Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage by Cristina Sierra, Alfons López-Soto, Antonio Coca

“…After age, hypertension is the most-important risk factor for cerebral white matter lesions, which are an important prognostic factor for stroke, cognitive impairment, dementia, and death. Studies have shown an association between white matter lesions and a number of extracranial systems affected by high BP and also suggest that correct antihypertensive treatment could slow white matter lesions progression. …”
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Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives by Marina de Tommaso, Lars Arendt-Nielsen, Ruth Defrin, Miriam Kunz, Gisele Pickering, Massimiliano Valeriani

“…The management of neurodegenerative diseases such as Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington’s disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. …”
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Clinical Correlates of Awareness for Balance, Function, and Memory: Evidence for the Modality Specificity of Awareness by Megan E. O'Connell, Vanina Dal Bello-Haas, Margaret Crossley, Debra Morgan

“…Awareness of function was higher for participants with mild cognitive impairment (aMCI and non-aMCI) than for those with dementia (due to Alzheimer disease; AD and non-AD), whereas awareness of memory was higher for both non-aMCI and non-AD dementia patients than for those with aMCI or AD. …”
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Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis by Antonella Cappa, Nicoletta Ciccarelli, Eleonora Baldonero, Marialuisa Martelli, Maria Caterina Silveri

“…Four clusters of cognitive impairment emerged: visuospatial/perceptual, memory, perceptual/calculation, and language. …”
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A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study by J. Campbell, D. Langdon, M. Cercignani, W. Rashid

“…Methods. 38 patients with MS and cognitive impairment on the Brief International Cognitive Assessment for MS (BICAMS) were enrolled. …”
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Accumulation of Deficits as a Proxy Measure of Aging by Arnold B. Mitnitski, Alexander J. Mogilner, Kenneth Rockwood

“…For different patterns of cognitive impairments the average within-group index value increases with the severity of the cognitive impairment, and the relative variability of the index is significantly reduced. …”
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Effect of Vitamin B12 supplementation in late-life depression: A randomized controlled trial by Pooja Misal, Shrikant Srivastava, Akanksha Sonal, Vivek Agarwal, Wahid Ali

“…Hindi Mental Status Examination was used at baseline to exclude primary cognitive impairment. Results: There was a significant decline in the depression scores in the Vitamin B12 supplementation group on both the HAM-D (P = 0.01, partial η2 = 0.113) and GDS (P = 0.01, partial η2 = 0.102) between days 0 and 28, with statistically more remitted subjects in the supplementation group (78% vs. 47%, P = 0.001). …”
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia by Jingjin Li, Chonglong Shi, Zhengnian Ding, Wenjie Jin

“…Prophylactic administration of lithium chloride (2 mM/kg) can inhibit the expression of proinflammatory mediators in the hippocampus, reduce the hippocampal expression of NF-κB, and increase both the downregulation of M1 microglial-related genes (inducible nitric oxide synthase and CD86) and upregulation of M2 microglial-related genes (IL-10 and CD206), to alleviate the cognitive impairment caused by orthopedic surgery. In vitro, LiCl reversed LPS-induced production of proinflammatory mediators and M1 polarization of microglia. …”
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Efficacy of a Multimodal Cognitive Rehabilitation Including Psychomotor and Endurance Training in Parkinson's Disease by I. Reuter, S. Mehnert, G. Sammer, M. Oechsner, M. Engelhardt

“…Mild cognitive impairment, especially executive dysfunction might occur early in the course of Parkinson's disease. …”
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Physical, cognitive, and mental function in patients with pre- and post cardiac surgery: A pre–post comparative study by Dipika Prajapati, Aishwarya Nair

“…About 70% of patients already had moderate-to-severe cognitive impairment 1 day before surgery, which increased to 70.2% severe impairment on POD 3. …”
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How do sepsis survivors experience life after sepsis? A Danish qualitative study exploring factors of importance by Annmarie Touborg Lassen, Mikkel Brabrand, Christina Østervang, Dorthe Susanne Nielsen, Camilla Schade Skov

