A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…First, we leveraged non-coding genome-wide association studies (GWAS) loci effects on five types of brain-specific quantitative trait loci (xQTLs, including expression, protein, splicing, methylation and histone acetylation) under the protein–protein interactome (PPI) network. …”
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Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study by Su Li, Su Li, Su Li, Luan Zhang, Yangyang Wang, Yangyang Wang, Runsheng Xie, Runsheng Xie, Wenjia Chen, Wenjia Chen, Myeong Soo Lee, Yasser Sami Amer, Yasser Sami Amer, Yasser Sami Amer, Amin Sharifan, Heba Hussein, Hui Li, Hui Li, Hui Li

“…BackgroundTo develop a rational and standardized traditional Chinese medicine (TCM) good practice recommendation (GPR) methodology model that guides the formulation of recommendations grounded in clinical experience.MethodsWe adopted an exploratory sequential mixed-method to develop a methodology model by coding systematically collected literature on methodology and TCM guidelines related to TCM GPR using a best-fit framework synthesis. …”
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Fermentation characteristics of lactofermented cucumbers using an isolated Lactiplantibacillus plantarum NCHU–FC1 strain by Hsuan-Min Wang, Shwu-Jene Tsai, Jin-Yuarn Lin

“…The isolated LAB strain was identified as a Lactiplantibacillus (Lpb.) plantarum strain coding as Lpb. plantarum NCHU–FC1. The pH value was quickly lower than 4.6 (aka high-acid foods), while total nitrite contents were below the standard limit using 1 × 107 colony forming unit (CFU)/mL Lpb. plantarum NCHU–FC1 at 4 °C for 5 days. …”
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The clinical application of artificial intelligence in cancer precision treatment by Jinyu Wang, Ziyi Zeng, Zehua Li, Guangyue Liu, Shunhong Zhang, Chenchen Luo, Saidi Hu, Siran Wan, Linyong Zhao

“…In specific fields, including target prediction, targeted drug generation, immunotherapy response prediction, neoantigen prediction, and identification of long non-coding RNA, artificial intelligence offers promising perspectives. …”
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Operative Versus Nonoperative Management of Pyogenic Flexor Tenosynovitis: An Analysis of the National Readmissions Database by Justin D. Sawyer, MD, Justin Davis, MD, Steven Scaife, MS, Michael W. Neumeister, MD, Timothy H.F. Daugherty, MD

“…Methods: International Classification of Diseases, Tenth Revision codes were used to identify patients admitted with PFT from the National Readmissions Database for the years 2016–2019. …”
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Preparation and application evaluation of monoclonal antibodies against Monkeypox virus A29 protein by Ai Xiangjun, Zhang Xinlan, Xu Ye, Tan Chufan, Tan Chufan, Duan Chen, Liao Nami, Liu Junxi, Qiu Yilan, Qiu Yilan, Hou Defu, Hou Defu, Wang Qinglin, Wang Qinglin, Liu Rushi, Liu Rushi

“…The MPXV A29 protein not only plays an important role in the virus lifecycle but also serves as a promising target for developing specific antibodies, which have significant potential for application in the diagnosis of MPXV. The coding sequences of the MPXV A29 protein, Cowpox virus (CPXV) 163 protein homolog and Vaccinia virus (VACV) A27 protein homolog were chemically synthesized, and all three recombinant proteins were expressed in Escherichia coli (BL21 Star). …”
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The Effects of Different Phase on Independent Visual Fields SSVEP Responses by Dalu Zheng, Songyun Xie, Xinzhou Xie, Michael Scholz, Hao Tang

“…By stimulating only half of the visual field and “coding” the stimulus further with different phases individual contributions of pathways and eyes can be easily separated and thus the mode of action becomes clearer. …”
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A study to identify individuals at risk to be affected by late-onset Pompe disease who had previously been given a non-specific or tentative diagnosis for their muscle weakness (Po... by Dawn A. Laney, Kayla A. Banks, Eleanor G. Botha, Maria Keever, Valynne Long, Allison L. Foley

“…Results Initial data pulls identified 80,070 patients with one of the ICD-10 codes of interest. Chart review found 551 of these patients also had at least one lab value commonly abnormal in individuals with LOPD and of these 110 scored as “at-risk”. …”
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Chinese nurses’ perspectives on child-friendly healthcare practice assessment: a qualitative study by Wei Xiao Huang, Mei Chan Chong, Li Yoong Tang, Xiao Xia Liu, Mei Fang, Yun Yun Shen, Xiao Li Guo

“…These units were classified into 58 codes across 4 categories and 17 subcategories. The four categories were identified: services designed for children’s interests, tailoring the environment adapted for children, facilitating social interactions, and promoting childhood development. …”
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The first two mitochondrial genomes for the genus Ramaria reveal mitochondrial genome evolution of Ramaria and phylogeny of Basidiomycota by Qiang Li, Lijiao Li, Ting Zhang, Peng Xiang, Qian Wu, Wenying Tu, Zhijie Bao, Liang Zou, Cheng Chen

