Pre-injury frailty and clinical care trajectory of older adults with trauma injuries: A retrospective cohort analysis of A large level I US trauma center. by Oluwaseun Adeyemi, Corita Grudzen, Charles DiMaggio, Ian Wittman, Ana Velez-Rosborough, Mauricio Arcila-Mesa, Allison Cuthel, Helen Poracky, Polina Meyman, Joshua Chodosh

“…We controlled for age, sex, race/ethnicity, health insurance type, body mass index, Charlson Comorbidity Index, injury type and severity, and Glasgow Coma Scale score. We performed multivariable logistic and quantile regressions to measure the influence of frailty on post-trauma care trajectories.…”
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Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain by Kristian N. Mortensen, Albert Gjedde, Garth J. Thompson, Peter Herman, Maxime J. Parent, Douglas L. Rothman, Ron Kupers, Maurice Ptito, Johan Stender, Steven Laureys, Valentin Riedl, Michael T. Alkire, Fahmeed Hyder

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Machine learning-based prediction of in-hospital mortality for critically ill patients with sepsis-associated acute kidney injury by Tianyun Gao, Zhiqiang Nong, Yuzhen Luo, Manqiu Mo, Zhaoyan Chen, Zhenhua Yang, Ling Pan

“…According to the SHAP plots, old age, low Glasgow Coma Scale (GCS) score, high AKI stage, reduced urine output, high Simplified Acute Physiology Score (SAPS II), high respiratory rate, low temperature, low absolute lymphocyte count, high creatinine level, dysnatremia, and low body mass index (BMI) increased the risk of poor prognosis.Conclusions The RF model developed in this study is a good predictor of in-hospital mortality for patients with SA-AKI in the intensive care unit (ICU), which may have potential applications in mortality prediction.…”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…The fatal group displayed lower Glasgow Coma Scale (GCS) scores and severe complications. …”
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An analysis of referral patterns of traumatic brain injury at Groote Schuur Hospital Trauma Centre by N Parker, T Navsaria, M Lopez, L Marineau, R Maine, K Chu, T Govender, D McPherson, P Navsaria

“…Demographic data (age, sex), mechanism of injury and Glasgow Coma Score were recorded. Referral pathways were determined, and final disposition of patients was recorded. …”
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Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury by Bharti Sharma, Winston Jiang, Munirah M. Hasan, George Agriantonis, Navin D. Bhatia, Zahra Shafaee, Kate Twelker, Jennifer Whittington

“…We found statistically significant differences in SLs at H admission, ICU admission, and ICU discharge when compared to the Injury Severity Score (ISS) and the Glasgow Coma Scale (GCS) at admission. A linear regression analysis revealed a statistically significant positive correlation between ICU admission SLs and ISS. …”
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Functional outcomes following injury in pediatric patients without traumatic brain injury by Ryo Yamamoto, Lillian Liao, Keitaro Yajima, Akira Endo, Kazuma Yamakawa, Junichi Sasaki

“…The GEE model revealed that female sex, physical disability before injury, prehospital transfusion, lower Glasgow Coma Score (GCS) score on arrival, neck surgery, and higher AIS in the neck and extremity/pelvis were independently associated with unfavorable function at discharge. …”
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A Comparison of Cooling Techniques to Treat Cardiac Arrest Patients with Hypothermia by Anna Finley Caulfield, Shylaja Rachabattula, Irina Eyngorn, Scott A. Hamilton, Rajalakshmi Kalimuthu, Amie W. Hsia, Maarten G. Lansberg, Chitra Venkatasubramanian, J. J. Baumann, Marion S. Buckwalter, Monisha A. Kumar, James S. Castle, Christine A. C. Wijman

