From the depths of the Java Trench: genomic analysis of Priestia flexa JT4 reveals bioprospecting and lycopene production potential by Ocky K. Radjasa, Ray Steven, Yosua Natanael, Husna Nugrahapraja, Septhy K. Radjasa, Tati Kristianti, Maelita R. Moeis, Joko P. Trinugroho, Haekal B. Suharya, Alfito O. Rachmatsyah, Ari Dwijayanti, Mutiara R. Putri, Charlie E. de Fretes, Zen L. Siallagan, Muhammad Fadli, Rafidha D. A. Opier, Jandinta D. Farahyah, Viana Rahmawati, Meirifa Rizanti, Zalfa Humaira, Ary S. Prihatmanto, Nugroho D. Hananto, R. Dwi Susanto, Agus Chahyadi, Elfahmi, Neil Priharto, Kamarisima, Fenny M. Dwivany

“…Moreover, our analysis uncovered eight biosynthetic gene clusters (BGCs) using the common genome mining pipeline, antiSMASH. Two non-ribosomal peptide synthetase (NRPS) BGCs within these clusters exhibited the potential to generate novel biological compounds. …”
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Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction by Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho

“…Background Liver fibrosis is a common outcome of chronic liver disease and is primarily driven by hepatic stellate cell (HSC) activation. …”
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Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…Four DAMs—3‐hydroxybutyric acid (BHB), 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF), glycochenodeoxycholate and citrulline—were common to both tissue and serum and showed a similar pattern of differential abundance in both groups. …”
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Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanced tumor progression, metastasis, and therapeutic resistance. …”
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Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China by Wanjun Wang, Mo Xian, Ruchong Chen, Jing Li, Lulu Wu

“…Methods: We redesigned the dataset of the China Alliance of Research on Respiratory Allergic Disease secondary survey, and after stratified sampling, a subsample of 2422 subjects were enrolled for the analysis of a questionnaire, skin prick tests (SPT), and specific immunoglobulin E (sIgE) titer measurements against 8 common allergens. Fecal microbiotal composition was also sequenced by 16S rRNA and regression-based analyses with covariate adjustment applied. …”
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Smaller sizes of polyethylene terephthalate microplastics mainly stimulate heterotrophic N2O production in aerobic granular sludge systems by Yingrui Liu, Yanying He, Qian Lu, Tingting Zhu, Yufen Wang, Yindong Tong, Yingxin Zhao, Bing-Jie Ni, Yiwen Liu

“…In this study, the effects of PET MPs with two common particle sizes of effluent from WWTPs (0.1 and 0.5 mm) on N2O turnovers, production pathways and N2O-sink capability were systematically disclosed in AGS systems by a series of biochemical tests and molecular biological means to achieve the goal of carbon neutrality. …”
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Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line by Mohammed Nihal Hasan, Syed Shoeb Razvi, Hani Choudhry, Mohammed A. Hassan, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Khalid Omer Abualnaja, Majed A. Halwani, Abdulrahman Labeed Al-Malki, Jiannis Ragoussis, Wei Wu, Christian Bronner, Tadao Asami, Mahmoud Alhosin

“…Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therapy. …”
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The efficacy analysis of laparoscopic-assisted Soave procedure for Hirschsprung’s disease in neonates and infants within 3 months of age by Renpeng Xia, Tidong Ma, Fan Zhao, Yong Xiao, Yong Feng, Ming Li, Chanjuan Zou, Guang Xu, Chonggao Zhou

“…There were 37 cases (13.9%) of long-segment type, 226 cases (84.6%) of common type, and 4 cases (1.5%) of short-segment type. …”
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Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations by Jian Yuan, Ruowen Qiu, Yuhan Wang, Zhen Ji Chen, Haojun Sun, Wei Dai, Yinghao Yao, Ran Zhuo, Kai Li, Shilai Xing, Myopia Associated Genetics and Intervention Consortium, Xiaoguang Yu, Liya Qiao, Jia Qu, Jianzhong Su

“…We generate, optimize, and validate an exome-wide genetic risk score (ExGRS) for HM prediction by combining rare risk genotypes with common variant GRS (cvGRS). ExGRS improved the AUC from 0.819 (cvGRS) to 0.856 for 1219 Han Chinese individuals of an independent testing dataset. …”
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Development and validation of nomograms for predicting pentafecta outcomes before and after robot-assisted radical prostatectomy: a retrospective study by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…Abstract Prostate cancer (PCa) is one of the most common cancers among men worldwide, and robot-assisted radical prostatectomy (RARP) is a widely used treatment for localized PCa. …”
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Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent by Baraa Mohammed Yaseen, Farag M. A. Altalbawy, Farag M. A. Altalbawy, Rafid Jihad Albadr, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Hiba Mushtaq, Khursheed Muzammil, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel

