Delayed-release prednisone improves fatigue and health-related quality of life: findings from the CAPRA-2 double-blind randomised study in rheumatoid arthritis by Frank Buttgereit, Rieke Alten, Amy Grahn, Robert J Holt, Patricia Rice

“…Compared with placebo/DMARD, DR prednisone/DMARD showed a significantly greater improvement in SF-36 vitality score (5.6, p=0.001), physical component of SF-36 (2.3, p=0.0003) and general score with FACT-G (2.6, p=0.0233).Conclusions DR prednisone in addition to a DMARD significantly improves fatigue and other aspects of health-related quality of life in patients with symptomatic RA compared with DMARD treatment alone.Trial registration number ClinicalTrials.gov NCT00650078.…”
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Patient-reported outcomes for diabetes and hypertension care in low- and middle-income countries: A scoping review. by Sarah Masyuko, Carrie J Ngongo, Carole Smith, Rachel Nugent

“…<h4>Methods</h4>We searched PubMed, EMBASE, and ClinicalTrials.gov for English-language studies published between August 2009 and August 2019 that measured at least one PROM related to diabetes or hypertension in LMICs. …”
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The effect of anesthesia on postoperative cognitive dysfunction in adults undergoing cataract surgery: a systematic review by Elaheh Foroughi, Etrusca Brogi, Francesco Forfori, Seyyed Taghi Hashemi

“…Results We included 9 clinical trials with 1014 participants, which analyzed the incidence of POCD after anesthetic interventions. …”
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Effectiveness of Space Maintainers in Pediatric Patients: A Systematic Review and Meta-Analysis by MDolores Casaña-Ruiz, Juan Ignacio Aura-Tormos, Laura Marques-Martinez, Esther Garcia-Miralles, Marcelino Perez-Bermejo

“…<b>Results:</b> The total number of patients treated in the studies was 479, with four observational studies and seven randomized clinical trials. Fixed space maintainers, such as band and loop (BL) or lingual arch (LA), are preferred due to their long-term stability and lower risk of loss. …”
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Ascending aortic replacement versus aortic root replacement in patients with type A aortic dissection involving the aortic root by Fausto Biancari, Giuseppe Gatti, Timo Mäkikallio, Tatu Juvonen, Giovanni Mariscalco, Zein El-Dean, Matteo Pettinari, Javier Rodriguez Lega, Andrea Perrotti, Francesco Onorati, Konrad Wisniewki, Till Demal, Petr Kacer, Dario Di Perna, Igor Vendramin, Mauro Rinaldi, Luisa Ferrante, Eduard Quintana, Joscha Buech, Caroline Radner, Antonio Fiore, Angelo M. Dell’Aquila, Paola D’Errigo, Stefano Rosato, Gianluca Polvani, Sven Peterss

“…Trial registration: ClinicalTrials.gov: NCT04831073 ( https://clinicaltrials.gov/study/NCT04831073 ).…”
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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth, Iceland Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…Methods: A total of seven electronic databases were screened for an article on trypanocide resistance in AATr by using keywords on preclinical and clinical trials with the number of animals with treatment relapse, days taken to relapse, and resistant gene markers using the PRISMA checklist. …”
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Local Anesthesia Versus Saddle Block for Open Hemorrhoidectomy: Cost-Analysis From a Randomized, Double Blind Controlled Trial. by Sikakulya, Franck Katembo, Ssebuufu, Robinson, Okedi, Xaviour Francis, Baluku, Moris, Lule, Herman, Kiyaka, Sonye Magugu, Muhumuza, Joshua, Selamo, Fabrice Molen, Bassara, Godefroy Nyenke, Waziri, Musa Abbas, Kithinji, Stephen Mbae, Mugisho, Munyerenkana Leocadie, Byamungu, Pahari Kagenderezo, Munihire, Jeannot Baanitse, Vahwere, Bienfait Mumbere, Kiswezi, Ahmed, Kyamanywa, Patrick

“…Trial registration Pan African Clinical Trials Registry, PACTR202110667430356. Registered on 08/10/2021.…”
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Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

“…When used in real-world settings, tisagenlecleucel has shown similar efficacy and improved safety compared with previous clinical trials. However, long-term data on real-world outcomes are lacking.Methods Clinical data from a cohort of patients treated with tisagenlecleucel in a real-world setting were captured in the Center for International Blood and Marrow Transplant Research registry. …”
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Deep Brain Stimulation in the treatment of disorders of consciousness by Joanna Olszak, Karolina Zalewa, Lidia Bartoszek, Dominika Orłowska, Wojciech Kapłan, Mikołaj Poleszczuk, Karol Poleszczuk, Alicja Milewska, Anna Czuba, Marta Kaus

“…While the results are promising, more controlled and larger-scale clinical trials areneeded to better understand the long-term efficacy, optimal timing, and appropriate patient selection.  …”
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Survival and risk factors for metastatic colorectal cancer patients with a history of prior malignancy by Yiwen Qiu, Nida Cao, Dan Meng, Jian Yuan, Yingjie Zhu

