Clinical analysis and case series report on autoimmune glial fibrillary acidic protein astrocytopathy presenting with autonomic dysfunction by Xiao Ke Wu, Guojie Zhai, Jin Ru Zhang, Hua Ping Du, Lan Hu, Shu Ye Yu, Hai Lun Hang, Sirui Han, Yanlin Zhang, Yuan Xu

“…These additional symptoms have implications for prognosis, necessitating heightened attention from clinicians toward GFAP-A patients.…”
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Systemic Inflammatory Markers for Predicting Overall Survival in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis by Xiaotong Song, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaocheng Yang, Jinzhu Liu, Yanshuo Han, Zhaozhou Ren

“…Worsened prognosis may be related to high levels of NLR, CRP, and GPS before treatment rather than LMR or PLR, which can provide the basis for clinicians to judge the outcomes of prognosis. Trial Registration. …”
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CT-based skeletal muscle loss predicts long term prognosis in patients with distal cholangiocarcinoma undergone pancreaticoduodenectomy by Guangzhen Qu, Shao-Cheng Lyu, Yong Zhang, Kun Gao, Chuanguo Zhou

“…The combination of CT quantified SML and clinical features can help clinicians predict the long-term survival of DCC patients after PD.…”
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Reflections of Foster Youth Engaging in the Co-Design of Digital Mental Health Technology: Duoethnography Study by Ifunanya Ezimora, Tylia Lundberg, Dylan Miars, Jeruel Trujeque, Ashley Papias, Margareth V Del Cid, Johanna B Folk, Marina Tolou-Shams

“…ObjectiveThe aim of this paper is to reflect on the experiences of 4 foster youth involved in the co-design of FostrSpace, a mobile app designed through a collaboration among foster youth in the San Francisco Bay Area; clinicians and academics from the Juvenile Justice Behavioral Health research team at the University of California, San Francisco; and Chorus Innovations, a rapid technology development platform specializing in participatory design practices. …”
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Pathological and radiological assessment of benign breast lesions with BIRADS IVc/V subtypes. should we repeat the biopsy? by Wesam Rjoop, Anwar Rjoop, Alia Almohtaseb, Lama Bataineh, Zeina Nser Joubi, Maha Gharaibeh, Abdalrahman Al-Qwabah, Yousef Alasheh, Ismail Matalka

“…The study recommends a correlation between clinical and radiological findings and encourages multidisciplinary decision-making among radiologists, pathologists, and clinicians to determine if a repeat biopsy is warranted. …”
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Cross-Platform Ecological Momentary Assessment App (JTrack-EMA+): Development and Usability Study by Mehran Sahandi Far, Jona M Fischer, Svea Senge, Robin Rathmakers, Thomas Meissner, Dominik Schneble, Mamaka Narava, Simon B Eickhoff, Juergen Dukart

“…JTrack-EMA+ was designed and implemented per the FAIR (findable, accessible, interpretable, and reusable) principles in both its architecture and data management layers, thereby reducing the burden of integration for clinicians and researchers. MethodsJTrack-EMA+ was built using the Flutter framework, enabling it to run seamlessly across different platforms. …”
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Predicting abatacept retention using machine learning by Rieke Alten, Claire Behar, Pierre Merckaert, Ebenezer Afari, Virginie Vannier-Moreau, Anael Ohayon, Sean E. Connolly, Aurélie Najm, Pierre-Antoine Juge, Gengyuan Liu, Angshu Rai, Yedid Elbez, Karissa Lozenski

“…By predicting clinical outcomes, machine learning can provide clinicians with a valuable tool for refining precision medicine approaches and improving treatment outcomes. …”
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CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…Our case demonstrates the extent of dissemination of CMV in a severely immunocompromised patient by showing clear cut pancreatitis secondary to said viral infection with exclusion of other possible causes. Our hope is that clinicians will change their practice to include a more scrutinized study into causes of pancreatitis especially in their immunocompromised patients.…”
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Comparing clinical only and combined clinical laboratory models for ECPR outcomes in refractory cardiac arrest by Chun-Chieh Chiu, Yu-Jun Chang, Chun-Wen Chiu, Ying-Chen Chen, Yung-Kun Hsieh, Shun-Wen Hsiao, Hsu-Heng Yen, Fu-Yuan Siao

“…This emphasizes the importance of early prognostic evaluation and supports the use of clinical data as a practical tool for clinicians in decision-making for this difficult situation.…”
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Development of Evidence-Based COVID-19 Management Guidelines for Local Context: The Methodological Challenges by Sarah Nadeem, Salima Saleem Aamdani, Bushra Ayub, Nashia Ali Rizvi, Fatima Safi Arslan, Russell Seth Martins, Maria Khan, Syed Faisal Mahmood

“…The coronavirus disease 2019 (COVID-19) pandemic has presented as a therapeutic challenge for clinicians worldwide due to its rapid spread along with evolving evidence and understanding of the disease. …”
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Parents'/caregivers' fears and concerns about their child's epilepsy: A scoping review. by Bernie Carter, Georgia Cook, Lucy Bray, Amber Collingwood, Holly Saron, Alison Rouncefield-Swales

“…<h4>Conclusions</h4>The review concludes with a proposal that a more compassionate agenda underpins the dialogue between parents/caregivers and clinicians to encompass and mitigate the wider emotional, psychosocial, and societal threats that impact on the parent/caregivers of children with epilepsy.…”
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Associations between disease severity, depression, health-related quality of life, and physical activity in adults with sickle cell disease by Adekola B. Ademoyegun, Mutiu A. Adeyemo, Babatunde Y. Adewuyi, Adebukola G. Ibitoye, Olalekan I. Akerele, Taofeek O. Awotidebe, Chidozie E. Mbada

