Case report of twins with Bardet-Biedl syndrome exhibiting a rare mutation in the TTC8 gene by Agnieszka Murawska, Kamil Możdżeń, Grzegorz Horosin, Edward Pędziwiatr, Joanna Makowska, Jakub Pośpiech, Konrad Kaleta, Dorota Drożdż, Katarzyna Zachwieja

“…Both twins presented several symptoms characteristic of BBS, such as retinopathy, visceral obesity, postaxial polydactyly, renal dysfunction, cognitive impairment, facial dysmorphia, and dental abnormalities. …”
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The Brain’s Aging Resting State Functional Connectivity by Ali F. Khan, Nada Saleh, Zachary A. Smith

“…By providing an overview of the current state of knowledge in this field, this review aims to guide future research endeavors aimed at promoting healthy brain aging and developing effective interventions for age-related cognitive impairment and neurodegenerative diseases.…”
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Enhancing sleep quality in synucleinopathies through physical exercise by Jacopo Canonichesi, Laura Bellingacci, Francesco Rivelli, Alessandro Tozzi

“…This accumulation in different brain regions leads to a spectrum of clinical manifestations, including hypokinesia, cognitive impairment, psychiatric symptoms, and neurovegetative disturbances. …”
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Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus by Termpanit Chalermpalanupap, David Weinshenker, Jacki M. Rorabaugh

“…The LC is the main source of norepinephrine (NE) in the forebrain, and its degeneration is highly correlated with cognitive impairment and amyloid-beta (Aβ) and tangle pathology. …”
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Fibromyalgia: Presentation and Management with a Focus on Pharmacological Treatment by Janice E Sumpton, Dwight E Moulin

“…Pain is the primary symptom, often accompanied by overwhelming fatigue, sleep dysfunction and cognitive impairment. In 1990, the American College of Rheumatology developed diagnostic criteria for the diagnosis of fibromyalgia. …”
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TREM1—Microglia crosstalk: Neurocognitive disorders by Huashan Li, Wanqiu Yu, Xue Zheng, Zhaoqiong Zhu

“…Emerging evidence suggests that microglial inflammatory activation within the hippocampus underlies the pathogenesis of cognitive impairment. Triggering receptor expressed on myeloid cells 1 (TREM1), a pattern-recognition receptor on microglia, becomes upregulated in response to injury and synergistically amplifies inflammatory responses mediated by other pattern-recognition receptors, leading to uncontrolled inflammation. …”
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Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease by María José Pérez, Rodrigo A. Quintanilla

“…Alzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by protein aggregates, synaptic failure, and cognitive impairment. In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (Aβ) peptide and the neurofibrillary tangles composed of modified tau protein, which both lead to cellular damage and progressive neurodegeneration. …”
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Clinical Application of Standardized Cognitive Assessment Using fMRI. I. Matrix Reasoning by Mark D. Allen, Alina K. Fong

“…Practical application of the f-MRT is demonstrated via a contrastive case-study of two individuals with cognitive impairment in which fMRI data identifies subtleties in patient deficits otherwise missed by conventional measures of performance.…”
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Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease by Linyu Wu, Xiaohui Xian, Guangyu Xu, Zixuan Tan, Fang Dong, Min Zhang, Feng Zhang

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disease that primarily manifests as memory deficits and cognitive impairment and has created health challenges for patients and society. …”
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Cognitive decline in relation to later-life high temperature exposure in a Chinese nationwide cohort by Yu-Qian Huang, Lian-Sheng Zhang, Ji-Xing Yang, Fang Wang, Ya-Qi Wang, Li-Feng Zhu, Yuan-Yuan Zhang, Bo-Ning Deng, Qian-Qian Xiang, Yun-Quan Zhang

“…Despite varied evidence by heat exposure metrics and cognitive dimensions, stratified analyses suggested possibly higher susceptibility among females, less-educated, and urban-dwelling residents to heat-related cognitive impairment. These results provided suggestive evidence for the role of exposure to heat in triggering cognitive impairment in middle-aged and older individuals. …”
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Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study by Ilaria Maestrini, Marta Altieri, Laura Di Clemente, Edoardo Vicenzini, Patrizia Pantano, Eytan Raz, Mauro Silvestrini, Leandro Provinciali, Isabella Paolino, Carmine Marini, Matteo Di Giuseppe, Tommasina Russo, Francesco Federico, Cristiana Coppola, Maria Pia Prontera, Domenico Maria Mezzapesa, Vincenzo Lucivero, Lucilla Parnetti, Paola Sarchielli, Maria Peducci, Domenico Inzitari, Giovanna Carlucci, Carlo Serrati, Carla Zat, Anna Cavallini, Alessandra Persico, Giuseppe Micieli, Stefano Bastianello, Vittorio Di Piero

“…We investigated low-dose aspirin (ASA) efficacy and safety in subjects with silent brain infarcts (SBIs) in preventing new cerebrovascular (CVD) events as well as cognitive impairment. Methods. We included subjects aged ≥45 years, with at least one SBI and no previous CVD. …”
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Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones by Zhuoqi Zhu, Juanhua Li, Yang Peng, Ning Qin, Jiemei Li, Ying Wei, Biwen Wang, Yunfei Liao, Huaicai Zeng, Lu Cheng, Han Li

“…Ti, Se, Rb, Mo, Ba and Cu were significantly associated with cognitive impairment risk. Mixed exposure to Mo and Rb was linked to an increased risk of cognitive impairment. …”
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Hubungan Konsumsi Makanan Fungsional Sumber Antioksidan dengan Fungsi Kognitif dan Kadar 4-Hydroxynonenal (4-HNE) Plasma Lansia by Widia Rahmawati, Nur Indrawati Lipoeto, Yuliarni Syafrit Syafrita

“…Functional Food sources of antioxidant consumption  had a stronger relation with cognitive impairment at intake  of vegetables, fruits, herbs, tea and chocolate.  …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…These disturbances developed more frequently in case of postural instability. Mild cognitive impairment, disorders of language and executive function were diagnosed more frequently in PD group. …”
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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…Cognitive impairment is one of the many symptoms reported by individuals suffering from long-COVID and other post-viral infection disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). …”
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Research progress of rehabilitation nursing for stroke patients (脑卒中康复护理研究进展) by WANG Li (王丽)

“…Hemiplegia, aphasia and cognitive impairment are common consequences of stroke and have direct implications for post-stroke functioning and quality of life. …”
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Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry by Xiaojing Long, Chunxiang Jiang, Lijuan Zhang

“…Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer’s disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. …”
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A Review of Healthcare Challenges in the UK and the US: Medical Errors, Aging, Private Healthcare and Governance by John S. Bolwell

“…Most are due to failures in the processes of care exacerbated by poor communication between healthcare providers and with patients, particularly the elderly with varying degrees of cognitive impairment. The global phenomenon of aging populations due to declining birthrates and increased life expectancy may have detrimental consequences for societies and is briefly considered. …”
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Novel Mutations in the MKKS, BBS7, and ALMS1 Genes in Iranian Children with Clinically Suspected Bardet–Biedl Syndrome by Roghayeh Dehghan, Mahdiyeh Behnam, Mansoor Salehi, Roya Kelishadi

“…Bardet–Biedl syndrome is a rare autosomal recessive form of syndromic obesity which is characterized by retinal degeneration, obesity, polydactyly, cognitive impairment, and renal and urogenital anomalies. …”
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo by G. D. Rabinovici, W. J. Jagust

“…PIB binds specifically to fibrillar beta-amyloid (Aβ) deposits, and is a sensitive marker for Aβ pathology in cognitively normal older individuals and patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). …”
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