Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling by Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang

“…Chemotherapy-induced neuropathic pain (CINP) is a serious adverse effect of commonly used chemotherapeutics. Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception, presenting an analgesic potential. …”
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Acute stress triggers sex-dependent rapid alterations in the human small intestine microbiota composition by Bruno K. Rodiño-Janeiro, Bruno K. Rodiño-Janeiro, Olfat Khannous-Lleiffe, Olfat Khannous-Lleiffe, Marc Pigrau, Marc Pigrau, Marc Pigrau, Jesse R. Willis, Jesse R. Willis, Eloísa Salvo-Romero, Eloísa Salvo-Romero, Eloísa Salvo-Romero, Adoración Nieto, Adoración Nieto, Elba Expósito, Elba Expósito, Elba Expósito, Marina Fortea, Marina Fortea, Cristina Pardo-Camacho, Cristina Pardo-Camacho, Cristina Pardo-Camacho, Mercé Albert-Bayo, Mercé Albert-Bayo, Ana María González-Castro, Ana María González-Castro, Ana María González-Castro, Ana María González-Castro, Danila Guagnozzi, Danila Guagnozzi, Danila Guagnozzi, Danila Guagnozzi, Cristina Martínez, Cristina Martínez, Cristina Martínez, Beatriz Lobo, Beatriz Lobo, Beatriz Lobo, Beatriz Lobo, María Vicario, María Vicario, Javier Santos, Javier Santos, Javier Santos, Javier Santos, Toni Gabaldón, Toni Gabaldón, Toni Gabaldón, Toni Gabaldón, Carmen Alonso-Cotoner, Carmen Alonso-Cotoner, Carmen Alonso-Cotoner, Carmen Alonso-Cotoner

“…Background/aimsDigestive disorders of gut-brain interaction (DGBI) are very common, predominant in females, and usually associated with intestinal barrier dysfunction, dysbiosis, and stress. …”
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Untargeted Metabolomics Reveals Key Differences Between Yak, Buffalo, and Cow Colostrum Based on UHPLC-ESI-MS/MS by Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang

“…In comparison to CC, both YC and BC shared common features, including reduced choline levels and elevated O-acetylcarnitine. …”
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Time Series Classification of Raw Voice Waveforms for Parkinson's Disease Detection Using Generative Adversarial Network-Driven Data Augmentation by Marta Rey-Paredes, Carlos J. Perez, Alfonso Mateos-Caballero

“…In this context, many recent studies have focused on the automatic detection and progression tracking of PD from voice-related characteristics, being feature engineering the most common approach. This work intends to address an existing research gap by introducing a novel strategy that analyzes raw voice waveforms. …”
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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis and contributing factors are not yet fully elucidated. …”
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases by Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

“…Although we could not find a common pattern of circadian variance, we observed daily variation in histone H3 acetylation levels, and their coefficient of variances (CVs) were approximately 48.3%. …”
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Emergence of invasive Streptococcus dysgalactiae subsp. equisimilis in Spain (2012-2022): genomic insights and clinical correlations by Guillem López de Egea, Aida González-Díaz, Randall J Olsen, Gérard Guédon, Dàmaris Berbel, Immaculada Grau, Jordi Càmara, Lucía Saiz-Escobedo, Sara Calvo-Silveria, Irene Cadenas-Jiménez, José María Marimón, Emilia Cercenado, Antonio Casabella, Sara Martí, M. Ángeles Domínguez, Nathalie Leblond-Bourget, James M Musser, Carmen Ardanuy

“…Whole genome sequencing revealed a high genetic diversity, with the most common lineages being CC15, CC17, and CC20. Various virulence factors, including the superantigen speG, were identified. …”
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Evaluation of Ligamentum Mucosum in Anterior Cruciate Ligament Injuries by Mehmet Ali Tokgöz, Ethem Burak Oklaz, Muhammet Baybars Ataoğlu, Muhammed Şakir Calta, Anıl Köktürk, Ulunay Kanatlı

“…Results: The non-presence of the LM was significantly more common in chronic ACL tears compared to the other groups (p=0.021), while the presence of the LM (either intact or ruptured) was similar between acute ACL tears and intact ACLs. …”
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Congenital Malaria and Its Associated Factors at Issaka Gazobi Maternity of Niamey in Niger by I. Tahirou, M. O. Zara, M. L. Moustapha, M. Kamayé, D. Mahamadou, A. Ibrahim, M. Daou, A. Soumana, M. L. Ibrahim

