Increased Phenotype Severity Associated with Splice-Site Variants in a Hungarian Pediatric Neurofibromatosis 1 Cohort: A Retrospective Study by Klára Veres, Benedek Nagy, Zsófia Ember, Judit Bene, Kinga Hadzsiev, Márta Medvecz, László Szabó, Zsuzsanna Zsófia Szalai

“…Intracranial malformations were the second most common feature (55.6%), followed by Lisch nodules (35.6%), neurofibromas (33.3%), and skeletal abnormalities (31.1%). …”
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Identification of ketamine and norketamine in dried bloodstains on crime-scene surfaces by Risha Jasmine Nathan, Babajide Okeleye, Rabiu Abdullahi, Waliyu Oyebode

“…The present study has analysed the stability of ketamine and norketamine in DBS aged on common crime scene surfaces under various storage temperatures. …”
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Single-nucleotide variant rs1800139 of the LRP1 gene as a factor in the development of obesity in children by O.Ye. Abaturov, A.O. Nikulina

“…In patients with MHO, the CC genotype was significantly less common (p<0.05) and the TT genotype of SNV rs1800139 of the LRP1 gene was more often registered than in the general human population (p<0.02). …”
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Needle tracking and segmentation in breast ultrasound imaging based on spatio-temporal memory network by Qiyun Zhang, Jiawei Chen, Jinhong Wang, Haolin Wang, Yi He, Yi He, Bin Li, Zhemin Zhuang, Huancheng Zeng

“…IntroductionUltrasound-guided needle biopsy is a commonly employed technique in modern medicine for obtaining tissue samples, such as those from breast tumors, for pathological analysis. …”
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Single-cell sequencing analysis reveals cancer-associated pericyte subgroup in esophageal squamous cell carcinoma to predict prognosis by Kai Xiong, Bing Pan, Hao Fang, Ziyou Tao

“…Drug prediction and molecular docking was further used to validate the medicinal value of drug targets.ResultsCAPs in the ESCC TME were found to be highly heterogeneous, and we identified six pericyte subtypes: c1_ARHGDIB, c2_BCAM, c3_LUM, c4_SOD2, c5_TYMS, and c6_KRT17, which have commonality in a part of their functions, and each of them has a major function to play, by having different strengths of interaction with different components in the TME. …”
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Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial by Melissa Voigt Hansen, Michael Tvilling Madsen, Lærke Toftegård Andersen, Ida Hageman, Lars Simon Rasmussen, Susanne Bokmand, Jacob Rosenberg, Ismail Gögenur

“…Sleep disturbances and cognitive dysfunction are common in patients with breast cancer. Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction. …”
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Complications of Estimating Hatchery Introgression in the Face of Rapid Divergence: A Case Study in Brook Trout (Salvelinus fontinalis) by Bradley Erdman, Wesley Larson, Matthew G. Mitro, Joanna D. T. Griffin, David Rowe, Justin Haglund, Kirk Olson, Michael T. Kinnison

“…If this is the case, then commonly used genomic clustering methods and their associated model selection criteria may result in underestimation of hatchery introgression in the face of rapid drift.…”
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Identification of biomarkers for chronic lymphocytic leukemia risk: a proteome-wide Mendelian randomization study by Changyu Jin, Zehong Lu, Yuzhan Chen, Huijie Hu, Miao Zhou, Yanli Zhang, Guifang Ouyang, Tongyu Li, Lixia Sheng

“…Abstract Background Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy. Although previous research has explored associations between plasma proteins and CLL, the causal relationships remain unclear. …”
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Evaluation of the Effect of Nanosilver and Bismuth oxide on the Radiopacity of a Novel Hydraulic Calcium Silicate-based Endodontic Sealer: An In vitro Study by Teena Sheethal Dsouza, Aditya Shetty, Kelvin Peter Pais, Meenakumari Chikkanna, Fahad Hamoud Almutairi, Yazeed Abdulaziz Alharbi, J. Suresh Babu, C. Swarnalatha, Abhishek Singh Nayyar

“…In this pretext, silver nanoparticles (AgNPs) are among the most commonly used nanoparticles which are exceptionally noteworthy for their role in medical applications as an antibacterial agent. …”
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A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Significant (p-value ≤ 0.05 and log fold change ≤ − 1.5 or ≥  + 1.5) common genes from six studies were subjected to network analysis and functional enrichment analysis to identify enriched Gene ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes pathways and hub genes. …”
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Associations between autistic traits and early ear and upper respiratory signs: a prospective observational study of the Avon Longitudinal Study of Parents and Children (ALSPAC) ge... by Amanda Hall, Dheeraj Rai, Jean Golding, Yasmin Iles-Caven, Steven Gregory, Richard Maw

