The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…Methods This investigation tested and evaluated the cognitive impact of obesity and T2D induced by high‐fat diet (HFD) and the effect of the host genetic background on the severity of cognitive decline caused by obesity and T2D in collaborative cross (CC) mice. …”
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Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study by Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

“…After controlling for all potential confounding variables, our analysis showed a statistically significant positive association between WWI and cognitive decline. Specifically, for every 1 cm/√kg increase in WWI, the risk of cognitive impairment increased by 17% (HR = 1.17, 95% CI: 1.02–1.35). …”
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Nomogram for predicting mild cognitive impairment in Chinese elder CSVD patients based on Boruta algorithm by Yanzi Huang, Wendie Huang, Xiaoming Ma, Guoyin Zhao, Jingwen Kang, Huajie Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Shiying Sheng, Fengjuan Qian

“…ROC and calibration curves indicate its high discriminative ability.ConclusionWhile CSVD is prevalent among middle-aged and older individuals, cognitive decline trajectories differ. Endocrine metabolic indicators like IGF-1 offer early predictive value. …”
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A case of neuronal intranuclear inclusion disease (NIID) presenting with hydrocephalus-like clinical features: case report by Yonghong Wang, Yongxiang Li, Wei Pan, Yuezhen Shen, Junxia Li, Ying Liu, Yuhua Peng, Shulai Zhu

“…Over the past year, she noticed stiffening at the root of her tongue, cognitive decline, and slower reaction times compared to her previous state. …”
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Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion by Zhao-Hui Yao, Xiao-li Yao, Shao-feng Zhang, Ji-chang Hu, Yong Zhang

“…Chronic cerebral hypoperfusion (CCH) is a common pathophysiological mechanism that underlies cognitive decline and degenerative processes in dementia and other neurodegenerative diseases. …”
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Associations between cerebral blood flow and progression of white matter hyperintensities by Siriluk Thammasart, Danielle J. Harvey, Pauline Maillard, Charles DeCarli, Corinne A. Donnay, Gregory J. Wheeler, Audrey P. Fan, Audrey P. Fan

“…IntroductionIn an aging population, white matter hyperintensities (WMHs), observed on FLAIR MRI sequences, are indicators of cognitive decline, motor impairment, and increased vascular risk. …”
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Detecting early cognitive deficits in preclinical Alzheimer’s disease using a remote digital multi-day learning paradigm by Roos J. Jutten, Daniel Soberanes, Cassidy P. Molinare, Stephanie Hsieh, Michelle E. Farrell, Aaron S. Schultz, Dorene M. Rentz, Gad A. Marshall, Keith A. Johnson, Reisa A. Sperling, Rebecca E. Amariglio, Kathryn V. Papp

“…Our results suggest that diminished MDLCs track with advanced AD pathophysiology, and demonstrate how a digital multi-day learning paradigm can provide novel insights about cognitive decline during preclinical AD.…”
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Comparison of 3 Aging Metrics in Dual Declines to Capture All-Cause Dementia and Mortality Risk: Cohort Study by Anying Bai, Shan He, Yu Jiang, Weihao Xu, Zhanyi Lin

“…ObjectiveWe aim to compare the predictive capacities of 3 distinct aging metrics—motoric cognitive risk syndrome (MCR), physio-cognitive decline syndrome (PCDS), and cognitive frailty (CF)—for incident dementia and all-cause mortality among community-dwelling older adults. …”
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Codon Usage is Influenced by Compositional Constraints in Genes Associated with Dementia by Taha Alqahtani, Rekha Khandia, Nidhi Puranik, Ali M. Alqahtani, Yahia Alghazwani, Saad Ali Alshehri, Kumarappan Chidambaram, Mohammad Amjad Kamal, Mohammad Amjad Kamal, Mohammad Amjad Kamal, Mohammad Amjad Kamal

“…Dementia is a clinical syndrome characterized by progressive cognitive decline, and the symptoms could be gradual, persistent, and progressive. …”
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Assessment of Cognitive Functions in Multimorbid Patients in Lithuanian Primary Care Settings: A Cross-Sectional Study Using MMSE and LT-GPCOG by Silvija Valdonė Alšauskė, Ingrida Grabauskytė, Ida Liseckienė, Jūratė Macijauskienė

