Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism by Ayan Biswas, Suman Santra, Debasree Bishnu, Gopal Krishna Dhali, Abhijit Chowdhury, Amal Santra

“…Chronic hepatitis (CH) has emerged as a distinct outcome of drug-induced liver injury (DILI). Combination therapy of Isoniazid (INH) and Rifampicin (RMP) which is widely used for prolonged periods can cause acute hepatotoxicity and has been also incriminated in chronic DILI. …”
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A study comparing the effectiveness of ondansetron versus ondansetron combined with dexamethasone for preventing postoperative nausea and vomiting in laparoscopic surgeries by Rajan B. Pandya, Deepika Sathe, Ankita Joshi, Vishwas Sathe

“…Thus, the effectiveness of combination therapy surpassed that of ondansetron alone.…”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Multiple myeloma (MM) is an intractable hematological malignancy caused by abnormalities in plasma cells. Combination therapy using antibodies and natural killer (NK) effectors, which are innate immune cells with safe and potent antitumor activity, is a promising approach for cancer immunotherapy and can enhance antitumor effects. …”
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The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China by Shang-Chen Yang, Sindy Hu, Sheng-Zheng Zhang, Jin-wen Huang, Jing Zhang, Chao Ji, Bo Cheng

“…There were 76 (45.8%) patients receiving systemic steroid and intravenous immunoglobulin (IVIG) in combination therapy, especially for TEN (80.3%), and others were treated with systemic steroids alone. …”
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Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Me... by Zixuan Chu, Zhiyuan Wang, Teng Liu, Shan Xiong, Bin Liu

“…Combination therapy is opted as a potential therapeutic strategy for cancer treatment. …”
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What Is New Since the Last (1999) Canadian Asthma Consensus Guidelines? by Louis-Philippe Boulet, Tony R Bai, Allan Becker, Denis Bérubé, Robert Beveridge, Dennis M Bowie, Kenneth R Chapman, Johanne Côté, Donald Cockcroft, Francine M Ducharme, Pierre Ernst, J Mark FitzGerald, Thomas Kovesi, Richard V Hodder, Paul O’Byrne, Brian Rowe, Malcolm R Sears, F Estelle R Simons, Sheldon Spier

“…New developments, such as combination therapy, and recent major trials, such as the Children’s Asthma Management Project (CAMP) study, are discussed.…”
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Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient by Nu T. Lu, Jeffrey Raizer, Erwin P. Gabor, Natalie M. Liu, James Q. Vu, Dennis J. Slamon, John L. Barstis

“…We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. …”
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Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer by Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter

“…Nonetheless, this suppression was circumvented in a mouse model of HER-2pos breast disease by supplying recombinant interferon-gamma to achieve a combination therapy significantly more potent than either agent.…”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…COX-2 inhibitors suppress these actions and inhibit carcinogenesis. Combination therapy using drugs found by drug repositioning and current anticancer drugs may increase efficacy and reduce adverse drug reactions. …”
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The Effect of Adjuvant Therapy on Metabolic Syndrome in Schizophrenia Patients at Madani Hospital by Indah Kurnia Utami, Yasinta Rakanita, Patricia Novina Nurak, Niluh Puspita Dewi

“…Patients who had been using atypical antipsychotics, either monotherapy or combination therapy, for more than 3 were examined pretest to determine metabolic syndrome levels. …”
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Tacrolimus and mycophenolate mofetil in corticosteroid-resistant hepatitis secondary to tislelizumab: a case report by Chang Jiang, Shanxian Guo

“…The patient was a 67-year-old male, diagnosed with ES-SCLC, who received a combination therapy of etoposide, cisplatin, and tislelizumab. …”
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Safety and Efficacy of Everolimus Plus Exemestane in Postmenopausal Women with Treatment-refractory Hormone Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Adv... by Yuan-Ching Chang, Kun-Ming Rau, Dar-Ren Chen, Tsu-Yi Chao, Ming-Feng Hou, Chiun-Sheng Huang*

