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281
Efficacy of Exenatide Administered Twice Daily in Body Mass Index Reduction in Patients with Type 2 Diabetes Mellitus
Published 2022-01-01“…A total of 27 T2DM patients treated with combination therapy of exenatide twice daily and metformin for 52 weeks were included. …”
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282
Status of the Multidrug Resistance-1 Gene of Plasmodium falciparum in Four Malaria Epidemiological Strata, Two Decades after the Abolition of Chloroquine as First-Line Treatment fo...
Published 2023-01-01“…Chloroquine (CQ) was widely used in Cameroon for decades, but its declining clinical efficacy due to resistance prompted health authorities in 2004 to resort to artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. …”
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283
Results of a Randomized, Open-Label, Clinical Trial Investigating the Effects of Supplementation with Heracleum persicum Extract as an Adjunctive Therapy for Dyslipidemia
Published 2011-01-01“…Apart from HDL-C, the effects of atorvastatin (20 mg/day) on other lipid profile parameters do not appear to be significantly superior to those achieved by combination therapy with H. persicum + atorvastatin (10 mg/day).…”
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284
Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress
Published 2024-09-01“…However, there is noconsensus on a standard therapeutic protocol regarding the source of cells, optimal cell dose, timing and frequencyof cell injections, route of administration, or the use of combination therapy. This lack of consensus necessitates acomprehensive investigation to clarify these crucial yet undefined factors in cell-based therapy for CP patients. …”
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285
New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication
Published 2013-01-01“…We provide an update on current treatments for advanced prostate cancer and discuss whether metabolic dysfunction, developed during ADT, provides a unique therapeutic window for rapid translation of insulin-sensitising medication as combination therapy with antiandrogen targeting agents for the management of advanced prostate cancer.…”
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286
Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets
Published 2015-12-01“…The demographic shift toward older population increases the use of combination therapy as polypharmacy. Hydrochlorothiazide (HCTZ), as a model drug, is most commonly used in the treatment of hypertension, congestive heart failure and as a diuretic. …”
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287
Comparative efficacy of minoxidil alone versus minoxidil combined with low-level laser therapy in the treatment of androgenic alopecia: a systematic review and meta-analysis
Published 2025-12-01“…Randomized clinical trials comparing minoxidil monotherapy with minoxidil and LLLT combination therapy were included based on predefined criteria. …”
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288
Efficacy of Alginate-Antacid Medication in the Treatment of Patients with Gastroesophageal Reflux Disease
Published 2018-11-01“…We assess the dynamics of inflammatory process in patients with gastroesophageal reflux disease (GERD) treated with alginate-antacid medication used at conventional dosage, both as a monotherapy and as part of a GERD combination therapy. To this end, we set out to confirm the formation of the layer of unbuffered acidic gastric juice over the gastric chyme after eating, as well as to determine the acidneutralizing effect of alginate-antacid medication upon its interaction with the acidic contents of the stomach.Materials and methods. 36 case records of GERD patients were analyzed (20 women and 16 men, mean age 47.03 years old). …”
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289
Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade...
Published 2025-02-01“…No DLTs occurred in the combination therapy dose escalation cohort. The MTD was not formally reached and the RD for expansion was 600 µg. …”
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290
The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute...
Published 2024-09-01“…Blinatumomab in combination with TKIs is safe and effective and hence this combination therapy could be a viable therapeutic option in front‐line treatment of patients with Ph + ALL.…”
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291
Comparative analysis of real-world data on the efficacy and safety of and adherence to ICS/LABA combinations in asthma management
Published 2025-01-01“…Methods Utilizing South Korea’s National Health Insurance Service data, we conducted a population-based cohort study involving patients aged 18–80 years, newly diagnosed with asthma who received ICS/LABA combination therapy between January 2016 and December 2020. …”
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292
Acute Deterioration of Pulmonary Arterial Hypertension (PAH) in a Patient with Neurofibromatosis Type 1 (NF1)
Published 2019-01-01“…We then administrated upfront combination therapy with macitentan and tadalafil. Mean pulmonary arterial pressure rapidly improved. …”
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293
Risk Factors for Rebleeding after Emergency Endoscopic Treatment of Dieulafoy Lesion
Published 2020-01-01“…The 30-day rebleeding rate for pure injection therapy (epinephrine, cyanoacrylate, or lauromacrogol injection alone), nonpure injection therapy (argon plasma coagulation, band ligation, and hemoclip application alone), and combination therapy (combination of any >2 methods) was 45.2%, 12.8%, and 11%, respectively. …”
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294
Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana
Published 2024-01-01“…Artemether-lumefantrine (AL) is a highly effective and commonly used Artemisinin-based Combination Therapy (ACT) for treating uncomplicated malaria caused by Plasmodium falciparum, including drug-resistant strains. …”
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295
Emergency Combination of Four Drugs for Bloodstream Infection Caused by Carbapenem-Resistant Enterobacteriaceae in Severe Agranulocytosis Patients with Hematologic Malignancies aft...
Published 2020-01-01“…Therefore, four-drug combination therapy may be needed in CRE-BSI patients who experienced severe agranulocytosis after HSCT. …”
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296
The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout
Published 2025-02-01“…The results indicated no significant differences on relevant indicators among the three treatment regimens.ConclusionOur study did not identify a difference in the efficacy of reducing uric acid excretion in gout patients when comparing conventional dose febuxostat and benzbromarone monotherapy versus low-dose combination therapy.…”
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297
Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma
Published 2025-01-01“…Therefore, suppression of IL4I1 may represent a potential target for combination therapy in DLBCL.…”
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298
Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review
Published 2025-02-01“…Based on the pathological, the patient received combination therapy with anlotinib at different times and achieved a long survival time.…”
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299
A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarth...
Published 2025-01-01“…However, the efficacy and safety of combination therapy (PRP + HA) remain unclear. Aim The aim of this systematic review and meta-analysis is to assess the clinical effectiveness and safety profile of PRP + HA versus PRP monotherapy for KOA. …”
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300
Combined Use of Excimer Laser and High-Speed Rotational Atherectomy to Overcome a Severely Calcified Lesion in Endovascular Therapy
Published 2019-01-01“…The right ankle-brachial index of the patient improved from being unmeasurable to 0.79, and the intermittent claudication disappeared. This combination therapy, described as the “RASER” technique in coronary section, is accepted for reimbursement. …”
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