Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Gastric emptying and insulin secretion are also affected by GLP-1 RAs. Clinical trials consistently demonstrate significant weight loss, positive action on cardiovascular risk and better glycemic control. …”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…Trial registration ClinicalTrials.gov NCT03878589. Registered on March 18th, 2019.…”
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Is There Gender Disparity in Vascular Access for Hemodialysis with New Percutaneous Systems? A Systematic Review by Hugo Vergara-Pérez, Alejandro Pérez Alba, Pablo Baliño, Asunción Rius Peris, Javier Reque

“…Material and Methods: A systematic review of the literature was conducted by searching PubMed and Google Scholar using the following terms: “percutaneous arteriovenous fistula”, “endovascular arteriovenous fistula”, and “hemodialysis”. All clinical trials, comparative studies, and descriptive studies involving patients who underwent a pAVF were included. …”
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Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study by Josefine Schulze, Dagmar Lühmann, Jonas Nagel, Cornelia Regner, Christine Zelenak, Kristina Bersch, Christoph Herrmann-Lingen, Matthew M. Burg, Birgit Herbeck-Belnap

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Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect by Swetha Reddi, Liliia Senyshyn, Maryam Ebadi, Daniel Podlesny, Samuel S. Minot, Ted Gooley, Amanda J. Kabage, Geoffrey R. Hill, Stephanie J. Lee, Alexander Khoruts, Armin Rashidi

“…FMT is a holistic microbiota restoration approach that can be performed as a precision therapeutic. ClinicalTrials.gov identifier NCT06026371…”
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Real-World Evidence Evaluation on the Lipid Profile, Therapeutic Goals, and Safety of the Fixed-Dose Combination of Rosuvastatin/Ezetimibe (Trezete®) in Dyslipidemia Patients by Joel Rodríguez-Saldaña, Francisco Padilla-Padilla, Ernesto G. Cardona-Muñoz, Yulia Romero-Antonio, María Marcela Arguedas-Núñez, José G. Sander-Padilla, Alberto Martínez-Muñoz, Laura A. Lugo-Sánchez, Ileana C. Rodríguez-Vazquez, Jorge González-Canudas

“…Fixed-dose combination therapy has shown to be as safe as monotherapy treatment. ClinicalTrials.gov Identifier: NCT04862962.…”
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The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke by Emily R. Rosario, Stephanie E. Kaplan, Sepehr Khonsari, Garrett Vazquez, Niyant Solanki, Melanie Lane, Hiriam Brownell, Sheila S. Rosenberg

“…While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits. …”
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Protocol for evaluating the effects of integrating music with taekwondo training in children with autism spectrum disorder: A randomized controlled trial. by Clare C W Yu, Kam M Mok, Emma Mak, Chun T Au, Dorothy F Y Chan, Stanley Wu, Raymond C K Chung, Matthew C K Ip, Simpson W L Wong

“…ClinicalTrials.gov Identifier: NCT06277778. Registered on 15 February 2024.…”
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Protective Effect of Melatonin on Acute Pancreatitis by Jolanta Jaworek, Joanna Szklarczyk, Andrzej K. Jaworek, Katarzyna Nawrot-Porąbka, Anna Leja-Szpak, Joanna Bonior, Michalina Kot

“…The beneficial effects of melatonin shown in experimental studies suggest that melatonin ought to be employed in the clinical trials as a supportive therapy in acute pancreatitis and could be used in people at high risk for acute pancreatitis to prevent the development of pancreatic inflammation.…”
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The PainSMART project: Protocol for a research program on effectiveness, mechanisms of effect and patient-practitioner experiences of the PainSMART-strategy as an adjunct to usual... by Richard Thompson, Maria Fors, Ann-Sofi Kammerlind, Pia Tingström, Allan Abbott, Kajsa Johansson

“…<h4>Methods</h4>The PainSMART-project is a research program with a collective suite of studies utilising mixed methods, centred around a randomised controlled trial (ClinicalTrials.gov NCT06187428). Subjects: Adults (18 years or older) seeking primary care for MSKP who are triaged and booked for an initial physiotherapy consultation at five primary care physiotherapy departments within the Swedish public healthcare regions of Östergötland and Jönköping. …”
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Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review by Hasan Subhi, Nashwah Subhi, Salah Alhaidary, Mahmood S. Azeez, Abedelmalek Kalefh Tabnjh, Abedelmalek Kalefh Tabnjh, Abedelmalek Kalefh Tabnjh

