Attention Deficit Disorder and Allergic Rhinitis: Are They Related? by Isaac Melamed, Melinda Heffron

“…For allergy endpoints, combination therapy produced results superior to individual therapy. …”
Get full text

Effect on Intraocular Pressure of Switching from Latanoprost and Travoprost Monotherapy to Timolol Fixed Combinations in Patients with Normal-Tension Glaucoma by Ryoko Igarashi, Tetsuya Togano, Yuta Sakaue, Takaiko Yoshino, Jun Ueda, Takeo Fukuchi

“…Switching to fixed combination therapy from PG monotherapy, the mean IOP was 13.1±1.79 mmHg (P<0.001)  (-24.71% reduction from baseline) at 6 months. …”
Get full text

Efficacy and safety of camrelizumab combined with chemotherapy as second-line treatment for locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma by Yinfang Gu, Xiaofang Zou, Junlin Zhu, Guowu Wu

“…However, the median PFS was significantly longer in the combination therapy group compared to the chemotherapy group (4.7 months vs. 3.4 months, P = 0.048). …”
Get full text

Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic by Edwin C. Jones, J. Craig Rylands, Cortney L. Jardet

“…Treatment periods consisted of metformin therapy alone for 4 years followed by a metformin/glyburide combination therapy for 6 years, and eventually an insulin/metformin combination therapy for 4 years. …”
Get full text

Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis by Xiaoyan Sun, Wei Wei

“…The combination therapy group significantly increased the level of effectiveness and best-corrected visual acuity (BCVA) compared with the control group. …”
Get full text

Activating the Antitumor Immune Response in Non-Hodgkin Lymphoma Using Immune Checkpoint Inhibitors by Maansi Joshi, Stephen M. Ansell

“…Anti-PD-1 and anti-CTLA-4 antibodies have been tested as both single agents and combination therapy. Although success rates with anti-PD-1 antibodies are high in patients with Hodgkin lymphoma, the results are yet to be replicated in those with non-Hodgkin lymphomas. …”
Get full text

Mortality-related risk factors of carbapenem-resistant Enterobacteriaceae infection with focus on antimicrobial regimens optimization: a real-world retrospective study in China by Sheng Deng, Jinglan Chen, Pengxiang Zhou, Qin Hu

“…Among those 65.4% (51/78) received combination therapy and 34.6% (27/78) received monotherapy. …”
Get full text

Clinical Profile and Prescription Patterns in Culture-proven Enteric Fever in Children by Divya Priyadharshini, Mobill Clinton, Nandini Sethuraman, Mathrubootham Sridhar, Vidya Krishna

“…Fever typically resolved in 4–5 days, with paratyphoid fever resolving earlier. Combination therapy was used in over two-thirds of cases. …”
Get full text

Iron Chelators in Treatment of Iron Overload by Sarina Entezari, Seyedeh Mona Haghi, Narges Norouzkhani, Barsa Sahebnazar, Fatemeh Vosoughian, Diba Akbarzadeh, Muhammad Islampanah, Navid Naghsh, Mohammad Abbasalizadeh, Niloofar Deravi

“…This study aimed to introduce each of these iron chelators, combination therapy, usage doses, specific clinical applications, and their advantages, toxicity, and side effects.…”
Get full text

Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations by Nicholas New, Janaki Mohandas, George T. John, Sharad Ratanjee, Helen Healy, Leo Francis, Dwarakanathan Ranganathan

“…This combination therapy may be changing the historically poor prognosis of calcific uremic arteriolopathy reported in the literature. …”
Get full text

The Impact of Levothyroxine and Testosterone Administration on Bladder Contractility in the Rat Model of Propylthiouracil-Induced Hypothyroidism by Didem Yılmaz Oral, Berna Güven Ciloğlu, Serap Gür

“…In males with hypothyroidism and urogenital system dysfunction, combination therapy with thyroid hormones and T has a major impact on repairing detrusor smooth muscle contractility and bladder histomorphology.…”
Get full text

Bupropion Mediated Effects on Depression, Attention Deficit Hyperactivity Disorder, and Smoking Cessation by Austin Clark, Brendan Tate, Bretton Urban, Ryan Schroeder, Sonja Gennuso, Shahab Ahmadzadeh, David McGregor, Brook Girma, Sahar Shekoohi, Alan D. Kaye

