeraatian-Nejad, Peyman Sardari Nia

“…Abstract Introduction Congenital heart disease (CHD) represents the most common group of congenital anomalies, constitutes a significant contributor to the burden of non-communicable diseases, highlighting the critical need for improved risk assessment tools. …”
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Exploring the therapeutic potential of 18β-Glycyrrhetinic acid in pulmonary arterial hypertension by integrating network pharmacology and experimental validation by Wenli Yang, Long Ma, Meidong Si, Fang Zhao, Ru Zhou

“…Of these, 79 targets were identified as common to both 18β-GA and PAH. Through the analysis of the PPI network, identified key targets, including IL6, AKT1, ALB, BCL2, NFKB1, IL1B, SRC, MMP9, PPARG, MAPK3, PTGS2, ESR1, TNF, CTNNB1 and CASP3. …”
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A novel homozygous intronic variant in CDT1 that alters splicing causes Meier–Gorlin syndrome, and a review of published mutations and growth hormone treatments by Qing Li, Yichi Wu, Fucheng Meng, Zhuxi Li, Di Zhan, Xiaoping Luo

“…A literature review revealed that the most common variant type and inheritance state were missense and compound heterozygous, respectively. …”
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…As guinea pigs exhibit anatomical, physiological, and pharmacological features resembling human airways, including mast cell distribution and mediator release, we evaluated the effect of extracts from two common allergens, house dust mite (HDM) and cat dander (CDE), on histopathological changes and the composition of tryptase- and chymase-positive mast cells in the guinea pig lungs. …”
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The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family by Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

“…Abstract Background Lung adenocarcinoma is one of the most common malignant tumors worldwide. Its complex molecular mechanisms and high tumor heterogeneity pose significant challenges for clinical treatment. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Emerging evidence suggests a strong link between moderate to severe TBI and an elevated risk of PD, though the underlying mechanisms remain poorly understood.Materials and Methods: Common differentially expressed genes (DEGs) were identified in GEO datasets of patients with traumatic brain injury (TBI) and Parkinson’s disease (PD). …”
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Strength and Durability Performance of Hybrid Alkaline Clay Brick Waste –Coconut Shell Ash Cement by Victor Kiptoo Mutai, Mike Otieno, Joseph M. Marangu, Fredrick Mulei Mutunga, Najya Muhammed, Festus Ngui

“…The durability of a hybrid alkaline mortar made from a mixture of calcined clay brick waste (CBW) and coconut shell ash (CSA) was compared with that of ordinary Portland cement (OPC) and pozzolanic Portland cement (PPC), which are the two common types of Portland cement. In an open furnace, CSA was obtained by burning coconut shells collected from Kilifi County, Kenya. …”
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Multiple use of preservative-free single dose unit dexamethasone 0.1% eye drops is safe within 24 hours by Marco Rossi, Michael A Thiel, Frank Bochmann, Philipp B Baenninger, Claude Kaufmann, Fabienne C Fierz, Silvan Locher, Lucas Bachmann, Irena Mitrovic, Jeremy P Howell

“…Background Unpreserved single-dose unit (SDU) eye drops are commonly used to avoid benzalkonium chloride-related toxicity. …”
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Inguinal Lymph Node Dissection for Advanced Stages of Plantar Melanoma in a Low-Income Country by Ollo Roland Somé, Malick Diallo, Damien Konkobo, Nassirou Yabré, Valentin Konségré, Issouf Konaté, Sidy Ka

“…Advanced stages of plantar acral lentiginous melanoma are common in Africa. Inguinal lymph node dissection (ILND) in these cases plays a critical role in disease-free and overall survival. …”
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Risk prediction models for dysphagia after radiotherapy among patients with head and neck cancer: a systematic review and meta-analysis by You Pu, Jin Yang, Lian Shui, Qianlong Tang, Xianqin Zhang, Guangguo Liu

“…Meta-analysis of the predictive performance of the model was performed using the “metafor” package in R software.ResultsTwenty-five models predicting the risk of dysphagia after radiotherapy in patients with HNC were included, covering a total of 8,024 patients. Common predictors include mean dose to pharyngeal constrictor muscles, treatment setting, and tumor site. …”
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Effective treatment of severe acute pancreatitis and COVID-19 pneumonia with tocilizumab by Piotr Zielecki, Magdalena Kaniewska, Mariusz Furmanek, Tomasz Bulski, Grażyna Rydzewska