“…Early diagnosis of cognitive decline is crucial, especially in primary care, where time constraints and the limitations of diagnostic tools may hinder accurate detection. …”
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Association of cortical macrostructural and microstructural changes with cognitive performance and gene expression in subcortical ischemic vascular disease patients with cognitive... by Jing Huang, Runtian Cheng, Xiaoshuang Liu, Li Chen, Tianyou Luo

“…Conclusions: The specific cortical structural damage may be related to specific cognitive decline and specific risk genes in SIVD-CI patients.…”
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APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease by Marta Moreno-Rodriguez, Sylvia E. Perez, Michael Malek-Ahmadi, Elliott J. Mufson

“…Abstract The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is linked to demyelination and cognitive decline. However, its effects on the lipid transporters apolipoprotein E (ApoE) and fatty acid-binding protein 7 (Fabp7), which are crucial for the maintenance of myelin in white matter (WM) during the progression of AD remain underexplored. …”
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Altered individual-based morphological brain network in type 2 diabetes mellitus by Wang Yan, Ge Limin, Sun Zhizhong, Cao Zidong, Qiu Shijun

“…Type 2 diabetes mellitus (T2DM) is recognized as a risk factor for cognitive decline, potentially linked to disrupted network connectivity. …”
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Development of a psychological frailty index: results from the China health and retirement longitudinal study by Jinlong Zhao, Justina Yat Wa Liu, Justina Yat Wa Liu, Daniel Fernández, Stefanos Tyrovolas, Stefanos Tyrovolas, Stefanos Tyrovolas, Stefanos Tyrovolas

“…The study assessed the applicability of the PFI to adverse health outcomes as a secondary aim.ResultsFactor analysis of the 15-item PFI extracted four factors of psychological frailty (psychological distress, cognitive decline, physical vulnerability, and memory decline). …”
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Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms by Ali Mohammadkhanizadeh, Mohammad Sheibani, Soroush Taherkhani, Davood Nourabadi, Seyed Mahdi Mohamadi-Zarch, Farnaz Nikbakht, Yaser Azizi

“…Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons and neuronal connections, leading to cognitive decline, memory impairment, and motor dysfunction. …”
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Predominant polarity in bipolar affective disorder and its impact on cognition and quality of life by Shashank Bhardwaj, Deoraj Sinha, Ami Pawar, Astik Mane

“…There were substantial MoCA score differences between the groups with depressive polarity and no polarity, with the depressive polarity showing more cognitive decline.…”
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Understanding neurocognitive recovery in older adults after total hip arthroplasty—neurocognitive assessment, blood biomarkers and patient experiences: a mixed-methods study by Ulrica Nilsson, Karin Liander, Lina Bergman, Anahita Amirpour, Jeanette Eckerblad, Gabriela Markovic

“…The global postoperative recovery score was 40.9, indicating a low quality of recovery.Conclusion Many patients reported subjective cognitive decline that was not corroborated by delayed neurocognitive recovery in the performance-based tests. …”
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No Effect of Anodal tDCS on Verbal Episodic Memory Performance and Neurotransmitter Levels in Young and Elderly Participants by Annegret Habich, Johannes Slotboom, Jessica Peter, Roland Wiest, Stefan Klöppel

“…Healthy ageing is accompanied by cognitive decline that affects episodic memory processes in particular. …”
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Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice by Wei Wei, Zhicheng Lin, PeiTao Xu, Xinru Lv, Libin Lin, Yongxu Li, Yangjie Zhou, Taotao Lu, Xiehua Xue

“…Diet control plus swimming significantly reversed HFD-induced cognitive decline, reduced the time spent exploring the novel object, and ameliorated spontaneous alternation in the Y-maze test. …”
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Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review by Francesco Panza, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M. Colacicco, Alessandra Di Palo, Bruno P. Imbimbo, Gianluigi Vendemiale, Antonio Capurso, Vincenzo Solfrizzi

“…Given recent findings from randomized clinical trials (RCTs) in which n-3 PUFA supplementation was effective only in very mild AD subgroups or mild cognitive impairment (MCI), we suggest future intervention trials using measures of dietary supplementation (dietary n-3 PUFA and SAM plus B vitamin supplementation) to determine if such supplements will reduce the risk for cognitive decline in very mild AD and MCI. Therefore, key supplements are not necessarily working in isolation and the most profound impact, or in some cases the only impact, is noted very early in the course of AD, suggesting that nutriceutical supplements may bolster pharmacological approaches well past the window where supplements can work on their own. …”
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