“…We sought to compare the performance of endovascular cooling to conventional surface cooling after cardiac arrest. Methods. Patients in coma following cardiopulmonary resuscitation were cooled with an endovascular cooling catheter or with ice bags and cold-water-circulating cooling blankets to a target temperature of 32.0–34.0∘C for 24 hours. …”
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Improved Outcomes following the Establishment of a Neurocritical Care Unit in Saudi Arabia by Ibrahim Soliman, Waleed Tharwat Aletreby, Fahad Faqihi, Nasir Nasim Mahmood, Omar E. Ramadan, Ahmad Fouad Mady, Babar Kahlon, Abdulrahman Alharthy, Peter Brindley, Dimitrios Karakitsos

“…Secondary outcomes were ICU length of stay (LOS), predictors of ICU and hospital discharge, ICU discharge Glasgow Coma Scale (GCS), frequency of tracheostomies, ICP monitoring, and operative interventions. …”
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Corneal Cap Thickness and Its Effect on Visual Acuity and Corneal Biomechanics in Eyes Undergoing Small Incision Lenticule Extraction by Ting Liu, Ting Yu, Lina Liu, Kaijian Chen, Ji Bai

“…No statistically significant differences were found in manifest refraction, UCVA, SR, OSI, MTF cutoff, and mesopic and photopic contrast sensitivity at low frequency, photopic contrast sensitivity at high frequency, endothelial density, corneal coma, and total HOAs at 3 months after the procedure. …”
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Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study by Bo Zhang, Archana A Patel, Gretchen L Birbeck, Maitreyi Mazumdar, Suzanna Mwanza, Rosemary Nyirongo, Dixon Berejena, Joseph Kasolo, Tina Mwale, Violet Nambeye, Kafula Lisa Nkole, Nfwama Kawatu, Alexander Rotenberg

“…Outcome measures will include qualitative and quantitative analysis of routine EEG recordings, as well as clinical metrics in the acute and subacute period, including histidine-rich protein 2 levels of parasite burden, depth and length of coma, presence and severity of acute seizures, presence of hypoglycaemia, maximum temperature and 1-month post-CM neurodevelopmental assessment scores. …”
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A surveillance study to determine the accuracy of mild traumatic brain injury diagnosis in an emergency department: protocol for a retrospective cohort study by Ian D Cameron, Ilaria Pozzato, Ashley Craig, Bamini Gopinath, Mark Gillett, Annette Kifley, Kim Van Vu, Susanne Meares, Anthony Liang

“…The WHO operational criteria for the clinical identification of mTBI cases is the presence of: (1) a Glasgow Coma Scale (GCS) of 13–15 after 30 min postinjury or on presentation to hospital; (2) one or more of the following: post-traumatic amnesia (PTA) of less than 24 hours’ duration, confusion or disorientation, a witnessed loss of consciousness for ≤30 min and/or a positive CT brain scan. …”
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Pharmacoeconomics and Utilisation of Antidiabetic Medications among Type 2 Diabetes Mellitus Patients: A Longitudinal Study by Bikash Chandra Das, P Ansuman Abhisek, Deepak Choudhury, Suvendu Kumar Panda, Jayanti Prava Behera, Supriya Pradhan, Trupti Rekha Swain, Sasmita Mallick

“…Pregnant women and patients in diabetic coma were excluded from the study. A predesigned, pretested, semistructured questionnaire was used to collect data from the patients or their legally accepted relatives. …”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…Results Multivariable logistic regression analysis identified OTBI classification type C (p < 0.001), a Glasgow Coma Scale score (GCS) ≤ 8 (p < 0.001), subarachnoid hemorrhage (SAH) (p = 0.004), subdural hematoma (SDH) (p = 0.011), and coagulopathy (p = 0.020) as independent risk factors for poor prognosis. …”
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Do serial troponins predict the need for cardiac evaluation in trauma patients after ground-level fall? by Rachael A Callcut, Alyssa R Bellini, James T Ross, Madelyn Larson, Skyler Pearson, Anamaria J Robles

