Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

“…Quercetin, a naturally occurring flavonoid, has shown potential as a hypouricemic agent through XO inhibition.ObjectiveThis study aims to evaluate the potential hypouricemic effect of Quercetin Phytosome™ (QP) supplementation across three cohort studies involving healthy adults with various metabolic health profiles, exploring its potential as a safe, effective intervention for hyperuricemia.MethodsClinical data collected in various clinics in Italy between September 2021 and April 2024 under real-life clinical settings from three distinct cohort studies, were analyzed. …”
Get full text

A GDPR-compliant solution for analysis of large-scale genomics datasets on HPC cloud infrastructure by Silvia Gioiosa, Beatrice Chiavarini, Mattia D’Antonio, Giuseppe Trotta, Balasubramanian Chandramouli, Juan Mata Naranjo, Giuseppa Muscianisi, Mirko Cestari, Elisa Rossi

“…Indeed, the explosion of High Throughput Sequencing in medicine has raised tremendous opportunities for large-scale genomic data analysis. Cohort studies involving the processing of hundreds or thousands of input samples, combined with the integration of diverse diagnostic data, enable researchers to conduct integrative analyses at an unprecedented level of detail would have been impossible to achieve through single sample studies. …”
Get full text

Exome sequencing of 18,994 ethnically diverse patients with suspected rare Mendelian disorders by Heonjong Han, Go Hun Seo, Seong-In Hyun, Kisang Kwon, Seung Woo Ryu, Rin Khang, Eugene Lee, JiHye Kim, Yongjun Song, Won Chan Jeong, Joohyun Han, Dong-wook Kim, Soyeon Yang, Sohyun Lee, Sohyun Jang, Jungsul Lee, Hane Lee

“…The overall diagnostic rate is comparable to that observed in other large cohort studies with less diverse ethnic backgrounds.…”
Get full text

Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis by Yaqin Chen, Gang Wu, Hongmin Zhang, Hua Xu, Hong Li, Ling Chen, Yixuan Yang, Peng Hu, Dazhi Zhang, Hong Ren, Huaidong Hu

“…A meta-analysis was performed on 2 RCTs and 2 cohort studies comprising a total of 326 patients (171 of whom accepted interferon-based antiviral therapy). …”
Get full text

Digital Interventions for the Rehabilitation of First-Episode Psychosis: An Integrated Perspective by Annarita Vignapiano, Francesco Monaco, Ernesta Panarello, Stefania Landi, Benedetta Di Gruttola, Raffaele Malvone, Vassilis Martiadis, Fabiola Raffone, Alessandra Marenna, Maria Pontillo, Valeria Di Stefano, Martina D’Angelo, Luca Steardo, Giulio Corrivetti

“…Included studies focused on randomized controlled trials, cohort studies, and open studies of digital interventions for FEP rehabilitation. …”
Get full text

The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System by Armin Zittermann

“…However, evidence is also accumulating that in elderly people the risk of falls and fractures increases again at circulating 25OHD levels > 100 nmol/L. Cohort studies report a progressive increase in cardiovascular disease (CVD) events at 25OHD levels < 50 nmol/L. …”
Get full text

Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis by Yu Zhang, Haijiao Wang, Ling Liu

“…The Pubmed (MEDLINE), Embase, and Cochrane Library databases were searched for randomized controlled trials (RCTs), cohort studies, and retrospective case series from January 1, 2001, to February 30, 2021. …”
Get full text

Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease by Basma Abdelaleem Elsaadany, Eman Magdy Ahmed, Sana Maher Hasan Aghbary

“…Six studies were included: 2 randomized clinical trials (RCTs), 3 cohort studies, and 1 pre-post clinical trial. Results. …”
Get full text

Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children by Olesya Fedoryak, Charles Arama, Issa Diarra, Bouréma Kouriba, Michel Chrétien, Majambu Mbikay

“…Intriguingly, this allele did not negatively segregate with any of the clinical symptoms linked to mortality in this cohort. Studies are needed to determine whether PCSK9 inactivation promotes a protective immune response to malaria infection.…”
Get full text

Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) by Frank G Holz, Marlene Saßmannshausen, Thomas Ach, Leon von der Emde, Julius Ameln, Alessandra Carmichael-Martins, Wolf M Harmening

