Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease by Amtul Rahman, Zeenath Banu

“…AlCl3 disrupts normal brain function, potentially leading to oxidative stress, inflammatory responses, and cognitive decline, all of which are implicated in AD pathology. …”
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Prospective Evaluation of 24 h/2 Days’ Monitoring of Systemic Blood Pressure in Patients with Traumatic Paraplegia – A Single-center Study by Vandana Chaudhary, N S Verma, Bhupendra Kumar, Kumar Rahul, Satish Kumar

“…Background: Cardiovascular dysfunction and cognitive decline are more common in traumatic spinal cord injury (SCI). …”
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The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up by Yuan-Yuan Xu, Sheng-Han Kuo, Zheng Liang, Hui Xu, Wu-Ruo Feng, Cui-Yu Yu, Wei-Guo Liu

“…Higher baseline HDRS score (P<0.001) and greater decline on MMSE (P=0.001) were related to the occurrence of depression. In conclusion, cognitive decline is a disease related factor of worsening and the occurrence of depression. …”
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Reading Comprehension in Older Adults—Effects of Age, Educational Level, and Reading Habits by Bernardo Riffo, Carlos Rojas, Andrea Helo, Mónica Véliz, Paula Urzúa, Gloria Gutierrez, Ernesto Guerra

“…Strong reading habits were positively associated with better comprehension across both groups, suggesting that regular reading may buffer against age-related cognitive decline. Poor readers read less frequently and perceived greater difficulty with the tasks. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Progressive neurological deterioration and insurgence of symptoms like ataxia, seizure, and cognitive decline until severe dementia are pathognomonic features of the disease. …”
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Lecanemab’s Path Forward: Navigating the Future of Alzheimer’s Treatment in Europe Amidst the EMA's Rejection by Alessandro Martorana, Chiara Giuseppina Bonomi, Martina Gaia Di Donna, Caterina Motta

“…This commentary emphasizes the importance of real-world data on lecanemab's impact on cognitive decline, daily functioning, and side-effect management. …”
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Citrulline – The Powerhouse Nutrient for Cardiometabolic and Brain Health by Daria Pedrycz, Mateusz Drabczyk, Emilia Pedrycz, Karolina Karoń, Grzegorz Drapała, Wojciech Grabowski, Łukasz Karoń, Anna Zygmunt, Sławomir Karoń

“…By enhancing NO production, citrulline supports endothelial function, vasodilation, and cerebral circulation, thereby mitigating cognitive decline associated with aging and neurodegenerative diseases. …”
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Sex differences in the association between lipids and cognitive function in older adults by Jiahao Chen, Yinming Wang, Wenyan Guo, Muyuan Jiang, Zixuan Gai, Huinan Zhang, Mulei Chen, Yifan Fan

“…In older women, high TC levels are positively associated with cognitive decline while high TG levels may protect cognitive function.…”
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Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease by Kelly N. Z. Fuller, Edwin R. Miranda, John P. Thyfault, Jill K. Morris, Jacob M. Haus

“…These characterizations of sRAGE contribute evidence to the link between impaired metabolism and cognitive decline due to AD.…”
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Environmental Factors Promoting Neural Plasticity: Insights from Animal and Human Studies by Laura Mandolesi, Francesca Gelfo, Laura Serra, Simone Montuori, Arianna Polverino, Giuseppe Curcio, Giuseppe Sorrentino

“…Some individuals have a cognitive decline earlier and faster than others who are older in years but cerebrally younger. …”
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The Association between Hypertension and Dementia in the Elderly by Michiya Igase, Katsuhiko Kohara, Tetsuro Miki

“…Recent clinical trials and studies on animal models suggest that blockades of RAS system could have reduced cognitive decline seen in Alzheimer's disease and vascular dementia. …”
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Investigating the Therapeutic Mechanisms of Total Saikosaponins in Alzheimer’s Disease: A Metabolomic and Proteomic Approach by Huiling Wei, Tianyi Du, Weiwei Zhang, Wei Ma, Yao Yao, Juan Li

“…<b>Conclusions</b>: Our findings suggest that TSS ameliorate cognitive decline through regulating neuroinflammatory pathways, cAMP and cGMP signaling, and synaptic plasticity pathways, providing insights into its therapeutic potential in AD.…”
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Leveraging transformer models to predict cognitive impairment: accuracy, efficiency, and interpretability by Kai Ma, Junzhi Zhang, Xinhang Huang, Mengyang Wang

“…Conclusion The enhanced Transformer model offers superior accuracy and efficiency in predicting cognitive decline compared to traditional models. Its capacity to process both continuous and categorical data and its interpretability through attention mechanisms make it a promising tool for early detection of neurodegenerative diseases, potentially improving clinical decision-making and interventions.…”
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Relationship between social activities and cognitive impairment in Chinese older adults: the mediating effect of depressive symptoms by Qianke Yang, Shichong Lin, Zhuyun Zhang, Shuhao Du, Dan Zhou

“…BackgroundThe differential impacts of various social activities on dementia prevention and the mediating role of depression in this relationship remain unclear.ObjectivesThis study aimed to identify the effects of different social activities on cognitive function, examine the mediating role of depression, and provide evidence for targeted interventions to prevent cognitive decline.MethodsUsing data from CHARLS, we employed RCS analysis and Structural Equation Modeling to examine the relationships between social activities, depression, and cognitive function in older adults.ResultsSocial activity participation is non-linearly inversely related to both cognitive impairment and depression risk. …”
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Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment by Julia Schumacher, Stefan Teipel, Alexander Storch

“…We aimed to investigate the relationship between basal forebrain and hippocampus atrophy, cognitive decline, and neuropathology in a large autopsy sample. …”
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A case report of fatal familial insomnia with cerebrospinal fluid leukocytosis during the COVID-19 epidemic and review of the literature by Zheng Wang, Yueqi Huang, Shuqi Wang, Jiefang Chen, Gesang Meiduo, Man Jin, Xiaoying Zhang

“…Clinical symptoms include psychobehavioral abnormality, cognitive decline, sleep disturbance, and autonomic dysfunction. …”
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Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy by Ruwei Ou, Wei Song, Qianqian Wei, Ke Chen, Bei Cao, Yanbing Hou, Bi Zhao, Huifang Shang

“…Older PSP patients and late-onset patients are likely to be subjected to cognitive decline.…”
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Decline in Memory, Visuospatial Ability, and Crystalized Cognitive Abilities in Older Adults: Normative Aging or Terminal Decline? by R. Bendayan, A. M. Piccinin, S. M. Hofer, D. Cadar, B. Johansson, G. Muniz-Terrera

“…Results showed that the time to death model was the best option in analyses of change in all the cognitive measures considered (except for the Information Test). A significant cognitive decline over time was found for all variables. …”
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Effects of a 12-Week Exercise Training Program on Physical Function in Institutionalized Frail Elderly by Cristiane Batisti Ferreira, Pâmela dos Santos Teixeira, Geiane Alves dos Santos, Athila Teles Dantas Maya, Paula Americano do Brasil, Vinícius Carolino Souza, Cláudio Córdova, Aparecido Pimentel Ferreira, Ricardo Moreno Lima, Otávio de Toledo Nóbrega

“…However, longevity is usually accompanied by problems such as the loss of functional capacity, cognitive decline, frailty syndrome, and deterioration in anthropometric parameters, particularly among those living in long-term care facilities. …”
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Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention by Xuan Lu, Ying Chen, Yue Shi, Yi Shi, Xianbin Su, Peijie Chen, Die Wu, Hui Shi

“…Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. …”
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