Timeline of cognitive impairments after radiotherapy for head and neck cancer: A review by K. Wickborn, C.W.J. van der Weijden, E.F.J. de Vries, T.W.H. Meijer, M.C.A. Kramer, J.M. Spikman, A.M. Buunk, A. van der Hoorn

“…Long-term assessments demonstrated that these cognitive deficits persisted even beyond seven years, suggesting a potentially irreversible decline in cognition following radiotherapy. …”
Get full text

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy by Naizhen Zheng, Kun Li, Jing Cao, Zijie Wang, Liang Zhang, Zihao Zhao, Jiawei He, Yong Wang, Xiang Zhu, Yiqing Chen, Jian Meng, Dongdong Zhao, Mengxi Niu, Hong Luo, Xian Zhang, Hao Sun, Yun-wu Zhang

“…Finally, we showed that lentivirus-mediated HTRA2 overexpression in the hippocampus rescued PP2B reduction, alleviated tau hyperphosphorylation, and partially attenuated synaptic plasticity and cognitive deficits in the PS19 tauopathy model mice. Our study not only indicates that HTRA2 in neurons plays an important role in regulating synaptic plasticity under both physiological and pathological conditions, but also provides a novel, electrophysiology-based strategy to identify proteins regulating synaptic plasticity systematically.…”
Get full text

Acute effects of physical exercise on cognitive function and neurotrophins in patients with type 1 diabetes: A systematic review by Emanuele Zanardo, Giulia Quinto, Francesca Battista, Federica Duregon, Marco Vecchiato, Chiara Bergia, Kirk Erickson, Andrea Ermolao, Daniel Neunhaeuserer

“…Conclusions: In subjects with T1DM, preliminary evidence suggests that exercise training might increase plasma BDNF levels and ameliorate cognitive deficits. However, scientific evidence is still very limited and there is a significant need for further research to clarify the possible positive neurocognitive effects of exercise in T1DM.…”
Get full text

Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism by Hongbo Jiang, Xunling Wang, Yingwei Liang, Yinghan Hou, Xinping Yue, Zhiyi Zhang, Dan Chen, Xinyi Fan, Ailin Du

“…Conclusion: AOAA may alleviate cognitive deficits associated with chronic alcoholism by inhibiting CBS expression, reducing H₂S levels, and enhancing 5-HT release in the prefrontal cortex. …”
Get full text

Executive function deficit in patients with long COVID syndrome: A systematic review by Siti Maisarah Nasir, Noorazrul Yahya, Kah Hui Yap, Hanani Abdul Manan

“…The main outcome is the proportion of individuals with cognitive deficits, particularly in the EF domain, as detected by neuropsychological assessments. …”
Get full text

Characterization of cognitive functioning in complex PTSD compared to non-complex PTSD by Zoe-Sofia Schöndorf, Zoe-Sofia Schöndorf, Valentin Terhoeven, Anna Jaehn, Daniela Roesch-Ely, Hans-Christoph Friederich, Hans-Christoph Friederich, Christoph Nikendei, David Kindermann, David Kindermann

“…In multivariate regression, type of PTSD and age were found to significantly impact visual memory, while type of PTSD, age, and psychotropic medication showed significant effects on selective attention.ConclusionsGiven higher symptom severity and cognitive deficits in cPTSD, more intensive and diverse interventions should be considered in comprehensive treatment plans, for instance, cognitive training.…”
Get full text

Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…The additional challenge of pathophysiological levels of IL-6 resulted in altered cellular bioenergetics, which may be key to cognitive deficits associated with the loss of dystrophin.…”
Get full text

The relationship between cognitive function and neuropsychiatric disorders with quantitative electroencephalogram (qEEG) on long COVID syndrome patients by Yetty Ramli, Pukovisa Prawiroharjo, Winnugroho Wiratman, Eric Tenda, Nurhadi Ibrahim, Damar Susilaradeya, Abdi Reza, Jennifer Agatha, Rejoel Siagian, Hazrina Fauhan, Florencia Evelyn, Yoshikazu Ugawa, Prasandhya Yusuf

“…Results: Analyses revealed lower MoCA scores in the memory domain were lower in the long COVID group (Mann Whitney Utest), indicating that individuals with long COVID experience more substantial cognitive deficits. There is no statistical difference for spectrum examination and hemispheric asymmetry observed in the qEEG data between the COVID and long COVID groups. …”
Get full text

Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ by Jiawei Zhang, Yaxuan Zhang, Lan Liu, Mengyuan Zhang, Xiaojie Zhang, Jiangshan Deng, Fei Zhao, Qing Lin, Xue Zheng, Bing Fu, Yuwu Zhao, Xiuzhe Wang

“…Conclusions Collectively, our data demonstrate that chemerin-9 ameliorates cognitive deficits in APP/PS1 transgenic mice by boosting a neuroprotective microglial phenotype. …”
Get full text

Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients by Hong Li, Qijin Wu, Jiahui Wang, Xiaobin Zhang, Huihui Song, Dong Wang

“…Conclusion Our findings highlight abnormal neuronal networks involving multiple frontal brain regions and thalamus, which may contribute to cognitive deficits in individuals with euthymic BD. These findings may serve as potential hallmarks of BD, contributing to a better understanding of the neural mechanism of cognitive impairment during euthymia.…”
Get full text

