Comparative efficacy and safety of neoadjuvant radiotherapy for patients with borderline resectable, and locally advanced pancreatic ductal adenocarcinoma: a systematic review and... by Xin Wang, Dan Cao, Qingfeng Wang, Qiancheng Hu, Wanrui Lv

“…Electronic searching by titles using neoadjuvant treatments for PDAC will be performed in the annual meetings of European Society of Medical Oncology and American Society of Clinical Oncology (2018–2020). ClinicalTrials.gov will also be searched for grey literature. …”
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Economic evaluation of tranexamic acid for the treatment of acute gastrointestinal bleeding: a cost-effectiveness analysis using data from the HALT-IT randomised controlled trial by Ian Roberts, Vipul Jairath, Alec Miners, Jack Williams, Haleema Shakur-Still, Nuha Bazeer

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Effects of prenatal exercise interventions on maternal body composition: A secondary analysis of the FitMum randomized controlled trial. by Caroline Borup Roland, Parisa Seyedhosseini, Signe de Place Knudsen, Anne Dsane Jessen, Ida Karoline Bach Jensen, Jane M Bendix, Gerrit van Hall, Stig Molsted, Saud Abdulaziz Alomairah, Ellen Løkkegaard, Bente Stallknecht, Tine D Clausen

“…Trial registration: ClinicalTrials.gov; NCT03679130; 20/09/2018.…”
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Complementary and Alternative Medicine in Treating Children\'s Diseases in Iran: A Systematic Review by Pouran Varvani Farahani, Candan Ozturk

“…A search was done on published clinical trials, qualitative, observational, and quasi-experimental studies from January 1, 2020, to January 3, 2023, in nine scientific research databases, namely PubMed, Science Direct, Wiley Online, Scopus, SciELO, LILACS, Google Scholar, Magiran, and SID. …”
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Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice by Debajit Bhowmick, Kaushik Bhar, Sanjaya K. Mallick, Subhadip Das, Nabanita Chatterjee, Tuhin Subhra Sarkar, Rajarshi Chakrabarti, Krishna Das Saha, Anirban Siddhanta

“…Despite a huge number of clinical trials, any success to find a chemotherapeutic agent that can effectively destroy melanoma is yet to be achieved. …”
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YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…YAP1 is a novel negative biomarker of ICIs treatment in EGFR-mutant NSCLC population. Clinical Trials. This trial is registered with NCT03513666.…”
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Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Anal... by Xiaojie Yuan, Jiping Wang, Shuo Yang, Mei Gao, Lingxia Cao, Xumei Li, Dongxu Hong, Suyan Tian, Chenglin Sun

“…This study systematically reviewed the relevant clinical trials to evaluate the effects of intermittent fasting diet on glucose and lipid metabolism and insulin sensitivity in patients with metabolic syndrome. …”
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Impact of Preoperative Daytime Sleepiness and Insomnia on Therapy Adherence and Neurostimulation Amplitude in Unilateral Hypoglossal Nerve Stimulation by Pordzik J, Ludwig K, Ruckes C, Gouveris H

“…Johannes Pordzik,1,* Katharina Ludwig,1,* Christian Ruckes,2 Haralampos Gouveris1 1Department of Otolaryngology/Head and Neck Surgery & Sleep Medicine Center, University Medical Center Mainz, Mainz, 55131, Germany; 2Interdisciplinary Center for Clinical Trials, University Medical Center Mainz, Mainz, 55131, Germany*These authors contributed equally to this workCorrespondence: Haralampos Gouveris, Email haralampos.gouveris@unimedizin-mainz.deIntroduction: Average adherence to hypoglossal nerve stimulation (HGNS) therapy is more than 5 h/night. …”
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Statistical Fragility of Findings From Randomized Phase 3 Trials in Pediatric Oncology by Hannah E. Olsen, Pei‐Chi Kao, Caleb Richmond, David S. Shulman, Wendy B. London, Steven G. DuBois

