Local controllability and optimal control for\newline a model of combined anticancer therapy with control delays by Jerzy Klamka, Helmut Maurer, Andrzej Swierniak

“…The optimized protocols of the combined therapy for the model, considered as solutions to an optimal control problem with delays in control, are found using necessary conditions of optimality and numerical computations. …”
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Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma by Song Y, Tian S, Li Z, Miao J, Wu M, Xu T, Wu X, Qiao J, Zhang X, Zhao H, Kang L, Cao L, Zhu P, Miao M

“…Through the analysis, it is proposed that intratumor organisms can be used as markers for liver cancer diagnosis and treatment, drug carrier materials for targeting liver cancer tissues, and the research prospects of developing new combination therapies based on the in-depth understanding of the interactions between intratumor microorganisms and the tumor microenvironment, immune cells, liver cancer cells, etc. as well as exploring the prospects of developing new combination therapies based on these interactions. …”
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Evaluating the Efficacy of Combined Intravaginal Estriol Therapy and Kegel Exercises in Managing Menopausal Atrophic Vulvovaginitis by Lucian Șerbănescu, Vadym Rotar, Dragoș Brezeanu, Sebastian Mirea, Elena-Valentina Ionescu, Paris Ionescu

“…In the mild VVA group, 81.82% achieved complete remission with combined therapy compared to 68.18% with estriol alone. …”
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Precision oncology through next generation sequencing in hepatocellular carcinoma by Sayali Shinde, Carola Maria Bigogno, Ana Simmons, Nikita Kathuria, Aruni Ghose, Vedika Apte, Patricia Lapitan, Shania Makker, Aydin Caglayan, Stergios Boussios

“…The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. …”
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Cosmetic filler-induced hair loss: case series and literature review by Yutong Xie, Xi Chen, Aihua Wei

“…The third case described another female who experienced alopecia areata-like hair loss after autologous fat grafting, and received combined therapies including corticosteriod, 5% minoxidil and microneedling.Results All patients got gradual hair regrowth with treatments.Conclusions Early recognition and intervention are crucial to prevent permanent hair follicle damage. …”
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Phototherapy in vitiligo by Anuradha Bishnoi, Iltefat Hamzavi

“…Additionally, combination therapies involving phototherapy and topical and systemic agents (such as psoralens, corticosteroids, calcineurin inhibitors, azathioprine, and other systemic immunomodulators, basic fibroblast growth factor/decapeptide and Janus kinase inhibitors) and surgical management have demonstrated enhanced repigmentation outcomes. …”
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Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…This paper has two objectives: first to highlight the potential uses for PPARγ agonists in anticancer therapy with special emphasis on their role when used as adjuvant or combined therapy in the treatment of hematological malignancies found in the vasculature, marrow, and eyes, and second, to review the potential role PPARγ and/or its ligands may have in modulating cancer-associated angiogenesis and tumor-stromal microenvironment crosstalk in bone marrow.…”
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Two ways to one goal: new strategy of antiviral therapy for chronic hepatitis C by S. N. Batskikh

“…To analyze data of the clinical studies on chronic hepatitis C (CHC) treatment with application of new modes of combined therapy, including selective inhibitor of viral protease.Key points. …”
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Cyclosporine Regimens in Plaque Psoriasis: An Overview with Special Emphasis on Dose, Duration, and Old and New Treatment Approaches by M. D. Colombo, N. Cassano, G. Bellia, G. A. Vena

“…This paper will review the data on CsA regimens for plaque-type psoriasis and will focus the attention on dose, treatment duration, novel schedules, and role in combination therapies, including the association with biologicals.…”
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Discussion on the mechanism of HER2 resistance in esophagogastric junction and gastric cancer in the era of immunotherapy by Yan Zhang, Wenxuan Fan, Fei Su, Xiaoling Zhang, Yunyi Du, Weiling Li, Yangjun Gao, Wenqing Hu, Jun Zhao

“…Furthermore, the review discusses the Novel therapeutic approaches, including the use of antibody-drug conjugates (ADCs) and combination therapies are assessed for their potential to enhance outcomes. …”
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Antimicrobial Peptides, Their Production, and Potential in the Fight Against Antibiotic-Resistant Pathogens by Margarita Saubenova, Alexander Rapoport, Zhanerke Yermekbay, Yelena Oleinikova

“…It is assumed that such drinks can reduce the dose of antimicrobials in the combined therapy of various infectious diseases and be a preventive measure against contagion and the spread of antimicrobial resistance.…”
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Modeling critical dosing strategies for stromal-induced resistance to cancer therapy by Anna K. Kraut, Colleen M. Garvey, Carly Strelez, Shannon M. Mumenthaler, Jasmine Foo

“…We apply our general approach to identify a critical drug concentration threshold and study effective dosing regimens for single-drug and combination therapies.…”
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HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm. by Mengyao Zhou, Mengfan Xu, Xiangling Zhang, Xiaochun Xing, Yang Li, Guanghui Wang, Guiying Yan

“…Over the years, synergistic drug combinations therapies have attracted widespread attention due to its advantages of overcoming drug resistance, increasing treatment efficacy and decreasing toxicity. …”
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Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches by Yang-Jin Shen, Yin-Cheng Huang, Yi-Chuan Cheng

“…It emphasizes the limitations of single-regimen approaches, particularly their limited efficacy and suboptimal delivery to injured spinal cord tissue, while highlighting the synergistic potential of combination therapies that integrate multiple modalities to address the multifaceted pathophysiology of SCI. …”
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Management of connective tissue disease-associated interstitial lung disease by Keerthi Talari

“…Future research should focus on long-term efficacy, safety and head-to-head comparison of drugs, role of upfront combination therapies, supportive and palliative care.…”
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Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism by Lijun Zhao, Haonan Qi, Weiting Liu, Huiying Lv, Peixian Li, Wenyue Liu, Ruili Sun, Qiongzi Wang, Xiangpeng Wang

“…PDHB and Isoacteoside could be potential avenues for targeted and combination therapies in liver cancer.…”
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Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies by Dingtian Luo, Jing Zhou, Shuiliang Ruan, Binzhong Zhang, Huali Zhu, Yangming Que, Shijie Ying, Xiaowen Li, Yuanmin Hu, Zhengwei Song

“…We also discuss emerging strategies to overcome resistance, including combination therapies, novel immunotherapeutic approaches, and personalized treatment strategies based on tumor genomics and the immune microenvironment. …”
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Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives by Anandarajagopal Kalusalingam, Kamaliah Kamal, Abdullah Khan, Bama Menon, Ching Siang Tan, Venkateshan Narayanan, Sattanathan Kumar, Khang Wen Goh, Kah Seng Lee, Jactty Chew, Long Chiau Ming

“…Additionally, combination therapies and advanced drug delivery systems such as nanoemulsion have been reviewed. …”
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Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

“…Importantly, combining PAS with MMC reveals a synergistic effect (Combination Index of 0.59–0.67), suggesting the potential of utilizing PAS in combination therapies. Our findings demonstrate PAS’s mode of action and suggest its potential as a promising treatment for bladder cancer, warranting further clinical studies.…”
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Pancreatic Cancer: What the Oncologist Can Offer for Palliation by Malcolm J Moore

“…This drug is more effective than 5-fluorouracil (5-FU), can be used in patients who fail to respond to 5-FU and has only modest toxicity. Combination therapies including gemcitabine and other agents are being tested. …”
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