Impact of Order Set on Exocrine Pancreatic Insufficiency in Chronic Pancreatitis, Pancreatic Cancer, and Pancreatic Resection by Michael Ladna, Ishaan Madhok, Adnan Bhat, Nicole Ruiz, Jackson Brown, Jake Wilson, Peter Jiang, Robert Taylor, Mark Radetic, John George, Christopher Forsmark

“…The BPA fired if the patient was already on PERT or if an order for PERT was placed and directed the clinician to the smart set which provided PERT formulations each prefilled to the minimum therapeutic dose of 40,000 units of lipase. …”
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The Potential Clinical Utility of the Customized Large Language Model in Gastroenterology: A Pilot Study by Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee, Jonghyung Park, Eunsil Kim, Subeen Kim, Minjae Kimm, Seoung-Ho Choi

“…However, RAG capabilities by enabling real-time retrieval of external data not included in the training dataset, appear essential for managing complex, specialized content, and clinician oversight will remain crucial to ensure safe and effective use in clinical practice.…”
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Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials by Igho J Onakpoya, Elizabeth T Thomas, Joseph J Lee, Ben Goldacre, Carl J Heneghan

“…Our secondary outcomes were sleep disturbance, quality of life, Patient Global Impression of Change, Clinician Global Impression scale, anxiety and depression scores, overall discontinuations and discontinuations because of adverse events.Results We included 28 trials comprising 6087 participants. …”
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E-HEART score: A novel scoring system for undifferentiated chest pain in the emergency department by V. Yuvaraj, Sachin Sujir Nayak, S. Vimal Krishnan

“…CONCLUSION: The E-HEART score gives the clinician a quick and accurate forecast of outcomes in undifferentiated chest pain presenting to the ED. …”
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Intricacies of human–AI interaction in dynamic decision-making for precision oncology by Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov, Brian D. Gonzalez, Jamalina B. Jamaluddin, Jionghua Judy Jin, Yi Luo, Martha M. Matuszak, Randall K. Ten Haken, Alex K. Bryant, Thomas J. Dilling, Michael P. Dykstra, Jessica M. Frakes, Casey L. Liveringhouse, Sean R. Miller, Matthew N. Mills, Russell F. Palm, Samuel N. Regan, Anupam Rishi, Javier F. Torres-Roca, Hsiang-Hsuan Michael Yu, Issam El Naqa

“…Abstract AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals’ cancer progression for effective personalized care. …”
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Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression by Kasper Recourt, Joop Van Gerven, Joop Van Gerven, Nadieh Drenth, Jeroen van der Grond, Kantaro Nishigori, Nic J. Van Der Wee, Gabriël E. Jacobs, Gabriël E. Jacobs

“…We applied resting-state functional magnetic resonance imaging (rs-fMRI) to explore changes in functional brain connectivity directly at 50, 80 and 165 min (acute) and 24 h (delayed) following ketamine administration. A clinician-rated 10-item scale (MADRS) was administered at 165 min and 24 h after ketamine administration. …”
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Defining the Need for Causal Inference to Understand the Impact of Social Determinants of Health: A Primer on Behalf of the Consortium for the Holistic Assessment of Risk in Transp... by Nrupen A. Bhavsar, PhD, Rachel E. Patzer, PhD, David J. Taber, PharmD, Katie Ross-Driscoll, PhD, Rhiannon Deierhoi Reed, PhD, Juan C. Caicedo-Ramirez, MD, Elisa J. Gordon, PhD, MPH, Roland A. Matsouaka, PhD, Ursula Rogers, BS, Wendy Webster, MBA, Andrew Adams, MD, PhD, Allan D. Kirk, MD, Lisa M. McElroy, MD

“…We illustrate that biases can arise due to socioeconomic status, race/ethnicity, and incongruencies in language between the patient and clinician. Conclusions:. Progress towards an equitable transplant system requires establishing causal pathways between psychosocial risk factors, access, and outcomes. …”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The findings arising from the Delphi process provide valuable insights into the unmet needs in the management of moderate-to-severe ulcerative colitis from the clinician’s perspective, while emphasising the benefits of therapeutic individualization and suggesting areas that need additional study with the aim of optimising the treatment of patients with ulcerative colitis.…”
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Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease by K. El-Kersh, R. Bag, N. Bhatt, C. King, A. Waxman, F. Rischard, H. Kim, D. Cella, E. Shen, SD Nathan

“…Stepwise regression, Harrell’s c-index, and clinician input were used to derive 2 multivariable Cox PH models from a set of candidate variables. …”
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European ILD registry algorithm for self-assessment in interstitial lung diseases (eurILDreg ASA-ILD). by Ekaterina Krauss, Laurenz H Claas, Silke Tello, Jennifer Naumann, Sandra Wobisch, Stefan Kuhn, Raphael W Majeed, Karen Moor, Maria Molina-Molina, Oisin Byrne, Rebecca Borton, Marlies S Wijsenbeek, Nik Hirani, Carlo Vancheri, Bruno Crestani, Andreas Guenther, eurILDreg investigators

“…Pulse oximetry is integrated into the exercise testing within the application, following an automated in-app protocol developed with clinician involvement for safety and accuracy. The application will send reminders to participants to complete patient-reported outcome measures (PROMs) according to the study protocol.…”
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Addressing the “Black Hole” of Low Back Pain Care With Clinical Decision Support: User-Centered Design and Initial Usability Study by Robert S Rudin, Patricia M Herman, Robert Vining

