Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma by Yi He, Zhi Li, Yun-Xia Zuo

“…We hypothesize that nerve blockage may be effective in reducing postoperative inflammation and cognitive decline. The rats at the age of 4 weeks were subjected to general anesthesia and humeral fracture fixation, in combination with brachial plexus block, saline versus ropivacaine, respectively. …”
Get full text

Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis by Imrana Jazuli, Akeela Jazeel, Lakshmi Selvaratnam, Deepa Alex, Yatinesh Kumari

“… Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta plaques and tau protein neurofibrillary tangles, leading to cognitive decline. The lack of effective treatments compounds the significant human and financial burdens AD poses. …”
Get full text

Noradrenergic Modulation of Cognition in Health and Disease by Olga Borodovitsyna, Matthew Flamini, Daniel Chandler

“…We further assess the changes that occur in the noradrenergic system in Alzheimer’s disease, Parkinson’s disease, attention-deficit/hyperactivity disorder, and schizophrenia and how these changes contribute to cognitive decline in these pathologies.…”
Get full text

Cognitive Impairment in Heart Failure by Efthimios Dardiotis, Gregory Giamouzis, Dimos Mastrogiannis, Christina Vogiatzi, John Skoularigis, Filippos Triposkiadis, Georgios M. Hadjigeorgiou

“…Although the exact mechanisms remain unclear, microembolism, chronic or intermittent cerebral hypoperfusion, and/or impaired cerebral vessel reactivity that lead to cerebral hypoxia and ischemic brain damage seem to underlie the development of CI in HF. Cognitive decline in HF is characterized by deficits in one or more cognition domains, including attention, memory, executive function, and psychomotor speed. …”
Get full text

Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide by Kumju Youn, Chi-Tang Ho, Mira Jun

“…ABSTRACT: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive decline and memory impairment. Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various biochemical alteration including oxidative damage, mitochondrial dysfunction, neuroinflammation, signaling pathway and finally resulting in neuronal death. …”
Get full text

Role of Thyroid Hormone in Neurodegenerative Disorders of Older People by Arshag D. Mooradian, Michael J. Haas

“…Thyroid dysfunction is associated with a number of neuropsychiatric manifestations. Cognitive decline is a common feature of hypothyroidism and clinical or subclinical hyperthyroidism. …”
Get full text

Cognition and Vascular Risk Factors: An Epidemiological Study by Augusto Vicario, Mildren Del Sueldo, Ruth A. Fernández, Julio Enders, Judith Zilberman, Gustavo H. Cerezo

“…Thus, we demonstrated that the use of a Minimum Cognitive Examination (MCE), a brief, simple, and easy managed neuropsychological evaluation, detected a greater number of people with cognitive decline surpassing to the Minimal Mental Statement Examination alone (14.5% of the participants showed MMSE ≤24, 34,6% showed dys-executive function, and 45,8% memory impairment. …”
Get full text

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis by Simone A. van den Berge, Josta T. Kevenaar, Jacqueline A. Sluijs, Elly M. Hol

“…In conclusion, we have shown that cortical astrogliosis is not associated with the cognitive decline in Lewy body-related dementia.…”
Get full text

Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles by Qiong Pan, Ya-Qian Li, Ke Guo, Min Xue, Yu Gan, Kejian Wang, Da-Bao Xu, Qiu-Yun Tu

“…As a transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. The association between AD and gut microbiota has been reported in a number of studies; however, microbial research regarding MCI remains limited. …”
Get full text

Brain Stimulation Techniques in Research and Clinical Practice: A Comprehensive Review of Applications and Therapeutic Potential in Parkinson’s Disease by Ata Jahangir Moshayedi, Tahmineh Mokhtari, Mehran Emadi Andani

“…We explore the efficacy and safety profiles of these techniques in alleviating both motor impairments, such as bradykinesia and rigidity, and non-motor symptoms, including cognitive decline, depression, and impulse control disorders. …”
Get full text

Increased arterial stiffness is associated with poorer social cognition in older age by Sarah A. Grainger, Tom G. Bailey, Natalie K. Vear, Jessica K. Mead, Xanthia E. Bourdaniotis, Jeff S. Coombes, Jenna L. Taylor

“…Abstract It is now well established that vascular aging is a significant predictor of cognitive decline in older age. But what remains less clear is the role that vascular health plays in social cognitive aging. …”
Get full text

Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“… Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavioral disturbances. The pathogenic characteristics encompass the existence of amyloid plaques outside the cells, neurofibrillary tangles inside the cells, neuroinflammation, oxidative stress, and the loss of synapses. …”
Get full text

Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function by Carola Stockburger, Davide Miano, Thea Pallas, Kristina Friedland, Walter E. Müller

“…We here report that piracetam at therapeutically relevant concentrations improves neuritogenesis in the human cell line SH-SY5Y over conditions mirroring the whole spectrum of age-associated cognitive decline. These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the energetically more favorable fusion site. …”
Get full text

Validation of a New Cognitive Screening Method for Stroke Patients by Katri Saar, Hannu Nyrkkö, Asko Tolvanen, Pekka Kuikka, Erja Poutiainen, Tuija Aro

“…This study shows promising results for this new cognitive screening tool’s ability to identify poststroke cognitive decline and patients’ need for further detailed neuropsychological examination.…”
Get full text

When Stroke Disguises as Dementia: A Case of Missed Cerebral Venous Thrombosis by Tina Moghadam Fard, Mehrnaz Hosseinzadeh, MohammadAli Shokri, Mostafa Almasi‐Dooghaee, Fatemeh Sadat Mirfazeli

“…We report a 74‐year‐old female initially misdiagnosed with Alzheimer's because of cognitive decline and disorganized speech. Her symptoms did not improve with Alzheimer's treatment. …”
Get full text

Bidirectional association between breast cancer and dementia: a systematic review and meta-analysis of observational studies by Fuxing Bao, Liang Yu, Xiaolei Zhang, Qier Mu

“…Background Cognitive decline following cancer treatment can vary from mild cognitive impairment to severe dementia. …”
Get full text

Walking and Hippocampal Formation Volume Changes: A Systematic Review by Mohamed Hesham Khalil

“…These findings support the promotion of walking as a simple, effective strategy to enhance brain health and prevent cognitive decline, suggesting the design of physical environments with natural and biophilic characteristics and layouts with greater walkability and cognitive stimulation. …”
Get full text

Characteristics and clinical course of myoclonus in Cavalier King Charles Spaniels by Matthew James, Mark Lowrie, Clare Rusbridge

“…Progressive behavioral changes suggestive of cognitive decline are common. These findings support the possibility of an underlying neurodegenerative process.…”
Get full text

Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis by Ka Yin Chu, King Hei King Cheng

“…Conclusion: The combined intervention appears to effectively mitigate cognitive decline in the short term only. Optimal treatment protocol remains inconclusive due to heterogeneity among studies. …”
Get full text

Impact of dietary protein hydrolysates on cognitive performance: A systematic review of randomized controlled trials involving adults by Micah S. Adams, Ronald P. Mensink, Peter J. Joris

“…Changes in cerebral blood flow (CBF) - a marker of brain vascular function - may improve cognitive performance, and enhancing CBF through a healthy lifestyle could mitigate cognitive decline. Protein hydrolysates have shown potential to improve brain health. …”
Get full text