Exploring and validating key genetic biomarkers for diagnosis of Parkinson's disease by Wen-bin Teng, Hao-wei Deng, Bing-hua Lv, Shao-dan Zhou, Bin-ru Li, Rui-ting Hu

“…The function of genes was analyzed and verified by cells experiments. Results: Thirteen common upregulated genes were identified between PD tissue dataset and blood dataset. …”
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Combined surgical and interventional cardiology approach for central venous access salvage in children with intestinal failure: A case series by Emily Byrd, M. Jake Petersen, Minna M. Wieck, Frank Ing, Shinjiro Hirose

“…Indications for hybrid intervention included line fractures, occlusions, dislodgement, recurrent infections, and refractory central line infection. The most common procedures included vascular access, vein mapping, and balloon angioplasty of occluded central veins. …”
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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…Results: Twenty-eight adults (mean age, 26.9 years; 23 male participants), with 7 receiving 1 mg and 13 receiving 4 mg ASP2390, 8 receiving placebo, showed no serious adverse events or withdrawals due to treatment-emergent adverse events. The most common events were nasopharyngitis, coronavirus disease 2019, headache, fatigue, and diarrhea; fatigue and headache were the most frequent systemic reactions, and injection-site tenderness the most frequent local reaction. …”
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Minimizing skull defects in retrosigmoid approach: precision mapping of the sigmoid sinus with mastoid emissary vein canal by Artem V. Rozumenko, Mykola V. Yehorov, Vasyl V. Shust, Dmytro M. Tsiurupa, Anton M. Dubrovka, Petro M. Onishchenko, Volodymyr O. Fedirko

“…The retrosigmoid approach is a commonly used cranial approach to the cerebellopontine angle lesions, vascular and nerve pathologies. …”
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Medialization of shaft of humerus to provide medial buttress and prevent varus collapse in 3- and 4-part proximal humerus fractures: review of the surgical technique by Srinivas Kasha, MS(Ortho), Ranjith Kumar Yalamanchili, MS(Ortho), G.P.R.K. Rohit, MS(Ortho), Suresh Krishna Lokayah, MS(Ortho), Varun Kulkarni, MBBS

“…Locking plate designs offer promising solutions, yet technical guidelines for successful outcomes remain elusive. Complications are common, with fixation-related failures often attributed to varus collapse. …”
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The quality and technological parameters of milk obtained from dairy cows with subclinical mastitis by Magdalena Zalewska, Paulina Brzozowska, Magdalena Rzewuska, Ewelina Kawecka-Grochocka, Daria M. Urbańska, Tomasz Sakowski, Emilia Bagnicka

“…ABSTRACT: Mastitis is one of the most common diseases in dairy cattle. It significantly reduces milk quality and yield, thus incurring economic losses for farmers. …”
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Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review by Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang

“…Results Pulmonary dysfunction, particularly obstructive and restrictive ventilatory disorders, is common in pediatric HSCT recipients. Significant changes in PFT parameters, such as FEV1/FVC ratio and FEF25‐75%, were observed. …”
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Application of Laparoscopic Radical Resection for Type III and IV Hilar Cholangiocarcinoma Treatment by Sulai Liu, Xinyu Liu, Xuepeng Li, Ou Li, Weimin Yi, Junaid Khan, Pingzhou Yang, Chao Guo, Chuang Peng, Bo Jiang

“…All patients underwent total laparoscopic surgery, including basic surgery (laparoscopic gallbladder, hilar bile duct, and common bile duct resection and hepatoduodenal ligament lymph node dissection) combined with left hepatic and caudate lobe resection/portal resection. …”
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Efficacy and safety of first-line nivolumab plus ipilimumab treatment in elderly patients (aged ≥ 75 years) with non-small cell lung cancer by Satoshi Endo, Hisao Imai, Atsuto Mouri, Kasumi Tsukamoto, Kenji Masaki, Kosuke Hashimoto, Yu Miura, Ayako Shiono, Ou Yamaguchi, Junichi Nakagawa, Kyoichi Kaira, Kunihiko Kobayashi, Hiroshi Kagamu

“…Results The overall response rate was 42.1%, the disease control rate was 73.6%, the median progression-free survival (PFS) was 7.1 months, and the median overall survival (OS) was 14.1 months. Common Grade ≥ 3 AEs included pneumonitis, elevated aspartate transaminase, elevated alanine transaminase, adrenal insufficiency, and colitis. …”
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Immune checkpoint inhibitor-induced diabetes mellitus: clinical characteristics and risk factors by Mei Zhan, Mei Zhan, Qinran Long, Qinran Long, Jinhan He, Jinhan He, Jinhan He, Litao Huang, Bin Wu, Bin Wu, Haixia Xu, Li Mo, Ting Xu

“…BackgroundEmerging evidence indicates that immune checkpoint inhibitor-induced diabetes mellitus (ICI-DM) might be more common than initially reported, and more different clinical pictures associated with ICI-DM were described.ObjectiveThe aim of our study was to identify the clinical characteristics and possible predictive factors of ICI-DM.MethodsWe conducted a retrospective review of patients who received immune checkpoint inhibitors (ICI) at West China Hospital, Sichuan University until June 2023. …”
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Simultaneous Determination of Over-the-Counter Pain Relievers in Commercial Pharmaceutical Products Utilizing Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) Mult... by Heba Shaaban, Ahmed Mostafa, Zahra Almatar, Reem Alsheef, Safia Alrubh

