Development of a stable eukaryotic strain producing fully human monoclonal antibody on the basis of the human antibody against ectromelia virus by A. L. Matveev, Ya. A. Khlusevich, I. K. Baykov, I. V.  Babkin, E. P. Goncharova, V. V. Morozova, N. V. Tikunova

“…To develop the producing strain, random integration of the plasmid containing the gene encoding the target protein into the genome of the host cells is commonly used. The aim of this study was the development of an original expression system, using gene targeting to integrate the gene encoding the fully­human antibody into the transcriptionally active region of the genome of eukaryotic suspension cells CHO­S. …”
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Determination of antioxidant and phytochemical properties of premix extract of brown macroalgae Padinaaustralis, Sargassum licifolium and Stoechospermum marginatum from Chabahar co... by Paria Akbary

“…Most importantly, they contain a wide range of bioactive agents such as phenols, sterols and flavonoids, many of which are not commonly found in land plants. These bioactives, including phenols and macroalgae extracts containing these compounds, have been investigated as feed additives in aquatic nutrition. …”
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Unusual hypertrophic cardiomyopathy: case report of an early onset wild-type ATTR amyloidosis accompanied by a chromosomal duplication involving the MYH6 and MYH7 gene by Jassin Hamidi, Yvonne Hanel, Sven Dittmann, Wanda Maria Gerding, Huu Phuc Nguyen, Karin Klingel, Eric Schulze-Bahr

“…With an estimated prevalence of 1:200–500, HCM is among the most common genetically determined cardiac diseases. Functionally, enhanced tissue stiffness and reduced elasticity, combined with diastolic dysfunction and myocardial fibrosis, can eventually lead to life-threatening arrhythmias and impaired blood flow through the heart chamber. …”
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Accessibility of Patients With Special Healthcare Needs to Dental Care in the Eastern Province of Saudi Arabia: A Multicentre Study From Perspective of Caregiver and Dental Care Pr... by Tarek Ezzeldin, Mazin Algahtani, Nadia Abdulrahman Alghannam, Faisal Abdulkareem Alsafran, Intisar Ahmad Siddiqui, Hebah Zaki Al-Ghanim, Basma Mohamed Bader, Abdullah Abdulatif Alshubat, Adnan Hamad Almarry, Hussein Hejji IbnAhmed, Sarah Abdulhadi Kanakri, Reem Babiker Eltayeb, Mohammed Ibrahim Almuaybid, Khalaf Ali Al-Wasi

“…The second proforma had the dental care provider’s perspective about the common disabilities, factors that affect the decision to provide treatment, difficulties patients face in getting their dental treatment and, from the dentist’s experience, recommendations to improve the access to dental care for patients with SCN. …”
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation by Fan X, Liu S, Yu J, Hua J, Feng Y, Wang Z, Shen Y, Lan W, Wang J

“…Xiaoxu Fan,1 Shuangqiao Liu,1 Jing Yu,2 Jian Hua,1 Yingtong Feng,1 Zhen Wang,1 Yiwei Shen,1 Wei Lan,2 Jingxia Wang1 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2School of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, People’s Republic of ChinaCorrespondence: Jingxia Wang, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China, Email 601435@bucm.edu.cn Wei Lan, School of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, People’s Republic of China, Email lanwei516@sina.comBackground: Diabetic liver injury (DLI) is a common complication of diabetes mellitus (DM), which seriously endangers the health of diabetic patients. …”
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Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

“…Reoccurring barriers and facilitators to sepsis recognition and management were commonly identified across the TDF domains of Knowledge, Skills, Environmental Context and Resources, and Social Influences, including competency deficit (with facilitators including support from colleagues), workload or staffing, and equipment or resource availability. …”
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The Relationship Between Novel Inflammatory Markers and Serum 25‐Hydroxyvitamin D Among US Adults by Hang Zhao, Yangyang Zhao, Yini Fang, Weibang Zhou, Wenjing Zhang, Jiecheng Peng

“…Recent studies have investigated the correlation between serum 25‐hydroxyvitamin D (25(OH)D) and common inflammatory markers. However, few studies have incorporated novel inflammatory markers such as the platelet‐to‐lymphocyte ratio (PLR), platelet‐to‐high density lipoprotein cholesterol ratio (PHR), systemic inflammatory index (SII), neutrophil‐to‐lymphocyte ratio (NLR), systemic inflammatory response (SIRI), and neutrophil‐to‐high‐density lipoprotein cholesterol ratio (NHR). …”
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Increased Plasma Levels of 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in Patients with Pseudoexfoliation Glaucoma by Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Lubna Tabussum, Essam A. Osman, Saleh A. Al-Obeidan