“…Furthermore, patients with better HRQoL, especially physical health showed low depressive symptoms in adults with SCD. Clinicians and policymakers should consider incorporating PA assessments and interventions into the care of patients with SCD. …”
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Informal Caregivers Connecting on the Web: Content Analysis of Posts on Discussion Forums by Michelle L Foster, Chinenye Egwuonwu, Erin Vernon, Mohammad Alarifi, M Courtney Hughes

“…The domains identified on these forums may be helpful, as clinicians provide information to care recipients and their informal caregivers along their health journeys.…”
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Thrombotic vs. Bleeding Events of Interruption of Dual Antiplatelet Therapy within 12 Months among Patients with Stent-Driven High Ischemic Risk Definition following PCI by Hao-Yu Wang, Bo Xu, Chen-Xi Song, Chang-Dong Guan, Li-Hua Xie, Yan-Yan Zhao, Zhong-Xing Cai, Sheng Yuan, Ke-Fei Dou

“…In patients undergoing high-risk PCI, interruption of DAPT in the first 12 months occurred infrequently and was associated with a significantly higher adjusted risk of major adverse cardiovascular events and net adverse clinical events. 2017 ESC stent-driven high ischemic risk criteria may help clinicians to discriminate patient selection in the use of long-term DAPT when the ischemic risk certainly overcomes the bleeding one.…”
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Obesity is South Africa’s new HIV epidemic by Nomathemba Chandiwana, Willem Venter, Jennifer Manne-Goehler, Alisha Wade, Carel le Roux, Nzama Mbalati, Angelika Grimbeek, Petronell Kruger, Eunice Montsho, Zukiswa Zimela, Anele Yawa, Sibongile Tshabalala, Ndivhuwo Rambau, Ngqabutho Mpofu, Sasha Stevenson, Bridget McNulty, Ntobeko Ntusi, Yogan Pillay, Joel Dave, Angela Murphy, Sue Goldstein, Karen Hfman, Sameera Mahomedy, Elizabeth Thomas, Busi Mrara, Jeff Wing, Jeanne Lubbe, Zack Koto, Marli Conradie-Smit, Sean Wharton, Wayne May, Ian Marr, Hilton Kaplan, Mariam Forgan, Graham Alexander, John Turner, V R Fourie, Jocelyn Hellig, Mandy Banks, Kim Ragsdale, Marisa Noeth, Farzahna Mohamed, Landon Myer, Limakatso Lebina, Salome Maswime, Yunus Moosa, Sumy Thomas, Mzamo Mbelle, Phumla Sinxadi, Linda-Gail Bekker, Sindeep Bhana, June Fabian, Eric Decloedt, Zaheer Bayat, Reyna Daya, Bilal Bobat, Fiona Storie, Julia Goedecke, Kathleen Kahn, Stephen Tollman, Brett Mansfield, Mark Siedner, Vincent Marconi, Aaloke Mody, Ntombifikile Mtshali, Elvin Geng, Suman Srinivasa, Mohammed Ali, Samanta Lalla-Edwards, Alison Bentley, Gustaaf Wolvaardt, Andrew Hill, Jeremy Nel

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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…Conclusion A neuropsychological data-driven method to phenotype EOAD individuals uncovered a more detailed understanding of the presenting heterogeneity in this atypical AD sample compared to clinical judgment alone. Clinicians and patients may over-report memory dysfunction at the expense of non-memory symptoms. …”
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Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…Recommendations have been developed to: (i) aid clinicians in the evaluation of suspected gastrointestinal iron loss and iron malabsorption, and often a combination of these; (ii) improve clinical outcomes for patients with gastrointestinal causes of ID; (iii) provide current, evidence-based, context-specific recommendations for use in the management of ID; and (iv) conserve resources by ensuring rational utilisation of blood and blood products. …”
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Mortality risk prediction model in AIDS patients with pneumocystis pneumonia in China by Xi Wang, Letian Liu, Wen Wang, Yang Zhang, Hui Chen, Zhangli Wang, Jianwei Li, Yue Gao, Yanqun Huang, Lijun Sun, Tong Zhang, Aixin Li

“…The model is more convenient to use, allowing clinicians to obtain a determined probability value of PCP mortality with simple calculations within the first 72 hours of the patient’s admission.…”
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Validity, reliability and clinical utility of ASSIST-Y in assessing risk of substance-related harm and dependence in Spanish male adolescents by Núria Ibáñez-Martínez, Matthew William Richard Stevens, Núria Civit-Bel, Noemí Moreno-Ferrer, Sandra Lopez-Ferré, Ana Olivares-Casado, Juame Claramunt-Mendoza, Chris Holmwood, Robert Ali

“…Future research should investigate the effect of the linked brief intervention to reduce risk of harm, especially for non-specialist clinicians.…”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…Appropriate management for them remains a challenge for clinicians due to treatment-related complications. Methods To elucidate the histopathological characteristics and molecular mechanisms responsible for this severe toxicity in vivo, C57BL/6J mice were used to develop different lung injury models, including radiation-induced lung injury (RILI), bleomycin-induced pulmonary fibrosis (BIPF), and severe radiation-related lung injury (sRRLI) murine model. …”
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