Effects of specific inspiratory muscle training combined with whole-body endurance training program on balance in COPD patients: Randomized controlled trial. by Bilel Tounsi, Amal Acheche, Thierry Lelard, Zouhair Tabka, Yassine Trabelsi, Said Ahmaidi

“…<h4>Trial registration</h4>The trial registry name: Clinical Trials; Registration number: NCT04084405; URL: https://clinicaltrials.gov/ct2/show/NCT04084405.…”
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Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease by Magdalini Kreouzi, Nikolaos Theodorakis, Maria Nikolaou, Georgios Feretzakis, Athanasios Anastasiou, Konstantinos Kalodanis, Aikaterini Sakagianni

“…Emerging therapies, such as probiotics and postbiotics, aim to restore microbial diversity, while phage therapy selectively targets pathogenic bacteria like <i>Staphylococcus aureus</i> without disrupting beneficial flora. Clinical trials have demonstrated significant reductions in inflammatory lesions and improved quality-of-life metrics in patients receiving these microbiota-targeted treatments. …”
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Comparison of Efficacy and Safety of Lispro and Aspart Evaluated by Continuous Glucose Monitoring System in Patients with Newly Diagnosed Type 2 Diabetes by Bing-li Liu, Guo-ping Yin, Feng-fei Li, Yun Hu, Jin-dan Wu, Mao-yuan Chen, Lei Ye, Xiao-fei Su, Jian-hua Ma

“…This study was registered with ClinicalTrials.gov, number ChiCTR-IPR-17010338.…”
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Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study by Jennifer Moore, Alicia Aylott, Wen-Hung Chen, Jerzy Daniluk, Ian A. Hawes, Sergio Parra, Prosenjit Sarkar, Yasmin Sanchez-Pearson, Megan Turner, Amanda Peppercorn, Andrew Skingsley

“…To our knowledge, these are the first data to show that a >2 mL mAb injection into each deltoid muscle is well tolerated.Trial registration ClinicalTrials.gov identifier, NCT05280717…”
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Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial by Chuan-Ching Tsai, Jin Yong Kim, Qiyuan Chen, Brigid Rowell, X Jessie Yang, Raed Kontar, Megan Whitaker, Corey Lester

“…Trial RegistrationClinicalTrials.gov NCT06795477; https://clinicaltrials.gov/study/NCT06795477…”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…We meticulously examine the preclinical evidence and ongoing clinical trials, throwing light on the promising prospects of LDRT as a complementary therapy in melanoma treatment. …”
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Dose‐exposure‐response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin‐angiotensin‐aldosterone system in healthy dogs by Elizabeth Manson, Jessica L. Ward, Maria Merodio, Emilie Guillot, Thomas Blondel, Karin Allenspach, Oliver Domenig, Jonathan P. Mochel

“…These results could help inform clinical trials in dogs with heart disease.…”
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Does the transition from face-to-face to face-to-screen improve oral health literacy? A non-inferiority randomized controlled trial by Negar Ebrahimi, Katayoun Sargeran, Reza Yazdani, Ahmad Reza Shamshiri

“…Trial registration The trial protocol was registered in the Iranian Registry of Clinical Trials (IRCT) on 08–02-2022, (IRCT20220106053643N1|| http://www.irct.ir/ ).…”
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Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature by Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo, Matteo Bordoni, Eveljn Scarian, Camilla Viola, Veronica Bettoni, Giuseppe Fiamingo, Danilo Tornabene, Lucia Scanu, Orietta Pansarasa, Luca Diamanti, Stella Gagliardi

“…The possibility to cluster ALS patients based on their molecular signature pave the way for future personalized clinical trials and early diagnosis.…”
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The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review by Adam Sobiński, Matylda Czerwonka, Zuzanna Kościuszko, Katarzyna Kurza, Silvia Ciraolo, Julianna Podolec, Agnieszka Kulczycka-Rowicka, Katarzyna Lesiczka-Fedoryj, Joanna Wojda, Anna Walczak

“…Research Materials and Methods: The study is based on clinical trials, meta-analyses, and systematic reviews from the past decade. …”
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Effectiveness of the self-fatigue assessment in guiding early postoperative ambulation in gynaecological oncology patients: study protocol for a randomised controlled trial by Bo Chen, Xu Wang, Hong He, Xiaojie Huang, Qian Du, Shaoyong Xu, Xiaomin Qin, Tongting Kang

