Development and validation of a model to predict cognitive impairment in traumatic brain injury patients: a prospective observational studyResearch in context by Xiaofang Yuan, Qingrong Xu, Fengxia Du, Xiaoxia Gao, Jing Guo, Jianan Zhang, Yehuan Wu, Zhongkai Zhou, Youjia Yu, Yi Zhang

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Association of objective and subjective socioeconomic markers with cognitive impairment among older adults: cross-sectional evidence from a developing country by Shobhit Srivastava, T Muhammad, TV Sekher

“…Older adults with low subjective (adjusted OR (aOR): 2.04; p<0.05) and objective SES (aOR: 1.32; p<0.05) had higher odds of having cognitive impairment in comparison with their counterparts, with a stronger subjective SES–cognitive impairment association. …”
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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Previous studies indicated that BACE1 initially cleaves the amyloid precursor protein (APP) and may subsequently interfere with physiological functions of proteins such as PKA, which is recognized to be closely associated with long-term potentiation (LTP) level and can effectively ameliorate cognitive impairments. Therefore, revealing the underlying mechanism of BACE1 in the pathogenesis of AD might have a significant impact on the future development of therapeutic agents targeting dementia. …”
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Predicting Alzheimer Disease From Mild Cognitive Impairment With a Deep Belief Network Based on 18F-FDG-PET Images by Ting Shen MsD, Jiehui Jiang PhD, Jiaying Lu MD, Min Wang MsD, Chuantao Zuo MD, PhD, Zhihua Yu, Zhuangzhi Yan PhD

“…Patients were grouped into 2 classes: (1) stable mild cognitive impairment (n = 62) or (2) progressive mild cognitive impairment (n = 47). …”
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The impact of the interaction between BDNF rs7103411 gene polymorphism and social activities on mild cognitive impairment in community-dwelling elderly adults by Zhenkun Tan, Junjiao Ping, Ying Zhang, Chuijia Kong, Jiali Luo, Xinxia Liu

“…The participants included 52 patients with Mild Cognitive Impairment due to Alzheimer’s Disease and 55 cognitively normal elderly adults control subjects. …”
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CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats by Yuanyuan Deng, Lianzhi Ye, Cheng Yu, Caixia Yin, Jingshan Shi, Qihai Gong

“…The Morris water maze test revealed that CZYH (400 or 800 mg/kg) administration improved the Aβ25-35-induced cognitive impairments in rats, and Nissl staining demonstrated that CZYH mitigated the Aβ-caused neuron loss. …”
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VR Cognitive-based Intervention for Enhancing Cognitive Functions and Well-being in Older Adults with Mild Cognitive Impairment: Behavioral and EEG Evidence by Pattrawadee Makmee, Peera Wongupparaj

“…Objective: Mild cognitive impairment (MCI) has been recognized as a window of opportunity for therapeutic and preventive measures to slow cognitive decline. …”
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Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis by Ka Yin Chu, King Hei King Cheng

“… Introduction: We aimed to systematically evaluate the most recent evidence regarding the potential short-term and long-term synergistic effects of transcranial direct-current stimulation (tDCS) and cognitive training (CT) on the memory of individuals with mild cognitive impairment (MCI) or dementia and to explore the optimal treatment protocol. …”
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An EEG-based framework for automated discrimination of conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study by Yingfeng Ge, Jianan Yin, Caie Chen, Shuo Yang, Yuduan Han, Chonglong Ding, Jiaming Zheng, Yifan Zheng, Jinxin Zhang

Subjects: “…amnestic mild cognitive impairment…”
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Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study by Xiaozheng Liu, Yunhai Tu, Yirou Zang, Aiqin Wu, Zhongwei Guo, Jiawei He

“…Depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have an increased risk of dementia. …”
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Improving cognitive impairment through chronic consumption of natural compounds/extracts: a systematic review and meta-analysis of randomized controlled trials by Long Ngo Hoang, Haesung Lee, Sook Jeong Lee