“…The cohort included 560 patients evaluated for a possible syncopal fall, hemodynamically stable, Glasgow Coma Scale score of 15, and with a troponin drawn at presentation. …”
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Potential Risk Factors for In-Hospital Mortality in Patients with Moderate-to-Severe Blunt Multiple Trauma Who Survive Initial Resuscitation by Neslihan Yucel, Tuba Ozturk Demir, Serdar Derya, Hakan Oguzturk, Murat Bicakcioglu, Funda Yetkin

“…High ISS (OR 1.047, 95% CI 1.02-1.08), TBI (OR 8.922, 95% CI 2.57-31.00), sepsis (OR 4.956, 95% CI 1.99-12.36), acute respiratory distress syndrome (ARDS) (OR 8.036, 95% CI 1.85-34.84), respiratory failure (OR 9.630, 95% CI 2.64-35.14), renal failure (OR 74.803, 95% CI 11.34-493.43), and multiple organ failure [MOF] (OR 10.415, 95% CI 4.48-24.24) were risk factors for late in-hospital mortality. High Glasgow Coma Scale (GCS) was a good predictor for survival at 2, 7, and 28 or more days of hospitalization (OR 0.708 and 95% CI 0.56-0.09; OR 0.835 and 95% CI 0.73-0.95; OR 0.798 and 95% CI 0.71-0.90, resp.). …”
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Associated Factors of the Need for Mechanical Ventilation Following Traumatic Injuries; a Registry-Based Study on 2,708 Cases in Iran by Zahra Ramezani, Vali Baigi, Mohammadreza Zafarghandi, Vafa Rahimi-Movaghar, Reza Farahmand-Rad, Akram Zolfaghari Sadrabad, Seyed-Mohammad Piri, Mahgol Sadat Hassan Zadeh Tabatabaei, Khatereh Naghdi, Payman Salamati

“…The significant associated factors of need for MV based on the univariable analysis were age ≥ 65 years (p <0.001); penetrating trauma (p < 0.001) and falling (p = 0.01); private mode of transportation to ED (p < 0.001); site of injury (p < 0.001); heart rate ≥ 100/ minutes (p = 0.04); O2 saturation < 90 % on room air (p < 0.01); Glasgow Coma Scale (GCS) < 13 (p< 0.001); and injury Severity Score (ISS) ≥ 9 (p< 0.001). …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Through variable screening, this study identified age, Glasgow Coma Scale (GCS), blood glucose, uric acid, hemoglobin, and hematoma location as independent predictors of poor prognosis in intracerebral hemorrhage. …”
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Simultaneous Debridement and Titanium Mesh Reconstruction in Patients with Compound Depressed Skull Fracture: A Retrospective Descriptive Study by Srikant Das, Acharya Suryakant Pattajoshi, Mahesh Kumar Kusta, Dibakar Sarkar

“…The frequency of skull fractures was significantly higher in men 91 (92.8%) patients compared to women 7 (7.2%) patients. The mean Glasgow Coma Scale (GCS) score was 13.35 at admission, while it was 14.90 at discharge. …”
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Predictive value of the systemic immune–inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy—a single-center study by Ao Qian, Longyi Zheng, Hui He, Jia Duan, Shuang Tang, Wenli Xing

“…Multivariate analysis demonstrated that heightened SII was significantly related to HT (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.035–1.086, p &lt; 0.001), MBE (OR: 1.074, 95% CI: 1.045–1.103, p &lt; 0.001), adverse function (OR: 1.061, 95% CI: 1.031–1.092, p &lt; 0.001), and mortality (OR: 1.044, 95% CI: 1.018–1.070, p = 0.001), after adjusting sex, age, Glasgow Coma Scale (GCS) score at admission, initial National Institutes of Health Stroke Scale (NIHSS) score, baseline Alberta Stroke Program Early Computed Tomography Score (ASPECTS), present HMCAS, occluded vessel region, collateral score and successful revascularization. …”
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