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  1. 3841

    Effect of Codon Optimisation on the Production of Recombinant Fish Growth Hormone in Pichia pastoris by Hussin A. Rothan, Teh Ser Huy, Zulqarnain Mohamed

    Published 2014-01-01
    “…This study was established to test the hypothesis of whether the codon optimization of fish growth hormone gene (FGH) based on P. pastoris preferred codon will improve the quantity of secreted rFGH in culture supernatant that can directly be used as fish feed supplements. The optimized FGH coding sequence (oFGH) and native sequence (nFGH) of giant grouper fish (Epinephelus lanceolatus) were cloned into P. pastoris expression vector (pPICZαA) downstream of alcohol oxidase gene (AOX1) for efficient induction of extracellular rFGH by adding 1% of absolute methanol. …”
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  2. 3842

    Development of an overarching framework for anticipating and assessing adverse and other unintended consequences of public health interventions (CONSEQUENT): a best-fit framework s... by Jan M Stratil, Eva A Rehfuess, Ani Movsisyan, Kathryn Oliver, Renke L Biallas

    Published 2024-05-01
    “…To test the framework, it was coded against four systematic reviews of AUCs of PH interventions.Results The Cosequences of Public Health Interventions (CONSEQUENT) framework includes two components: the first focuses on AUCs and serves to categorise them; the second (supplementary) component highlights the mechanisms through which AUCs may arise. …”
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  3. 3843

    Therapeutic potential of SOX family transcription factors in osteoarthritis by Yue Huang, Zhuo Wang

    Published 2025-12-01
    “…The regulation of the WNT signalling pathway, Nrf2/ARE signalling pathway, NF-κB signalling pathway and SOX9 is implicated in the emergence of osteoarthritis. Non-coding RNA may play a role in the onset and progression of osteoarthritis by modulating various SOX family members, including SOX2, SOX4, SOX5, SOX6, SOX8, SOX9 and SOX11.Conclusion SOX9 has the capability of mitigating the onset and progression of osteoarthritis through means such as medication therapy, stem cell therapy, recombinant adeno-associated virus (rAAV) vector therapy, physical therapy and other approaches.…”
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  4. 3844

    Prioritizing implementation solutions for the urban family physician policy in Iran: a multi-criteria decision-making study by Lida Shams, Mohammadreza Mobinizadeh, Taha Nasiri, Fatemeh Mohammadi

    Published 2025-01-01
    “…Methods This is a qualitative study using semi-structured interviews with 22 snowball-sampled experts and managers of basic health insurers to extract problems and executive solutions through coding and data analysis using Atlas Ti software and content analysis in the first stage. …”
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  5. 3845

    CardioMEMS in a Busy Cardiology Practice: Less than Optimal Implementation of a Valuable Tool to Reduce Heart Failure Readmissions by Robby Singh, Leon Varjabedian, Georgy Kaspar, Marcel Zughaib

    Published 2018-01-01
    “…Methods. ICD-9/ICD-10 codes for chronic heart failure were used to identify patients who presented with congestive heart failure. …”
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  6. 3846

    Optimizing Secure AI Lifecycle Model Management With Innovative Generative AI Strategies by Alaa Omran Almagrabi, Rafiq Ahmad Khan

    Published 2025-01-01
    “…In our approach, the emphasis is placed on the multi-level security management strategy that incorporates the improvement of coding practices, validation and testing, and the implementation of advanced intrusion detection systems. …”
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  7. 3847

    ASSESSMENT OF ROMANIAN ALPINE HABITATS SPATIAL SHIFTS BASED ON CLIMATE CHANGE PREDICTION SCENARIOS by ADRIAN CONSTANTINESCU, JENICĂ HANGANU, ANTHONY LEHMANN, NICOLAS RAY

    Published 2014-12-01
    “…The predicted geographical distribution of Mesophilous oligotrophic mountain pasture and Subalpine oligotrophic pastures coded as VNG and PON habitat modeled by Maxent and BIOCLIM shows differences between the modeling approaches, with Maxent predicting smaller areas (12% less) of suitable habitat than BIOCLIM. …”
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  8. 3848

    Landscape of Alternative Splicing Events Related to Prognosis and Immune Infiltration in Glioma: A Data Analysis and Basic Verification by Hong-xin Su, Gang Yang, Fei Su, Chen-xiao Hu, Tao Zhang, Jun-tao Ran, Quan-lin Guan

    Published 2022-01-01
    “…Alternative splicing (AS), as a pervasive transcriptional regulatory mechanism, amplifies the coding capacity of the genome and promotes the progression of malignancies. …”
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  9. 3849

    Prevalence of angle’s classification of malocclusion among patients Attending Orthodontic Department in College of Dentistry‐ retrospective cross‐sectional study by Blend Hussein Mohammad, Mahmood Fawzi Abdul‐Jabbar, Mansour Hadi Mohammed

    Published 2022-02-01
    “…Methods: A total of 110 case sheets were collected from orthodontic clinic, patients that have asymmetric angle`s molar classification, any local or systemic problems, or undergone any orthodontic treatment before, were excluded, so, a sample size of 87 patients were taken (41 male and 46 female), with ages ranging from 6 to 25, after coding case sheets, data were inputting in an excel sheet of Microsoft Office and analyzed by chi‐square test. …”
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  10. 3850

    Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci. by Zeinab Mousavi, Marios Arvanitis, ThuyVy Duong, Jennifer A Brody, Alexis Battle, Nona Sotoodehnia, Ali Shojaie, Dan E Arking, Joel S Bader

    Published 2025-01-01
    “…In an application to cardiac electrophysiology with 226 GWAS loci, only 46 (20%) have within-locus evidence from Mendelian genes, protein-coding changes, or colocalization with eQTL signals. …”
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  11. 3851

    Comparative Evaluation of Intron Prediction Methods and Detection of Plant Genome Annotation Using Intron Length Distributions by Long Yang, Hwan-Gue Cho

    Published 2012-03-01
    “…Further, we evaluated the intron information of 10 complete plant genomes. As non-coding sequences, intron lengths are not limited by a triplet codon frame; so, intron lengths have three phases: a multiple of three bases (3n), a multiple of three bases plus one (3n + 1), and a multiple of three bases plus two (3n + 2). …”
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  12. 3852

    Theoretical and legal principles of forensic psychiatric examination in criminal proceedings by O. P. Makarova

    Published 2023-09-01
    “…A forensic psychiatric or comprehensive forensic psychological and psychiatric examination must be conducted by experts in accordance with the procedure set out in the Civil Procedure and Criminal Procedure Codes of Ukraine. Depending on the nature of the expert research, forensic psychiatric examination departments are divided into outpatient and inpatient. …”
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  13. 3853

    Challenges in the transition between medical and vocational rehabilitation: a qualitative focus group study with service providers in Germany by Eileen Wengemuth, Lara Kleist, Lukas Kühn, Kyung-Eun Anna Choi

    Published 2025-01-01
    “…Methods In this sub-study we made use of a qualitative approach and conducted semi-structured focus groups with service providers, namely employees of rehabilitation institutions which we analyzed using Qualitative Content analysis and an inductive-deductive Coding System. Results Twenty-four employees of rehabilitation institutions participated in five different focus groups. …”
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  14. 3854

    Dynamic Amplification Factor of Shear Force on Bridge Columns under Impact Load by Haiying Ma, Zhen Cao, Xuefei Shi, Junyong Zhou

    Published 2019-01-01
    “…Shear failure is a common mode for bridge column collapse during a vehicle-column collision. In current design codes, an equivalent static load value is usually employed to specify the shear capacity of bridge columns subject to vehicle collisions. …”
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  15. 3855

    Understanding Burnout among Surgical residents: a mixed method study by Fariba Khanipoor, Zhila Fereidouni, Sahar Neshat Far, Leila Bazrafkan, Mohammad Nabizadeh

    Published 2025-01-01
    “…In the qualitative phase of the study, 1047 codes were extracted after data analysis. The results showed three themes (and nine sub-themes) that emerged from the data analysis: A) Experienced burnout, B) Coping strategies, and C) Proposed strategies to reduce academic burnout. …”
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  16. 3856

    Glutathione S-transferase polymorphism in ethnic groups living in Eastern Siberia by E. V. Belyaeva, O. A. Yershova, T. A. Astahova, O. V. Bugun

    Published 2017-11-01
    “…It was found that the frequency of the allele A, which codes for the active variant enzyme, is significantly higher in the Buryat ethnic group (p = 0.012). …”
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  17. 3857

    Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

    Published 2025-01-01
    “…LRG mRNA and long non-coding RNA transcriptomes, epigenetic methylation data, and somatic mutation data from The Cancer Genome Atlas LUAD cohort were analyzed to identify lactylation cancer subtypes (CSs) using 10 multiomics ensemble clustering techniques. …”
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  18. 3858

    Motivations behind end-of-life care: a qualitative study of Iranian nurses’ experiences by Zahra Royani, Khadijeh Yazdi, Gholam Reza Mahmoodi-Shan

    Published 2024-11-01
    “…The data were collected through semi structured interviews and analyzed using Graneheim and Lundman’s five-step method. The coding process was facilitated by the useof MAXQDA version 10 software. …”
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  19. 3859

    New insights into the DNA extraction and PCR amplification of minute ascomycetes in the genus Laboulbenia (Pezizomycotina, Laboulbeniales) by Warre Van Caenegem, Danny Haelewaters

    Published 2024-06-01
    “…We generated 277 sequences from five loci, but amplification of the internal transcribed spacer region, the mitochondrial small subunit rDNA, and protein-coding genes remains challenging. The probability of successfully extracting DNA from Laboulbeniales was also impacted by specimen storage methods, with material preserved in > 95% ethanol yielding higher success rates compared to material stored in 70% ethanol and dried material. …”
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  20. 3860

    Identifying unstable CNG repeat loci in the human genome: a heuristic approach and implications for neurological disorders by Varun Suroliya, Bharathram Uppili, Manish Kumar, Vineet Jha, Achal K. Srivastava, Mohammed Faruq

    Published 2024-06-01
    “…Using a computational approach, 15,069 CNG repeat loci in the coding and noncoding regions of the human genome were identified. …”
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