“…IntroductionThis systematic review and meta-analysis aimed to compare the efficacy of extended supplementation (≥6 weeks) with natural compounds or extracts in improving cognitive function in patients with mild cognitive impairment (MCI) or Alzheimer’s disease (AD).MethodsA comprehensive literature search was conducted across Cochrane, PubMed, PsycARTICLES, Scopus, and Web of Science databases from inception to April 10, 2024. …”
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Developing assistive robots for people with mild cognitive impairment and mild dementia: a qualitative study with older adults and experts in aged care by Elizabeth Broadbent, Craig Sutherland, Ngaire Kerse, Mikaela Law, Ho Seok Ahn, Bruce A MacDonald, Kathy Peri, Deborah L Johanson, Dina-Sara Vajsakovic

“…Objectives This research is part of an international project to design and test a home-based healthcare robot to help older adults with mild cognitive impairment (MCI) or early dementia. The aim was to investigate the perceived usefulness of different daily-care activities for the robot, developed from previous research on needs.Design Qualitative descriptive analysis using semistructured interviews. …”
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Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study by Huaxing Meng, Bo Liu, Xiaoting Lu, Yan Tan, Shanshan Wang, Baolong Pan, Hui Zhang, Qiao Niu

Subjects: “…mild cognitive impairment…”
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Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

Subjects: “…Cognitive impairment…”
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Electroacupuncture combined with cognitive rehabilitation outperforms cognitive rehabilitation alone in treating post-stroke cognitive impairment: a randomized controlled trial by Yisha Guo, Tingting Sun, Fengxi Qiu, Xueyi Li, Weiwei Cui, Zhenhua Liao, Jiajia Yao

“…Thirty-four post-stroke cognitive impairment (PSCI) patients were randomly assigned to either an EA + CR group or a CR-only group, with both undergoing five weekly interventions for 12 weeks. …”
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Cerebrospinal Fluid Biomarkers and Prediction of Conversion in Patients with Mild Cognitive Impairment: 4-Year Follow-Up in a Routine Clinical Setting by Alessia Lanari, Lucilla Parnetti

“…Mild cognitive impairment (MCI) is a very common syndrome in elderly people, with a high risk of conversion to dementia. …”
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Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine by Marta Vicente-Rodríguez, Rosalía Fernández-Calle, Esther Gramage, Carmen Pérez-García, María P. Ramos, Gonzalo Herradón

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A User-Centered Design Approach for a Screening App for People With Cognitive Impairment (digiDEM-SCREEN): Development and Usability Study by Michael Zeiler, Nikolas Dietzel, Fabian Haug, Julian Haug, Klaus Kammerer, Rüdiger Pryss, Peter Heuschmann, Elmar Graessel, Peter L Kolominsky-Rabas, Hans-Ulrich Prokosch

“…MethodsThis research used qualitative and quantitative methods and involved 3 key stakeholder groups: the digiDEM research team, the software development team, and the target user group (older adults ≥65 years with and without cognitive impairments). The development of the screening app was based on an already existing and scientifically analyzed screening test (Self-Administered Tasks Uncovering Risk of Neurodegeneration; SATURN). …”
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Cortistatin-14 Exerts Neuroprotective Effect Against Microglial Activation, Blood-brain Barrier Disruption, and Cognitive Impairment in Sepsis-associated Encephalopathy by Qiang Wen, Qian Ding, Jinchao Wang, Yanhua Yin, Shangchen Xu, Yuanrong Ju, Hongsheng Ji, Bin Liu

“…NORT revealed that cortistatin treatment improved cognitive impairment in septic mice. OFT, EPMT, and TST indicated that cortistatin-14 relieved the anxiety-related behaviors of CLP mice. …”
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Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context by Xiaowen Zhou, Zhenxu Xiao, Wanqing Wu, Yuntao Chen, Changzheng Yuan, Yue Leng, Yao Yao, Qianhua Zhao, Albert Hofman, Eric Brunner, Ding Ding

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