“…With AOSLO-MP, the corresponding sensitivity loss was -20.1 ±4.8 dB.Conclusion We demonstrated that iRORA lesions are associated with a severe impairment in retinal sensitivity. Larger cohort studies will be necessary to validate our findings.…”
Get full text

Impact of Mouthwash-Induced Oral Microbiome Disruption on Alzheimer's Disease Risk: A Perspective Review by Ayoub Boulares, Hela Jdidi, Nicola Luigi Bragazzi

“…However, the relationship between CHX mouthwash use and AD remains largely indirect, necessitating further longitudinal and cohort studies to investigate whether a direct causal link exists. …”
Get full text

A Review of Adult Obesity Prevalence, Trends, Risk Factors, and Epidemiologic Methods in Kuwait by Stalo Karageorgi, Osama Alsmadi, Kazem Behbehani

“…There is a need for future studies, particularly surveillance surveys and prospective cohort studies utilizing advanced methods, to monitor trends and to comprehensively assess the factors contributing to the obesity epidemic in Kuwait.…”
Get full text

Frequency of Genital Involvement in Women with Oral Lichen Planus in Southern Iran by M. Davarmanesh, A. Samsami Dehaghani, Z. Deilami, A. Monabbati, L. Dastgheib

“…In spite of low genital involvement possibly due to inadequate patient population, lack of follow-up visits, and contribution of genetic or ethnic factors, for conservative patient care, women with the oral lichen planus in particular those having some relevant genital symptoms, should preferably be referred for careful vulvovaginal examination. Multicenter cohort studies on women of different geographical regions or ethnicities who have genital lichen planus alone or in combination with other common sites are encouraged.…”
Get full text

Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis by Xiao-Jie Wang, Zheng-Rong Zheng, Pan Chi, Hui-Ming Lin, Xing-Rong Lu, Ying Huang

“…Fifteen retrospective cohort studies representing 4431 patients met the inclusion criteria. …”
Get full text

Genetic Variants Related to Increased CKD Progression—A Systematic Review by Filipe S. Mira, Bárbara Oliveiros, Isabel Marques Carreira, Rui Alves, Ilda Patrícia Ribeiro

“…The selected studies included cohort studies, case-control studies, and genome-wide association studies (GWASs). …”
Get full text

Liver Injury Secondary to Anti-TNF-Alpha Therapy in Inflammatory Bowel Disease: A Case Series and Review of the Literature by Ravish Parekh, Nirmal Kaur

“…The mechanism of drug-induced injury is idiosyncratic. Larger cohort studies are needed to establish risk factors and injury patterns related to hepatotoxicity in these patients.…”
Get full text

Ambient Air Pollution and Congenital Heart Disease: Updated Evidence and Future Challenges by Francesca Gorini, Alessandro Tonacci

“…Future epidemiological cohort studies in countries with different degree of air pollution and experimental research on animal models are warranted to gain a comprehensive picture of the possible involvement of ambient air pollutants in CHD etiopathogenesis. …”
Get full text

Physical measures of physical functioning as prognostic factors in predicting outcomes for neck and thoracic pain: Protocol for a systematic review. by Rabea Begum, Alison Rushton, Alaa El Chamaa, David Walton, Paul Parikh

“…Included studies will be prospective longitudinal cohort studies in which physical measures of physical functioning are explored as prognostic factors for adults with neck and thoracic pain. …”
Get full text

Validity of Cardiovascular Risk Prediction Models in Kidney Transplant Recipients by Holly Mansell, Samuel Alan Stewart, Ahmed Shoker

“…Five databases were searched (MEDLINE, EMBASE, SCOPUS, CINAHL, and Web of Science) and cohort studies with at least one year of follow-up were included. …”
Get full text

Effect of Conservative Interventions for Musculoskeletal Disorders in Preprofessional and Professional Dancers: A Systematic Review by Justine Benoit-Piau, Christophe Benoit-Piau, Nathaly Gaudreault, Mélanie Morin

“…Prospective and retrospective cohort studies, as well as randomized and non-randomized controlled trials investigating conservative interventions for musculoskeletal disorders in preprofessional and professional dancers were included in this study. …”
Get full text