Meta-Analysis on Cognitive Benefit of Exercise after Stroke by Bo Yang, Shuming Wang

“…Higher benefits on cognition were found after combined therapy compared with other exercise programs, and the older the stroke survivors, the less the cognitive benefit of exercise. …”
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Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment by Amy Sarah Benjamin, Sunita Nayak

“…Iron oxide nanoparticles stand out in both therapeutic and diagnostic applications, offering a versatile platform for targeted drug delivery, hyperthermia, magneto-thermal therapy, and combinational therapy using modulation of ferroptosis pathways. …”
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Controversies in the management of anti-TNF therapy in patients with Crohn’s disease: a Delphi consensus by Ignacio Marin-Jimenez, Guillermo Bastida, Daniel Carpio, Fernando Muñoz, Yago González-Lama, Elena Ricart, Daniel Ceballos, Daniel Ginard, Luis Menchen

“…These statements cover: (1) use of first-line non-anti-TNF biological therapy; (2) role of HLA-DQA1*05 in daily practice; (3) attitudes in primary non-response and loss of response to anti-TNF therapy due to immunogenicity; (4) use of ustekinumab or vedolizumab if a change in action mechanism is warranted; (5) anti-TNF drug level monitoring; (6) combined therapy with an immunomodulator.Conclusion This document sought to pull together the best evidence, experts’ opinions, and treating physicians’ attitudes when using anti-TNF therapies in patients with CD.…”
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Silver nanoparticle induced immunogenic cell death can improve immunotherapy by Ara Sargsian, Xanthippi Koutsoumpou, Hermon Girmatsion, Can Egil, Kiana Buttiens, Carla Rios Luci, Stefaan J. Soenen, Bella B. Manshian

“…One particular hot topic is the use of combination therapies. Here, we set out to screen a variety of metallic nanoparticles and explored their in vitro toxicity against a series of tumor and non-tumor cell lines. …”
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Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

“…It is administered orally and efficacious as monotherapy as well as combined therapy with other T2DM drugs, such as pioglitazone and metformin. …”
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The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…This narrative review underscores the need for continued research into the molecular mechanisms underlying these interactions and suggests future directions for therapeutic development, including clinical trials, biomarker discovery, and combination therapies that synergistically target aging processes.…”
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Coronary Artery Spasm: New Insights by Anthony Matta, Frederic Bouisset, Thibault Lhermusier, Fran Campelo-Parada, Meyer Elbaz, Didier Carrié, Jerome Roncalli

“…Invasive strategies such as PCI (percutaneous coronary intervention) and CABG (coronary artery bypass graft) have shown benefits in CAS with significant atherosclerotic lesions. Combination therapies are proposed for refractory cases.…”
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Intravitreal Conbercept Injection with and without Grid Laser Photocoagulation in the Treatment of Diffuse Diabetic Macular Edema in Real-Life Clinical Practice by Yule Xu, Ao Rong, Yanlong Bi, Wei Xu

“…Results. 26 patients (31 eyes) received IVC alone and 25 patients (30 eyes) received combined therapy. At month 12, the mean best-corrected visual acuity (BCVA) letter score improvement was 9.1±4.5 and 7.5±4.2 in the IVC group and the combined group and the mean central retinal thickness (CRT) reduction was 145.1 ± 69.9 μm and 168.5±53.6 μm, respectively. …”
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The Effectiveness of ROMATIF Therapy (Mirror Therapy and Positive Affirmation) on Strength of Muscle and Self-acceptance in Post Stroke Patients by Putu Sintya Arlinda Arsa, Lie Liana Fuadiati, Desy Rinawaty

“…This study aims to determine the effectiveness of a combined therapy, namely mirror therapy and positive affirmations, referred to as ROMATIF therapy(Mirror Therapy and Positive Affirmations). …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…A mechanism-based precision medicine approach should enhance the clinical efficacy of dietary and related natural products as anticancer agents and decrease toxic side effects for some combination therapies.…”
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Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling by Qian Xing, Wendi Cheng, Wei Wang, Chunlin Jin, Haiyin Wang

“…Sensitivity analysis highlights that factors like combination therapies, faster mechanisms of action, and novel therapeutic parts notably influence the value dimension. …”
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PHARMACOTHERAPY IN PATIENTS WITH ERECTILE DYSFUNCTION AND BENIGN PROSTATIC HYPERPLASIA IN THE ABSENCE OF RISK OF DISEASE PROGRESSION by A. A. Kamalov, A. M. Tahirzade

“…In patients who are interested in improving erectile function, the following treatment options have been performed: monotherapy with tamsulosin 0.4 mg daily (n = 30), sildenafil monotherapy 25 mg daily (n = 31), tamsulosin 0.4 mg daily and sildenafil 25 mg daily (n = 34).Results. With combined therapy, statistically significant and most pronounced improvement occurred at all time points for all 5 parameters: IPSS, QoL, IIEF-5, maximum urination rate (Qmax), residual urine volume. …”
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Transjugular Retrograde Obliteration prior to Liver Resection for Hepatocellular Carcinoma Associated with Hyperammonemia due to Spontaneous Portosystemic Shunt by Fumio Chikamori, Nobutoshi Kuniyoshi

“…We conclude that the combined therapy of surgery and TJO is an effective means of treating HCC with hyperammonemia due to a spontaneous portosystemic shunt.…”
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Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway by A. Rimmon, A. Vexler, L. Berkovich, G. Earon, I. Ron, S. Lev-Ari

“…Synergistic effect of combined therapy was determined by CalcuSyn software. Cell cycle and induction of apoptosis were evaluated by FACS analysis. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…It also optimizes combination therapies by predicting the most effective treatment protocols. …”
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Pharmacotherapies for Obesity: Past, Current, and Future Therapies by Lisa L. Ioannides-Demos, Loretta Piccenna, John J. McNeil

“…This paper reviews the efficacy and safety of pharmacotherapies for obesity focusing on drugs approved for long-term therapy (orlistat), drugs approved for short-term use (amfepramone [diethylpropion], phentermine), recently withdrawn therapies (rimonabant, sibutamine) and drugs evaluated in Phase III studies (taranabant, pramlintide, lorcaserin and tesofensine and combination therapies of topiramate plus phentermine, bupropion plus naltrexone, and bupropion plus zonisamide). …”
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Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine by Serkan Sen, Kardelen Kocaman Kalkan, Canan Yilmaz, Sefa Celik

“…These findings highlight complex interactions between chemotherapeutic agents and natural compounds, warranting further exploration in combination therapies.…”
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siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…Several treatments are available for RA, including analgesics, corticosteroids, DMARDs, biological agents, combinational therapy, epigenetic and cell therapies which play a crucial role in preventing joint function deterioration, inflammation, synovial edema, etc. …”
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PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…These inhibitors have been validated in multiple clinical trials, underscoring their robustness and effectiveness. Combination therapies, such as olaparib with bevacizumab, further enhance therapeutic outcomes, showcasing the potential for synergistic effects. …”
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Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa, Mathew A. Coban

“…We explore the potential of gelatinase inhibition in combination therapies, particularly with conventional chemotherapy and emerging targeted treatments, to enhance therapeutic efficacy and overcome resistance. …”
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