Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative cl... by James D Berry, Melissa Hagan, Jeffrey Zhang, Ying Liu, Malgorzata Ciepielewska

“…Background: IV edaravone is US FDA approved for the treatment of ALS and was shown in clinical trials to slow the rate of physical functional decline. …”

Extensive Use of Interventional Therapies Improves Survival in Unresectable or Recurrent Intrahepatic Cholangiocarcinoma by Ricarda Seidensticker, Max Seidensticker, Kathleen Doegen, Konrad Mohnike, Kerstin Schütte, Patrick Stübs, Erika Kettner, Maciej Pech, Holger Amthauer, Jens Ricke

“…This trial is registered with German Clinical Trials Registry (Deutsche Register Klinischer Studien), DRKS-ID: DRKS00006237.…”
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Intracranial germ cell tumors: advancement in genomic diagnostics and the need for novel therapeutics by Kee Kiat Yeo, Kee Kiat Yeo, Joanna Gell, Joanna Gell, Joanna Gell, Girish Dhall, Girish Dhall, Ching Lau, Ching Lau, Ching Lau

“…In this review, we will discuss the potential novel therapeutics and the clinical trials that are currently under development.…”
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Web-based interventions for pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis protocol by Ping Xu, Wei Zhang, Xiaojuan Wang, Dan Dan Chen, Pingping Guo, Yin Jin, Zhenzhen Xiang, Minna Mao, Qiong Zheng, Suwen Feng

“…Six electronic databases (PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, CINAHL and PsycINFO) will be comprehensively searched from their inception to 26 January 2022 to identify randomised controlled trials and controlled clinical trials regarding the efficacy of web-based interventions for pregnant women with GDM on glycaemic control, behavioural outcomes, cognitive and attitudinal outcomes, mental health, maternal and neonatal clinical outcomes, and medical service utilisation and costs. …”
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Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review [version 1; peer review: 2 approved] by Mamata Hebbal, Albandri Mohammed Alowid, Praveen Jodalli, Shahad Saad Alkait, Ghadeer Ghalab Almutairi, Fatimah Salim Almufarji

“…Future research, including long-term clinical trials, is warranted to elucidate optimal dosage regimens and therapeutic approaches for the routine application of SDF in managing dental caries.…”
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Reduction effect of oral pravastatin on the acute phase response to intravenous zoledronic acid: protocol for a real-world prospective, placebo-controlled trial by Qi Liu, Min Zhang, Liyuan Tao, Chunli Song, Haiyan Li, Gengyu Han, Runting Li, Dongwei Fan, Guohong Du, Dongyang Liu

“…This study will determine the preventive effect of oral pravastatin on APR in Chinese patients with OP, supporting the clinical application of ZA to alleviate concerns regarding safety and increase patient compliance.Ethics and dissemination This study protocol has been registered with ClinicalTrials.gov. This study protocol was reviewed and approved by the Peking University Third Hospital Medical Science Research Ethics Committee. …”
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Unlocking the full potential of resistance training: a comparative analysis of low- and high-intensity effects on neurotrophic growth factors and homocysteine by Chongwen Zuo, Yi Yin, Zhiyang Zheng, Ren Mu, Yuxin Liang, Shan Wang, Chaoqun Ye

“…Trial registration ClinicalTrials.gov ID: NCT06114550. Date of registration 01/30/2024.  …”
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Comparative effects of Health Qigong and closed motor exercise on the physical and mental health of female drug rehabilitation participants: a randomized controlled trial by Guang Yang, Deyu Meng, Shichun He, Meiqi Wei, Man Li, Lu Zhang, Zhendong Pan, Ziheng Wang

“…Trial registration ClinicalTrials.gov NCT06454565. The date of registration is 2024.07.11 (Retrospectively registered).…”
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Effect of immunomodulation on cardiac remodelling and outcomes in heart failure: a quantitative synthesis of the literature by Navkaranbir S. Bajaj, Kartik Gupta, Nitin Gharpure, Mike Pate, Lakshay Chopra, Rajat Kalra, Sumanth D. Prabhu

“…Methods and results PubMed, Embase®, Cochrane CENTRAL, and ClinicalTrials.gov were systematically reviewed to identify RCTs that studied the effects of immunomodulation in patients with HFrEF. …”
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Laparoscopic suture repair for perforated peptic ulcer disease: a meta-review and trial sequential analysis by S. I. Panin, T. V. Nechay, I. V. Sazhin, K. Yu. Melnikov-Makarchuk, A. V. Sazhin, A. V. Puzikova, A. N. Akinchits, A. V. Bykov