“…Secondary outcome measures are the time to first bowel movement, the incidence of moderate to severe bloating, the incidence of bowel obstruction or venous thromboembolism, the incidence of adverse events (nausea, vomiting, dizziness), patient satisfaction, sleep quality scores, patient compliance with activities, hospital costs and days in hospital.Ethics and dissemination This study was approved by the Independent Ethics Committee of Xiangyang Central Hospital affiliated with Hubei University of Arts and Sciences and registered with the China Clinical Trials Registry in May 2021. The results of the trial will be disseminated through open access peer-reviewed journals and abstracts will be submitted to relevant national and international conferences.Trial registration number CTR2100046035.…”
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Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A... by Ci Song, Peter Kunovszki, Amélie Beaudet

“…**Background:** Agents targeting the prostacyclin (PGI~2~) pathway are important in managing pulmonary arterial hypertension (PAH). No head-to-head clinical trials have compared outcomes between the 3 different PGI~2~-pathway drugs most commonly available in countries with advanced healthcare: oral selexipag, inhaled iloprost, and parenteral (subcutaneous or intravenous) treprostinil. …”
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Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…ObjectiveThis meta-analysis evaluated pembrolizumab monotherapy and combination therapy’s efficacy and safety in recurrent or advanced endometrial cancer (EC).MethodsWe utilized PubMed, Embase, Cochrane Library, and Web of Science databases to identify clinical trials that were used to search literature from July 2013 to July 2023 to evaluate the efficacy and safety of pembrolizumab in patients with advanced EC. …”
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Evaluating the effectiveness of a mental health literacy module - A randomized controlled trial among school teachers by Vidya Prabhu, Lena Ashok, Veena Ganesh Kamath, Amitha Puranik, Sebastian Padickaparambil, Nikitha Sibil Rebello, Praveen Arhanthabailu, Varalakshmi Chandrasekaran

“…Conclusion: The present study found that the intervention module was effective in enhancing the MHL of teachers across all the domains, which may facilitate early intervention among adolescents at the school level.The trial has been registered with the Clinical Trials Registry of India prospectively. (CTRI/2017/11/010633)…”
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Planned, ongoing and completed tuberculosis treatment trials in Brazil, Russia, India, China and South Africa: a 2019 cross-sectional descriptive analysis by Tamara Kredo, Duduzile Edith Ndwandwe, Lindi Mathebula, Lovemore Mapahla, Dilyara Nurkhametova, Liliya Eugenevna Ziganshina, Mikateko Mazinu, Esme Jordan

“…We included only registered clinical trials conducted wholly in BRICS countries or with at least one recruitment centre in one of the BRICS countries that were investigating TB treatment.Results The search of the WHO-ICTRP yielded 408 trials and additional 32 trials were identified from the Russian registry. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Also, though inflammation is as a result of adverse HF in patients, but despite the fact that broad immunosuppression therapeutic target has been used in various clinical trials, no positive results have showed up, but rather, the focus on proinflammatory cytokines has proved more benefits in patients with HF. …”
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Real-World Clinical Outcomes and Treatment Patterns Among Black and Non-Black Patients With Prostate Cancer Initiated on Apalutamide in a Urology Setting by Benjamin H. Lowentritt, Carmine Rossi, Erik Muser, Frederic Kinkead, Bronwyn Moore, Patrick Lefebvre, Dominic Pilon, Shawn Du

“…**Discussion:** While clinical trials have demonstrated the efficacy and safety of apalutamide, there is limited real-world data describing treatment persistence and clinical outcomes among patients with mCSPC and nmCRPC who initiated apalutamide. …”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

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Therapeutic Effects of Medicinal Plants on Cutaneous Wound Healing in Humans: A Systematic Review by Tarcisio Vitor Augusto Lordani, Celia Eliane de Lara, Fabiana Borges Padilha Ferreira, Mariana de Souza Terron Monich, Claudinei Mesquita da Silva, Claudia Regina Felicetti Lordani, Fernanda Giacomini Bueno, Jorge Juarez Vieira Teixeira, Maria Valdrinez Campana Lonardoni

“…For this systematic review, we searched the PubMed, Scopus, and Web of Science databases to identify clinical trials that were published from 1997 to 2017. …”
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Neuromuscular monitoring and incidence of postoperative residual neuromuscular blockade: a prospective observational study by Alessandra Piersanti, Rossella Garra, Fabio Sbaraglia, Miryam Del Vicario, Rosa Lamacchia, Marco Rossi

“…Trial registration The study was registered at ClinicalTrials.gov ( NCT06193213 , date of registration: 05/01/2024).…”
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