Congenital cytomegalovirus - current state of knowledge on the treatment and prevention of fetuses and newborns by Katarzyna Miedzińska, Mateusz Grego, Łukasz Stojak, Dariusz Popiela, Karina Urbańska, Filip Kwiatkowski, Mateusz Baczewski, Witold Czyż

“…Symptomatic congenital cytomegalovirus occurs in about 10% of infected newborns and, among of the other things, can cause hearing loosing, vision impairment or cognitive impairment in the children. Importantly, a child who is asymptomatic at the time of delivery is still at risk of developing dysfunctions in the future. …”
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Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia by Yu-Ting Ling, Qian-Qian Guo, Si-Min Wang, Li-Nan Zhang, Jin-Hua Chen, Yi Liu, Ruo-Heng Xuan, Bo Qu, Li-Ge Liu, Zhi-Shuang Wen, Jia-Kun Xu, Lu-Lu Jiang, Wen-Biao Xian, Bin Wu, Chang-Ming Zhang, Ling Chen, Jin-Long Liu, Nan Jiang

“…Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson’s disease. …”
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Preoperative Altered Spontaneous Brain Activity and Functional Connectivity Were Independent Risk Factors for Delayed Neurocognitive Recovery in Older Adults Undergoing Noncardiac... by Zhaoshun Jiang, Xixue Zhang, Yating Lv, Xiaodong Zheng, Huibiao Zhang, Xuelin Zhang, Chongyi Jiang, Guangwu Lin, Weidong Gu

“…Recently, it has been demonstrated that patients with subtle preexisting cognitive impairment were susceptible to delayed neurocognitive recovery (DNR). …”
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Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity by Jessica M. V. Pino, Vitória F. Silva, Marcos Mônico-Neto, Danielle C. Seva, Melissa Y. Kato, July N. Alves, Gabriela C. Pereira, Hanna Karen M. Antunes, Thales D. Galvao, Lia R. A. Bitterncourt, Sergio Tufik, Lysien I. Zambrano, Ana R. Dâmaso, Lila M. Oyama, David Thivel, Raquel M. S. Campos, Kil S. Lee

“…Thus, iron dyshomeostasis observed in severe obesity may aggravate the cognitive impairment by altering metabolic homeostasis and enhancing oxidative stress. …”
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Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ by Jiawei Zhang, Yaxuan Zhang, Lan Liu, Mengyuan Zhang, Xiaojie Zhang, Jiangshan Deng, Fei Zhao, Qing Lin, Xue Zheng, Bing Fu, Yuwu Zhao, Xiuzhe Wang

“…Intriguingly, treatment with chemerin-9 significantly ameliorated Aβ deposition and cognitive impairment of the APP/PS1 mice, with decreased microglial proinflammatory activity and increased phagocytic activity. …”
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The association of sun-cured tobacco and cigarette use with global cognitive function, verbal fluency and memory in patients with chronic obstructive pulmonary disease: A cross-sec... by Xiaomei Chen, Jie Li, Jia Liu, Xiao Liu, Menghui Deng, Xunhu Dong, Yanni Yang

“…Results The participants of both cigarette-smoking (AOR=11.18; 95% CI: 1.28– 97.5) and sun-cured tobacco (AOR=10.46; 95% CI: 1.14–96.4) groups were more likely to develop mild cognitive impairment compared to the non-smoking group. The mean z scores of global cognitive function, verbal fluency, and memory were lower in cigarette-smoking and sun-cured tobacco groups than those in a non-smoking group; Multivariable linear regression showed that global cognitive function (β= -0.61; 95% CI: -1.04 – -0.18; and β= -0.48; 95% CI: -0.91 – -0.05) and verbal fluency (β= -0.79; 95% CI: -1.33 – -0.26; and β= -0.69; 95% CI: -1.23 – -0.16) of the sun-cured tobacco group and the cigarette-smoking group were significantly lower than those of the non-smoking group when adjusting for demographic and disease-related characteristics. …”
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Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice by Lu Xiu, Rongguang Ge, Siyu Lu, Linwei Li, Wenqi Huang, Guojun Du, Zengli Zhang, Jie Zhang, Zhongxiao Wan, Jie Chang

“…In conclusion, 10-HDA can regulate mTOR/ULK1 pathway to activate autophagy to alleviate hippocampal damage, thereby improving cognitive function in mice with diabetes, which may provide a new option for real-world cognitive impairment management.…”
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Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis by Jiaxuan He, Peiye Xu, Ting Xu, Haiyang Yu, Lei Wang, Rongbing Chen, Kun Zhang, Yueliang Yao, Yanyan Xie, Qinsi Yang, Wei Wu, Da Sun, Dejun Wu

“…HRW can significantly improve cognitive impairment and depression-like behavior in zebrafish AD model, reduce Aβ deposition (p < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels (p < 0.05), reduce neuroinflammation, and reduce oxidative stress. …”
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Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes by Manabu Midorikawa, Hiroaki Suzuki, Yasuhiro Suzuki, Kazuyoshi Yamauchi, Hiroyuki Sato, Kiyotaka Nemoto, Yoko Sugano, Hitoshi Iwasaki, Motohiro Sekiya, Shigeru Yatoh, Naoya Yahagi, Yasushi Hada, Tetsuaki Arai, Hitoshi Shimano

