Mapping outcomes for recovery of consciousness in studies from 1986 to 2020: a scoping review protocol by Monica Steiner, Elizabeth Burns, Trudy Mallinson, Joshua Rosenow, Jennifer Weaver, Alison Cogan, Parie Bhandari, Erica Jacobs, Ariana Pape, Chantal Nguyen, Ann Guernon, Tom Harrod, Theresa Bender Pape, Marilyn Pacheco, Catherine Burress Kestner, Kelsey Watters, Elizabeth Yost, Henk Eilander, Berno Overbeek, Sophie Leeds, Kelly Krese, Haylee Winden, Mary Philbin, Stefani Cleaver, Vanessa Silva, Konner Nelson, André Lindsey, Angela Hartman, Kristen Maisano, Erika Cooley, Jessica Rudin Portnoff, Bailey Widener, Sarah Hollingsworth, Coty Wardwell, Julianne Angel, Ladan Hakima, Jennifer Nebel, Bint-e Zainab Awan

“…To support knowledge translation efforts, we will involve clinicians and researchers experienced in TBI care throughout the project from conceptualisation of the study through dissemination of results.Ethics and dissemination No ethical approval is required for this study as it is not determined to be human subjects research. …”
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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review by Cristian Metrangolo, Simone Donati, Marco Mazzola, Liviana Fontanel, Walter Messina, Giulia D’alterio, Marisa Rubino, Paolo Radice, Elias Premi, Claudio Azzolini

“…Thus, in this perspective, clinicians will be able to allocate hospital resources in the best possible way and tailor treatment to the individual patient’s needs.…”
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Limitations of the Boston Carpal Tunnel Questionnaire in Assessing Severity in a Homogeneous Occupational Cohort by Venera Cristina Dinescu, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Bogdan Catalin, Alexandra Daniela Rotaru-Zavaleanu, Florentin Ananu Vreju, Lorena Sas, Marius Bunescu

“…Targeted questions addressing pain and sensory symptoms showed better sensitivity (>80%) and may guide clinicians in identifying slight CTS cases. <b>Conclusions</b>: While the BCTQ remains a valuable tool for assessing CTS, its limitations necessitate complementary use of objective diagnostic tools, particularly for severe cases. …”
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Differences in Characteristics of Peripartum Patients Who Did and Did Not Require an Upgrade to the Intensive Care Unit: A Propensity Score Matching Study by Jennifer A. Walker, Jerry M. Yang, Saad Pirzada, Manahel Zahid, Samantha Asuncion, Amanda Tuchler, Gillian Cooper, Allison Lankford, Emad Elsamadicy, Quincy K. Tran

“…Until further studies are performed to confirm our observation, clinicians should pay attention to these physiologic scores, since they may be associated with higher-risk patients.…”
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Comparing International Guidelines for the Remission of Hypertension After Bariatric Surgery by Carina Vieira Dias, Ana Lúcia Silva, Joana Dias, Paulo Cardoso, Rute Castanheira, Andreia Fernandes, Filipa Nunes, Tina Sanai, Mercedes Sanchez, João Maia-Teixeira, Ana Luísa De Sousa-Coelho

“…Dissimilar hypertension guidelines are available for clinicians, namely those prepared by the American Heart Association (AHA) and the European Society of Cardiology (ESC), which may lead to distinctive appreciation of health outcomes of patients with obesity after bariatric and metabolic surgery, such as hypertension remission. …”
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IMMUnity Unveiled: A Translational NETwork for tackling PARKinson's Disease – IMMUPARKNET [version 2; peer review: 2 approved] by Tamara Saksida, Alessia di Flora, Marina Romero-Ramos, Vladimirs Pilipenko, Laura Muñoz Delgado, Franca Marino, Yasemin Gursoy Ozdemir, Neda Nikolovski, Cristoforo Comi, Dale Lawson, Inês Figueira, Mitilda Gugu, Simona Poletti, Shubhra Acharya, Dogukan Pira

“…As we gather scientists and clinicians who study immunity in PD and related fields, IMMUPARKNET will establish the first nucleus of a multidisciplinary ecosystem that aims to harmonize efforts and approaches, both in research and clinical practice, to boost the development of ground-breaking treatments for PD. …”
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improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…This realist review will aim to understand how ambulance clinicians can provide improved prehospital acute pain management for CYP. …”
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New onset of isolated adrenocorticotropin deficiency associated with encephalopathy following coronavirus disease 2019 in a healthy elderly man by Yusuke Yamasaki, Ichiro Horie, Riyoko Shigeno, Shinpei Nishikido, Toshiyuki Ikeoka, Takuro Hirayama, Yohei Tateishi, Akira Tsujino, Atsushi Kawakami

“…A thorough consideration of the immunological and metabolic characteristics of SARS-CoV-2 is advisable when clinicians treat patients during and even after their COVID-19 disease period.…”
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Risk of angioedema and thrombolytic therapy among stroke patients: An analysis of data from the FDA Adverse Event Reporting System database by Hunong Xiang, Yu Ma, Xiaochao Luo, Jian Guo, Minghong Yao, Yanmei Liu, Ke Deng, Xin Sun, Ling Li

“…Our study suggested that alteplase is associated with a greater risk of angioedema among stroke patients, but there is insufficient evidence to support an association between tenecteplase and angioedema. Clinicians should be vigilant for this potentially life-threatening complication, particularly in patients with identified risk factors. …”
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Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…Equipping trainees to provide holistic care, immersing in and learning from First Nations, Inuit and/or Métis communities is essential for developing the next generation of clinicians and preceptors. We present educational recommendations for residency programs to optimize First Nations, Inuit and/or Métis health educational experiences and provide residents with skills to provide effective and culturally safe care.…”
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Online tools to predict individualised survival for primary oesophageal cancer patients with and without pathological complete response after neoadjuvant therapy followed by oesoph... by Jie Zhang, Xiang Chen, Dong Dong, Lijie Tan, Yajie Zhang, Hecheng Li, Yuqin Cao, Binhao Huang, Han Tang, Tianzheng Shen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao

