Blood Culture-Negative but Clinically Diagnosed Infective Endocarditis Complicated by Intracranial Mycotic Aneurysm, Brain Abscess, and Posterior Tibial Artery Pseudoaneurysm by Chao Jiang, Haibin Lu, Yaoqiang Guo, Li Zhu, Tianqi Luo, Wendy Ziai, Jian Wang

“…The clinical findings of this patient suggest that the confirmatory microbiology is essential for the treatment of blood culture-negative infective endocarditis. Clinicians should be aware of the detriment of blood culture-negative infective endocarditis for its multiple complications may occur in one patient. …”
Get full text

Usability Pitfalls of Diabetes mHealth Apps for the Elderly by Maša Isaković, Urban Sedlar, Mojca Volk, Janez Bešter

“…Based on a number of supervised tests, we show that the app, which was developed with the help of workshops and feedback from tech-savvy patients and clinicians, is difficult to use by elderly users. We demonstrate that with a small number of changes it is possible to raise the usability of the app in a number of categories. …”
Get full text

Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes by Jianqing Fang, Zhe Wang, Yu Shen, Xuenong Wu, Hao Fang, Xiaokui Sun, Ting Yu, Qingqing Zhang

“…Increasing evidence shows that metagenomic next-generation sequencing (mNGS) has excellent potential for the early identification of pathogens. To help clinicians better recognize Legionnaires’ disease in its early stage and to illustrate the diagnostic value of mNGS technology, we reviewed and summarized two cases of severe Legionnaires’ disease.Methods and analysisWe selected two patients with severe Legionnaires’ disease who were admitted to our department in recent years. …”
Get full text

A Case of John Cunningham Virus Induced Rhombencephalitis after Rituximab Therapy for Idiopathic Thrombocytopenic Purpura by Silpita Katragadda, Varshaa Koneru, Genevieve Devany, Aaron S. DeWitt, Vasudev H. Tati

“…The diagnosis of JC virus-related cerebellar disease can be missed, due to the subacute to chronic onset and challenges in detection. Clinicians should have a high degree of suspicion for development of these symptoms, even a few months after initiation of immune-modulatory therapy because the progression and outcomes can be disastrous.…”
Get full text

Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy by Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah

“…Amebic encephalitis is a highly lethal CNS infection, and it is important for clinicians to recognize early on the potential for infection in patients on ibrutinib therapy presenting with CNS symptoms.…”
Get full text

Current Management of Pancreatic Neuroendocrine Tumors: From Demolitive Surgery to Observation by Ilenia Bartolini, Lapo Bencini, Matteo Risaliti, Maria Novella Ringressi, Luca Moraldi, Antonio Taddei

“…The current management of PanNETs is analysed throughout the many available published guidelines and evidences with the aim of helping clinicians in the difficult decision-making process.…”
Get full text

Towards Transparent AI in Medicine: ECG-Based Arrhythmia Detection with Explainable Deep Learning by Oleksii Kovalchuk, Oleksandr Barmak, Pavlo Radiuk, Liliana Klymenko, Iurii Krak

“…Third, we implemented an interpretation method that explains CNN’s decisions using clinically relevant features, making the results understandable to clinicians. Using the MIT-BIH database, our approach achieved an accuracy of 99.43%, with F1-scores approaching 100% for major arrhythmia classes. …”
Get full text

Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…Given the above-mentioned uncertainties, clinicians may be reluctant to use nivolumab for this patient population, leading to potential denial of life-prolonging medications. …”
Get full text

Severe Erosive Pill Esophagitis Induced by Crizotinib Therapy: A Case Report and Literature Review by Patrick Jung, Kyle J. Fortinsky, Zane R. Gallinger, Piero Tartaro

“…This case illustrates the mechanism of pill esophagitis and reinforces the importance of patient education when it comes to medication administration. Clinicians may consider early imaging or investigations in patients with concerning symptomatology in the context of crizotinib therapy or other offending medications. …”
Get full text

Diagnostic Challenges of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the Hard Palate by Giacomo Setti, Stefania Caramaschi, Giuseppe Barile, Antonio d’Amati, Marta Forte, Giuseppe D’Albis, Pierantonio Bellini, Giovanna Garuti, Luisa Limongelli, Saverio Capodiferro

