Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) tri... by Hina Raheel, Sheela Sinharoy, Anaité Diaz-Artiga, Sarada S. Garg, Ajay Pillarisetti, Kalpana Balakrishnan, Marilu Chiang, Amy Lovvorn, Miles Kirby, Usha Ramakrishnan, Shirin Jabbarzadeh, Alexie Mukeshimana, Michael Johnson, John P. McCracken, Luke P. Naeher, Ghislaine Rosa, Jiantong Wang, Joshua Rosenthal, William Checkley, Thomas F. Clasen, Jennifer L. Peel, Lisa M. Thompson

“…Birth length-for-gestational age was only associated with BC.Clinical Trial Registration: The study has been registered with ClinicalTrials.gov (Identifier NCT02944682).…”
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Evaluating the efficacy of multi-incision and tube-dragging therapy combined with laser closure for high horseshoe-shaped anal fistula: Protocol of a prospective, randomized, contr... by Min Yang, Zubing Mei, Qingming Wang, Ye Han, De Zheng

“…Consequently, obtaining more definitive and authoritative evidence through scientifically rigorous clinical trials is of utmost importance in further validating this treatment approach.…”
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Integrated chronic care models for people with comorbid of HIV and non-communicable diseases in Sub-Saharan Africa: A scoping review. by Rumbidzai Chireshe, Tawanda Manyangadze, Keshena Naidoo

“…Data on some short-term benefits of integrated care was available, but evidence was absent on the long-term outcomes. Randomized clinical trials with clearly defined comparator groups and standardized measures of HIV and NCD outcomes are needed to demonstrate non-inferiority of integrated against non-integrated care.…”
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Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients by Loren Masterson, Bryan J. Thibodeau, Laura E. Fortier, Timothy J. Geddes, Barbara L. Pruetz, Rajwant Malhotra, Richard Keidan, George D. Wilson

“…Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical. This study aimed to identify biomarkers with prognostic significance. …”
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Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis by Zhen Cao, Zhiming Deng, Jieyi Lu, Ying Yuan

“…Methods Articles published before April 5, 2024 were searched across four databases: PubMed, Web of Science, Embase, and Cochrane Library, and studies exploring the association of FGF21 levels and GDM or PE were collected. Additionally, ClinicalTrials.gov was also searched for completed and ongoing trials. …”
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Effect of pocket compression device on pocket hematoma after cardiac implantable electronic device implantation by Narawudt Prasertwitayakij, Jakkapun Yanyongmathe, Natnicha Pongbangli, Teerapat Nantsupawat, Siriluck Gunaparn, Cheeranun Pisespongsa, Chanya Tawaditap, Arintaya Phrommintikul, Wanwarang Wongcharoen

“…Trial registration number: The study was registered in the Thai Clinical Trials Registry (TCTR) at https://www.thaiclinicaltrials.org/ , with the identification number TCTR20230913005, date of first trial registration 13/09/2023.…”
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Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling by Thomas M.B. Ware, Adilson Fonseca Teixeira, Josephine Iaria, Rodney B. Luwor, Hong-Jian Zhu

“…This is despite the large number of clinical trials that have attempted to replicate the success of therapeutics developed for other cancer types. …”
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Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening by Jungan Zhang, Yixin Ren, Yixin Ren, Yun Teng, Han Wu, Jingsu Xue, Lulu Chen, Xiaoyue Song, Yan Li, Ying Zhou, Zongran Pang, Zongran Pang, Hao Wang, Hao Wang, Hao Wang

“…Although extensive research has been conducted on PRMT1, the reported inhibitors have not successfully passed clinical trials. In this study, deep learning was employed to analyze the characteristics of existing PRMTs inhibitors and to construct a classification model for PRMT1 inhibitors. …”
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Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment by Julie Vinkel, Alfonso Buil, Ole Hyldegaard

“…Trial registration Biological material was collected during the INFECT study, registered at ClinicalTrials.gov (NCT01790698) 04/02/2013.…”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Materials and Methods: The study utilized a comprehensive approach, combining literature reviews, clinical trials, experimental studies, and microbiota analyses to investigate zinc's role in immune function, infection management, and antimicrobial resistance. …”
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Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease by Edoardo Abed, Giorgio Placidi, Luigi Calandriello, Marco Piccardi, Francesca Campagna, Matteo Bertelli, Angelo Maria Minnella, Maria Cristina Savastano, Benedetto Falsini

