Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review by Natasha Cox, Christian D. Mallen, Ian C. Scott

“…These showed moderate- to high-quality evidence from clinical trials in more contemporary time-periods (mainly 1990s/2000s for synthetic DMARDs and post-2000 for biological/targeted synthetic DMARDs) that, in patients with active RA, short-term glucocorticoids and synthetic, biologic, and targeted synthetic DMARDs have efficacy at reducing pain intensity relative to placebo. …”
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Effectiveness of breathing exercises on urinary symptoms, muscle activity, and strength in women with multiple sclerosis and urinary incontinence—a study protocol for a randomized... by Atieh Nazem, Shabnam ShahAli, Mehdi Dadgoo, Holakoo Mohsenifar, Ismail Ebrahimi Takamjani, Laleh Abadi Marand

“…Trial registration The trial was registered in the Iranian Registry of Clinical Trials with code IRCT20180916041051N3 and was approved on 23 May 2024. …”
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Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis by Huibin Yang, Ting An, Yuxuan Zhao, Xiaojing Shi, Bangmao Wang, Qingyu Zhang

“…We aim to assess the cardiovascular risks associated with JAKinibs in IBD patients.Patients and Methods Systematic searches of seven databases and ClinicalTrials.gov from inception to February 2024 were conducted. …”
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The Potential Applications of Stem Cell Conditioned Medium Secretome in Knee Cartilage Regeneration: A Systematic Review by I Gusti Ngurah Wien Aryana, Febyan Febyan, Nyoman Gede Grenata Nanda Ustriyana

“…Further research and clinical trials are needed to refine these approaches for practical application.…”
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Cell-Based Strategies for Meniscus Tissue Engineering by Wei Niu, Weimin Guo, Shufeng Han, Yun Zhu, Shuyun Liu, Quanyi Guo

“…Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. …”
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Integrated Management of Cardiovascular–Renal–Hepatic–Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs by Nikolaos Theodorakis, Maria Nikolaou

“…By synthesizing evidence from landmark clinical trials, we highlight the paradigm-shifting potential of these therapies. …”
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Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties by Roel C. Kwakernaak, Victor J. Brand, Jesús Rojo-Santiago, Femke E. Froklage, Mischa S. Hoogeman, Steven J.M. Habraken, Maaike T.W. Milder

“…The clinical impact of the achieved sparing is subject of ongoing clinical trials.…”
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Components of cognitive–behavioural therapy for mitigating core symptoms in attention-deficit hyperactivity disorder: a systematic review and network meta-analysis by Sayo Hamatani, Kazuki Matsumoto, Yoshihiko Kunisato, Yoshifumi Mizuno

“…We searched MEDLINE (via PubMed), Embase, PsycINFO, ClinicalTrials.gov and Cochrane Library for literature published up to 31 March 2022. …”
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Extracellular Vesicles Derived from Human Umbilical Mesenchymal Stem Cells Transfected with miR-7704 Improved Damaged Cartilage and Reduced Matrix Metallopeptidase 13 by Kun-Chi Wu, Hui-I Yang, Yu-Hsun Chang, Raymond Yuh-Shyan Chiang, Dah-Ching Ding

“…Further investigations should focus on optimizing dosage, understanding mechanisms, ensuring safety and efficacy, developing advanced delivery systems, and conducting early-phase clinical trials to establish the therapeutic potential of HUCMSC-derived EVs for OA management.…”
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Effectiveness of a Foam Roller Warm-Up in Professional Basketball Players: A Randomized Controlled Trial by Daniel Casado, Ivan Nacher, Juan Pardo, Javier Reina

“… # Level of Evidence 3\. Registered as a clinical trial at ClinicalTrials.gov with registration number: NCT05971316.…”
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Identification of Cognitive Training for Individuals with Parkinson’s Disease: A Systematic Review by Marina Francesca Gattoni, Silvia Gobbo, Sarah Feroldi, Anna Salvatore, Jorge Navarro, Sandro Sorbi, Francesca Lea Saibene

“…Randomised controlled trials and randomised clinical trials concerning cognitive training with cognitive outcomes in PwPD were selected. …”
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Impact of social media on triggering nonsuicidal self-injury in adolescents: a comparative ambulatory assessment study by Andreas Goreis, Dorothy Chang, Diana Klinger, Heidi-Elisabeth Zesch, Bettina Pfeffer, Sofia-Marie Oehlke, Ulrich W. Ebner-Priemer, Laurence Claes, Paul L. Plener, Oswald D. Kothgassner

“…Trial registration This study has been registered at the German Clinical Trials Register (ID: DRKS00025905, https://drks.de/search/en/trial/DRKS00025905 ).…”
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Effect of optimized food-based recommendations on nutrient intakes, hemoglobin levels, and memory performance of adolescent girls in East Java, Indonesia by Dini Suciyanti, Risatianti Kolopaking, Annasari Mustafa, Sugeng Iwan, Fiastuti Witjaksono, Umi Fahmida

“…Trial registration The study was registered on ClinicalTrials.gov (ID No: NCT03946475).…”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is notably resistant to conventional chemotherapy and radiation treatment. However, clinical trials indicate that carbon ion radiotherapy (CIRT) with concurrent gemcitabine is effective for unresectable locally advanced PDAC. …”
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PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…These inhibitors have been validated in multiple clinical trials, underscoring their robustness and effectiveness. …”
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Alzheimer’s Disease and Cardiovascular Disease: A Particular Association by Giacomo Tini, Riccardo Scagliola, Fiammetta Monacelli, Giovanni La Malfa, Italo Porto, Claudio Brunelli, Gian Marco Rosa

“…This review is based on the material obtained via MEDLINE (PubMed), EMBASE, and Clinical Trials databases, from January 1980 until May 2019. …”
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NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…The drug is not registered in Russia yet, its approval in combination to asunaprevir is expected soon.Conclusion. Clinical trials have demonstrated that combination of daclatasvir with other medications possessing direct antiviral action, in particular with asunaprevir, and with pegilated interferon and ribavirin significantly increases treatment response rate at different categories of patients with chronic HCV-infection; that allows to reduce treatment duration of these patientsgroups. …”
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Avelumab + axitinib treatment in older patients with advanced renal cell carcinoma in Japan: Subgroup analyses of post‐marketing surveillance data by age by Mototsugu Oya, Taito Ito, Masashi Sato, Makiko Morita, Masahiro Kajita, Norio Nonomura

“…The favorable benefit–risk profile was generally consistent with that observed in previous clinical trials.…”
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Variation in clinical and patient‐reported outcomes among complex heart failure with preserved ejection fraction phenotypes by Kelsey M. Flint, Sanjiv J. Shah, Eldrin F. Lewis, David P. Kao

“…These differences may inform the design of targeted clinical trials focusing on improvement in outcomes most relevant for specific HFpEF phenotypes.…”
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Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review by Harinivaas Shanmugavel Geetha, Yi Xiang Teo, Sharmitha Ravichandran, Amos Lal

“…The controversy surrounding prophylactic antibiotics persists, but promising new strategies have been proposed; however, they are still awaiting well-designed clinical trials.…”
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