“…The predictive models for pCR and non-pCR patients demonstrated good calibration and clinical utility, with acceptable discrimination that surpassed that of the current tumour, node, metastases staging system.Conclusions The web-based dynamic nomograms for pCR (https://predict-survival.shinyapps.io/pCR-eso/) and non-pCR patients (https://predict-survival.shinyapps.io/non-pCR-eso/) developed in this study can facilitate the calculation of OS probability for individual patients undergoing neoadjuvant therapy and radical oesophagectomy, aiding clinicians and patients in making personalised treatment decisions.…”
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A perspective on the current state of smartphone-based mobile applications for scar assessment by Peter Moortgat, Jill Meirte, Mieke Anthonissen, Koen Maertens, Thibau Demarbaix, Ulrike Van Daele

“…All devices demonstrated moderate to high feasibility for use in various settings and required specialized software for analysis.The development of smartphone-based tools for scar assessment represents a significant advancement, offering accessible and portable solutions for both patients and clinicians. While only two scar-specific smartphone tools currently exist, applications, such as skin hydration and color measurement show promise for future integration. …”
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Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial by Carl Skröder, Laila Hellkvist, Ulla Westin, Pernilla Sahlstrand‐Johnsson, Kerstin Hansson, Agneta Karlsson, Åslög Dahl, Leif Bjermer, Lars Olaf Cardell

“…These results suggest that systemic corticosteroids may not provide additional benefits over antihistamines, and clinicians should prioritize individualized treatment based on patient preferences and tolerability.…”
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Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma: a prospective multi-arm cohort study (CANCER COG) by Paul Lesueur, Florence Joly, Benedicte Clarisse, Justine Lequesne, Dinu Stefan, Jacques Balosso, Marie Lange, Sebastien Thureau, Aurelie Capel, Marie Castera, Berenice Legrand, Nicolas Goliot, Jean Michel Grellard, Thomas Tessonier, Helene Castel, Samuel Valable

“…CANCER COG aims to help clinicians to choose the best irradiation techniques with the best benefit/risk ratio. …”
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The externalization of internal experiences in psychotherapy through generative artificial intelligence: a theoretical, clinical, and ethical analysis by Yuval Haber, Dorit Hadar Shoval, Inbar Levkovich, Dror Yinon, Karny Gigi, Oori Pen, Tal Angert, Zohar Elyoseph, Zohar Elyoseph

“…To address these challenges, we propose the SAFE-AI protocol, offering clinicians structured guidelines for responsible AI integration in therapy. …”
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Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland by Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J. Mäkinen, Pia Jaatinen

“…To shorten the delay, clinicians should be informed and alert to consider the possibility of hypoglycemia and insulinoma, when symptomatic attacks are investigated in different sectors of the healthcare system. …”
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Are changes in pain intensity related to changes in balance control in individuals with chronic non-specific low back pain? A systematic review and meta-analysis by Daniel K.Y. Zheng, Jae Q.J. Liu, Jeremy R. Chang, Jeffrey C.Y. Ng, Zhixing Zhou, Jinlong Wu, Chelsia K.C. Cheung, Frank F. Huang, Sabina M. Pinto, Dino Samartzis, Manuela L. Ferreira, Kanchana Ekanayake, Stephen Lord, Xueqiang Wang, Arnold Y.L. Wong

“…Conclusion: Depending on the type of balance assessment, pain relief following conservative interventions may slightly to moderately enhance balance control in individuals with CNSLBP. Clinicians should pay close attention to the balance control in patients with CNSLBP, particularly among older adults.…”
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MultiTax-human: an extensive and high-resolution human-related full-length 16S rRNA reference database and taxonomy by Zhiwei Bao, Bin Zhang, Jianhua Yao, Ming D. Li

“…This resource enhances the ability of researchers and clinicians to explore the roles of microorganisms in health and disease, potentially leading to improved diagnostics, treatments, and insights into various medical conditions.…”
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Clinical validation and optimization of machine learning models for early prediction of sepsis by Xi Liu, Meiyi Li, Xu Liu, Yuting Luo, Dong Yang, Hui Ouyang, Jiaoling He, Jinyu Xia, Fei Xiao, Fei Xiao, Fei Xiao

“…The SHAP method identified procalcitonin, albumin, prothrombin time, and sex as the important variables contributing to the prediction of sepsis.DiscussionThe RF model we developed showed the greatest potential for early prediction of sepsis in admitted patients, which could aid clinicians in their decision-making process. Our findings also suggested that male patients with bacterial infections and high procalcitonin levels, lower albumin levels, or prolonged prothrombin times were more likely to develop sepsis.…”
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Designing an online intervention for adults with addictive eating: a qualitative integrated knowledge translation approach by Phillipa Hay, Amanda L Baker, Clare Collins, Tracy Burrows, Mark Leary, Kirrilly Pursey, Antonio Verdejo-García, Janelle Skinner, Megan C Whatnall

“…The secondary aim is to describe our intervention in detail according to the TIDieR checklist.Design This study applies the IKT process and describes the codesign and refinement of an intervention through a series of online meetings, workshops and interviews.Participants This study included researchers, clinicians, consumers and health professionals.Primary outcome measure The primary outcome was a refined intervention for use in adults with symptoms of FA for a research trial.Results A total of six female health professionals and five consumers (n=4 female) with lived overeating experience participated in two interviews lasting 60 min each. …”
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