4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

“…IntroductionAlzheimer’s disease (AD) is a neurodegenerative disorder that significantly impacts the cognitive function and memory of a person. Despite the significant research efforts, the ability to completely prevent or effectively treat AD and its related dementias remains limited. …”
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Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…In conclusion, AMSC-derived exosomes can improve cognitive function in CPB rats through inhibiting the TLR2/TLR4 signaling pathway.…”
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Intermittent hypoxia training improves cerebral blood flow without cognitive impairment by Qihan Zhang, Qing Wang, Feiyang Jin, Dan Huang, Xunming Ji, Yuan Wang

“…Other indicators including cognitive function, cerebral perfusion pressure, and oxygen saturation did not exhibit significant differences between groups. …”
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The Effect of Cognitive-Motor Dual Tasks on the Risk of Falls in Female Saudi Students: A Cross-Sectional Study by Alatawi SF, Mahmoud HM

“…Salem F Alatawi,1 Hayam M Mahmoud2 1Department of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia; 2Department of Medical Rehabilitation Science, Faculty of Applied Medical Sciences, Umm Al-Qura University-Makkah-Saudi Arabia; Cairo University, Cairo, EgyptCorrespondence: Salem F Alatawi, Department of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk City, Saudi Arabia, Tel +966144563434, Email sfalatawi@ut.edu.saIntroduction: Dual tasking (DT) requires individuals to carry out two actions simultaneously, comparable to how the brain can perform a cognitive function while the body is in motion, which eventually enhances human balance. …”
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Prevalence and associated factors of postpartum anemia after cesarean delivery in public hospitals of Awi zone, North West Ethiopia, 2023; a cross-sectional study. by Gebretsadek Habtamu, Asmare Talie, Tinsae Kassa, Dawit Misganaw Belay

“…Due to this it leads to poor quality of life, palpitations, an increase in maternal infections, exhaustion, diminished cognitive function and postpartum depression. Therefore, this study aimed to assess the prevalence and associated factors of postpartum anemia after cesarean delivery in public hospitals of Awi zone, North West Ethiopia, 2023.…”
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The Localization Research of Brain Plasticity Changes after Brachial Plexus Pain: Sensory Regions or Cognitive Regions? by Shuai Wang, Zhen-zhen Ma, Ye-chen Lu, Jia-jia Wu, Xu-yun Hua, Mou-xiong Zheng, Jian-guang Xu

“…This research confirmed the involvement of cognitive function, which brought novel information to the potential new therapy for brachial plexus pain.…”
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Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database by Hui Wang, Sensen Wu, Dikang Pan, Yachan Ning, Cong Wang, Jianming Guo, Yongquan Gu

“…Background and aimChanges in cognitive function are commonly associated with aging in patients with cardiovascular diseases. …”
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Cerebellar Volume Measures Differentiate Multiple Sclerosis Fallers from Non-Fallers by Taylor N. Takla, Jennie Feldpausch, Erin M. Edwards, Shuo Han, Peter A. Calabresi, Jerry Prince, Kathleen M. Zackowski, Nora E. Fritz

“…Relationships between cerebellar volumes and motor and cognitive function were evaluated using Spearman correlations. …”
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Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer’s Disease by Rattana Summat, Pornthip Waiwut, Supawadee Daodee, Natsajee Nualkaew, Khemjira Phemphunananchai, Puguh Novi Arsito, Yaowared Chulikhit, Orawan Montakantirat, Charinya Khamphukdee, Chantana Boonyarat

“…Alzheimer’s disease (AD) is a neurodegenerative condition characterized by a gradual decline in cognitive function, for which few effective treatments exist. …”
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Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats by Fred Kim, Padmanabh Singh, Hyunji Jo, Tianyang Xi, Dong-Keun Song, Sae Kwang Ku, Jai Jun Choung

“…The drug, which is currently used for treatment of erectile dysfunction, reduces Aβ and pTau levels and improves cognitive function in mouse models of Alzheimer's disease. …”
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Modifiable facilitators and barriers to exercise adherence in older adults with MCI/dementia using the Theoretical Domains Framework: a systematic review protocol by Jie Wang, Lina Wang, Xueting Zhen, Hang Yan, Hong Tao, Yaxiu Cai, Haiqin Chen, Chenxi Ge

