Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature by Elias G. Tzelepis, Elena Barengolts, Steven Garzon, Joseph Shulan, Yuval Eisenberg

“…Although this concurrence is even rarer than MSO, clinicians should routinely investigate for possible synchronous thyroid cancer in all cases of MSO and also consider aggressive postoperative treatment including thyroidectomy and radioiodine ablation therapy in cases of MSO.…”
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Biomarkers of Chronic Inflammatory State in Uremia and Cardiovascular Disease by Vincenzo Panichi, Alessia Scatena, Massimiliano Migliori, Valentina Marchetti, Sabrina Paoletti, Sara Beati

“…As a consequence of the expanding research base and availability of assays, the number of inflammatory marker tests ordered by clinicians for cardiovascular disease (CVD) risk prediction has grown rapidly and several commercial assays have become available. …”
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Outcome measures in muscular dystrophy rehabilitation: an ICF content comparison approach to the most commonly used MD scales by Mihaela Taranu, Raquel Sebio-García, José C. Milisenda, Aida Alejaldre, Xavier Pastor, Sarah Laxe

“…Conclusions: The application of ICF in this research enhances the understanding of functioning of patients with MDs and the need to develop more specific but comprehensive scales tailored to the needs of MD patients, and can guide clinicians in a assessing patients through a biopsychosocial perspective. …”
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A protocol to assess the Knee cartilage thickness in healthy older adults and analyze its correlation with patient-reported outcomes by Dias Tina Thomas, Charu Eapen, Atmananda S. Hegde, Prajwal Prabhudev Mane, Ajit R. Mahale

“…. • Helps identify KOA in early stages through USG-based cartilage thickness evaluation • Enables clinicians to target rehabilitation efforts effectively and potentially improve patients' outcomes and quality of life.…”
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Large Right Atrial Thrombus Associated with Central Venous Catheter Requiring Open Heart Surgery by Nasir Hussain, Paul Eric Shattuck, Mourad Hussein Senussi, Erwin Velasquez Kho, Mubeenkhan Mohammedabdul, Devang K. Sanghavi, Usman Mustafa, Arvind Balavenkataraman, Dragic M. Obradovic

“…It also underscores the importance of transesophageal echocardiography in the detection of thrombus and perhaps guides clinicians on which treatment modality to be used according to the size of the thrombus.…”
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Lactococcus garvieae: An Uncommon Human Pathogen Causing Infective Endocarditis in a Valve-in-Valve Transcatheter Aortic Valve Replacement by Diego H. González-Bravo, Sergio Alegre-Boschetti, Richard Silva-Cantillo, Joshua Mercado-Maldonado, Reyshley Ramos-Márquez, Gabriel Torres-Rivera, Carlos Cortés, Josue Mercado-Crespo

“…We aim to emphasize that despite not being recognized as a typical endocarditis microorganism by the Duke Criteria, the possibility of endocarditis needs to be highly entertained in patients with L. garvieae bacteremia, especially when prosthetic valves are present. Consequently, clinicians should pursue further this diagnosis with transesophageal echocardiogram and/or alternative imaging modalities (e.g., PET-CT scan and MRI) regardless of an initial negative transthoracic echocardiogram. …”
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Reproducibility of the Time of Intraocular Pressure Peaks During Water-drinking Test in Patients Treated for Open-angle Glaucoma by Carolina TN Susanna, C. Gustavo De Moraes, Paula Alhadeff, Bianca TN Susanna, Fernanda TN Susanna, Renato Antunes Schiave Germano, Remo Susanna Jr

“…In light of these findings, clinicians should avoid performing simplified versions of the WDT to evaluate IOP peaks. …”
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Adrenal Insufficiency: A Forgotten Diagnosis in HIV/AIDS Patients in Developing Countries by David D. Nassoro, Mkhoi L. Mkhoi, Issa Sabi, Alfred J. Meremo, Paul S. Lawala, Issakwisa Habakkuk Mwakyula

“…Development of simple screening algorithms may help clinicians reach the diagnosis when approaching these patients. …”
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Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives by Marina de Tommaso, Lars Arendt-Nielsen, Ruth Defrin, Miriam Kunz, Gisele Pickering, Massimiliano Valeriani

“…Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. …”
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Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis by Aleksandar Arsenijevic, C. Randall Harrell, Crissy Fellabaum, Vladislav Volarevic

“…Efficient and safe MSC-based therapy for PBC remains a challenging issue that requires continuous cooperation between clinicians, researchers, and patients.…”
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Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis by Xiao Zhang, Wenbo Gu, Di Luo, Xi Zhu, Xusheng Li, Haifeng Yuan

