Cancer Risk in Inflammatory Bowel Disease by Anders M Ekbom

“…There is an increased risk of cancer in both ulcerative colitis and Crohn's disease. In 3121 patients with ulcerative colitis, 225 cases of cancer were diagnosed compared with 142.1 expected (standardized incidence ratio [SIR] 1.6, 95% CI 1.4 to 1.8), and in 1655 patients with Crohn's disease, 58 cases of cancer were detected compared with 47.1 expected (SIR 1.2, 95% CI 0.9 to 1.6). …”
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The Establishment of a National Tissue Bank for Inflammatory Bowel Disease Research in Canada by Stephen M Collins, Kevin McHugh, Ken Croitoru, Micheal Howorth

“…The Crohn’s and Colitis Foundation of Canada (CCFC) has established a national bank for tissue, serum and blood from patients with inflammatory bowel disease (IBD). …”
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Potential Human Models of Infammatory Bowel Disease by Stephen B Hanauer

“…Newly defined colitides, such as microscopic and collagenous colitis and diversion colitis, also provide potential comparative models to evaluate mucosal immune, inflammatory, reparative, secretory and absorptive regulation.…”
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Prospective Evaluation of Neutrophil Autoantibodies in 500 Consecutive Patients with Inflammatory Bowel Disease by Hugh Freeman, Brenda Roeck, Dana Devine, Cedric Carter

“…Overall, 194 (38.8%) of all patients with IBD were positive, including 164 (66.3%) with ulcerative colitis and 30 (11.9%) with Crohn's disease. …”
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Pouchitis by W. R. Schouten

“…When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical course, the endoscopic findings and the histologic abnormalities resemble those of ulcerative colitis. …”
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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…The aforementioned alterations were also observed in mice with DSS-induced colitis. The study revealed a correlation between dysbiosis of the gut microbiota and modifications in the profile of colonic bile acids, notably LCA observed in both patients with IBD and mice with DSS-induced colitis. …”
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Research Topics in Gastrointestinal Disease: A Report on the 10th Meeting and an Announcement of the 11th Meeting by Nicola Jones, Ken Croitoru, Stephen Vanner, Rohini Soni, Louise Hope

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Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut by Mehari Endale, H. Ibrahim Aksoylar, Kasper Hoebe

“…Inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis is often precipitated by an abnormal immune response to microbiota due to host genetic aberrancies. …”
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Complete Histological Resolution of Collagenous Sprue by Hugh J Freeman, Jennifer E Davis, Danny M Myers

“…A 65-year-old woman developed a watery diarrhea syndrome with collagenous colitis. Later, weight loss and hypoalbuminemia were documented. …”
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Unusual Presentation of Primary Sclerosing Cholangitis by BC Pineau, LP Pattee, S McGuire, A Sekar, LJ Scully

“…Disordered immune regulation as a major factor in the mechanism of injury in PSC is supported by its increased association with other immunologically mediated disorders, most notably ulcerative colitis. Autoimmune hemolytic anemia, however, has been reported to be associated with PSC on only two occasions, and ankylosing spondylitis in the absence of ulcerative colitis is also unusual. …”
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Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease by Guangxi Zhou, Lin Yu, Wenjing Yang, Wei Wu, Leilei Fang, Zhanju Liu

“…Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronically remittent and progressive inflammatory disorders. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Here, we show that Pellino1 levels are elevated in patients with colitis, patients with colitis-associated colon cancer (CAC), and murine models of these conditions. …”
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Pitfalls in the Histological Diagnosis of Inflammatory Bowel Disease on Colorectal Biopsies by DA Malatjalian

“…Pitfalls, however, appear because overlapping histological features occur among the various forms of colitis or because a specific form of colitis may exhibit incomplete expression of its characteristic features. …”
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Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease by Hugh J Freeman

“…Atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis but only in a minority of those with Crohn's disease. …”
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High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement? by Alena Sekerkova, Martin Fuchs, Eva Cecrdlova, Veronika Svachova, Ivana Kralova Lesna, Ilja Striz, Helena Tlaskalova-Hogenova

“…Food protein-induced proctitis/proctocolitis (FPIP) is the most common noninfectious colitis in children in the first year of life. Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease. …”
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Indications and Relative Utility of Lower Endoscopy in the Management of Clostridium difficile Infection by Nora E. Burkart, Mary R. Kwaan, Christopher Shepela, Robert D. Madoff, Yan Wang, David A. Rothenberger, Genevieve B. Melton

“…Most endoscopies (73%) had positive findings, including pseudomembranous colitis (49%) and nonspecific colitis (24%). Biopsies were performed in 31 cases, more with nonspecific colitis (10/11, 92%) compared to pseudomembranous colitis (14/22, 64%). …”
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RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8 by Xianwen Ran, Yue Li, Yahui Ren, Weilong Chang, Rui Deng, Huifen Wang, Weiwei Zhu, Yize Zhang, Yudie Cai, Jia Hu, Di Wang, Zhibo Liu

“…Overall, our study underscores the anti-inflammatory role of RNF128 in macrophages during the progression of colitis and highlights the potential of targeting the RNF128-Tollip-S100A8 axis to attenuate intestinal inflammation for the treatment of colitis.…”
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Genetic Counselling and Family in IBD: 30 years' Experience at the Cleveland Clinic by WM Michener, M Caulfield, RG Farmer, R Wyllie, K Cotman, J Hertzer

“…Of the 437 patients with mucosal ulcerative colitis, the index patient had one or more family members develop IBD. …”
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Inflammatory Bowel Disease, the Oral Contraceptive Pill and Pregnancy by Robert N Allan

“…IBD and pregnancy, including the impact on the fetus and the mother with ulcerative colitis or Crohn’s disease, is considered. The safety of drug treatment during pregnancy, the outcome of surgical treatment during pregnancy and the problems that may be encountered during pregnancy in patients with an ileostomy or ileo-anal pouch are discussed, followed by a review of the short and long term prognosis of ulcerative colitis and Crohn’s disease partition.…”
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Pancolitis with Ischemic Injury as a Complication of Immunosuppressive Treatment in a Patient with Autoimmune Hepatitis: A Case Report by A. Dalbeni, E. Capoferro, L. Bernardoni, P. Capelli, A. Caliò, A. Gabbrielli, F. Capra

“…Ischemic colitis is a serious drug-induced adverse event. There are only few cases of immunosuppression-associated ischemic colitis described in the literature, but none with a pancolitis-like manifestation. …”
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