Reversible Pulmonary Arterial Hypertension Associated with Interferon-Beta Treatment for Multiple Sclerosis by E Gibbons, S Promislow, RA Davies, G Chandy, DJ Stewart, V Contreras-Dominguez, C Pugliese, R Dunne, LM Mielniczuk

“…The patient experienced significant clinical and hemodynamic improvement, with normalization of her pulmonary pressures after the initiation of combination therapy for PAH. At 28 months after diagnosis, she remains asymptomatic with no hemodynamic evidence of PAH and has been off all PAH therapy for 10 months.…”
Get full text

Severe Myositis, Myocarditis, and Myasthenia Gravis with Elevated Anti-Striated Muscle Antibody following Single Dose of Ipilimumab-Nivolumab Therapy in a Patient with Metastatic M... by Mahdieh Fazel, Patrick M. Jedlowski

“…A case of a 78-year-old woman with metastatic melanoma status after combination therapy with ipilimumab-nivolumab that developed transaminitis, myositis, myocarditis, and myasthenia gravis (with positive anti-striational antibodies) five days after the first cycle, is presented. …”
Get full text

THERAPY FOR HYPERTENSION WITH ACUPUNTURE AND HERBAL CUCUMBER (Cucumis sativus (L.)) by Yuninda Asyroful Kamaliyah, Ario Imandiri, Myrna Adianti

“…Purpose: To determine the effect of acupuncture combination therapy at Shenmen (HT 7), Fuliu (KI 7), Taichong (LR 3), Xingjian (LR 2), and Yinlingquan (SP 9) herbal fruit and herbal cucumber (Cucumis sativus) in diseases hypertension. …”
Get full text

The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice by J. N. Boampong, E. O. Ameyaw, B. Aboagye, K. Asare, S. Kyei, J. H. Donfack, E. Woode

“…Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. …”
Get full text

IRREGULAR MENSTRUATION THERAPY WITH ACUPUNCTURE, POMEGRANATE PEEL AND GINGER HERBS by Sinta Diyah Dimyati, Suhariningsih Suhariningsih, Nurmawati Fatimah

“…Purpose: To determine the effect of acupuncture combination therapy at the Taichong (LV3), Sanyinjiao (SP6), Diji (SP8) and Qihai (CV6) point with herbal pomegranate peel (Punica granatum L.) and ginger (Zingiber officinale Rosc.) in irregular menstrual patients. …”
Get full text

Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease by Nunzia Maisto, Dalila Mango

“…The combination of nano vesicular systems, as colloidal systems, and nose to brain (NtB) delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases, including the use of natural molecules in combination therapy for AD. Herein, we will provide an updated overview, examining the literature of the last 20 years and using specific keywords that provide evidence on natural products with the ability to restore synaptic plasticity alterations in AD models, and the possible application using safe and non-invasive strategies focusing on nano vesicular systems for NtB delivery.…”
Get full text

Natural products as part of triple negative breast cancer by Yozlem Kobakova, Maria Moneva-Sakelarieva, Spiro Konstantinov, Georgi Momekov, Stefka Achkova Ivanova, Ventseslava Atanasova, Maria Chaneva, Radoslav Tododrov, Nikolay Bashev, Petar Atanasov

“…More and more research in this field is focused on single or combination therapy based on compounds obtained from natural sources. …”
Get full text

Effectiveness of acupuncture on glycolipid metabolism in patients with coronary heart disease: A systematic review and meta-analysis by Yuxin Sun, Yu Liu, Jian Xiong, Xiao Li, Ying Wei, Qianhua Zheng, Xiang Li, Wenchuan Qi, Fanrong Liang

“…For secondary outcome measures, combination therapy improved TC (SMD = −0.97; 95 % CI, −1.44 to −0.51; P < 0.0001), TG (MD = −0.39; 95 % CI, −0.58 to −0.20; P < 0.0001), hs-CRP (MD = −0.98; 95 % CI, −1.43 to −0.52; P <0.0001), 2hPG (MD = −1.45; 95 % CI, −1.74 to −1.16; P < 0.00001), and ORR (RR, 1.27; 95 % CI, 1.19–1.36; P < 0.00001) levels more than standard therapy alone.However, the combination therapy did not prevail in lowering HDL-C (MD = 0.11; 95 % CI, 0.07–0.14; P < 0.00001) compared with standard therapy alone. …”
Get full text