“…Antimicrobial evaluations were carried out on Common bacterial strains in wastewater and values of MIC (minimum inhibitory concentration) and MBC (Minimum Bactericidal Concentration) were reported. …”
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Involvement of the posterior limb of the internal capsule independently predicts the prognosis of patients with basal ganglia and thalamic hemorrhage by Sohan Gupta, Mengxuan Xiao, Na Liu, Na Liu, Yunxiao Zhao, Xiaolin Zhao, Yunqiang Huang, Yongming Wu, Zhenzhou Lin, Zhong Ji, Haihao Xu, Minzhen Zhu, Suyue Pan, Kaibin Huang

“…Basal ganglia hemorrhage and thalamic hemorrhage are the most common types of ICH, accounting for 50–70% of all ICH cases, leading to disability and death, and it involves the posterior limb of the internal capsule to varying degrees. …”
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Phenotypic Presentation of Children with Joint Hypermobility: Preclinical Signs by Mateus Marino Lamari, Neuseli Marino Lamari, Michael Peres de Medeiros, Gerardo Maria de Araújo Filho, Adriana Barbosa Santos, Matheus Gomes Giacomini, Vitor Roberto Pugliesi Marques, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino

“…Results: The concave sitting position was the most common, followed by W, F, and S in decreasing order. …”
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Development and validation of the “Adjustment Disorder Scale for Medically Ill Patients - ETAM” by Juan Pablo Zapata-Ospina, Natalia Rodríguez, Ayda Margarita Rodríguez, Jenny García-Valencia, Mercedes Jiménez-Benítez, Nicolás Martínez-Ramos, Diana Restrepo Bernal, Ana Lucía Gallego, Carolina Gómez, Luis Fernando Tabares, Carlos Cardeño-Castro, Daniel Camilo Aguirre-Acevedo

“…BackgroundAdjustment disorder (AD) is common among medically ill patients, yet current evaluation methods do not address the specific characteristics in this population. …”
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Maintaining Fat-Free Mass and Muscle Mass during obesity therapy with Incretin-Mimetic Drugs by Dariusz Popiela, Karina Urbańska, Łukasz Stojak, Mateusz Grego, Filip Kwiatkowski, Mateusz Baczewski, Katarzyna Grego, Witold Czyż

“…The analysis included articles concerning FFM and MM loss in the most common obesity treatment therapies and articles that provided information about the impact of exercise and nutrition combined with IMDs in obesity treatment and proper weight maintenance. …”
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Use of Digital Health Interventions for Cancer Prevention Among People Living With Disabilities in the United States: A Scoping Review by Chinenye Lynette Ejezie, Lea Sacca, Sylvia Ayieko, Sara Burgoa, Yasmine Zerrouki, Diana Lobaina, Goodness Okwaraji, Christine Markham

“…Digital health strategies consisted of educational content delivered online, text messaging, interactive educational games, and downloadable informational applications. The common outcome of interest across all manuscripts was intervention efficacy. …”
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Projected distribution patterns of Alpinia officinarum in China under future climate scenarios: insights from optimized Maxent and Biomod2 models by Yong Kang, Yong Kang, Fei Lin, Junmei Yin, Junmei Yin, Yongjie Han, Min Zhu, Yuhua Guo, Fenling Tang, Yamei Li

“…Alpinia officinarum, commonly known as Galangal, is not only widely used as a medicinal plant but also holds significant ornamental value in horticulture and landscape design due to its unique plant structure and floral aesthetics in China. …”
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Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers by Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo

“…Results MPLCs and SPLCs share significant similarities in genetic, transcriptomic and immune profiles, suggesting common therapeutic strategies such as EGFR‐TKIs andICIs. …”
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Real-world experiences with brentuximab vedotion-based regimens in systemic anaplastic large cell lymphoma: a multi-center retrospective study by Zhiqiang Zhao, Qinchuan Yu, Liping Su, Jianxia He, Jie Tao, Yanfeng Xi, Yujiao Guo, Yanhong Luo, Lieyang Wang

“…Neurological toxicities were commonly observed but resolved following the completion of treatment.ConclusionBV has proven to be effective and well-tolerated in real-world settings for the treatment of sALCL, reinforcing its potential as a promising option for first-line or subsequent therapy. …”
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Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes by Bo Hu, Ying Yu, Xin-Wen Yu, Min-Hua Ni, Yan-Yan Cui, Xin-Yu Cao, Ai-Li Yang, Yu-Xin Jin, Sheng-Ru Liang, Si-Ning Li, Pan Dai, Ke Wu, Lin-Feng Yan, Bin Gao, Guang-Bin Cui

“…Abstract Background Episodic memory decline is a common complication of type 2 diabetes (T2D). To comprehensively explore the neural mechanisms underlying it, we aimed to explore the sequence that episodic memory-related behavioral and brain-imaging biomarkers appear abnormal in the progression of T2D. …”
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