Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease by Weimin Qi, Xiaoyan Niu, Xiuping Zhan, Yazhou Ren, Jianhang He, Jianxia Li, Xiaolin Hou, Haining Li

“…These MRI parameters were correlated with clinical scale scores assessing non-motor symptoms, including cognitive function, sleep quality, olfaction, autonomic function, anxiety, depression, and fatigue. …”
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MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…Moreover, significantly greater CD31 expression, less DLAT accumulation, more mitochondria, and fewer mitochondrial abnormalities were observed in the CPOMT2A+ group than in the CPO group, accompanied by significantly improved cerebral blood perfusion and cognitive function. Conclusion MT2A can promote angiogenesis in chronically ischemic brains by neutralizing excessive copper ions and rescuing CPO-induced mitochondrial dysfunction.…”
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Functional MRI study of neurovascular coupling in patients with non-lesional epilepsy by Zhisen Li, Xiaoxia Hou, Yanli Lu, Huimin Zhao, Meixia Wang, Qian Gui, Guanhui Wu, Qinrong Xu, Xiaofeng Dong, Qingzhang Cheng, Xiaowen Xu, Hongxuan Feng

“…Hence, we intend to explore the alterations of NVC in NLE patients and their influences on cognitive function.MethodsClinical data of 24 patients with NLE (15 female; age range 19–40 years; median age 30.5 years) and 39 healthy controls (27 female; age range 19–40 years; median age 30 years) were collected, and resting-state functional magnetic resonance imaging (rs-fMRI) and 3D arterial spin labeling (ASL) were performed. …”
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Effects of intermittent theta burst stimulation on cognitive and swallowing function in patients with MCI and dysphagia risk: a randomized controlled trial by Jie Wang, Mengqing Zhang, Xiaomei Wei, Cheng Yang, Meng Dai, Zulin Dou, Yonghui Wang

“…Methods Thirty-six participants with MCI were randomly allocated to receive real (n = 18) or sham (n = 18) iTBS. Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and executive function was evaluated with the Trail Making Test (TMT), Digital span test (DST) and Stroop color word test (SCWT). …”
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Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…Participants with mild cognitive impairment (MCI) or normal cognitive function who visited Oita University Hospital or had participated in the USUKI study and met the study eligibility criteria were included. …”
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Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism by Andrea Fumagalli, Anna Castells-Nobau, Dakshat Trivedi, Josep Garre-Olmo, Josep Puig, Rafel Ramos, Lluís Ramió-Torrentà, Vicente Pérez-Brocal, Andrés Moya, Jonathan Swann, Elena Martin-Garcia, Rafael Maldonado, José Manuel Fernández-Real, Jordi Mayneris-Perxachs

“…The relationship between bacteria, cognitive function and obesity is well established, yet the role of archaeal species remains underexplored. …”
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Longitudinal impact of cross-clamp duration on postoperative sleep disturbance and quality of life in elderly cardiac surgery patients: a secondary analysis of the MINDDS trial by Grace E. Namirembe, Jamie Sparling, Alexis Novak, Ariel Mueller, Julia Bertsch, Kwame Wiredu, Jason Z. Qu, M. Brandon Westover, Timothy T. Houle, Oluwaseun Akeju

“…Secondary outcomes encompassed cognitive function and health-related quality of life in various domains. …”
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Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments by Elizaveta Vinogradova, Zharkyn Jarmukhanov, Madiyar Nurgaziyev, Alibek Kossumov, Ayaulym Nurgozhina, Nurislam Mukhanbetzhanov, Shynggys Sergazy, Laura Chulenabyeva, Argul Issilbayeva, Sholpan Askarova, Aiym Kaiyrlykyzy, Saule Rakhimova, Ulan Kozhamkulov, Ulykbek Kairov, Zhanagul Khassenbekova, Dinar Tarzhanova, Ainur Akilzhanova, Joseph H. Lee, Joseph Terwilliger, Aliya Sailybayeva, Makhabbat Bekbossynova, Zhaxybay Zhumadilov, Samat Kozhakhmetov, Almagul Kushugulova

“…These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.…”
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Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis by Yi Chen, Peihua Shen, Qi Li, Shun Seng Ong, Yunzhi Qian, Hai Lu, Ming Li, Tianshu Xu