“…However, randomized clinical trials with well-designed and robust methodologies are required in order to provide information about its clinical behaviour.…”
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How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…The knowledge of the main adverse events described in the pilot clinical trials can avoid unnecessary withdrawal of regorafenib. …”
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Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 M^pro by Jiayi Ren, Zhengfu Zhang, Yi Xia, Daqun Zhao, Dingqin Li, Shujun Zhang

“…This review summarizes the recent research progress on the novel coronavirus’s main proteases, including the pivotal role of M^pro in the virus’s life cycle, the structure and catalytic mechanism of M^pro, the self-maturation mechanism of M^pro, the role of M^pro in virus immune escape, the current methods of developing antiviral drugs targeting M^pro, and the key drugs that have successfully entered clinical trials. The aim is to provide researchers involved in the development of antiviral drugs targeting M^pro with systematic and comprehensive information.…”
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Effect and Safety of Pioglitazone-Metformin Tablets in the Treatment of Newly Diagnosed Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease in Shaanxi Province: A Random... by Fu Jianfang, Xiao Wanxia, Gao Xiling, Xu Jing, Yang Wenjuan, Liu Jianrong, He Qingzhen, Ma Kaiyan, Lian Jingxuan, Chen Taixiong, Xu Qian, Li Mengying, Ming Jie, Ji Qiuhe

“…This trial is registered with ClinicalTrials.gov NCT03796975.…”
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Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review by Jakub Fiegler-Rudol, Natalia Zięba, Radosław Turski, Maciej Misiołek, Rafał Wiench

“…Inclusion criteria encompassed preclinical in vitro and in vivo studies and clinical trials focusing on HY-PDT for head and neck malignancies and its subtypes. …”
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Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy by Li X, Yu B, Li H, Liu Z, Fu X, Jiao P, Wang L

“…Additionally, ethanol, doxycycline, tigecycline, and minocycline lock solutions can be effective in treating fungal infections.Conclusion: More comprehensive investigations and additional rigorous clinical trials are essential to thoroughly understand the safety and efficacy of ALT. …”
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Futility in TAVI: A scoping review of definitions, predictive criteria, and medical predictive models. by Charlie Ferry, Jade Fiery-Fraillon, Mario Togni, Stephane Cook

“…<h4>Information sources</h4>We identified 129 studies from five key sources: CINAHL, PUBMED, the Cochrane Library, ClinicalTrials.gov, and EMBASE. The literature search was conducted in two rounds-first in February 2024 and again in October 2024-using no restrictions on the year of publication or the language of the studies. …”
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Cost-Minimization Analysis for Subcutaneous Daratumumab in the Treatment of Newly Diagnosed Multiple Myeloma in Three Gulf Countries by Anas Hamad, Shereen Elazzazy, Ruba Y. Taha, Hani Osman, Sana Alblooshi, Islam Elkonaissi, Mustaqeem A. Siddiqui, Khalil Al-Farsi, Mohammed Al Lamki, Sali Emara, Gihan H. Elsisi

“…The safety and efficacy of daratumumab regimens in the treatment of newly diagnosed MM (NDMM) is demonstrated in clinical trials. **Objective:** To assess the financial effects of the adoption of subcutaneous daratumumab (dara-SC) rather than intravenous daratumumab (dara-IV) for the treatment of NDMM in three Gulf countries (Qatar, Oman and the United Arab Emirates; UAE), a cost-minimization model was constructed. …”
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CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 Cell/μL: The DART Trial STI Substudy by Jennifer Serwanga, Susan Mugaba, Auma Betty, Edward Pimego, Sarah Walker, Paula Munderi, Charles Gilks, Frances Gotch, Heiner Grosskurth, Pontiano Kaleebu

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A Pooled Analysis of Growth and Tolerance of Infants Exclusively Fed Partially Hydrolyzed Whey or Intact Protein-Based Infant Formulas by Laura A. Czerkies, Brian D. Kineman, Sarah S. Cohen, Heidi Reichert, Ryan S. Carvalho

“…A pooled analysis of seven clinical trials was conducted to examine growth, stool consistency, and stool frequency of infants fed an intact cow’s milk-based formula (CMF) or a partially hydrolyzed whey formula (PHF-W) from a single manufacturer. …”
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