First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…The most common adverse events reported in monotherapy-treated patients were fatigue, anemia, and nausea, and those in combination therapy-treated patients were pruritus, fatigue, nausea, and anemia. …”
Get full text

THERAPY LOW BACK PAIN WITH SWEDISH MASSAGE, ACUPRESSURE AND TURMERIC by Dyah Ayu Rhomandhoni Putri, Ario Imandiri, Rakhmawati Rakhmawati

“…Purpose: To prove the effect of combination therapy for Swedish massage in the back and waist area, acupressure at Shenshu (BL23), Dachangshu (BL25), Taixi (KI3), Taibai (SP3), Fenglong (ST40) and turmeric herbs (Curcuma longa Linn) on low back pain sufferers. …”
Get full text

Effect of an “Autogenous Leukocyte Platelet-Rich Fibrin Tooth Graft” Combination around Immediately Placed Implants in Periodontally Compromised Sites: A Randomized Clinical Trial... by Walid ElAmrousy, Dalia Rasheed Issa

“…The ATBG- L-PRF combination therapy enhances new bone formation and appeared to be a favorable procedure with immediate implant placement, particularly in severe periodontitis cases.…”
Get full text

Microneedling in Combination with Topical Pimecrolimus 1% versus Topical Pimecrolimus 1% for the Treatment of Refractory Stable Vitiligo: A Randomized Clinical Trial by Fariba Iraji, Ali Asilian, Zahra Talebzadeh, Mina Saber, Fatemeh Mokhtari, Amirhossein Siadat, Seyed Mohsen Hosseini

“…This study established that combination therapy results in more significant patient improvement. …”
Get full text

Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy by Steen Neldam, Dingliang Zhu, Helmut Schumacher

“…Early use of such combination therapy should be considered to quickly reach BP targets, particularly in patients with added risk.…”
Get full text

Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy by Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu

“…Conversely, the combination therapy of Amodiaquine and Ciprofloxacin had a significant antiplasmodial effect at all the doses administered. …”
Get full text

Lifestyle and behavioral interventions for urinary incontinence in frail older adults: An integrative review of recent evidence by Kristine M.C. Talley, Janie Thompson

“…The most evidence existed for prompted voiding and individualized combination therapy that includes functional training. Discussion:: Frail older adults are rarely included in research on lifestyle and behavioral interventions for incontinence and are overlooked in clinical practice guidelines. …”
Get full text

Hepatitis in Disseminated Bacillus Calmette-Guérin Infection by Markus U Göttke, Philip Wong, Channy Muhn, Mansour Jabbari, Suzanne Morin

“…Empirical treatment was started with antituberculous combination therapy. A short course of an oral corticosteroid was given. …”
Get full text

Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report by Hannah Haile, Pavan S. Upadhyayula, Esma Karlovich, Michael B. Sisti, Brian J. A. Gill, Laura E. Donovan

“…Subsequent recurrences were managed with re-resection and dabrafenib/trametinib combination therapy. Notably, a new, non-clonal BRAFV600E -negative tumor developed in a distant location, highlighting the challenge of clonal evolution and resistance in GBM management. …”
Get full text

Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…A number of studies focused on novel methods for drug monitoring or graft tracking, and combination therapy with stem cells and medicine, such as cytokines or trophic factors. …”
Get full text

Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells by Séin O'Connell, Craig Slattery, Michael P. Ryan, Tara McMorrow

“…These synergistic alterations may have been due to an increase in CTGF which was not evident when the immunosuppressive drugs were used alone. The CsA/SRL combination therapy significantly enhanced Smad signalling and altered the extracellular matrix regulator matrix metalloproteinase 9 (MMP-9). …”
Get full text

Pulmonary and Meningeal Cryptococcosis after Corticosteroid Therapy for Autoimmune Hepatitis: Coexistence of Cryptococci within Pulmonary Cancer Nodule by Takashi Yuri, Ayako Kimura, Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Airo Tsubura

“…Cryptococcal meningitis was diagnosed as positive for cryptococcal antigen from both serum and cerebrospinal fluid (CSF) as well as the growth of Cryptococcus neoformans (C. neoformans) in fungal culture. A combination therapy of amphotericin B and flucytosine was started, and the corticosteroid therapy was gradually reduced and finally discontinued. …”
Get full text