“…In addition, the evolutionary rates of different core protein coding genes (PCGs) in Phallomycetidae mitogenomes varied. …”
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Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma by Lin Wang, Xinyu Liu, Haoze Lv, Han Zhang, Rimei Lin, Shan Xu, Chaojing Zhang, Shilei Lou, Zhidong Qiu, Cong Sun, Ning Cui

“…miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. …”
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Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames by Lei Chen, Xia Gao, Xiangshen Liu, Ye Zhu, Dong Wang

“…Mutations in PKD1 coding sequence and abnormal PKD1 expression levels contribute to the development of autosomal-dominant polycystic kidney disease, the most common genetic disorder. …”
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Validation of a one-step reverse transcription PCR detection method for Tobamovirus maculatessellati, in tomato (Solanum lycopersicum L.) and pepper (Capsicum annuum L.) by Chellappan Padmanabhan, Andrea Gilliard, Kai-Shu Ling, Yazmín Rivera

“…In this study, we report the validation of a previously described reverse transcription polymerase chain reaction (RT-PCR) assay that amplifies a 289 bp fragment of the coat protein coding region of ToMMV genome. This assay has 100% specificity for ToMMV. …”
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Maternal singing and speech have beneficial effects on preterm infant’s general movements at term equivalent age and at 3 months: an RCT by Manuela Filippa, Gianluca Filippa, Elisa Della Casa, Alberto Berardi, Odoardo Picciolini, Sara Chiara Meloni, Clara Lunardi, Alessandra Cecchi, Alessandra Sansavini, Luigi Corvaglia, Luigi Corvaglia, Didier Grandjean, EVC Group, Fabrizio Ferrari

“…GMs were recorded both before and after the intervention – which took place at term equivalent age – and again at 3 months corrected age. The GMs were blindly coded based on the muted video tracks to produce both a general score and a detailed score.ResultsBefore the intervention, there were no significant differences between the two groups. …”
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Splicing and expression dynamics of SR genes in hot pepper (Capsicum annuum): regulatory diversity and conservation under stress by Lin Li, Yueqin Zhang, Rui Zhang, Rui Zhang, Xiangtao Cen, Yongxiang Huang, Yongxiang Huang, Hanqiao Hu, Hanqiao Hu, Xingyu Jiang, Xingyu Jiang, Yu Ling, Yu Ling

“…Interestingly, a cross-species comparative study with Arabidopsis (Arabidopsis thaliana) and tomato (Solanum lycopersicum) showed that many AS events impact the region which codes the RNA recognition motif (RRM) domain of the protein, indicating a conserved regulatory mechanism of SR proteins in plants. …”
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Bridging the Gap: Misaligned Perceptions of Urban Agriculture and Health Between Planning and Design Experts and Urban Farmers in Greater Lomé, Togo by Akuto Akpedze Konou, Kossiwa Zinsou-Klassou, Pablo Txomin Harpo De Roulet, Armel Firmin Kemajou Mbianda, Jérôme Chenal

“…Methodologically, 11 experts were selected in Greater Lomé and interviewed virtually via Zoom 5.6.6, and their audio files were anonymized, transcribed, and manually coded. According to the experts, the impacts of UA practices on human health and the built environment in Greater Lomé are mixed. …”
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Factors Affecting the Dividend Policy of Companies: A Meta-analysis Approach by Yalda Hassani, Bagher Asgarnezhad Nouri, Ghasem zarei, Allahyar Beigi Firoozi

“…Based on systematic elimination sampling, the number of remaining studies that had the necessary characteristics to enter the meta-analysis process was equal to 123 studies. We coded and entered the extracted data into CMA2 statistical software. …”
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Deciphering the role of epigenetics in plant pathogen resistance: Strategies for sustainable sugarcane management by Faisal Mehdi, Yuanli Wu, Shuzhen Zhang, Yimei Gan, Zhengying Cao, Shuting Jiang, Limei Zan, Benpeng Yang

“…Additionally, chromatin remodelers and non-coding RNAs work together to boost plant defenses, improving resistance and productivity in various environmental conditions. …”
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Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

“…The purpose of this study was to determine whether long non-coding RNAs (lncRNAs) are involved in regulation of estrogen independent growth and tamoxifen resistance in ER positive breast cancer. …”
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Maternal Opioid Drug Use during Pregnancy and Its Impact on Perinatal Morbidity, Mortality, and the Costs of Medical Care in the United States by Valerie E. Whiteman, Jason L. Salemi, Mulubrhan F. Mogos, Mary Ashley Cain, Muktar H. Aliyu, Hamisu M. Salihu

“…We conducted a cross-sectional analysis of pregnancy-related discharges from 1998 to 2009 using the largest publicly available all-payer inpatient database in the United States. We scanned ICD-9-CM codes for opioid use and perinatal outcomes. Costs of care were estimated from hospital charges. …”
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