“…From a clinical perspective, clinicians should be vigilant about the possibility of gouty lumbar spinal stenosis with tophi in young patients presenting with back pain, hyperuricemia, and elevated inflammatory markers. …”
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Ciprofloxacin and Clozapine: A Potentially Fatal but Underappreciated Interaction by Jonathan M. Meyer, George Proctor, Michael A. Cummings, Laura J. Dardashti, Stephen M. Stahl

“…Given the potentially fatal pharmacokinetic interaction between clozapine and ciprofloxacin, clinicians are advised to monitor baseline clozapine levels prior to adding strong CYP450 1A2 inhibitors, reduce the clozapine dose by at least two-thirds if adding a 1A2 inhibitor such as ciprofloxacin, check subsequent steady state clozapine levels, and adjust the clozapine dose to maintain levels close to those obtained at baseline.…”
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Optimizing Maxillary Aesthetics of a Severe Compromised Tooth through Orthodontic Movement and Dental Implants by Rafael Scaf de Molon, Erica Dorigatti de Avila, Joni Augusto Cirelli, Mauricio de Almeida Cardoso, Leopoldino Capelozza-Filho, Luiz Antonio Borelli Barros

“…Treatment of severe compromised tooth in the maxillary anterior area still poses great challenge to the clinicians. Several treatment modalities have been proposed to restore the function and aesthetics in teeth with advanced periodontal disease. …”
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Spontaneous Heterotopic Pregnancy: Dual Case Report and Review of Literature by Annika Chadee, Shadi Rezai, Catherine Kirby, Ekaterina Chadwick, Sri Gottimukkala, Abraham Hamaoui, Vasiliy Stankovich, Theodore Hale, Hamid Gilak, Mohammad Momtaz, Harvey Sasken, Cassandra E. Henderson

“…Heterotopic pregnancy should be suspected in patients with an adnexal mass, even in the absence of risk factors. Clinicians must be alert to the fact that confirming an intrauterine pregnancy clinically or by ultrasound does not exclude the coexistence of an ectopic pregnancy. …”
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Seronegative Myasthenia Gravis, as a Rare Autoimmune Condition in Turner Syndrome by Rimah Sharief, Amir Miodovnik, Roja Motaghedi

“…At the age of 11 years due to short stature and developmental delay, a karyotype was done and revealed the mosaic isochromosome 45,X/46,X,i(X)(q10). Overall, clinicians should be aware of the vulnerability of girls with TS to autoimmunity, especially if the isochromosome 46,X,i(X)(q10) karyotype is identified. …”
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Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors by Gianluigi Zaza, Paola Tomei, Paolo Ria, Simona Granata, Luigino Boschiero, Antonio Lupo

“…Although most of the adverse effects are dose related, it is extremely important for clinicians to early recognize them in order to reduce dosage or discontinue mTOR-I treatment avoiding the onset and development of severe clinical complications.…”
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Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance by Fabrizia d'Apuzzo, Salvatore Cappabianca, Domenico Ciavarella, Angela Monsurrò, Armando Silvestrini-Biavati, Letizia Perillo

“…The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. The relevance for clinicians of evaluating the rate of some substances as valid biomarkers of periodontal effects during orthodontic movement, by means of two models of study, mice and men, is underlined.…”
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Unveiling promising sepsis biomarkers: a clinical perspective by Hong Zhang, Junpeng Zhao, Zhiping Wang, Mengxiang Huang, Zhonghua Tan, Feng Jiang, Yuhong Zhou, Linhua Wang, Mingbing Xiao

“…With the increasing consumption of antibiotics and the growing prevalence of antimicrobial resistance, clinicians are in greater need of easily accessible and effective inflammatory markers to monitor the infection process, guide treatment, and assess patient prognosis. …”
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Papillary Thyroid Carcinoma in a Branchial Cleft Cyst without a Thyroid Primary: Navigating a Diagnostic Dilemma by Douglas S. Ruhl, Mark F. Sheridan, Joseph C. Sniezek

“…Ectopic thyroid tissue within a branchial cleft cyst is an unusual phenomenon, and papillary thyroid carcinoma arising from this tissue is extremely rare. Clinicians are left with a diagnostic dilemma when presented with thyroid tissue neoplasm within a neck cyst in the absence of a thyroid primary—is this a case of metastatic disease with a missed primary or rather carcinoma arising in ectopic thyroid tissue? …”
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Metastatic Non-Small-Cell Lung Cancer in the Setting of Unilateral Agenesis of the Left Pulmonary Artery: A Case Report and Comprehensive Literature Review by John Agzarian, Jakub Kadlec, Lori Whitehead, Yaron Shargall

“…In the setting of UAPA, clinicians should have a high index of suspicion for the possibility of malignancy, and if proven, they should consider early resection following appropriate staging.…”
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