“…We investigated the relationship between cognitive function and olfactory and physical functions in middle-aged persons with and without type 2 diabetes (T2D) to examine the potential of olfactory and physical functions as biomarkers for early cognitive impairment. Methods. Enrolled were 70 T2D patients (age 40 to <65 y) and 81 age-matched control participants without diabetes. …”
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Tracking Persistent Symptoms in Scotland (TraPSS): a longitudinal prospective cohort study of COVID-19 recovery after mild acute infection by Jane Ormerod, Nicholas F Sculthorpe, Marie McLaughlin, Luke Cerexhe, Eilidh Macdonald, Antonio Dello Iacono, Nilihan E M Sanal-Hayes, Joanne Ingram, Rachel Meach, David Carless, Lawrence D Hayes

“…Older age increased the likelihood of reporting pain (p=0.028, estimate=0.07) and cognitive impairment (p&lt;0.001, estimate=0.93). Female gender increased the likelihood of headaches (p=0.024, estimate=0.53) and post-exertional malaise (PEM) frequency (p=0.05, estimate=137.68), and increased time x gender effect for PEM frequency (p=0.033, estimate=18.96).Conclusions The majority of people fully recover from acute COVID-19, although often slowly. …”
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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats by Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen, Ruth M. Barrientos

“…Moreover, deviations in gut microbiome composition have been associated with obesity and cognitive impairment, but how diet and aging interact to impact the gut microbiome, or how rapidly these changes occur, is less clear. …”
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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Mechanistically, the knockout of Cd2ap activated p38 mitogen-activated protein kinase (MAPK) signaling, which contributed to increased tau phosphorylation, synaptic injury, neuronal apoptosis and cognitive impairment. Furthermore, the phenotypes of neuronal Cd2ap knockout were ameliorated by a p38 MAPK inhibitor. …”
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Differences in EEG complexity of cognitive activities among subtypes of schizophrenia by Hang Qi, Jilin Zou, Zhenzhen Yao, Gaofeng Zhao, Jing Zhang, Chunlei Liu, Min Chen

“…IntroductionThe neural mechanisms that underpin cognitive impairments in patients with schizophrenia remain unclear. …”
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Impact of pubertal timing on growth progression and final height in subjects affected by RASopathies by Federica Tamburrino, Laura Mazzanti, Dino Gibertoni, Concetta Schiavariello, Annamaria Perri, Eleonora Orlandini, Cesare Rossi, Marco Tartaglia, Marcello Lanari, Emanuela Scarano

“…They are clinically characterized by failure to thrive, facial dysmorphisms, congenital heart defects, lymphatic malformations, skeletal anomalies, and variable cognitive impairment, with variable prevalence in the different conditions and subtypes. …”
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Development and Validation of a Routine Electronic Health Record-Based Delirium Prediction Model for Surgical Patients Without Dementia: Retrospective Case-Control Study by Emma Holler, Christina Ludema, Zina Ben Miled, Molly Rosenberg, Corey Kalbaugh, Malaz Boustani, Sanjay Mohanty

“…Patients with preexisting dementia or mild cognitive impairment were excluded. POD was identified using Confusion Assessment Method records and delirium International Classification of Diseases (ICD) codes. …”
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Antipsychotic prescribing practices and patient, family member and healthcare professional perceptions of antipsychotic prescribing in acute care settings: a scoping review protoco... by Zahinoor Ismail, Daniel Niven, Kirsten Fiest, Lisa Burry, Karla D Krewulak, Natalia Jaworska, Stephana Julia Moss, Zara Stelfox

“…Long-term use of antipsychotics is associated with increased risk of sudden cardiac death, falls and cognitive impairment. An understanding of acute care off-label antipsychotic prescribing practices and healthcare professional, patient and family perceptions related to antipsychotic prescribing and deprescribing is necessary to facilitate in-hospital deprescribing initiatives.Methods and analysis We present the protocol for a scoping review following the methodology proposed by Arksey and O’Malley and the Scoping Review Methods Manual by the Joanna Briggs Institute. …”
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Youth Involvement in Pornography and Academic Engagement in Selected Secondary Schools in Kabale Municipality. by Kanyesigye, Bens Rogers

“…The study further found out that those adolescent students who encounter explicit materials in the form of images of naked persons, sex videos, and written material, were likely to experience potential addiction, reduced self-control, and cognitive impairment. Social media platforms, internet sources, and private messaging applications were revealed as the primary sources for obtaining pornographic content, together with the widespread use of the internet and smartphones in the area of study, and unrestricted access and absence of proper supervision mechanisms by parents, teachers, and other school administrators on what the youth should watch in the digital era. …”
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Subclinical Inflammatory Status in Rett Syndrome by Alessio Cortelazzo, Claudio De Felice, Roberto Guerranti, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Gloria Zollo, Claudia Landi, Giuseppe Valacchi, Lucia Ciccoli, Luca Bini, Joussef Hayek

“…Inflammation has been advocated as a possible common central mechanism for developmental cognitive impairment. Rett syndrome (RTT) is a devastating neurodevelopmental disorder, mainly caused by de novo loss-of-function mutations in the gene encoding MeCP2. …”
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Effects of Dual-Site Anodal Transcranial Direct Current Stimulation on Attention, Decision-Making, and Working Memory during Sports Fatigue in Elite Soccer Athletes by Fengxue Qi, Na Zhang, Michael A. Nitsche, Longyan Yi, Yingqiu Zhang, Tian Yue

“…However, its potential to ameliorate cognitive impairment during sports fatigue remains largely unexplored. …”
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Consensus on rapid screening for prodromal Alzheimer’s disease in China by Yao Lu, Ying Wang, Jianping Jia, Qihao Guo, Ya Miao, Lin Huang, Xiaochun Chen, Qinjie Li, Fengfeng Pan, Liang Cui, Tianlu Chen, Yatian Li, Jingnan Wu

“…The prodromal stage of AD (pAD) refers to patients with mild cognitive impairment (MCI) and evidence of AD’s pathology. …”
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