“…Congenital malaria is a serious and common infection in tropical Africa. It has multiple consequences on the newborn and the mother. …”
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The prevention opportunities of retinopathy in diabetic patients – position paper endorsed by the Polish Lipid Association by Maciej Banach, Stanisław Surma, Grzegorz Dzida, Jacek Jóźwiak, Bogusław Okopień, Jacek Rysz, Konrad Szosland, Andrzej Grzybowski

“…This intervention – well-recognized and already in common use in diabetic patients – may significantly improve population health in Poland and worldwide.…”
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Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke by Payam Saadat, Alijan Ahmadi Ahangar, Mansor Babaei, Mandana Kalantar, Mohammad Ali Bayani, Hiva Barzegar, Hemmat Gholinia, Farbod Zahedi Tajrishi, Sekineh Faraji, Fatemeh Frajzadeh

“…Stroke is one of the most common neurological disorders with high mortality rates. …”
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High-flow nasal cannula oxygen therapy versus non-invasive ventilation in healthy respiratory physicians: a non-randomized study by Hong Ye, Dandan Xiang, Xiangyu Zhu, Xiuwei Du, Shengyun Shang, Jing Xu, Yu Li, Yunyun Cheng, Zhongfei Yang

“…BackgroundHigh-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) are commonly used for respiratory support. This study aims to first establish whether to use HFNC or NIV based on comfort levels, and subsequently evaluate diaphragmatic function under equivalent comfort levels to determine the optimal modality for clinical application.MethodsA self-controlled, non-randomized study was conducted with 10 healthy respiratory physicians as participants. …”
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Calcium-binding site in AA10 LPMO from Vibrio cholerae suggests modulating effects during environmental survival and infection by Mateu Montserrat-Canals, Kaare Bjerregaard-Andersen, Henrik Vinther Sørensen, Eirik Kommedal, Gabriele Cordara, Gustav Vaaje-Kolstad, Ute Krengel

“…Between outbreaks, the bacterium responsible for the disease, Vibrio cholerae, survives in aquatic environmental reservoirs, where it commonly forms biofilms, for example, on zooplankton. …”
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Prevalence of posttraumatic stress disorder (PTSD) in Canada during the COVID-19 pandemic: results from the Survey on COVID-19 and Mental Health by Murray Weeks, Danielle Marion, Anne-Marie Robert, R. Nicholas Carleton

“…ConclusionPTSD prevalence in Canada varies significantly across sociodemographic groups and is more common among those with indicators of lower mental health and well-being, as well as those more adversely affected by the COVID-19 pandemic. …”
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An updated overview of Juvenile systemic sclerosis in a French cohort by Léa Jacquel, Rouba Bechara, Joëlle Terzic, Anne-Cécile Rameau, Emmanuel Chatelus, Linda Rossi-Semerano, Isabelle Kone-Paut, Ulrich Meinzer, Irène Lemelle, Charlotte Rebelle, Diego Urbina, Pascal Pillet, Pauline Choquet, Jad El Maamari, Ariane Zaloszyc, SOFREMIP

“…All children tested positive for antinuclear antibodies, with anti-Scl70 being the most common specificity, even among children with limited cutaneous subsets. …”
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Evaluation of post-earthquake fractures according to anatomical body parts: A retrospective study by Muhammed Furkan Arpaci, Ferhat Tas, Gokce Bagci Uzun, Mehmet Akcicek, Feyza Inceoglu, Mine Argali Deniz, Emre Demirel, Hidir Pekmez

“…In the region of the most common fragmentary fracture type (48.9%); omos (3%), brachium (1%), thorax (15%), viscerocranium (7%) and neurocranium (3%), in oblique fractures (25.5%); pes (26%), in transverse fractures (20.4%); antebrachi (21%), manus (32%) and vertebral column (4%), in spiral fractures; pelvis (14%), femur (14%) and crus (57%) region. …”
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Exploring the Therapeutic Role of Physical Activity in Psychotic Disorders: Cognitive, Somatic, and Mental Health Impacts by Klaudia Fikas, Kamil Chwaliszewski, Dorota Waz, Michał Mazur, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Sebastian Samuła

“…These conditions are commonly associated with somatic symptoms, fatigue, and impaired psychosocial functioning. …”
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How fast is the frequency of precipitation extremes doubling in global land regions? by Guillaume Chagnaud, Juliette Blanchet, Guillaume Evin, Benoit Hingray, Thierry Lebel, Geremy Panthou, Théo Vischel

“…In addition, the rarest events are found to have smaller FDT compared to more ‘common’ extremes; infrastructures designed to withstand the strongest events are thus more exposed to premature obsolescence.…”
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The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

“…Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers. …”
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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

“…Abstract Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, a common feature of solid tumor, is associated with drug resistance and a poor prognosis in BC. …”
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