“…Introduction Exercise has multiple benefits on maintaining or improving cognitive function for people with mild cognitive impairment (MCI)/dementia. …”
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Towards a common definition of hospital-acquired deconditioning in adults: a scoping review by Katie Robinson, Alison Cowley, Meri Westlake, Adam L. Gordon

“…Background Hospital-acquired deconditioning is a term used in clinical practice, describing a loss of physical and/or cognitive function associated with hospitalisation. Previous reviews have addressed interventions, its prevalence in older adults and potential assessment tools. …”
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Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice by Gaifen Li, Qiong Wu, Chao Wang, Pin Deng, Jiaxin Li, Zhiguang Zhai, Yubo Li

“…Morris water maze and novel object recognition were used to detect the cognitive function of each mouse. Immunofluorescence assays, including Fluoro-Jade C (FJC) and bromodeoxyuridine (BrdU), were used to detect neuronal degeneration and neurogenesis. …”
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Comparison of desflurane and sevoflurane as maintenance inhalational anaesthetic agents for adult patients undergoing neurosurgeries: A systematic review and meta-analysis of rando... by Hori Hariyanto, Monika Widiastuti, Carla Oktaviani Pandrya, Kevin Anderson Surya, William Audi

“…Desflurane was associated with better postoperative cognitive function, as evidenced by higher short orientation memory concentration test scores – a measure of attention and memory – at 15 min (MD: 2.26; 95% CI: 0.13, 4.39, P = 0.04, I2 = 91%) and 60 min (MD: 0.29; 95% CI: 0.09, 0.50, P = 0.005, I2 = 0%) after extubation. …”
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Case report: 10-year follow-up of a patient with neuronal intranuclear inclusion disease and a literature review by Kenji Yoshida, Tomotsugu Kaga, Sachiko Hosoyama, Jun-ichi Niwa, Jun Sone, Naoki Mabuchi

“…Her brain MRI DWI signal intensity gradually increased over 10 years, and her cognitive function progressively declined. The DWI signal changes were related to the clinical manifestations in this case. …”
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Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation... by Xiang Li, Qingyong Ding, Xinxin Wan, Qilong Wu, Shiqing Ye, Yongliang Lou

“…The results demonstrated that FMT treatment improved cognitive function and reduced the expression levels of inflammatory factors by regulating the TLR4/MyD88/NF-κB signaling pathway in mice, which was accompanied by the restoration of gut microbial dysbiosis. …”
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Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain by Xiaoang Zhang, Yuping Liao, Daying Zhang, Weichen Liu, Zhijian Wang, Yaxin Jin, Shushu Chen, Jianmei Wei

“…Data collected included patients’ general information, cognitive function, pain level, depression, and sleep quality. …”
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Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment by Wen Li, Huimin Zhou, Xiaona Li, Gengyao Hu, Dong Wei

“…Escape latency in the MWM further suggested that ASIC1a regulates cognitive function in mice with chronic epilepsy. LPS stimulation in vitro mimicked inflammatory responses, increasing ASIC1a after 24 h, which increased the concentration of intracellular calcium and extracellular expression of Glu; inhibition of ASIC1a expression reversed this process. …”
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The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials by Liang Ding, Lijie Lou, Mingyang Zhang, Xing Zhang

“…Aerobic and resistance exercises are widely recognized as essential for preserving and enhancing cognitive function. However, the effects of concurrent exercise on cognition in older adults remain unclear. …”
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Exploring the impact of different types of exercise on working memory in children with ADHD: a network meta-analysis by Xiangqin Song, Yaoqi Hou, Wenying Shi, Yan Wang, Feifan Fan, Liu Hong

“…Recently, exercise interventions have gained attention as a potential strategy to improve cognitive function in children with ADHD. However, the effects of different types of exercise on working memory remain unclear. …”
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