Quercetin can improve anesthesia induced neuroinflammation and cognitive dysfunction by regulating miR-138-5p/ LCN2 by Linjie Lou, Wanning Yu, Ying Cheng, Quan Lin, Yanyan Jiang, Dalong Wang, Lei Che, Meiqing Du, Shuai Wang, Haining Zhen

“…Conclusion Que may inhibit ISO-induced hippocampal neuroinflammation and ameliorate functional cognitive deficits in rats by modulating miR-138-5p/ LCN2.…”
Get full text

Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment by Julia Schumacher, Stefan Teipel, Alexander Storch

“…Conclusion In a heterogeneous autopsy sample, AD and LB pathology both contribute to cholinergic basal forebrain degeneration whereas hippocampus atrophy is more specifically related to AD pathology. Cognitive deficits are primarily associated with tau pathology which is partly mediated by hippocampus, but not basal forebrain atrophy.…”
Get full text

Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis. by Elisabeth Janecek, Patrick Waindok, Marion Bankstahl, Christina Strube

“…<h4>Background</h4>Neuroinvasive larvae of the worldwide occurring zoonotic roundworms Toxocara canis and T. cati may induce neurotoxocarosis (NT) in humans, provoking a variety of symptoms including cognitive deficits as well as neurological dysfunctions. …”
Get full text

A Comparative Study of Two Anesthetic Agents Thiopentone Sodium and Propofol in Modified Electroconvulsive Therapy by Sanagapalli S. V. L. Manasa, E. Ananda Reddy, V. Harshitha, Velama Pooja Prasanna, Chennuru Kavya Lekha, Javangula Swetha Krishna

“…Conclusion: The study showed that propofol was a better anesthetic agent than thiopentone sodium as propofol had faster recovery time with stable hemodynamic parameters, and less cognitive deficits, but had shorter seizure duration.…”
Get full text

A Systematic Review on Serious Games in Attention Rehabilitation and Their Effects by Leila Shahmoradi, Fatemeh Mohammadian, Meysam Rahmani Katigari

“…The search strategy consisted of three main concepts of “serious game”, “cognitive deficits”, and “cognitive rehabilitation”. The inclusion criteria were (1) journal articles, (2) English language, (3) being published in the last 10 years, (4) human participants, and (5) game-based intervention. …”
Get full text

The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach by Abraham Nunes, Selena Singh, Anouar Khayachi, Shani Stern, Thomas Trappenberg, Martin Alda

“…Conclusions Excitability variance in CA3 pyramidal cell–like neurons observed in lithium nonresponders may predict pattern completion deficits in these patients. These cognitive deficits may not be fully corrected by medications that minimize excitability. …”
Get full text

The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…It is imperative to further understand the relationship between obesity, T2D, and cognitive deficits. Methods This investigation tested and evaluated the cognitive impact of obesity and T2D induced by high‐fat diet (HFD) and the effect of the host genetic background on the severity of cognitive decline caused by obesity and T2D in collaborative cross (CC) mice. …”
Get full text

Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study by Aishwarya Raje, Abhijit R. Rozatkar, Urvakhsh Meherwan Mehta, Ritu Shrivastava, Ameya Bondre, Manaal Amir Ahmad, Anshika Malviya, Yogendra Sen, Deepak Tugnawat, Anant Bhan, Tamonud Modak, Nabagata Das, Srilakshmi Nagendra, Erlend Lane, Juan Castillo, John A. Naslund, John Torous, Soumya Choudhary

“…Introduction: Cognitive deficits represent a core symptom of schizophrenia and a principal contributor to illness disability, yet evaluating cognition in routine clinical settings is often not feasible as cognitive assessments take longer than a standard doctor's visit. …”
Get full text

Individualized prediction of multi-domain intelligence quotient in bipolar disorder patients using resting-state functional connectivity by Xiaoyu Li, Wei Wei, Linze Qian, Xiaojing Li, Mingli Li, Ioannis Kakkos, Qiang Wang, Hua Yu, Wanjun Guo, Xiaohong Ma, George K. Matsopoulos, Liansheng Zhao, Wei Deng, Yu Sun, Tao Li

“…Regarding the contributed FCs, we observed a widespread distribution of internetwork FCs across somatomotor, visual, dorsal attention, and ventral attention networks, demonstrating their correspondence with aberrant FCs correlated to cognition deficits in BD patients. A convergent pattern in terms of contributed FCs for different IQ domains was observed, as evidenced by the shared-FCs with a leftward hemispheric dominance. …”
Get full text

The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases by Rojin Sarallah, Shima Jahani, Alireza Soltani Khaboushan, Amir Kian Moaveni, Maryam Amiri, Masoumeh Majidi Zolbin

“…ALS research indicates that the CXCL12/CXCR4/CXCR7 pathway is involved in motor neuron degeneration and associated cognitive deficits. Across these diseases, the axis influences neuroinflammation, synaptic plasticity, and neuronal survival through various signaling cascades, including PI3K/AKT, MAPK, and JAK/STAT pathways. …”
Get full text