Re-analysis of the current status of clinical trial registration in China by Shuwen Li, Shuwen Li, Jianhao Li, Wenjing Zeng, Zhicheng Li, Jietong Zhang, Siying Wang, Nenggui Xu, Zeli Li, Zeli Li

“…NoteExpress software was used for screening, EXCEL for data organization and analysis, the Word Cloud website for constructing word frequency maps, and Origin software for visualization.ResultsAmong the 94 articles included, common analysis items included the number of registered projects, types of research, registration time, types of registration institutions, and regional distribution. …”
Get full text

Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…Abstract Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline combination chemoimmunotherapy, DLBCL carries persistently poor prognosis for those with relapsed or refractory (rel/ref) disease, despite recent advances in immunotherapy. …”
Get full text

Pulse oximeter perfusion index as a new predictor of hypotension following subarachnoid block in lower segment Cesarean section: A prospective randomized study by Ashish Mohan M, Suman Gupta, Kavya Kanjikkal, Vankudoth Bhaskar

“…Background: Hypotension is a common adverse effect of spinal anesthesia, especially during pregnancy, due to the blockade of pre-ganglionic sympathetic fibers, resulting in reduced peripheral vascular resistance. …”
Get full text

Anti-inflammatory and antioxidant properties of oleuropein in human keratinocytes characterized by bottom-up proteomics by Huifang Li, Ni Deng, Jiayi Yang, Yang Zhao, Xiaoxuan Jin, Ang Cai, Navindra P. Seeram, Hang Ma, Dongli Li, Huilan Yang, Chang Liu, Chang Liu

“…Oleuropein is a phenolic compound commonly found in cosmetic ingredients including olive leaves and jasmine flowers with various skin-beneficial effects. …”
Get full text

Larval Cytotoxic and Subacute Toxicity of Gardenia ternifolia, Rourea coccinea, and Cassytha filiformis Used in Traditional Medicine of Benin (West Africa) by E. Agbodjento, J. R. Klotoé, T. I. Sacramento, T. V. Dougnon, E. Déguenon, J. Agbankpé, K. Fabiyi, P. Assogba, M.-P. Hounkanrin, R. Akotegnon, T. J. Dougnon, J.-M. Atègbo

“…The use of medicinal plants in traditional medicine is a common practice in developing countries. However, this unregulated or irrational use may pose a risk of toxicity to humans in the short and/or long term. …”
Get full text

Mosquito populations originating from nonendemic areas have the potential to transmit recently emerging Japanese encephalitis virus genotype IV by Astri Nur Faizah, Daisuke Kobayashi, Faustus Akankperiwen Azerigyik, Ryo Matsumura, Izumi Kai, Yoshihide Maekawa, Yukiko Higa, Kentaro Itokawa, Toshinori Sasaki, Kris Cahyo Mulyatno, Sri Subekti, Maria Inge Lusida, Etik Ainun Rohmah, Yasuko Mori, Yusuf Ozbel, Chizu Sanjoba, Tran Vu Phong, Tran Cong Tu, Shinji Kasai, Kyoko Sawabe, Haruhiko Isawa

“…Japanese encephalitis virus (JEV) genotype IV (GIV) is one of the least common and most neglected genotypes worldwide, having been identified only on a few Indonesian islands until it was recently found to be the cause of outbreaks that occurred in several Australian states in early 2022. …”
Get full text

Vial-coated thin film microextraction for perfluoroalkyl carboxylic acids (PFCAs) determination in water by GC–MS by J․Mabel Luna-Díaz, Luz O․ Leal-Quezada, Laura Ferrer, Edwin Palacio

“…Perfluoroalkyl carboxylic acids (PFCAs), a subclass of perfluoroalkyl substances (PFAs) commonly detected in water, are of increasing concern due to their persistence, bioaccumulative nature, and harmful effects on health. …”
Get full text

Reduction of monoclonal antibody viscosity using interpretable machine learning by Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters, Peter M. Tessier

“…Our model was trained on antibody viscosity data (>100 mg/mL mAb concentration) obtained at a common formulation pH (pH 5.2), and it identifies three key Fv features of antibodies linked to viscosity, namely their isoelectric points, hydrophobic patch sizes, and numbers of negatively charged patches. …”
Get full text

Efficacy of Neoadjuvant Chemotherapy DOX and XELOX Regimens for Patients with Resectable Gastric or Gastroesophageal Junction Adenocarcinoma by Yuan Tian, Qun Zhao, Yong Li, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Bibo Tan, Dong Wang, Peigang Yang

“…There were 56 (61.3%) patients in the DOX group who presented with surgical complications, 22 (23.9%) patients in the XELOX group, and 37 (38.9%) patients in the surgery group. The most common grade 3-4 adverse events in these three groups were neutropenia (32.3%, 30.4%, and 21.1%), leucopenia (21.5%, 22.8%, and 15.8%), nausea (15.1%, 16.3%, and 12.6%), and fatigue (10.8%, 7.6%, and 8.4%). …”
Get full text

Corticomuscular coherence existed at the single motor unit level by Yang Zheng, Bofang Zheng, Wei Qiang, Yu Peng, Guanghua Xu, Gang Wang, Lili Li, Henry Shin

“…In contrast to the CMC only occurring in β and γ bands, CMnC occurred across the four common EEG frequency bands (θ, α, β and γ). Further, we identified individual MUs that showed significant interactions with the motor cortex. …”
Get full text

Causal associations between socioeconomic status and prostate cancer using two-sample Mendelian randomization study by Zhenxing Wang, Chunyan Wang, Xing Gou, Liang Pei, Xiaoyuan Qiao