“…Therefore, we advocate for active standardized treatment for these patients and propose expanding the range of prior malignancies included in clinical trials based on publication timelines, primary tumour locations, and genetic testing results. …”
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The Application of Incretin-Based Pharmacotherapy in the Contemporary Management of Type 2 Diabetes: A Review of the Literature by Jakub Waszczyński, Wojciech Kulej, Wiktor Biesiada, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna Mariia Chernysh, Aleksandra Dusińska, Kamila Fuczyło, Karolina Stankević

“…Materials and Methods Data was sourced from recent clinical trials and literature (post-2020) from PubMed, Google Scholar, Lancet, New England Journal of Medicine, Nature, American Diabetes Association, Research Gate. …”
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Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review by Simone Schiavo, Julian DeBacker, Carine Djaiani, Anuj Bhatia, Marina Englesakis, Rita Katznelson

“…This narrative review was conducted after searching the following databases (Medline, Embase, Cochrane, PsycINFO, the Web of Science, Scopus, ClinicalTrials. gov, WHO ICTRP, and ProQuest Digital Dissertation) from January 1946 to March 2020. …”
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Outcomes of combined liver-lung transplant in pediatric patients with cystic fibrosis: An ISHLT transplant registry study by Renita Wilson, BS, J. Asher Jenkins, MD, Juan Maria Farina, MD, Blake Langlais, MS, Bashar Aqel, MD, Ashraf Omar, MD, Jonathan D’Cunha, MD PhD, Pedro Reck dos Santos, MD PhD

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Management of tuberculosis risk, screening and preventive therapy in patients with chronic autoimmune arthritis undergoing biotechnological and targeted immunosuppressive agents by Andrea Picchianti-Diamanti, Alessandra Aiello, Chiara De Lorenzo, Giovanni Battista Migliori, Delia Goletti

“…In this review, we evaluate the current evidence from randomized clinical trials, long-term extension studies, and real-life studies regarding the risk of TB in patients with RA, PsA, and AS treated with bDMARDs and tsDMARDs. …”
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Cardiovascular Therapy Benefits of Novel Antidiabetic Drugs in Patients With Type 2 Diabetes Mellitus Complicated With Cardiovascular Disease: A Network Meta‐Analysis by Saixian Shi, Xiaofeng Li, Ye Chen, Jiahao Li, Yan Dai

“…Methods Conduct a comprehensive search of all relevant literature from PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials.gov from their establishment until December 13, 2023, and select randomized controlled trials (RCTs) that meet the pre‐established inclusion and exclusion criteria. …”
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Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. by Dimuthu Muthukuda, Chamini Kanatiwela de Silva, Saumiyah Ajanthan, Namal Wijesinghe, Anuradha Dahanayaka, Arunasalam Pathmeswaran

“…<h4>Trials registration</h4>The trial was registered with the Sri Lanka Clinical Trials Registry: SLCTR/2021/011.…”
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Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open‐Label, Noninferiority Study (PARASOL... by Koichi Yamamoto, Daisuke Yarimizu, Ayano Shimanishi, Shunsuke Eguchi, Kazuma Iekushi, Yoichi Takami, Yoichi Nozato, Kazuomi Kario, Hiromi Rakugi

“…ABSTRACT Sacubitril/valsartan, an angiotensin receptor‐neprilysin inhibitor, has demonstrated a superior blood pressure‐lowering effect compared with renin‐angiotensin system inhibitors in several clinical trials. However, there has been no available evidence on the comparison between sacubitril/valsartan and calcium channel blockers (CCBs), a well‐established class of antihypertensive drugs. …”
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Prenatal labor analgesia education program on outcomes for primiparas: study protocol for a randomized controlled trial by Jiali Wu, Jing Chen, Weiwen Zhang, Jiangtao OuYang, Jia Li, Xujuan Zheng

“…Trial Registration Registered at the Chinese Clinical Trials.gov on January 11th, 2024. Trial Registration Number: ChiCTR2400079767.…”
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Real-time seizure detection in paediatric intensive care patients: the RESET child brain protocol by Kristen Gibbons, Andreas Schibler, Anthony Slater, Louise Sparkes, Michaela Waak, Stephen Malone, Jane Harnischfeger, Sandra Gurr

“…Results will be made available to the funders, critical care survivors and their caregivers, the relevant societies, and other researchers.Trial registration number Australian New Zealand Clinical Trials Registry (ANZCTR) 12621001471875.…”
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Effect of Nebivolol and Olmesartan on 24-Hour Brachial and Aortic Blood Pressure in the Acute Stage of Ischemic Stroke by Eleni Georgianou, Panagiotis I. Georgianos, Konstantinos Petidis, Konstantinos Markakis, Ioanna Zografou, Asterios Karagiannis

“…This study suggests that during the acute phase of ischemic stroke, nebivolol is equally effective with olmesartan in improving 24-hour aortic pressure and arterial stiffness indices. ClinicalTrials.gov identifier number: NCT03655964.…”
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