“…For example, for discharge of pus or sticky mucus from ears the adjusted odds ratio (aOR) for autism at 30 months was 3.29 (95% CI 1.85 to 5.86, p&lt;0.001), and for impaired hearing during a cold the aOR was 2.18 (95% CI 1.43 to 3.31, p&lt;0.001).Conclusions Very young children exhibiting common ear and upper respiratory signs appear to have an increased risk of a subsequent diagnosis of autism or demonstrated high levels of autism traits. …”
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The Effect of Chicory Consumption on Oxidative Stress Indices of the Kidney Tissue in Female Wistar Rats Consuming Testosterone Enanthate during eight weeks Resistance Training by Khadijeh Molaei, Sanaz Mirzayan Shanjani, Ali Gorzi, Yaser Kazemzadeh, Abdolali Banaeifar

“…Background and Aim: Testosterone enanthate is one of the common drugs among female athletes, and one of its basic side effects is the oxidative stress increase. …”
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Discrepancies in reported results between trial registries and journal articles for AI clinical researchResearch in context by Zixuan He, Lan Yang, Xiaofan Li, Jian Du

“…Discrepancies and omissions of results were common, and no complete agreement was observed between the two sources. …”
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Design and Evaluation of a Low-Cost Mount for Attaching a Laser Tracker’s SMR to a Robot Flange by Florian Stöckl, Silvan Müller, Marcus Strand, Markus Gardill

“…Robot calibration and modelling measurements are commonly performed using a laser tracker. To capture three-dimensional positions, a SMR is attached to the robot. …”
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The impact of gestational age limits on abortion-related outcomes: a synthesis of legal and health evidence by Fiona de Londras, Amanda Cleeve, Maria I. Rodriguez, Alana Farrell, Magdalena Furgalska, Antonella F. Lavelanet

“…Abstract Background Gestational age limits (GLs) are common in abortion laws and policies. They restrict when lawful abortion may be accessed by reference to the gestational duration of a pregnancy, in some cases specifying that abortion is a criminal offense after, but not before, the GL. …”
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Proximally based sural artery flap for the reconstruction of soft tissue defects around the knee and proximal third of the leg in India: a clinical study by Lakshmi Palukuri, Sreedharala Srinivas, Dharmapuri Madhulika, Sanujit Pawde, Ajo Sebastian, Swathi Sankar, Sandeep Reddy Chintha

“…Results There were 10 cases, all of which involved men aged 20 to 65 years. The most common cause of injury was trauma resulting from road traffic accidents. …”
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Conversational Therapy through Semi-Immersive Virtual Reality Environments for Language Recovery and Psychological Well-Being in Post Stroke Aphasia by A. Giachero, M. Calati, L. Pia, L. La Vista, M. Molo, C. Rugiero, C. Fornaro, P. Marangolo

“…Therefore, new approaches to common speech therapies are urgently needed in order to maximize the recovery from aphasia. …”
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Completion of the Central Italy daily precipitation instrumental data series from 1951 to 2019 by Gamal AbdElNasser Allam Abouzied, Guoqiang Tang, Simon Michael Papalexiou, Martyn P. Clark, Eleonora Aruffo, Piero Di Carlo

“…To address this, gap filling is commonly used to produce complete hydrometeorological data series without missing values. …”
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Barriers and enablers to implementing clinical practice guidelines in primary care: an overview of systematic reviews by Tao Wang, Xian-Liang Liu, Jing-Yu (Benjamin) Tan, Isabella Zhao

“…Six categories of barriers and enablers were identified, which include (1) political, social and culture factors, (2) institutional environment and resources factors, (3) guideline itself related factors, (4) healthcare provider-related factors, (5) patient-related factors and (6) behavioural regulation-related factors. The most commonly reported barriers within the above-mentioned categories were suboptimal healthcare networks and interprofessional communication pathways, time constraints, poor applicability of CPGs in real-world practice, lack of knowledge and skills, poor motivations and adherence, and inadequate reinforcement (eg, remuneration). …”
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Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p by Wei Peng, Yun Yang, Jiaquan Chen, Zeyao Xu, Yuanlei Lou, Qi Li, Ning Zhao, Kejian Qian, Fen Liu

“…Sepsis-induced acute lung injury is a common critical illness in intensive care units with no effective treatment is currently available. …”
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