Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus by Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón

“…Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. …”
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Does Depression Impact Cognitive Impairment in Patients with Heart Failure? by Z. N. Sohani, Z. Samaan

“…Prevalence studies have noted the cooccurrence of cognitive decline and depression in persons with heart failure. …”
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The Impact of Online Interactive Platform Services on Oral Health Behaviors in Older Adults With Mild Cognitive Impairment: Protocol for a Randomized Controlled Trial by Yin Q, Chai Z, Tao B, Liu P, Luo Y, Zhao Q, Yang B

“…Here we describe the protocol for a study with the following aims: to enhance oral health behaviors through online education tailored to the cognitive load of older adults and to maintain or delay cognitive decline.Patients and Methods: This randomized, parallel, single-blind controlled trial will evaluate the effectiveness of an oral health behavior intervention based on an online interactive platform (e-COM[OH]) in older adults with MCI. …”
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Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…After adjusting for confounding factors, significant negative correlations were found between WWI and both CERAD (β: − 0.48; 95% CI: − 0.92 to − 0.05; P=0.03) and DSST (β: − 1.15; 95% CI: − 2.09 to − 0.21; P=0.017) scores, suggesting a link to cognitive decline. No association was found with AFT scores. …”
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Results of Cultural Adaptation of Cognitive Stimulation Therapy (CST) for Elderly and Old Age People with Cognitive Impairment in Russia by A.A. Shvedovskaya, I.F. Roshchina, M.V. Kalantarova, A.I. Khromov

“…The aim of this study was the cultural adaptation of the Cognitive Stimulation Therapy (CST) program for elderly people with cognitive decline and dementia in a Russian-speaking sample with a pilot study of the use of CST in residential institutions on a group of elderly people with mild dementia. …”
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Slowing of Event-Related Potentials in Primary Progressive Aphasia. A case report by Salvatore Giaquinto, Francesca Ranghi

“…Event–related electrical potentials are recommended in the field of aphasia and cognitive decline. They permit observation of a speed decline in higher cognitive abilities, when pathological changes at a central level begin and language comprehension seems to be unaffected.…”
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Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction by Yue Liu, Yiqing Yin

“…Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy. …”
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From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience by Dian Jiao

“…This study synthesizes findings from neuroimaging, behavioral science, and longitudinal studies, illustrating how daily routines can mitigate hypoxia-induced cognitive decline and promote resilience. By integrating insights from centenarians, hypoxia-adapted species, and multimodal intervention studies, this framework highlights the transformative potential of lifestyle-based strategies in addressing cerebral oxygen deficits. …”
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Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes by Masafumi Ihara, Hidekazu Tomimoto

“…Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently responsible for the cognitive decline of the elderly. It is characterized by cerebrovascular white matter changes; thus, in order to investigate the underlying mechanisms involved in white matter changes, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. …”
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Delirium after Deep Brain Stimulation in Parkinson’s Disease by Hanyi Li, Shunchang Han, Juan Feng

“…However, the clinical attention toward this complication remains insufficient. Advanced age, cognitive decline, and the severity of the disease may all be risk factors for delirium. …”
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Coaching 5.0, coaching for the fifth industrial revolution by Jazz Rasool

“…The author calls for prevention of cognitive decline in human beings as machines get smarter. …”
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Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

“…Elderly with rapid cognitive decline had 24% higher mortality risk than those with stable cognitive (AHR = 1.24, 95%CI 1.10–1.39). …”
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Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment by Lucas Luchesi Barnes, Lucas Francisco Botequio Mella, Francisca Daniele Ferreira Lopes, Amilton dos Santos Junior, Paulo Dalgalarrondo

“…Neuropsychiatric symptoms (NPS) such as depression, anxiety, and apathy are present in mild cognitive impairment (MCI) and are risk factors for cognitive decline. However, the relationship between NPS and specific cognitive domains is less clear. …”
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A Case of Lung Cancer with Brain Metastasis following Late-Onset Bipolar Disorder by Shin-Heng Shen, Shwu-Hua Lee

“…However, he experienced abrupt cognitive decline for 2 months and was referred to the emergency room for physiological examination. …”
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Effects of a periodic intermittent theta burst stimulation in Alzheimer’s disease by Yue Wu, Lu Wang, Kai Wang, Shanshan Zhou, Pan Wu, Yibing Yan, Ling Wei, Bensheng Qiu, Yanghua Tian, Zhi Geng, Xingqi Wu, Panpan Hu, Guixian Xiao, Gongjun Ji, Hesheng Liu

“…However, the long-term effects of iTBS on cognitive decline and brain structure in patients with AD are unknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised, assessor-blinded, controlled trial, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of 42 patients with AD for 14 days every 13 weeks. …”
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CLN6‐related continuum phenotype caused by aberrant splicing by Federica Invernizzi, Barbara Castellotti, Chiara Reale, Celeste Panteghini, Isabel Colangelo, Roberta Solazzi, Francesca Ragona, Lucio Giordano, Jessica Galli, Davide Rossi Sebastiano, Gianluca Marucci, Valeria Cuccarini, Giuseppe Didato, Cinzia Gellera, Barbara Garavaglia, Tiziana Granata, Laura Canafoglia

“…However, the presence of a delay, and the early cognitive decline suggested a continuum phenotype connecting late‐infantile and adult CLN6‐related forms. …”
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo by G. D. Rabinovici, W. J. Jagust

“…Amyloid imaging studies support a model in which amyloid deposition is an early event on the path to dementia, beginning insidiously in cognitively normal individuals, and accompanied by subtle cognitive decline and functional and structural brain changes suggestive of incipient AD. …”
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Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia by Amanda Louise White, Grant M. Talkington, Blake Ouvrier, Saifudeen Ismael, Rebecca J. Solch-Ottaiano, Gregory Bix

“…Vascular dementia (VaD) is a progressive neurodegenerative condition prevalent among elderly adults marked by cognitive decline resulting from injured and/or improperly functioning cerebrovasculature with resultant disruptions in cerebral blood flow. …”
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Subclinical depressive symptoms and job stress differentially impact memory in working and retired older adults by Lorena A. Ferguson, Amritha Harikumar, Stephanie L. Leal

“…Abstract Retirement has been associated with cognitive decline beyond normal age-related decline. However, there are many individual differences in retirement that can influence cognition. …”
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The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

“…Lifestyle modifications and multidomain prevention strategies, including exercise, cognitive training, and diet, demonstrate potential in reducing cognitive decline, particularly in at-risk populations. …”
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