“…<b>Results Conclusions</b>: Although TUGSE is a benign lesion, the clinical presentation as a proliferative and ulcerative lesion may be challenging for clinicians mainly when arising in rare sites of occurrence (e.g., the hard palate).…”
Get full text

Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease by Do-Young Kwon, Byung Kyu Park, Ji Won Kim, Gwang-Moon Eom, Junghwa Hong, Seong-Beom Koh, Kun-Woo Park

“…Evaluation of motor symptoms in Parkinson’s disease (PD) is still based on clinical rating scales by clinicians. Reaction time (RT) is the time interval between a specific stimulus and the start of muscle response. …”
Get full text

Cerebrovascular Accident Secondary to Paradoxical Embolism Following Arteriovenous Graft Thrombectomy by Jolina Pamela Santos, Zaher Hamadeh, Naheed Ansari

“…Paradoxical cerebral embolism is uncommon but can occur after thrombectomy of clotted vascular access in ESRD patients. Clinicians and patients should be aware of this serious and potentially fatal complication of vascular access procedure.…”
Get full text

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree by Hamed Mortazavi, Yaser Safi, Maryam Baharvand, Somayeh Rahmani

“…In total, 29 entities were organized in the form of a decision tree in order to help clinicians establish a logical diagnosis by stepwise progression.…”
Get full text

Advanced Imaging Modalities in the Detection of Cerebral Vasospasm by Jena N. Mills, Vivek Mehta, Jonathan Russin, Arun P. Amar, Anandh Rajamohan, William J. Mack

“…Advances in imaging have provided clinicians with a multifaceted approach to assist in the detection of cerebral vasospasm and the diagnosis of delayed ischemic neurologic deficits (DIND). …”
Get full text

Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review by Erin K. Yeung, Haritha Saikumar, Jose Castaneda-Nerio, Sandra G. Adams, Mark Wong

“…In the three cases described, icatibant administration did not appear to elicit a response in intubated patients, which has been described in previous case reports. For clinicians considering icatibant in the treatment of ACEI-induced angioedema, earlier administration upon arrival to the ED or immediately upon arriving to the intensive care unit is strongly advised. …”
Get full text

Woman with Pregnancy and Lactation-Associated Osteoporosis (PLO) by Nasrin Bazgir, Elham Shafiei, Neda Hashemi, Hassan Nourmohamadi

“…Based on the patient’s clinical course, imaging finding, and exclusion of other causes of osteoporosis, the patient was diagnosed with PLO. Conclusion. Clinicians should be aware of PLO as rare complication of pregnancy. …”
Get full text

Modulating gene expression as a strategy to investigate thyroid cancer biology by Diego Claro de Mello, Joice Moraes Menezes, Antonio Tarelo Freitas de Oliveira, Marcella Maringolo Cristovão, Edna Teruko Kimura, Cesar Seigi Fuziwara

“…Exploring the possibilities for gene modulation allows the improvement of the scientific quality of the studies and the integration of clinicians and basic scientists, leading to better development of translational research.…”
Get full text

The Art and Craft of Music Therapy for Stroke Rehabilitation in a Remote North Indian Community by Sahitya Rajagopal, Alex Street, Stephen W. Philip

“…The description provides a unique insight into conditions, culture, and lifestyle in this location, and how these two clinicians were able to merge broader arts-based and holistic approaches, on a journey towards client-centered and functional neurologic music therapy exercises to help the client regain more independence. …”
Get full text

Indications for Dental Specialists for Treating Obstructive Sleep Apnea with Mandibular Advancement Devices: A Narrative Review by Antonino Lo Giudice, Salvatore La Rosa, Vincenzo Ronsivalle, Gaetano Isola, Marco Cicciù, Giulio Alessandri-Bonetti, Rosalia Leonardi

“…Such expertise is crucial in determining the appropriate treatment indications and helps clinicians establish a consolidated position within the multidisciplinary OSA team. …”
Get full text

Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan by Maryse Delehedde, Lucie Devenyns, Claude-Alain Maurage, Romain R. Vivès

“…This highlights Endocan as a multifaceted molecule with a great interest for researchers and clinicians to better understand tumor development, from the bench to the clinics. …”
Get full text