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    Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes by Guoqing Li, Hongyi Chen, Jiacheng Shen, Yimin Ding, Jingqiong Chen, Yongbin Zhang, Mingrui Tang, Nan Xu, Yuxuan Fang

    Published 2025-01-01
    “…In this study, samples of RA patients with insufficient response to methotrexate (MTX-IR), combined use of tumor necrosis factor inhibitors (TNFi) were followed up for half a year, and 56 circRNA samples of self-test data were stratified into training, testing, and external validation cohorts according to whether American College of Rheumatology 20% improvement criteria (ACR20) was achieved. …”
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    Global Trends in the Incidence and Primary Causes of Femoral Fractures, Excluding Femoral Neck Fractures: A Global Epidemiological Study by Fu F, Liu B, Pu H, Wang Y, Zhang P, Wei S, Gu H, Zhang Q, Ye H

    Published 2025-01-01
    “…Fanyu Fu,1,* Bo Liu,2,* Haifang Pu,3 Yuebin Wang,3 Pengfei Zhang,1 Song Wei,1 Hao Gu,1 Qian Zhang,4 Hengli Ye5 1College of Physical Education and Health Science, Yibin University, Yibin, 644000, People’s Republic of China; 2Department of Orthopedics and Traumatology, Yibin Hospital of Traditional Chinese Medicine, Yibin, 644600, People’s Republic of China; 3Department of Pain, the Second People’s Hospital of Yibin, Yibin, 644000, People’s Republic of China; 4Department of Rheumatology and Immunology, Taizhou First People’s Hospital, Taizhou, 318020, People’s Republic of China; 5Department of Orthopaedics and Joints, Huangyan Hospital of Traditional Chinese Medicine, Taizhou, 318020, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hengli Ye, Huangyan Hospital of Traditional Chinese Medicine, 83 Century Avenue, Xinqian Street, Huangyan District, Taizhou, 318020, China, Email dryehengli@126.comPurpose: Fractures pose a significant global health challenge, with varying incidence trends and causes across demographics and regions. …”
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