“…Additional research is needed to determine the drug's full clinical potential, particularly in the areas of adolescent depression and combination therapy with varenicline or dextromethorphan. …”
Get full text

First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours by Michael Smith, Aung Naing, Todd Bauer, Kyriakos P Papadopoulos, Osama Rahma, Elena Garralda, Glenn J Hanna, Michael J Pishvaian, Xuejun Chen, Sven Gogov, Omar Saavedra, Howard Kallender, LuLu Cheng, Emil Kuriakose

“…The most common INCB001158-related AEs were fatigue (n=10/107 (9.3%)) and nausea (n=10/107 (9.3%)) with monotherapy and diarrhoea (n=24/147 (16.3%)) and fatigue (n=22/147 (15.0%)) with combination therapy. The highest response rate was seen in the anti–PD-1/PD-L1–naive combination therapy group with head/neck squamous cell carcinoma (overall response rate, 19.2%; 4/26 partial responses, 1/26 complete response). …”
Get full text

Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…The improvement of effect may be due to the decrease of MMP-3 and MMP-9 expression in combination therapy.Keywords: bone marrow mesenchymal stem cell, fractional carbon dioxide laser, photoaging, matrix metalloproteinase, mouse model…”
Get full text

The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…In terms of whether combination therapy was used or not, compared with the combination therapy group (I2 = 29%, MD = −1.39, 95%CI = −2.30 to −0.48, p = 0.003), the non-combination therapy group had a better treatment effect (I2 = 0%, MD = −2.93, 95%CI = −3.36 to −2.50, p &lt; 0.00001).ConclusionrTMS significantly improves sleep quality in patients with more than mild depression. …”
Get full text

National Trends of Antiparkinsonism Treatment in Taiwan: 2004–2011 by Weng-Ming Liu, Ruey-Meei Wu, Chia-Hsuin Chang, Jou-Wei Lin, Ying-Chun Liu, Chin-Hsien Lin

“…Levodopa monotherapy or combination therapy was the mainstay. Levodopa monotherapy comprised 37.4% of prescriptions in 2004 and 44.2% in 2011, with an annual increase rate of 18.14%. …”
Get full text

COMBINATION OF ULTRASOUND THERAPY, MUSCLE ENERGY TECHNIQUE, AND SUSTAINED NATURAL APOPHYSEAL GLIDES IN NON-SPECIFIC NECK PAIN – A CASE SERIES by Ni Komang Ayu Juni Antari, Anak Agung Gede Angga Puspa Negara, Made Hendra Satria Nugraha

“…Purpose: To find out the efficacy of the combination therapy in individuals with non-specific neck pain. …”
Get full text

IVIG plus Glucocorticoids versus IVIG Alone in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Systematic Review and Meta-Analysis by Robin Rauniyar, Aman Mishra, Sanjeev Kharel, Subarna Giri, Rohit Rauniyar, Shikha Yadav, Gajendra Chaudhary

“…This study supports the use of IVIG with glucocorticoids compared to IVIG alone, as the combination therapy significantly lowered the risk of treatment failure and the need for adjunctive immunomodulatory therapy.…”
Get full text

Trends in prescribing sodium‐glucose cotransporter 2 inhibitors for individuals with type 2 diabetes with and without cardiovascular‐renal disease in South Korea, 2015–2021 by Kyoung Hwa Ha, Soyoung Shin, EunJi Na, Dae Jung Kim

“…However, the proportion of individuals receiving monotherapy or dual combination therapy decreased by 9.2 percentage points, whereas the proportion prescribed triple or more combination therapy increased. …”
Get full text

Montelukast Use and Patterns of Ambulatory Care among Asian versus Non-Asian Adult Patients with Asthma and/or Allergic Rhinitis in the United States by Joseph Vasey, Shalini Bagga, Huan Huang, Tongsheng Wang, David Thompson

“…**Results:** Overall patterns of use of montelukast were similar for Asian and non-Asian patients, but Asians were more likely to receive it as part of a combination therapy regimen. Changes in treatment regimen followed similar patterns for both groups. …”
Get full text