“…The EA + TB treatment significantly ameliorated depression and anxiety-like behaviors, restored cognitive function, and enhanced gastrointestinal motility in chronic unpredictable mild stress (CUMS) mice. …”
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Exploring the Effects of Sleep Deprivation on Physical Performance: An EEG Study in the Context of High-Intensity Endurance by Shanguang Zhao, Majed M. Alhumaid, Hai Li, Xin Wei, Steve SHYH-Ching Chen, Hongke Jiang, Yuwu Gong, Yun Gu, Haiquan Qin

“…Abstract Background While the effects of sleep deprivation on cognitive function are well-documented, its impact on high-intensity endurance performance and underlying neural mechanisms remains underexplored, especially in the context of search and rescue operations where both physical and mental performance are essential. …”
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Maternal phthalates exposure promotes neural stem cell differentiation into phagocytic astrocytes and synapse engulfment via IRE1α/XBP1s pathway by Fengzhen Cui, Shiyu Deng, Yan Fu, Tongtong Xu, Shuangshuang Bao, Siyi Wang, Yahang Lin, Xianghui Wang, Faming Zhao, Tingting Zhang, Shunqing Xu, Zhijun Zhang, Wanlu Li, Guo-Yuan Yang, Huanwen Tang, Jixian Wang, Xia Sheng, Yaohui Tang

“…Conditional knockout or pharmacological inhibition of IRE1α markedly inhibits NSC differentiation into astrocytes and astrocyte reactivity, attenuates synapse phagocytosis, and improves cognitive function. This phenotype is further recapitulated in a human brain organoid model. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…Following model induction, rats were orally administered with DM extract (100, 200, and 400 mg/kg/day) or donepezil (5 mg/kg/day) for 21 days. Cognitive function was assessed using the radial arm water maze behavioral test. …”
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Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study by Vincent Dore, Christopher C Rowe, Meinir Krishnasamy, Haryana Dhillon, Adam K Walker, Karla Gough, Priscilla Gates, Carlene Wilson, Eliza Hawkes, Yuliya Perchyonok, Janette L Vardy, Michiel de Ruiter

“…All patients will be assessed for self-reported cognitive difficulties and objective cognitive function using Stroop Colour and Word, Trail Making Test Part A and B, Hopkins Verbal Learning Test-Revised, Controlled Oral Word Association and Digit Span. …”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…The primary outcome of this study will be the change in frailty between both admission and discharge, and admission and 30 days, and secondary outcomes include length of stay, adverse events, discharge destination, quality of life, depression, cognitive function, functional independence, pain scores, pain management intervention (type and frequency) and unplanned 30-day readmissions. …”
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Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei by Maznah Alhesain, Ayman Alzu’bi, Ayman Alzu’bi, Ayman Alzu’bi, Niveditha Sankar, Niveditha Sankar, Charles Smith, Charles Smith, Janet Kerwin, Ross Laws, Susan Lindsay, Gavin J. Clowry

“…Higher order thalamic nuclei, relaying information between cortical regions and important in higher cognitive function, are greatly expanded.MethodsThis study mapped the emergence of thalamic nuclei in human fetal development (8–16 post conceptional weeks; PCW) by revealing gene expression patterns using in situ hybridization and immunohistochemistry for previously established thalamic development markers.ResultsIn the proliferative thalamic ventricular zone, OLIG3 and NR2F1 immunoreactivity marked the extent of the thalamus, whereas PAX6 and NR2F2 were expressed in gradients, suggesting an early protomap. …”
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Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…Secondary end points include the composite end point of coma, delirium or death, in addition to delirium severity and motor activity patterns, levels of circulating biomarkers of neuronal injury, cognitive function and frailty status 1 and 6 months after surgery.Ethics and dissemination This trial is approved by the Regional Committee for Ethics in Medical Research in Norway (South-East Norway) and by the Norwegian Medicines Agency. …”
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Meta-Analysis of Acupuncture on Physical and Activity Participation Related Functions of Children with Autism Spectrum Disorders by CHEN Qiang, KAN Mengfan, JIANG Xiaoyu, LIU Huifen, SUN Wenyu, BI Hongyan