“…ObjectivesWe designed, developed, and initially tested the usability of a LBP diagnosis and treatment decision support tool based on the available evidence for use by clinicians who treat LBP, with an initial focus on chiropractic care. …”
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Comparison of Accuracy in Expert Clinical Examination versus Magnetic Resonance Imaging and Arthroscopic Exam in Diagnosis of Meniscal Tear by Seyed Ali Hashemi, Mohammad Reza Ranjbar, Mohammad Tahami, Reza Shahriarirad, Amirhossein Erfani

“…Many clinical tests and diagnostic studies have been developed to increase the clinician’s ability to accurately diagnose disorders of the knee. …”
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External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB by B.F. Melingui, E. Leroy-Terquem, J.V. Taguebue, T.C. Eap, L. Borand, C. Khosa, R. Moh, J. Mwanga-Amumpaire, S. Beneteau, M.T. Eang, I. Manhiça, A. Mustapha, O. Marcy, E. Wobudeya, P.Y. Norval, M. Bonnet, on behalf of the TB-Speed study group

“…The performance was assessed by the proportion of discordant interpretations and the sensitivity and specificity of clinicians’ vs re-readers’ interpretations. Challenges were retrieved from country reports. …”
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Estimated inpatient malnutrition prevalence, screening tool utilization, and dietitian referral rates across hospitals during extension of phase 2 of More-2-Eat by Yingying Xu, Rachel A. Warren, Shirley M. Peters, Sonya Boudreau, Tina N. Strickland, Mari Somerville, Brenda L. MacDonald, Heather Keller, Leah E. Cahill

“…Investigation is needed to assess and overcome barriers to screening, consequences to clinician workload, and the burden of malnutrition on prognosis and hospital stay.…”
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How do palliative care doctors recognise imminently dying patients? A judgement analysis by Nicola White, Priscilla Harries, Adam JL Harris, Victoria Vickerstaff, Philip Lodge, Catherine McGowan, Ollie Minton, Christopher Tomlinson, Adrian Tookman, Fiona Reid, Patrick Stone

“…Six of the seven prognostic variables included in the hypothetical vignettes were significantly associated with clinician predictions of death. The Palliative Performance Score was identified as being the most influential in the doctors’ prognostic decision making (β=0.48, p<0.001).Conclusions This study identified six clinical signs and symptoms which influenced the judgement policies of palliative care doctors. …”
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Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach by Jonathan Dounel, Carolyn Lamorte, Heather Patton, Ponni Perumalswami, Heather McCurdy, Nicole J. Kim, Lauren A. Beste, Dawn Scott, Jessimarie Casey, Patrick Spoutz, Linda Chia, Yiwen Yao, Elliott Lowy, Sandra Gibson, Timothy R. Morgan, Shari S. Rogal

“…Methods VHA hepatology clinicians (“champions”) were invited to participate in a pilot program from June 2020 to October 2022. …”
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Developing a Prototype Machine Learning Model to Predict Quality of Life Measures in People Living With HIV by Mercadal-Orfila G, Serrano López de las Hazas J, Riera-Jaume M, Herrera-Perez S

“…Evidence-Based Medicine principles focus on using the best available scientific evidence for clinical decision-making, enhancing healthcare quality and consistency by integrating this evidence with clinician expertise and patient values. Patient-Reported Outcome Measures (PROMs) and Patient-Reported Experience Measures (PREMs) have become essential in evaluating the broader impacts of treatments, especially for chronic conditions like HIV, reflecting patient health and well-being comprehensively.Purpose: The study aims to leverage Machine Learning (ML) technologies to predict health outcomes from PROMs/PREMs data, focusing on people living with HIV.Patients and Methods: Our research utilizes a ML Random Forest Regression to analyze PROMs/PREMs data collected from over 1200 people living with HIV through the NAVETA telemedicine system.Results: The findings demonstrate the potential of ML algorithms to provide precise and consistent predictions of health outcomes, indicating high reliability and effectiveness in clinical settings. …”
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Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…We investigated barriers and facilitators to running a more efficient design.Design An RCT aiming to reduce antibiotic prescribing among children presenting with acute cough and a respiratory tract infection (RTI) with a clinician-focused intervention, embedded at the practice level. …”
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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome by Kathleen Campbell, Jeffrey L. Neul, David N. Lieberman, Elizabeth Berry-Kravis, Tim A. Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L. Carpenter, Eric D. Marsh, Jana von Hehn

“…Exploratory efficacy endpoints included change in clinician- and caregiver-rated measures of RTT features, brain activity on electroencephalography, and wearable biosensors to measure respiration, heart rate, sleep, and activity. …”
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Implementation of prehospital point-of-care ultrasound using a novel continuous feedback approach in a UK helicopter emergency medical service by Salman Naeem, Shadman Aziz, Thomas Hirst, Johannes Strobel, Jamin M. Mulvey, Ailidh Lang, Jankee Patel, Alexander Smith, Ka Jun Cheng, Michael Palmer, Jonas Schlautmann, Michael D. Christian, Daniel Nevin

“…Scans were archived in a cloud-based server and reviewed weekly by expert clinicians. They were graded in adequacy, agreement between reviewer and clinician was recorded and fed back to the clinicians allowing continuous feedback learning. …”
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