“…Among these survivors, one patient was admitted to the ICU.Results Three main themes were derived from the analysis: new roles in life, cognitive impairment and anxiety. Although many survivors described a physical decline, they experienced psychological and cognitive impairments after sepsis as the most influential factors in daily life. …”
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Multivariate Analyses with Two-Step Dimension Reduction for an Association Study Between ¹¹C-Pittsburgh Compound B and Magnetic Resonance Imaging in Alzheimer’s Disease... by Atsushi Kawaguchi, Fumio Yamashita

“…The differences in PiB scores among the diagnosis groups 12 months after PiB imaging were significant between the normal and AD groups (<i>p</i> = 0.0284), but not between the normal and mild cognitive impairment (MCI) groups or the MCI and AD groups (<i>p</i> = 0.3508). …”
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Ability of Different Heat-treated Egg Yolk Lipids to Alleviate Cognitive Decline in Mice by Yao WU, Mingkun LIU, Bing FANG, Ming ZHANG

“…This study utilized a mouse model of cognitive impairment to compare the varying impacts on learning and cognitive functions resulting from 95 ℃ (30 min in water bath) and 121 ℃ (30 min in sterilization pot) heat treatments of egg yolk lipid components. …”
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Genomic exploration of pediatric neurological disorders: a case series by Naresh Tayade, Gautham Manoj, Akshay Kewat, Anjali Krishna A, Rajiv Devulapalli, Somesh Kumar, Sunil Kumar Polipalli, Bipin G. Nair, Obul Reddy Bandapalli, Prashanth Suravajhala

“…Abstract Background Pediatric neurological disorders include neurodegenerative diseases causing cognitive impairment and vision loss. They are one of the important causes of morbidity and mortality in children with diverse etiologies. …”
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The effect of physical exercise and cognition-orientated interventions on post-stroke cognitive function: Protocol for an overview of reviews. by James Smith, Philip Nagy, David Tod, Carol Holland, Hannah Jarvis

“…Almost half of chronic stroke survivors are cognitively impaired, and healthcare services are struggling to manage these patients, leaving some feeling "abandoned". …”
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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives by Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon

“…In contrast, second-generation MABs, including aducanumab, lecanemab, donanemab, and gantenerumab directed against pathogenic Aβ species and aggregates have shown that reducing Aβ deposition can be an effective strategy to slow cognitive impairment in AD. In this review, we provide a comprehensive overview of the current status, mechanisms, outcomes, and limitations of second-generation MABs for the clinical treatment of AD. …”
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Apolipoprotein E genotyping variations and their influence on cognitive outcome among idiopathic generalized epileptic patients by Nancy El-Salhy, Noura R. Eissa, Salma Ragab, Gamil M. Abd-Allah, Sara M. Sayed

“…The study showed that a highly significant association (P<0.001) between IGE and cognitive impairment especially attention, memory, and fluency. …”
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Dietary Fatty Acids and Predementia Syndromes by Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D' Introno, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panza

“…Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. …”
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Validation of a Spanish Version of the Lille Apathy Rating Scale for Parkinson’s Disease by Rocio García-Ramos, Clara Villanueva Iza, María José Catalán, Abilio Reig-Ferrer, Jorge Matías-Guíu

“…Total LARS score is influenced by the presence of depression and cognitive impairment. However, both disorders are independent identities with respect to apathy. …”
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The rural risk of digital exclusion: A case study of municipal digital health and social care services in Denmark by Barbara Fersch, Egon Bjørnshave Noe, Annette Aagaard Thuesen, Beate Langer

“…Drawing on the concept of digital capital, we identify several preconditions and contextual aspects, such as cognitive impairment, that in combination with missing digital capital leads to digital exclusion, and we show how social capital such as family and acquaintances mitigates digital exclusion and the lack of a high enough level of digital capital in various ways. …”
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