Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility by Jun Wang, Chen Chen, Jinhui Zhou, Zinan Xu, Lanjing Xu, Xinwei Li, Zhuchun Zhong, Yuebin Lv, Xiaoming Shi

“…We examined the association of combined lifestyle factors and genetic risk with changes in cognitive function and six specific dimensions of cognition among older adults from the Chinese Longitudinal Healthy Longevity Survey (1998–2018, n = 18,811, a subset of 6301 participants with genetic information). …”
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Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability by S. Migliore, A. Ghazaryan, I. Simonelli, P. Pasqualetti, F. Squitieri, G. Curcio, D. Landi, M. G. Palmieri, F. Moffa, M. M. Filippi, F. Vernieri

“…This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. …”
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Functional connectivity in burnout syndrome: a resting-state EEG study by Natalia Afek, Dmytro Harmatiuk, Magda Gawłowska, João Miguel Alves Ferreira, Krystyna Golonka, Sergii Tukaiev, Sergii Tukaiev, Anton Popov, Anton Popov, Tadeusz Marek

“…Chronic occupational stress is associated with a pronounced decline in emotional and cognitive functioning. Studies on neural mechanisms indicate significant changes in brain activity and changed patterns of event-related potentials in burnout subjects. …”
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Effects of an intervention combining physical activity and components of Amygdala and Insula Retraining (AIR) on sleep and working memory among older male adults by Monireh Asadi Ghaleni, Forouzan Fattahi Masrour, Narjes Saryar, Alexandra J. Bratty, Ebrahim Norouzi, Matheus Santos de Sousa Fernandes, Georgian Badicu

“…All participants completed measurements for sleep quality, depressive symptoms, working memory, and emotion regulation at baseline, 12 weeks (immediately after the intervention), and 8 weeks later.ResultsAmong the 36 individuals who finished the study, their sleep quality, working memory, and emotion regulation improved, and their depressive symptoms were reduced from baseline to 12 weeks (post-intervention) and 8 weeks later; these effects were seen even more so for the PAAIR group compared to the control group, with large to extremely large effect sizes.ConclusionThe findings suggest that PAAIR has the potential to enhance sleep quality, cognitive function, and emotion regulation and reduce depressive symptoms among older men, thus contributing to their quality of life and mental health.…”
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Modulation of Cognition: The Role of Gnidia glauca on Spatial Learning and Memory Retention in High-Fat Diet-Induced Obese Rats by Wycliffe Makori Arika, Cromwell Mwiti Kibiti, Joan Murugi Njagi, Mathew Piero Ngugi

“…Therefore, the current study sought to explore the modulatory effects of dichloromethane leaf extracts of Gnidia glauca on cognitive function in the high-fat diet- (HFD-) induced obese rats. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

“…Physical function and QOL indicated that many patients exhibited consistent trends of either recovery or deterioration. In contrast, cognitive function and mental health revealed considerable variability, with many patients showing fluctuating ratings in the later surveys. …”
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Trajectories of self-rated health in an older general population and their determinants: the Lifelines Cohort Study by Barbara C van Munster, Nynke Smidt, Sophia E de Rooij, Marlies Feenstra, Janet L MacNeil Vroomen

“…Covariates included demographics (age, gender, education), chronic diseases, health-risk behaviour (physical activity, smoking, drinking) and physiological markers (body mass index, cardiovascular function, lung function, glucose metabolism, haematological condition, endocrine function, renal function, liver function and cognitive function).Results Four stable trajectories were identified, including excellent (n=607, 6%), good (n=2111, 19%), moderate (n=7677, 65%) and poor SRH (n=1205, 10%). …”
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Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice by Wei Wei, Zhicheng Lin, PeiTao Xu, Xinru Lv, Libin Lin, Yongxu Li, Yangjie Zhou, Taotao Lu, Xiehua Xue

“…Twenty-week-old ApoE-/- mice were fed a HFD for 8 weeks and then were treated with diet control and/or swimming for 8 weeks. Cognitive function was assessed using the novel object recognition test (NORT) and Y-maze test. …”
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A rare case of adult-onset vanishing white matter leukoencephalopathy with movement disorder, expressing homozygous EIF2B3 and PRKN pathogenic variants by Bashar Kamal Ali Douden, Yazan Mohammad Abdullah Abufara, Mahmood Fayez Ali Aldrabeeh, Naela Ramadan Mohammad Tell, Ismail Abudaya

“…The patient’s sibling showed comparable symptoms but was never diagnosed, as he passed away because of colon cancer. Reduced cognitive function, spastic quadriparesis, hyperreflexia, bradykinesia, and shuffling gait were found during a neurological examination. …”
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Persistent depressive symptom trajectory is associated with cognitive impairment: a population-based longitudinal study of aging in Taiwan by Hsiao-Chen Lin, Wai-Lam Lao, Te-Chia Tseng, Chih-Jung Yeh

“…Depressive symptom trajectories were analyzed using the 10-item Centre for Epidemiological Studies Depression scale, and cognitive function was assessed using the Short Portable Mental State Questionnaire. …”
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Oral cannabidiol did not impair learning and memory in healthy adults by Hanna H. Gebregzi, Joanna S. Zeiger, Jeffrey P. Smith, Libby Stuyt, Luann Cullen, Jim Carsella, Daniel C. Rogers, Jordan Lafebre, Jennah Knalfec, Alfredo Vargas, Moussa M. Diawara