“…Background: This phase IIIb, open-label study enrolled patients from nine Asian and Middle Eastern countries to evaluate the safety and efficacy of the combination therapy in underrepresented patient populations from the Breast Cancer Trials of Oral Everolimus-2 (BOLERO-2). …”
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Use of High-Flow Nasal Cannula Oxygen Therapy in a Pregnant Woman with Dermatomyositis-Related Interstitial Pneumonia by Tomohiro Shoji, Takeshi Umegaki, Kota Nishimoto, Natsuki Anada, Akiko Ando, Takeo Uba, Munenori Kusunoki, Kanako Oku, Takahiko Kamibayashi

“…In order to save the life of the patient, the use of combination therapy with immunosuppressants was necessary. …”
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Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors: A Prospective Subgroup Analysis of a Ra... by Harold Bays, Pingjin Gao, Birgit Völker, Michaela Mattheus, Luis M. Ruilope, Dingliang Zhu

“…Report of prespecified and post hoc subgroup analyses of a randomized, controlled trial comparing telmisartan 80 mg/hydrochlorothiazide 25 mg (T80/H25) combination therapy with T80 monotherapy, according to the presence of cardiovascular disease (CVD) risk factors. …”
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Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA’s adverse event reporting system database by Qun Li, Wenya Shan, Saiwei Wu

“…The most frequent AEs were analyzed, and it was found that women generally have a higher susceptibility to experiencing AEs, including pain, nausea, fatigue, myalgia, diarrhea, dyspnea, headache, weakness, and dizziness.ConclusionClinicians should pay more attention to the AEs of gastrointestinal and muscular system during combination therapy, and it is recommended to strengthen pharmaceutical care during clinical application.…”
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Eco-Friendly Hydrogels Loading Polyphenols-Composed Biomimetic Micelles for Topical Administration of Resveratrol and Rutin by Beatriz N. Guedes, Tatiana Andreani, M. Beatriz P. P. Oliveira, Faezeh Fathi, Eliana B. Souto

“…This approach aims to associate the advantages of hydrogels for topical administration of drugs and of lipid micelles that mimic skin composition for the delivery of poorly water-soluble compounds in combination therapy. Biomimetic micelles composed of L-α-phosphatidylcholine loaded with two distinct polyphenols (one non-flavonoid and one flavonoid) were produced using hot shear homogenisation followed by the ultrasonication method. …”
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Correlation of disease activity score using erythrocyte sedimentation rate and C-reactive protein with clinical disease activity index in rheumatoid arthritis patients by Viraj Panchal, Puja Srivastava, Dhaiwat Shukla, Devang Rana, Supriya Malhotra, Sapan Pandya

“…Methotrexate was the most prescribed drug in our set up as mono or combination therapy.…”
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Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models by Chrystal Paulos, Gregory B Lesinski, Zachary S Buchwald, Nabil F Saba, Vikash Kansal, Andre J Burnham, Brendan L C Kinney, Nicole C Schmitt

“…Results from flow cytometry of tumors and tumor-draining lymph nodes suggested T cell activation and shifts from M2 to M1 macrophage predominance as potential mechanisms of combination therapy.Conclusions These results suggest that statins deserve further study as well-tolerated, inexpensive drugs that may enhance responses to PD-1 checkpoint blockade and other immunotherapies for HNSCC.…”
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ACUPRESSURE AND AROMATIC GINGER HERB FOR A MIGRAINE by Mayla Khayra Al ‘Amali, Ario Imandiri, Sukardiman Sukardiman

“…Purpose: Knowing the effect of acupressure and aromatic ginger herbs (Kaempferia galangal Linn.) combination therapy in reducing migraine complaints. Methods: Acupressure at Fengchi point (GB20) 50 times, Taiyang (EX-HN5) 50 times, Sanyinjiao (SP6) 30 times, Taichong (LR3) 50 times and aromatic ginger herbs (Kaempferia galangal Linn.) 15 grams for 28 days. …”
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Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy by Dong-Mei Zhu, Jing Xie, Chun-Yan Ye, Mei-Yun Qian, Yuan Xue

“…The incidence of HCC in patients receiving nucleoside analogues, nucleotide analogues, and combination therapy was 34.7%, 38.1%, and 33.3%, respectively, and the difference showed no significant differences (P = 0.95). …”
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