“…The assay was performed in duplicate on an automated ELISA analyzer. Two common polymorphisms (rs1048661 and rs3835942) in LOXL1 gene were genotyped by Sanger sequencing. …”
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The Association between Serum Level of Vitamin D and Inflammatory Biomarkers in Hospitalized Adult Patients: A Cross-Sectional Study Based on Real-World Data by Xiaomin Zhang, Zhiqi Chen, Yi Xiang, Yiquan Zhou, Molian Tang, Jun Cai, Xinyi Xu, Hongyuan Cui, Yi Feng, Renying Xu

“…The deficiency and insufficiency of vitamin D in the hospitalized adult patients was very common. However, the results should be interpreted with caution for limited representation of the whole inpatients. …”
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Fecal carriage of carbapenemase and AmpC-β-lactamase producers among extended spectrum β-Lactamase-producing E. coli and Klebsiella spp. isolates in patients attending hospitals by Zakaria Garba, Isidore J. O. Bonkoungou, Namwin Siourimè Somda, Magloire H. Natama, Georges Somé, Lassana Sangaré, Nicolas Barro, Halidou Tinto

“…High co-resistances were reported for commonly used antibiotic agents. Therefore, screening for carbapenem-resistant Enterobacterales (CRE) carriage is necessary to limit its spread within hospitals.…”
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Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-se... by Youdi Xue, Kun Shi, Weixiang Dai, Chao Ma, Jie Li

“…Abstract Subsequent vertebral fracture (SVF) is a common and refractory complication after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fracture (OVCF). …”
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Prevalence of Helicobacter pylori infection and its Associated Risk Factors among symptomatic Residents of Sulaimani city, Kurdistan region, Iraq, 2020 by Seerwan Hama Rashid Ali, Sabiha Sharif Salih, Taib Ahmed Hama Sour, Goran Mohammad Raouf, Araz Latif Rahim

“…Infection by H. pylori bacteria is rife in dyspeptic patients; and is more common in the age group of 31-40 years. One of noninvasive test to diagnosis H. pylori is Urea breath test.  …”
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Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study by Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

“…Background: Breast cancer is the most common malignancy in women and the leading cause of cancer-related death. …”
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Time to antiretroviral therapy initiation in HIV-positive patients with opportunistic infections/AIDS-defining illness in Southern Thailand: a prospective cohort study by Chanadda Wuttikul, Nattasiri Thanawuth, Malee Rojpibulsatit, Sutthiporn Pattharachayakul

“…Results A total of 253 patients were included. The three most common OIs were tuberculosis (36.8%), Pneumocystis jirovecii pneumonia (26.1%), and candidiasis (19.0%). 39.9% of patients learned about their HIV-serostatus after OIs/ADI diagnosis. …”
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Synthetic CT generation from CBCT and MRI using StarGAN in the Pelvic Region by Paritt Wongtrakool, Chanon Puttanawarut, Pimolpun Changkaew, Supakiet Piasanthia, Pareena Earwong, Nauljun Stansook, Suphalak Khachonkham

“…We also compared the performance and benefits of StarGAN to the commonly used CycleGAN. Materials and methods StarGAN and CycleGAN were employed in this study. …”
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Assessment of Risk Factors for Fractures in Patients with Type 2 Diabetes over 60 Years Old: A Cross-Sectional Study from Northeast China by Yan Guo, Yingfang Wang, Feng Chen, Jiabei Wang, Difei Wang

“…This study investigated the prevalence of bone fractures in elderly subjects (with and without type 2 diabetes) and identified any fracture risk factors, especially the risk factors for common known fractures in particular diabetic populations. …”
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Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes by Guoqing Li, Hongyi Chen, Jiacheng Shen, Yimin Ding, Jingqiong Chen, Yongbin Zhang, Mingrui Tang, Nan Xu, Yuxuan Fang

“…A diagnostic xgboost model was developed using common hub genes identified by random forest and least absolute shrinkage and selection operator (LASSO), with intersection genes derived from overlapping machine learning-selected genes. …”
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Serum Alkaline Phosphatase in Free-Ranging Male Moose Alces alces (Linnaeus 1758) of Different Age Groups by Maria A. Perevozchikova, Igor A. Domsky, Yulia A. Berezina, Professor Zhitkov Russian Research Institute of Game Management and Fur Farming, Kirov, Russia, Alexandr V. Economov

“…Serum alkaline phosphatase activity is one of the most common clinical biochemical tests in this respect. …”
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Twelve-Month Retention in and Impact of Enhance®Fitness on Older Adults in Hawai‘i by Michiyo Tomioka, Kathryn L. Braun, Yan Yan Wu, Kay Holt, Paula Keele, Lori Tsuhako, Johnny Yago

“…Asian or Pacific Islander), to self-report depression as a chronic condition, and to have lower levels of fitness at baseline. Common reasons for dropping out were illness, relocation, time conflicts, lost interest, and transportation issues. …”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Abstract Objective Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with a high metastasis rate and a poor prognosis. …”
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