“…Abstract Prostate cancer (PCa) is a common form of malignancy among men. The associations between socioeconomic status (SES) indicators and PCa risks remain incompletely elucidated. …”
Get full text

Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads by Kathrin Machetanz, Eliane Weinbrenner, Thomas Volkmar Wuttke, Silke Ethofer, Randolph Helfrich, Josua Kegele, Stephan Lauxmann, Michael Alber, Sabine Rona, Marcos Tatagiba, Holger Lerche, Jürgen Honegger, Georgios Naros

“…Normative connectomes on MRI data enable to link different symptoms and lesion locations to a common functional network. The present study applied connectomics to disentangle epilepsy networks from insular SEEG recordings and to describe their relationship to seizure semiology.MethodsWe retrospectively extracted functional networks by normative connectome analysis from 118 insular contacts depicting epileptic discharges during SEEG in 20 epilepsy patients. …”
Get full text

Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease by Cristine de Paula Nascimento-Castro, Ana Claudia Wink, Victor Silva da Fônseca, Claudia Daniele Bianco, Elisa C. Winkelmann-Duarte, Marcelo Farina, Ana Lúcia S. Rodrigues, Joana Gil-Mohapel, Andreza Fabro de Bem, Patricia S. Brocardo

“…Depression is one of the most common psychiatric disturbances in HD, present even before manifestation of motor symptoms. …”
Get full text

The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis by Jaime Fernández-Sarmiento, Sushitra Ranjit, L. Nelson Sanchez-Pinto, Vinay M. Nadkarni, Roberto Jabornisky, Niranjan Kissoon

“…Fluid therapy and vasoactive drugs are cornerstone therapies for circulatory problems in sepsis. Fluid boluses are a common first-line treatment for actual and relative hypovolemia. …”
Get full text

Development and Implementation of an IoT-Based Early Flood Detection and Monitoring System Utilizing Time Series Forecasting for Real-Time Alerts in Resource-Constrained Environmen... by Nik Nor Muhammad Saifudin Nik Mohd Kamal, Ahmad Anwar Zainuddin, Abu Ubaidah Shamsudin, Muhamad Syariff Sapuan, Muhammad Hazim Amin Samsudin, Mohammad Adam Haikal Zulkfli

“…To solve these issues, this research aims to design an Early Flood Detection and Monitoring System that uses Internet of Things (IoT) technology to provide a cost-effective, efficient, and real-time solution for detecting increasing water levels and sending early alerts. The system uses commonly accessible components such as NodeMCU ESP8266, HC-SRO4 Ultrasonic Sensors, and MAX7219 Dot Matrix Displays to build a sensor network in flood-prone locations. …”
Get full text

Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life by Sebastiano Montante, Rym Ben-Othman, Nelly Amenyogbe, Asimenia Angelidou, Anita van den Biggelaar, Bing Cai, Yixuan Chen, Alansana Darboe, Joann Diray-Arce, Rebecca Ford, Olubukola Idoko, Amy Lee, Mandy Lo, Kerry McEnaney, Mehrnoush Malek, David Martino, Geraldine Masiria, Oludare A. Odumade, William Pomat, Casey Shannon, Kinga Smolen, The EPIC Consortium, Al Ozonoff, Peter Richmond, Scott Tebbutt, Ofer Levy, Beate Kampmann, Ryan Brinkman, Tobias Kollmann

“…Our results suggest a common trajectory of immune development in newborns and possible association with timing of breastfeeding initiation, which may contribute to immune-mediated protection from infection in early life. …”
Get full text

Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss by O. L. Posukh, M. S. Bady-Khoo, M. V. Zytsar, V. Yu. Mikhalskaia, S. A. Lashin, N. A. Barashkov, G. P. Romanov

“…The start for these events was the breakdown of the deep social isolation of deaf people, which occurred about 300 years ago in Europe, and later in the US, when special schools for the deaf with learning sign language as a common tool for communication were established (linguistic homogamy). …”
Get full text

Presence of Rickettsia Species in a Marginalized Area of Yucatan, Mexico by Gaspar Peniche-Lara, Bertha Jimenez-Delgadillo, Claudia Munoz-Zanzi, María Cárdenas-Marrufo, Carlos Pérez-Osorio, Juan Arias-León

“…In the state of Yucatan, Mexico, rickettsiosis has become a common vector-borne disease in the general population. …”
Get full text

Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers by Grzegorz Woźniak, Tomasz Rutkowski, Wojciech Majewski, Aleksandra Napieralska, Jerzy Wydmański, Agnieszka Czarniecka, Cezary Szymczyk, Adam Bekman, Żaneta Kaniszewska Dorsz, Tomasz Latusek, Bogusław Maciejewski

“…Radiation therapy is commonly used as a postoperative treatment. Delivering radiation dose during surgery, defined as intraoperative radiotherapy (IORT), can be very useful especially in case of high risk of recurrence or where gross or macroscopic residual disease are present. …”
Get full text

Ezrin Polarization as a Diagnostic Marker for Circulating Tumor Cells in Hepatocellular Carcinoma by Ibrahim Büdeyri, Olaf Guckelberger, Elsie Oppermann, Dhruvajyoti Roy, Svenja Sliwinski, Felix Becker, Benjamin Struecker, Thomas J. Vogl, Andreas Pascher, Wolf O. Bechstein, Anna Lorentzen, Mathias Heikenwalder, Mazen A. Juratli

“…Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related death worldwide, with no precise method for early detection. …”
Get full text