“…In this study, the multivariate curve resolution-alternating least squares (MCR-ALS) chemometric method was developed and validated for the resolution and quantification of the most commonly consumed OTC pain relievers (acetaminophen, acetylsalicylic acid, ibuprofen, naproxen, and caffeine) in commercial drug formulations. …”
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Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo by Meng Minjun, Yang Qiaolu, Ouyang Zhong, Yang Qingmo, Wu Xinyi, Huang Yufan, Su Yonghui, Chen Shuanglong, Chen Wenlin

“…Breast cancer is one of the most common malignant tumors in women and it is the most frequently diagnosed cancer in the world. …”
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Comparison of ultrasound features and lesion sites in dysfunctional arteriovenous fistula by Yin Wang, Xiao-mei Huang, Yi Zhang, Jingjing Li, Jun Li, Zheng Ye, Yu Peng, Xian-jin Zhang, Na Tang, Wen-wen Qiu, Li Xu

“…Diabetes mellitus was most common in the intima-dominant group (42.0%). In Kaplan–Meier and univariate Cox analysis, type III lesion location (stenosis in the venous confluence site) was associated with the lower post-intervention primary patency. …”
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Rabies vaccinations at the rural–urban divide: successes and barriers to dog rabies vaccination programs from a rural and urban campaign in Zambia by Ricky Chazya, Chilufya Aneta Susan Mulenga, Andrew D. Gibson, Frederic Lohr, Cassandra Boutelle, Sarah Bonaparte, Oline Sinywibulula, Gareth Thomas, Patricia Bwalya, George Dautu, Linous Munsimbwe, Geoffrey Muuka, Luke Gamble, Ryan M. Wallace, Michelle A. Waltenburg

“…Private veterinary services were commonly utilized among surveyed dog owners in urbanized communities in Lusaka, suggesting that they are an important collaborator for achieving rabies herd immunity. …”
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The prevalence of online food delivery service usage and its association with anthropometric measurements in Muscat, Oman; a cross-sectional study by Ahmed Yahya Al Kharusi, Safa Khamis Ambusaidi, Marwa Abdullah Al Raisi, Haitham Mohammed Al Mahrouqi, Asma Ali Al Kendi, Muna Mohammed Almatrushi, Mohammed Juma Al Abdali, Sanjay Jaju, Maisa Hamed Al Kiyumi

“…While participants reported fair to good control over online food ordering, living alone emerged as a significant influencing factor, with dinner being the most commonly ordered meal. Conclusions: Our findings align with global trends, highlighting the convenience of online food services. …”
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National and subnational plans for primary prevention and early detection of oral and oropharyngeal cancer: a scoping review by Marcia Frias Pinto Marinho, Maria Clara Frias Lobo Marinho, Guido Artemio Marañón-Vásquez, Keith Bullia da Fonseca Simas, Mário José Romañach, Aline Corrêa Abrahão, Maria Augusta Visconti Rocha Pinto, Lucianne Cople Maia de Faria, Michelle Agostini

“…Opportunistic examination was the most common strategy for early detection, recommended by 29% of self-governing political entities, followed by screening in high-risk individuals (14.5%), self-examination (5.6%), and population-based screening (2.4%). …”
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Acute Stroke in northern Portugal: outcomes and characteristics of patients in a Medical-Surgical Emergency Department by Sandra Domingues, Tiago Barros, João Correia, Arlindo Cruz, Nuno Araújo, Liliana Silva

“…Ischemic stroke was most common (64.8%, 95% CI: 62.1-67.4%). Thrombolysis rates increased from 21.96% to 27.27% (p<0.01), and thrombectomy from 4.67% to 21.21% (p<0.001). …”
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Management of acute bacterial meningitis in a limited resource setting: an Egyptian consensus model by Samy Zaky, Mohamed Elbadry, Maysaa A. Saeed, Hanaa Fathelbab, Fatma Abdelsalam, Mohammed Gamal Abdel-Hamid, Alshaimaa Eid, Asmaa Bakr, Amira Maher, Mona Mohammed Abdelrahman, Mohamed A. Metwally, Mahmoud Saad Berengy, Enaam Ali AlMowafy, Hassan Goabar, Amin Abdel Baki, Ahmed Corie, Osama Hammad, Entesar Elsharkawy, Ahmed Saad, Fatma Ali-Eldin, Ahmed Mahdy, Ramadan Zaky, Reham Hammad, Gamal Essmat

“…It is a globally serious disease and is considered endemic in Egypt, affecting all age groups and being common in low-standard and overcrowded areas. Early and appropriate antimicrobial therapy is crucial for suspected bacterial meningitis, even before the causative pathogen is identified. …”
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Research trends on lymphedema after mastectomy for breast cancer patients from 2000 to 2023: a scientometric analysis by Ling Chen, Yuxian Zheng, Daitian Zheng, Zhiyang Li, Hongwu Chen, Chujun Chen, Chujun Chen, Shuxian Yu

“…BackgroundBreast cancer-related lymphedema (BCRL) is a common and debilitating complication following breast cancer treatment. …”
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Comparative genomics analyses of Actinobacteriota identify Golgi phosphoprotein 3 (GPP34) as a widespread ancient protein family associated with sponge symbiosis by Cláudia Ferreira, Ilia Burgsdorf, Tzipora Perez, Gustavo Ramírez, Maya Lalzar, Dorothée Huchon, Laura Steindler

“…To understand these genetic adaptations, we conducted a comparative genomics analysis on 350 genomes of Actinobacteriota, a phylum commonly associated with sponges. Results Our analysis uncovered several differences between symbiotic and free-living bacteria, including an increased abundance of genes encoding prokaryotic defense systems (PDSs) and eukaryotic-like proteins (ELPs) in symbionts. …”
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