“…Meta-epidemiology, as a form of evidence synthesis, allows for the pooling of data and assessment of the diversity present in multiple and overlapping SRs.Aim of the researchThis study aimed to summarize evidence from systematic reviews of randomized controlled trials and reanalyze outcome data on laparoscopic suture repair of perforated peptic ulcers using trial sequential analysis (TSA).Materials and methodsThe Cochrane Library, PubMed, Embase, CINAHL, eLibrary, and ClinicalTrials.gov were searched before 1 June 2024. A meta-epidemiological approach and TSA were used.ResultsIn total, 16 relevant Cochrane and non-Cochrane SRs that addressed laparoscopic repair of perforated peptic ulcers (PPUs) were identified and critically appraised. …”
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Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial by Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

“…Trial RegistrationClinicalTrials.gov NCT05553210; https://clinicaltrials.gov/study/NCT05553210…”
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A human acellular dermal matrix coated with zinc oxide nanoparticles accelerates tendon repair in patients with hand flexor tendon injuries in zone 5 of the hand by Seyedeh-Sara Hashemi, Mohsen Pirmoradi, Alireza Rafati, Mehdi Kian, Ali Akbar Mohammadi, Mohamad Ali Hoghoughi

“…However, more comprehensive clinical trials are still needed.…”
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Early effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial by Fatemeh Hajtalebi, Fariba Alaei-Shahmiri, Fatemeh Golgiri, Najmeh Shahini, Hamideh Akbari, Kasra Assadian, Seyedarad Mosalamiaghili

“…Trial registration The study was registered with the Iranian Registry of Clinical Trials (IRCT) and assigned the registration number IRCT20200410047012N1 on 2022–08-07. …”
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Multicomponent intervention for schoolchildren with asthma: Pilot cluster randomized controlled trial by Marina Reznik, MD, MS, Florinda Islamovic, MD, Jill S. Halterman, MD, MPH, Cheng-Shiun Leu, PhD, Jiaqing Zhang, PhD, Philip O. Ozuah, MD, PhD

“…Analyses used generalized linear mixed models with generalized estimating equation adjusting for clustering. Clinical Trial Registration: ClinicalTrials.gov NCT01873755. …”
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An Overview of Innovative Techniques to Improve Cervical Cancer Screening by Esther R. Nijhuis, Nathalie Reesink-Peters, G. Bea A. Wisman, Hans W. Nijman, Jelmer van Zanden, Haukeline Volders, Harry Hollema, Albert J. H. Suurmeijer, Ed Schuuring, Ate G. J. van der Zee

“…In our opinion the results of large clinical trials should be awaited before proceeding to implement HPV DNA detection. …”
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Randomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia by Elena Markaryan, Matthew Dodd, Stephen Allen, Carol Howell, Angela Allen, Paul Rahden, Abdoulie Fatty, Momodou Lamin Jobarteh, Abdoulwahab Sallah, Ebrahim Jaiteh, Doreen Umoh, Fanta Bass, Radovan Hnatič

“…One serious event (death) occurred in the control arm.Conclusions A randomised, controlled trial is feasible. Further clinical trials are warranted to confirm the efficacy of polymethylsiloxane polyhydrate in acute diarrhoea and inform management guidelines.Trial registration number PACTR202302683128875.…”
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Ketogenic diet in psychiatry: application in treating depression among athletes by Paulina Kumięga, Zuzanna Kudas, Nikola Perchel, Aleksandra Litwin, Karolina Krzywicka, Paweł Nowocin, Piotr Wasiński, Natalia Dąbrowska, Martyna Koszyk, Dawid Kulczyński

“…This review synthesizes findings from recent clinical trials, meta-analyses, and case studies focusing on KD's neurological and psychological effects. …”
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In vitro evaluation of the immunomodulatory and antibacterial activities of calcitriol (1,25-dihydroxy-vitamin D3) as a potential application for aerobic vaginitis treatment - prel... by Anna Tomusiak-Plebanek, Grażyna Więcek, Edyta Golińska, Magdalena Strus

“…However, conclusions regarding the potential use of calcitriol in the treatment of AV require further confirmation in in vivo studies as well as in well-designed clinical trials.…”
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Adjuntive nicergoline therapy for severe persistent corneal epithelial defects. by Valeria Oliva-Biénzobas, Enrique O. Graue-Hernandez, Guillermo Raul Vera-Duarte, Jesus Cabral-Macías, Juan Serna-Ojeda, Victor Boullosa, Arturo Ramirez-Miranda, Vishal Jhanji, Victor L. Perez, Alejandro Navas

“…Further studies and clinical trials must be conducted to prove safety and efficacy as a treatment for persistent corneal epithelium defects in humans.…”
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Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis by Lu Chen, Lu Chen, Pengxiang Zhou, Pengxiang Zhou, Zhengqian Li, Ziyang Wu, Suodi Zhai, Suodi Zhai

“…ObjectiveTo compare the efficacy and safety of pharmaceutical interventions to prevent etomidate-induced myoclonus (EIM), providing the optimal intervention for clinical practice.MethodsPubMed, Embase, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Chinese National Knowledge Infrastructure, WanFang database, and SinoMed database were searched from the inception to sixth May 2024. …”
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