“…ABSTRACT Purpose The fragility index (FI) is an adjunctive metric to facilitate the interpretation of p‐values in clinical trials. The FI has not been studied in phase 3 trials in pediatric oncology. …”
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Role of artificial intelligence in imaging and endoscopy for the diagnosis, monitoring and prognostication of inflammatory bowel disease: a scoping review protocol by Mallory Chavannes, Bram Verstockt, Mariangela Allocca, David T Rubin, Kerri Novak, Lynn Kysh, Noa Krugliak Cleveland, Michael Todd Dolinger, Tom S Robbins, Shintaro Sagami

“…We will include both observational studies and clinical trials. Study characteristics will be extracted using a data extraction form. …”
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Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer by Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos, Wei Bo Li

“…Similar tendencies were observed in clinical trials of other authors. The highest absorbed dose coefficients were found for bone endosteum, liver and red marrow, followed by kidneys and colon. …”
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Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current Development by Whi-An Kwon, Ho Kyung Seo, Geehyun Song, Min-Kyung Lee, Weon Seo Park

“…For advanced-stage diseases, clinical trial participation is strongly recommended to address the lack of robust evidence. …”
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Preliminary Evidence for Feasibility, Use, and Acceptability of Individualized Texting for Adherence Building for Antiretroviral Adherence and Substance Use Assessment among HIV-In... by David J. Moore, Jessica L. Montoya, Kaitlin Blackstone, Alexandra Rooney, Ben Gouaux, Shereen Georges, Colin A. Depp, J. Hampton Atkinson, The TMARC Group

“…This trial is registered with ClinicalTrials.gov NCT01317277.…”
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The comparison of biodistribution of glutathione PEGylated nanoliposomal doxorubicin formulations prepared by pre‐insertion and post‐insertion methods for brain delivery in normal... by Amin Mehrabian, Saba Dadpour, Mohammad Mashreghi, Javad Zarqi, Anis Askarizadeh, Ali Badiee, Leila Arabi, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari

“…Here, the 5% pre‐inserted PEG2000‐GSH PEGylated liposomal doxorubicin was conducted according to 2B3‐101 being tested in clinical trials. In addition, PEGylated nanoliposomal doxorubicin connected to the spacer‐GSH targeting ligand (GSGGCE) and the PEG3400 was conducted using post‐insertion method. …”
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Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies by Aekkhaluck Intharuksa, Warunya Arunotayanun, Mingkwan Na Takuathung, Yaowatat Boongla, Siripat Chaichit, Suthiwat Khamnuan, Anchalee Prasansuklab

“…However, further studies, including in vivo and clinical trials, are essential to evaluate the safety, optimal dosages, and long-term effectiveness of herbal treatments for patients under chronic PM exposure.…”
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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…Tetracyclines have demonstrated significant immunomodulatory effects, including the inhibition of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), which are critical in RA pathology. Clinical trials, including double-blind, placebo-controlled studies, have shown efficacy in reducing RA symptoms, particularly in early and refractory cases. …”
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Investigations of Long-Acting Formulations in Children, Adolescents, and Pregnant Women: A Systematic Review by Lynn Bertagnolli, Zhengyi Deng, Melissa Davy-Rothwell, Elaine J. Abrams, Charles Flexner, Ethel D. Weld

“…Special populations, specifically infants, children, young people, and pregnant and postpartum women, could greatly benefit from access to these strategies but are often excluded from clinical trials. We conducted a systematic review of all clinical studies involving the use of a long-acting intramuscular injection or implant in infants, children, young people, and pregnant and postpartum people. …”
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Study on the Analgesic Efficacy of Femoral Nerve Block for Post-Hip Arthroscopy Pain by Mengwen Xue, Li Zhang, Ruiping Bai, Rui An, Jiarui Li, Xin Shen

“…Trial Registration Chinese Clinical Trials Registry (ChiCTR2400091579).…”
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Malapposed Struts with Cre8, Biomatrix, and Xience Stents Assessed with OCT Immediately after Implantation and at 6-Month Follow-Up: Can the Different Biomechanical Characteristics... by Cristina Giglioli, Emanuele Cecchi, Chiara Formentini, Marco Chiostri, Niccolò Marchionni, Salvatore Mario Romano

“…This trial is registered with Clinical Trials.gov Identifier: NCT02850497.…”
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Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions by Alessandra Bitto, Francesco Squadrito, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Anna Mecchio, Federica Galfo, Domenica Altavilla

“…Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models. Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen. …”
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