“…A precise assessment of macular cone function by FERG recording may be useful to monitor the progression of STGD1 and to select the optimal candidates to include in future clinical trials to treat this disease.…”
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The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases by Xueyan Zhang, Yihan Yu, Hanyu Lei, Yufeng Cai, Jie Shen, Ping Zhu, Qingnan He, Mingyi Zhao

“…Research has demonstrated the clinical application of Nrf2/HO-1 in pediatric cardiovascular disease; further clinical trials will help elucidate the potential of the Nrf2/HO-1 signaling axis.…”
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Development and validation of a high-throughput qPCR platform for the detection of soil-transmitted helminth infections. by Nils Pilotte, Victor Omballa, Monica Voss, Leah Padgett, Malathi Manuel, Jeanne L Goodman, Tim Littlewood, Zayina Zondervenni Manoharan, Lisette van Lieshout, Jaco J Verweij, Manigandan Sekar, Ajith Kumar Muthukumar, Gretchen Walch, Abriana Warren, Mariyam Sheikh, Andrew Gonzalez, Sean R Galagan, Sitara Swarna Rao Ajjampur, Moudachirou Ibikounlé, Steven A Williams, Doug Rains, Ushashi Dadwal, Judd L Walson

“…Testing the feasibility of such an approach requires large-scale clinical trials, such as the DeWorm3 cluster randomized trial. …”
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Noninvasive high-frequency oscillation ventilation as post- extubation respiratory support in neonates: Systematic review and meta-analysis. by Rameshwar Prasad, Bijan Saha, Md Habibullah Sk, Jagdish Prasad Sahoo, Bhupendra Kumar Gupta, Subhash Chandra Shaw

“…Data sources were MEDLINE (via Pubmed), Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, WHO international clinical trials registry platform and Clinical Trial Registry, forward and backward citation search. …”
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Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Minyi Chen, Runkai Hu, Weichao Han, Shaobo Ding

“…We conducted a systematic literature search including Embase, PubMed, ClinicalTrials.gov, Cochrane Controlled Trials Register databases, Chinese Clinical Trial Registry, and Web of Science from building database to February 2020. …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…This new strategy may be a promising treatment for SCLC but needs to be confirmed in future clinical trials.…”
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Investigating the Efficacy of an Individualized Alpha/Delta Neurofeedback Protocol in the Treatment of Chronic Tinnitus by Dominik Güntensperger, Christian Thüring, Tobias Kleinjung, Patrick Neff, Martin Meyer

“…In sum, this study confirms the alpha/delta neurofeedback as a suitable option for the treatment of chronic tinnitus and represents a first step towards the development of individual neurofeedback protocols. This clinical trial was registered online at ClinicalTrials.gov (NCT02383147) and kofam.ch (SNCTP000001313).…”
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Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates by Panagiotis N. Lalagkas, Rachel D. Melamed

“…Some drugs for other conditions, such as metformin, an antidiabetic, have been tested in clinical trials for repurposing for breast cancer. Here, we exploit the genetics of breast cancer and linked predisposing diseases to propose novel drug repurposing opportunities. …”
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Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice by Menglin Chen, Hong Yao, Huizi Tan, Wenqi Huang, Quanyong Wu, Shaoping Nie

“…However, differences between human and animal microbiota may confound the data reproducibility from rodent experiments to clinical trials. In this study, the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis were investigated using mice colonized with either native or humanised microbiota. …”
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Rapid Improvement in Neck Disability, Mobility, and Sleep Quality with Chronic Neck Pain Treated by Fu’s Subcutaneous Needling: A Randomized Control Study by Ching-Hsuan Huang, Lung-Hung Tsai, Mao-Feng Sun, Zhonghua Fu, Jian Sun, Li-Wei Chou

“…These findings demonstrated that FSN could be an effective alternative treatment option for patients with chronic neck pain. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT03605576, registered on July 30, 2018.…”
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