“…On 11th March 2020 COVID-19 was declared a pandemic by the World Health Organisation [2]. The most common symptoms are fever, cough, shortness of breath, fatigue, myalgia, and loss of smell and taste [3], but gastrointestinal symptoms like vomiting, diarrhoea, and abdominal pain are also reported [4, 5]. …”
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Evaluating the Impact of Data Transformation Techniques on the Performance and Interpretability of Software Defect Prediction Models by Yu Zhao, Zhiqiu Huang, Lina Gong, Yi Zhu, Qiao Yu, Yuxiang Gao

“…However, SDP methods designed in the past research rarely consider the impact of data transformation methods, simple but commonly used preprocessing techniques, on the performance and interpretability of SDP models. …”
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Acute Neurotoxicity in Children Treated for Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: A 10-Year Single-Centre Experience by Izabela Kranjčec, Nada Rajačić, Tamara Janjić, Monika Kukuruzović, Filip Jadrijević-Cvrlje, Maja Pavlović, Jelena Roganović

“…Acute neurotoxic events were registered in 11 patients (19.6%), most commonly in the 6–10-year age group (66.7%), predominately in females (72.7%) and high-risk group (54.5%). …”
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Cluster of symptoms in kidney failure: A systematic review by Jaime Gomariz-Ruiz, David Pérez-Cruzado, Daniel Gutiérrez-Sánchez

“…Constraining the selection of articles to those written in Spanish or English could be a limitation as not all articles dealing with symptom clusters in kidney failure were considered. Conclusions: Common symptoms in clusters of symptoms in kidney failure were nausea or vomiting (gastrointestinal problems), fatigue or muscle weakness (neuromuscular symptoms/problems), low interest in sex or difficulty feeling sexually excited (sexual symptoms), dry skin or skin itching (skin problems), lack of appetite, feeling squeezed, feeling weak or dizzy and difficulty breathing (uraemic), fatigue or muscle weakness (energy/vitality), and chest pain (cardiac-related problems). …”
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Prediction of postoperative myocardial injury in patients undergoing laparoscopic pheochromocytoma/paraganglioma resection: protocol for an ambispective cohort study by Yuguang Huang, Yuelun Zhang, Ling Lan, Yi Zhang, Ye Ma, Le Shen, Yifei Zhao, Yaohan Li

“…Introduction Pheochromocytoma/paraganglioma (PPGL) resection remains a high-risk surgical procedure owing to severe haemodynamic instability, which can lead to myocardial injury after non-cardiac surgery (MINS). MINS is the most common and easily overlooked cardiovascular complication and results in increased postoperative mortality and prolonged inpatient hospitalisation. …”
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Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control by Danyan Chen, Jiaying Lu, Hucheng Zhou, Jiehui Jiang, Ping Wu, Qihao Guo, Jingjie Ge, Huiwei Zhang, Kuangyu Shi, Chuantao Zuo

“…Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. …”
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Exploring the immunohistochemical profile of basosquamous carcinoma and its clinicopathological associations by Cemile Tuğba Altunel, Gonca Özgün, Arzu Karataş, Özlem Özen, Deniz Seçkin, Tülin Güleç, Deren Özcan

“…Results: One hundred and four BSCs (68 males, mean age 67.99+-14.95) were included. The most common location was the nose. Ulceration rate and margin positivity were 70.2% and 22.1%, respectively. …”
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A deep contrastive learning-based image retrieval system for automatic detection of infectious cattle diseases by Veerayuth Kittichai, Morakot Kaewthamasorn, Apinya Arnuphaprasert, Rangsan Jomtarak, Kaung Myat Naing, Teerawat Tongloy, Santhad Chuwongin, Siridech Boonsang

“…Alternatively, algorithms could support local employees in tracking disease transmission and quick action, especially in Thailand where this cattle disease is common. As a result, the study intends to create an automated tool based on a deep neural network linked with an image-retrieval procedure for recognizing infections in microscopic pictures. …”
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High levels of soluble P-selectin, neutrophil extracellular traps, and myeloperoxidase as risk factor of deep vein thrombosis in malignancy patients receiving platinum-based chemot... by Ketut Suega, I Made Bakta, Ni Made Renny Anggreni Rena

“…In the case group, cervix malignancy was the most common malignancy (32.3%), whereas in the control group, it was nasopharyngeal malignancy (25.8%). …”
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