“…For assessment of L&M, Montreal Cognitive Assessment (MOCA) was used to evaluate verbal baseline cognitive function; RAVLT-R tests (List A and List B recalls, Proactive and Retroactive Interference ratios, and Forgetting Speed ratio) were used to evaluate verbal declarative memory; and total prose recall was used to evaluate verbal logical memory. …”
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Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort by Ashani Jeyadevan, Megan C. Bakeberg, Michelle Byrnes, Jade Kenna, Soumya Ghosh, Rick Stell, Sue Walters, Tess Evans, Sarah McGregor, Malcolm Horne, Frank L. Mastaglia, Ryan S. Anderton

“…Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). …”
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Effects of physical activity on brain function: Mechanisms, adaptations and clinical implications by Dariusz Fabian, Klaudia Maria Kufel, Mateusz Teofilak, Natalia Maria Smyl, Olga Śpiołek, Jan Siwiec, Aleksandra Słowikowska, Julia Szatkowska, Marcelina Paula Sztyler-Krąkowska, Agnieszka Alicja Wąsowicz, Franciszek Kędziora

“…The article identifies key neurotrophic factors, such as BDNF (brain-derived neurotrophic factor) and VEGF (vascular endothelial growth factor), which are regulated by physical activity and contribute to improved cognitive function and mental health. The paper demonstrates the multifaceted effects of physical activity on neuroplasticity and brain health. …”
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Effectiveness of a Dyadic Technology–Enhanced Home-Based Horticultural Therapy on Psychosocial Well-Being Among People With Dementia and Their Family Caregivers: Multimethods Pilot... by Patrick Pui Kin Kor, Justina Yat Wa Liu, Arkers Kwan Ching Wong, Alex Pak Lik Tsang, Han Zhi Tan, Daphne Sze Ki Cheung, Humphrey Kwong Wai Leung, Frances Kam Yuet Wong

“…Outcomes were measured at baseline and postintervention (at week 11), including feasibility outcomes, cognitive function, neuropsychiatric symptoms, and happiness levels of people with dementia. …”
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Domain‐Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach by Marlene Tahedl, Ulrich Bogdahn, Bernadette Wimmer, Dennis M. Hedderich, Jan S. Kirschke, Claus Zimmer, Benedikt Wiestler

“…Finding: No associations were found for cognitive function. The extremity‐specific MAP predicted extremity‐specific motor progression over 1 and 3 years above chance level. …”
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Thyroid function abnormalities in individuals with sickle cell disease: a meta-analysis by Sagad O. O. Mohamed, Hussein Ahmed, Mohammed A. H. Mohammednoor, Khalefa B. K. Alzubeir, Safaa Fadlelmoula, Osman O. A. Abdallah, Izzut Awad Ahmed

“…Thyroid disorders can have significant clinical consequences, including growth retardation and impaired cognitive function. However, there is a disparity in the available data concerning the magnitude and spectrum of thyroid abnormalities in this population. …”
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Acute Kidney Injury, Mild Cognitive Impairment, and Dementia: A Cohort Study of Patients from SPRINT by Kristen L. Nowak, Anna Ostrow, Ester S. Oh, Zhiying You, Michel Chonchol

“…These results suggest that cognitive function should be monitored following AKI in this patient population.…”
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Physical activity and the outcome of cognitive trajectory: a machine learning approach by Bettina Barisch-Fritz, Jay Shah, Jelena Krafft, Yonas E. Geda, Teresa Wu, Alexander Woll, Janina Krell-Roesch

“…Abstract Background Physical activity (PA) may have an impact on cognitive function. Machine learning (ML) techniques are increasingly used in dementia research, e.g., for diagnosis and risk stratification. …”
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A synergistic effect of secondhand smoke with vitamin D deficiency on cognitive impairment in older adults: a cross sectional study by Yan Li, Qianqian Shen, Chengyu Chen, Xueru Yin, Xinru Wang, Xiyue Yang, Xueqian Zhang, Lei Chen, Jian Xu, Guifang Gong

“…ObjectivesTo investigate whether exposure to secondhand smoke (SHS) aggravates the detrimental effect of vitamin D deficiency (VDD) on cognitive performance in the elderly.MethodsBased on National Health and Nutrition Examination Surveys (NHANES) 2011–2014, 1,446 non-smoking participants (≥ 60 years old) with detailed serum 25-hydroxyvitamin D [25(OH)D], concentration of cotinine and tests score of cognitive function were included. Cognitive impairment was defined as having a cognitive score in the lowest quartile. …”
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Effect of exogenous free Nε-(carboxymethyl)lysine on diabetes-associated cognitive dysfunction: neuroinflammation, and metabolic disorders by Huang Zhang, Lan Mo, Xi Chen, Mei Li, Maiquan Li, Yang Xu, Maomao Zeng, Zhiyong He, Qingwu Shen, Jie Chen, Wei Quan

“…However, the effect of one of the best-characterized exogenous AGEs Nε-(carboxymethyl)lysine (CML) on cognitive function is not fully reported. In the present study, diabetical Goto-Kakizaki (GK) rats were treated with free CML for 8-weeks. …”
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