“…Meta-analysis results showed that, (1) In terms of physical function: compared with the control group, the emotional function score of the experimental group was significantly higher [<italic>SMD</italic>=0.76, 95% <italic>CI</italic> (0.50, 1.03), <italic>P</italic>&lt;0.000 01]; sleep function score was significantly lower [<italic>MD</italic>=-6.74, 95% <italic>CI</italic> (-8.31, -5.17), <italic>P</italic>&lt;0.000 01], and cognitive function score was significantly higher [<italic>SMD</italic>=1.14, 95% <italic>CI</italic> (0.85, 1.42), <italic>P</italic>&lt;0.000 01]. (2) In terms of activity participation: compared with the control group, the score of healthy behavior in the experimental group was significantly lower [<italic>MD</italic>=-2.63, 95% <italic>CI</italic> (-3.68, -1.59), <italic>P</italic>&lt;0.000 01], the score of expression ability was significantly higher [<italic>SMD</italic>=0.81, 95% <italic>CI</italic> (0.55, 1.08), <italic>P</italic>&lt;0.000 01], and the score of social ability was significantly lower [<italic>SMD</italic>=-0.70, 95% <italic>CI</italic> (-0.88, -0.53), <italic>P</italic>&lt;0.000 01].ConclusionAcupuncture can significantly improve the physical and activity participation functions such as emotion, sleep, cognition, social interaction, and language expression of children with ASD, which is recommended for further clinical application.…”
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Beta-alanine supplementation in patients with COPD receiving non-linear periodised exercise training or neuromuscular electrical stimulation: protocol of two randomised, double-bli... by Martijn A Spruit, Emiel F M Wouters, Eline bij de Vaate, Peter Klijn, Frits M E Franssen, Wim Derave, Chris Burtin, Florence N Schleich, Roy Meys, Anouk A F Stoffels, Jana de Brandt, Hieronymus W H van Hees, Maurice J H Sillen, Bram van den Borst, Jacqueline M Otker, Jos Donkers, Maurice Hayot, Pascal Pomiès, Inge Everaert

“…Furthermore, quadriceps muscle strength and endurance, cognitive function, carnosine levels (in muscle), BA levels (in blood and muscle), markers of oxidative stress and inflammation (in blood, muscles and lungs), physical activity and quality of life will be measured.Ethics and dissemination Both trials were approved by CMO Regio Arnhem-Nijmegen, The Netherlands (NL70781.091.19. and NL68757.091.19).Trial registration number NTR8427 (BASE-TRAIN) and NTR8419 (BASE-ELECTRIC).…”
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Hippocampal connectivity dynamics and volumetric alterations predict cognitive status in migraine: A resting-state fMRI study by Seyda Cankaya, Behcet Ayyildiz, Dila Sayman, Umutcan Duran, Dogukan Ucak, Ramazan Karaca, Sevilay Ayyildiz, Ece Ozdemir Oktem, Hatice Lakadamyalı, Ceyhun Sayman, Ahmet Ozsimsek, Ali Yalçınkaya, Lutfu Hanoglu, Halil Aziz Velioglu, Burak Yulug

“…This pioneering study unveils critical hippocampal alterations linked to cognitive function in migraine sufferers, underscoring the potential for these changes to impact dementia development.…”
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Effect of Electroacupuncture on Hippocampal Functional Activity and Molecular Expression Profile in Rats with Vascular Cognitive Impairment by WANG Zeyu, DING Yanyi, DAI Yaling, YANG Minguang, HUANG Jia, ZHANG Shenghang

“…A total of 399 genes with 2-fold differential expression of hippocampal mRNA between the electroacupuncture group and the model group (<italic>P</italic>&lt;0.05), of which 166 genes (such as Klhl14, Bmp3, Npsr1, Cacna1e, etc.) were up-regulated, of which 233 genes (such as Insl6, Ube2k, Cdkn1c, Camp, Upk1b,etc.) were down-regulated.ConclusionThe "Tongdu Tiaoshen" electroacupuncture at Baihui and Shenting acupoints can improve the cognitive function of rats with vascular cognitive impairment, and its mechanism may be related to enhance the function of hippocampus, prefrontal lobes and other brain regions, regulate the expression of calcium ions and energy metabolism-related molecules by regulating nerve activity activity.…”
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